CN102149379A - 调节肝细胞生长因子(分散因子)活性的方法和肝细胞生长因子(分散因子)活性的小分子调节剂组合物 - Google Patents

调节肝细胞生长因子(分散因子)活性的方法和肝细胞生长因子(分散因子)活性的小分子调节剂组合物 Download PDF

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CN102149379A
CN102149379A CN2009801353421A CN200980135342A CN102149379A CN 102149379 A CN102149379 A CN 102149379A CN 2009801353421 A CN2009801353421 A CN 2009801353421A CN 200980135342 A CN200980135342 A CN 200980135342A CN 102149379 A CN102149379 A CN 102149379A
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alkoxy
aryl
independently selected
halogen
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蔡伟忠
普拉卡什·纳拉扬
比乔伊·帕尼克
戴维·E·史密斯
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Elicio Therapeutics Inc
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Angion Biomedica Corp
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CN2009801353421A 2008-07-10 2009-07-09 调节肝细胞生长因子(分散因子)活性的方法和肝细胞生长因子(分散因子)活性的小分子调节剂组合物 Pending CN102149379A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13448508P 2008-07-10 2008-07-10
US61/134,485 2008-07-10
PCT/US2009/004014 WO2010005580A2 (en) 2008-07-10 2009-07-09 Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity

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CN102149379A true CN102149379A (zh) 2011-08-10

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CN2009801353421A Pending CN102149379A (zh) 2008-07-10 2009-07-09 调节肝细胞生长因子(分散因子)活性的方法和肝细胞生长因子(分散因子)活性的小分子调节剂组合物

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US (4) US8772326B2 (https=)
EP (1) EP2313093A4 (https=)
JP (2) JP5775452B2 (https=)
CN (1) CN102149379A (https=)
CA (1) CA2767331A1 (https=)
IL (1) IL210544A (https=)
WO (1) WO2010005580A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114026085A (zh) * 2019-04-11 2022-02-08 安吉昂生物医药公司 (e)-3-[2-(2-噻吩基)乙烯基]-1h-吡唑的固体形式
CN119504599A (zh) * 2024-11-18 2025-02-25 安徽医科大学 一种用于治疗肾脏纤维化的吡唑类化合物及其应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5775452B2 (ja) 2008-07-10 2015-09-09 アンジオン バイオメディカ コーポレイション 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法
CN102802969A (zh) 2009-06-12 2012-11-28 住友橡胶工业株式会社 车辆
JP6155187B2 (ja) 2010-03-30 2017-06-28 ヴァーセオン コーポレイション トロンビンの阻害剤としての多置換芳香族化合物
JP2014509297A (ja) * 2010-10-05 2014-04-17 アンジオン バイオメディカ コーポレイション 肝細胞増殖因子（散乱因子）活性の小分子モジュレーターの使用方法
HK1214252A1 (zh) 2013-03-15 2016-07-22 Verseon Corporation 作為凝血酶抑制劑的鹵代吡唑
CN110179795A (zh) 2013-03-15 2019-08-30 维颂公司 作为丝氨酸蛋白酶抑制剂的多取代芳族化合物的制药用途
US10189810B2 (en) 2014-09-17 2019-01-29 Verseon Corporation Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
CN107405333A (zh) 2015-02-27 2017-11-28 维颂公司 作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物
JP6830158B2 (ja) * 2016-12-22 2021-02-17 諾貝兒寶貝股▲ふん▼有限公司Ｎｏｒｂｅｌ Ｂａｂｙ Ｃｏ．， Ｌｔｄ． 肝損傷を予防または治療する医薬組成物の調製における（２ｒ，４ｒ）−１，２，４−トリヒドロキシヘプタデカ−１６−インの応用
EP4051271A4 (en) * 2019-10-31 2023-11-29 Angion Biomedica Corp. IMPROVEMENT IN KIDNEY FUNCTION AFTER KIDNEY TRANSPLANT

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1747730A (zh) * 2002-12-21 2006-03-15 安吉翁生物医药有限公司 肝细胞生长因子(分散因子)活性的吡唑衍生物调节剂

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE138770C (https=)
JPS48713Y1 (https=) 1967-12-19 1973-01-09
DD138770A1 (de) 1978-09-20 1979-11-21 Juergen Liebscher Verfahren zur herstellung von 5-styryl-pyrazolen und ihren vinylogen
US4806535A (en) 1987-07-22 1989-02-21 Rorer Pharmaceutical Corporation Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds and their use for increasing cardiatonic contractility
JPH02193994A (ja) 1989-01-23 1990-07-31 Kyowa Hakko Kogyo Co Ltd ピリダジノン誘導体
US6566098B1 (en) 1990-09-14 2003-05-20 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding truncated hepatocyte growth factor variants
JP3680114B2 (ja) 1993-09-17 2005-08-10 敏一 中村 脳神経障害治療剤
US5837676A (en) 1993-10-18 1998-11-17 Long Island Jewish Medical Center Use of scatter factor to enhance angiogenesis
US6498144B1 (en) 1993-10-18 2002-12-24 North Shore - Long Island Jewish Research Institute Use of scatter factor to enhance angiogenesis
JP3818322B2 (ja) 1994-04-28 2006-09-06 敏一 中村 コラーゲン分解促進剤
KR100765687B1 (ko) 1995-08-29 2007-10-11 안제스에무지 가부시키가이샤 Ｈｇｆ 유전자를 함유하는 약제
US5830879A (en) 1995-10-02 1998-11-03 St. Elizabeth's Medical Center Of Boston, Inc. Treatment of vascular injury using vascular endothelial growth factor
JPH11288112A (ja) 1998-04-06 1999-10-19 Mitsubishi Paper Mills Ltd 電子写真感光体
US6677333B1 (en) 1999-01-26 2004-01-13 Ono Pharmaceutical Co., Ltd. 2H-phthalazin-1-one derivatives and drug containing its derivatives as active ingredient
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
US6437006B1 (en) * 1999-09-27 2002-08-20 American Cyanamid Company Pharmaceutical carrier formulation
US7459536B1 (en) 1999-11-09 2008-12-02 The United States Of America As Represented By The Secretary, Department Of Health And Human Services HGF-SF monoclonal antibody combinations
EP2206720A1 (en) 2000-04-12 2010-07-14 Human Genome Sciences, Inc. Albumin fusion proteins
EP1355921A2 (en) 2000-06-29 2003-10-29 North Shore-Long Island Jewish Health System Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof
DE10047486A1 (de) * 2000-09-26 2002-04-11 Bayer Ag Phenoxyphenyl Alkansulfonate
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US6610726B2 (en) 2001-06-29 2003-08-26 North Shore-Long Island Jewish Research Institute Compositions and agents for modulating cellular proliferation and angiogenesis
US6589997B2 (en) * 2001-06-29 2003-07-08 North Shore-Long Island Jewish Health System Small-molecule modulators of hepatocyte growth factor/scatter factor activities
US20030073692A1 (en) 2001-08-07 2003-04-17 Pharmacia & Upjohn S.P.A. Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
CA2662899A1 (en) 2002-02-22 2003-09-04 Schering Corporation Pharmaceutical formulations of antineoplastic agents, in particular temozolomide, processes of making and using the same
AU2002313690A1 (en) 2002-07-19 2004-02-09 Targacept, Inc. Five-membered heteroaromatic olefinic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of ncotinic cholinergic receptors
FR2868519B1 (fr) * 2004-03-30 2006-06-16 Christian Muller Generateur thermique a materiau magneto-calorique et procede de generation de thermies
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
EP1799651A2 (en) 2004-09-28 2007-06-27 Angion Biomedica Corp. Small molecule modulators of cytokine activity
US20110230407A1 (en) 2005-03-14 2011-09-22 Alexander Yuzhakov Hepatocyte growth factor pathway activators in demyelinating diseases and central nervous system trauma
US7879898B1 (en) 2006-02-14 2011-02-01 Angion Biomedica Corp. Hepatocyte growth factor pathway activators in chronic obstructive pulmonary disease
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
US8193177B2 (en) 2007-11-13 2012-06-05 Angion Biomedica Corp. Hepatocyte growth factor pathway activators in fibrotic connective tissue diseases
JP5775452B2 (ja) 2008-07-10 2015-09-09 アンジオン バイオメディカ コーポレイション 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法
US20110098304A1 (en) 2008-10-22 2011-04-28 Bijoy Panicker Small molecule inhibitors of PARP activity
WO2011019400A2 (en) 2009-08-12 2011-02-17 Angion Biomedica Corp. Enhancement of cellular transplantation using small molecule modulators hepatocyte growth factor (scatter factor) activity
JP2014509297A (ja) 2010-10-05 2014-04-17 アンジオン バイオメディカ コーポレイション 肝細胞増殖因子（散乱因子）活性の小分子モジュレーターの使用方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1747730A (zh) * 2002-12-21 2006-03-15 安吉翁生物医药有限公司 肝细胞生长因子(分散因子)活性的吡唑衍生物调节剂

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114026085A (zh) * 2019-04-11 2022-02-08 安吉昂生物医药公司 (e)-3-[2-(2-噻吩基)乙烯基]-1h-吡唑的固体形式
CN119504599A (zh) * 2024-11-18 2025-02-25 安徽医科大学 一种用于治疗肾脏纤维化的吡唑类化合物及其应用
CN119504599B (zh) * 2024-11-18 2025-09-26 安徽医科大学 一种用于治疗肾脏纤维化的吡唑类化合物及其应用

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