JP2011526898A5 - - Google Patents
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- Publication number
- JP2011526898A5 JP2011526898A5 JP2011516438A JP2011516438A JP2011526898A5 JP 2011526898 A5 JP2011526898 A5 JP 2011526898A5 JP 2011516438 A JP2011516438 A JP 2011516438A JP 2011516438 A JP2011516438 A JP 2011516438A JP 2011526898 A5 JP2011526898 A5 JP 2011526898A5
- Authority
- JP
- Japan
- Prior art keywords
- particles
- particle
- opioid receptor
- receptor antagonist
- additive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 44
- 239000000654 additive Substances 0.000 claims 12
- 229940079358 peripheral opioid receptor antagonist Drugs 0.000 claims 10
- 230000000996 additive effect Effects 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000002378 acidificating effect Effects 0.000 claims 4
- 239000002702 enteric coating Substances 0.000 claims 4
- 238000009505 enteric coating Methods 0.000 claims 4
- 208000003243 intestinal obstruction Diseases 0.000 claims 4
- 230000007935 neutral effect Effects 0.000 claims 4
- 229940123257 Opioid receptor antagonist Drugs 0.000 claims 3
- 239000007900 aqueous suspension Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000003401 opiate antagonist Substances 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- JVLBPIPGETUEET-WIXLDOGYSA-O (3r,4r,4as,7ar,12bs)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one Chemical group C([N@+]1(C)[C@@H]2CC=3C4=C(C(=CC=3)O)O[C@@H]3[C@]4([C@@]2(O)CCC3=O)CC1)C1CC1 JVLBPIPGETUEET-WIXLDOGYSA-O 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- 206010010774 Constipation Diseases 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229960002921 methylnaltrexone Drugs 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- PCSQOABIHJXZMR-MGQKVWQSSA-O (4r,4as,7ar,12bs)-4a,9-dihydroxy-3-methyl-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CC[N+](C)(CC=C)[C@@H]3CC5=CC=C4O PCSQOABIHJXZMR-MGQKVWQSSA-O 0.000 claims 1
- HJDWPCLBBHHTIG-NNJWZEOZSA-O (4r,7s,7ar,12bs)-3-methyl-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7,9-diol Chemical compound O([C@H]1[C@H](C=CC23)O)C4=C5[C@@]12CC[N+](C)(CC=C)[C@@H]3CC5=CC=C4O HJDWPCLBBHHTIG-NNJWZEOZSA-O 0.000 claims 1
- 206010004663 Biliary colic Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010011953 Decreased activity Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 206010021518 Impaired gastric emptying Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000003840 Opioid Receptors Human genes 0.000 claims 1
- 108090000137 Opioid Receptors Proteins 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 229920000388 Polyphosphate Polymers 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 241000270666 Testudines Species 0.000 claims 1
- 206010046555 Urinary retention Diseases 0.000 claims 1
- 208000024248 Vascular System injury Diseases 0.000 claims 1
- 208000012339 Vascular injury Diseases 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000030136 gastric emptying Effects 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 230000005176 gastrointestinal motility Effects 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical group C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 claims 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical group O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 230000001769 paralizing effect Effects 0.000 claims 1
- 239000011236 particulate material Substances 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000001205 polyphosphate Substances 0.000 claims 1
- 235000011176 polyphosphates Nutrition 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 150000003839 salts Chemical group 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 235000019832 sodium triphosphate Nutrition 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 230000035900 sweating Effects 0.000 claims 1
- AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 claims 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7724208P | 2008-07-01 | 2008-07-01 | |
| US61/077,242 | 2008-07-01 | ||
| PCT/US2009/047372 WO2010002576A1 (en) | 2008-07-01 | 2009-06-15 | Particles containing an opioid receptor antagonist and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014247340A Division JP2015091825A (ja) | 2008-07-01 | 2014-12-05 | オピオイド受容体アンタゴニスト含有の粒子および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011526898A JP2011526898A (ja) | 2011-10-20 |
| JP2011526898A5 true JP2011526898A5 (enExample) | 2012-08-02 |
| JP5985824B2 JP5985824B2 (ja) | 2016-09-06 |
Family
ID=41466277
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516438A Active JP5985824B2 (ja) | 2008-07-01 | 2009-06-15 | オピオイド受容体アンタゴニスト含有の粒子および使用方法 |
| JP2014247340A Pending JP2015091825A (ja) | 2008-07-01 | 2014-12-05 | オピオイド受容体アンタゴニスト含有の粒子および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014247340A Pending JP2015091825A (ja) | 2008-07-01 | 2014-12-05 | オピオイド受容体アンタゴニスト含有の粒子および使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20110250278A1 (enExample) |
| EP (1) | EP2306829B1 (enExample) |
| JP (2) | JP5985824B2 (enExample) |
| AU (1) | AU2009265034B2 (enExample) |
| CA (1) | CA2729582C (enExample) |
| ES (1) | ES2620373T3 (enExample) |
| WO (1) | WO2010002576A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011109340A1 (en) | 2010-03-01 | 2011-09-09 | Nova Southeastern University | Epinephrine nanop articles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| WO2014007972A2 (en) | 2012-06-15 | 2014-01-09 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinphrine |
| US20160045457A1 (en) | 2005-09-09 | 2016-02-18 | Ousama Rachid | Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| CA2853084C (en) | 2011-10-21 | 2022-04-26 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| EP3326585B1 (en) | 2012-01-31 | 2019-06-19 | Mitral Valve Technologies Sàrl | Mitral valve docking devices and systems |
| CA2872400A1 (en) * | 2012-05-04 | 2013-11-07 | University Of Chicago | Bioavailability of oral methylnaltrexone increases with a phosphatidylcholine-based formulation |
| US10485798B2 (en) | 2012-08-22 | 2019-11-26 | Aptapharma Inc. | Methylnaltrexone nasal formulations, methods of making, and use thereof |
| ES2882530T3 (es) | 2013-03-22 | 2021-12-02 | Univ Nova Southeastern | Partículas finas de epinefrina y métodos para uso de las mismas para el tratamiento de condiciones que responden a la epinefrina |
| CN104274414B (zh) * | 2013-07-02 | 2018-03-09 | 天津康鸿医药科技发展有限公司 | 一种甲基纳曲酮复合物、口服片剂及其制备方法 |
| WO2016004290A1 (en) * | 2014-07-03 | 2016-01-07 | Bind Therapeutics, Inc. | Targeted therapeutic nanoparticles and methods of making and using same |
| JP2021512924A (ja) * | 2018-02-08 | 2021-05-20 | タイワンジェ ファーマシューティカルズ カンパニー リミテッドＴａｉｗａｎｊ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． | オピオイド受容体拮抗薬の固体剤形の医薬製剤 |
| WO2019169108A1 (en) * | 2018-02-28 | 2019-09-06 | Celista Pharmaceuticals Llc | Oxycodone and methylnaltrexone multi-particulates and suspensions containing them |
| WO2020081952A1 (en) | 2018-10-19 | 2020-04-23 | Nova Southeastern University | Sublingual epinephrine compositions including ph-modifying excipients and penetration enhancers and methods for use thereof |
| WO2021222545A1 (en) * | 2020-04-29 | 2021-11-04 | The Texas A&M University System | Naloxone nanoparticle compositions and methods thereof |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1420015B1 (de) | 1959-10-16 | 1971-08-26 | Boehringer Sohn Ingelheim | 2'-Hydroxy-5,9-dimethyl-6,7-benzomorphane |
| US4176186A (en) | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| US4311833A (en) | 1979-03-06 | 1982-01-19 | Daicel Chemical Industries Ltd. | Process for preparing ethylcarboxymethylcellulose |
| US4377568A (en) | 1981-08-12 | 1983-03-22 | Merck Sharp & Dohme (I.A.) Corp. | Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same |
| DK150008C (da) | 1981-11-20 | 1987-05-25 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat |
| US4457907A (en) | 1982-08-05 | 1984-07-03 | Clear Lake Development Group | Composition and method for protecting a therapeutic drug |
| US4518433A (en) | 1982-11-08 | 1985-05-21 | Fmc Corporation | Enteric coating for pharmaceutical dosage forms |
| US4462839A (en) | 1983-06-16 | 1984-07-31 | Fmc Corporation | Enteric coating for pharmaceutical dosage forms |
| US4556552A (en) | 1983-09-19 | 1985-12-03 | Colorcon, Inc. | Enteric film-coating compositions |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
| JPS6229515A (ja) | 1985-07-30 | 1987-02-07 | Shinjiro Tsuji | 硬カプセル剤のフイルムコ−テイング方法 |
| US4719215A (en) | 1986-03-07 | 1988-01-12 | University Of Chicago | Quaternary derivatives of noroxymorphone which relieve nausea and emesis |
| US4861781A (en) | 1986-03-07 | 1989-08-29 | The University Of Chicago | Quaternary derivatives of noroxymorphone which relieve nausea and emesis |
| US5597564A (en) | 1986-08-28 | 1997-01-28 | Enzacor Properties Limited | Method of administering a microgranular preparation to the intestinal region of animals |
| DE3777658D1 (de) | 1986-08-28 | 1992-04-23 | Enzacor Pty Ltd | Tierwachstumserreger. |
| US5102887A (en) | 1989-02-17 | 1992-04-07 | Arch Development Corporation | Method for reducing emesis and nausea induced by the administration of an emesis causing agent |
| US5270328A (en) | 1991-03-29 | 1993-12-14 | Eli Lilly And Company | Peripherally selective piperidine opioid antagonists |
| CA2110899C (en) | 1991-06-21 | 2006-08-08 | Jacob G. Michael | Orally administrable therapeutic proteins and method of making |
| AU4198793A (en) * | 1992-07-24 | 1994-01-27 | Takeda Chemical Industries Ltd. | Microparticle preparation and production thereof |
| AU5171293A (en) * | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
| SG52402A1 (en) | 1992-12-22 | 1998-09-28 | Univ Cincinnati | Oral administration of immunologically active biomolecules and other therapeutic proteins |
| US5536507A (en) | 1994-06-24 | 1996-07-16 | Bristol-Myers Squibb Company | Colonic drug delivery system |
| US5614222A (en) | 1994-10-25 | 1997-03-25 | Kaplan; Milton R. | Stable aqueous drug suspensions and methods for preparation thereof |
| ES2094694B1 (es) | 1995-02-01 | 1997-12-16 | Esteve Quimica Sa | Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. |
| ES2114502B1 (es) * | 1996-07-29 | 1999-07-01 | Univ Santiago Compostela | Aplicacion de nanoparticulas a base de polimeros hidrofilicos como formas farmaceuticas. |
| AU4414497A (en) | 1996-09-13 | 1998-04-02 | University Technology Corporation | Biocompatible cationic detergents and uses therefor |
| DE19651551C2 (de) * | 1996-12-11 | 2000-02-03 | Klinge Co Chem Pharm Fab | Opioidantagonisthaltige galenische Formulierung |
| US6274591B1 (en) | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
| US5972954A (en) | 1997-11-03 | 1999-10-26 | Arch Development Corporation | Use of methylnaltrexone and related compounds |
| US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
| ES2226886T3 (es) * | 1999-08-31 | 2005-04-01 | Grunenthal Gmbh | Forma de administracion de accion retardada que contiene sacarinato de tramadol. |
| US6451806B2 (en) | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
| US6469030B2 (en) | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
| EP1284736A2 (en) * | 2000-05-05 | 2003-02-26 | Pain Therapeutics, Inc. | Opioid antagonist compositions and dosage forms |
| EP1404323B1 (en) | 2001-06-05 | 2009-10-28 | The University of Chicago | Use of methylnaltrexone to treat immune suppression |
| US7056500B2 (en) | 2001-10-18 | 2006-06-06 | Nektar Therapeutics Al, Corporation | Polymer conjugates of opioid antagonists |
| AU2003220290B2 (en) * | 2002-03-14 | 2007-06-14 | Euro-Celtique S.A. | Naltrexone hydrochloride compositions |
| BRPI0409128A (pt) * | 2003-04-08 | 2006-03-28 | Progenics Pharm Inc | uso de antagonistas de opióides periféricos, especialmente metilnaltrexona para tratar sìndrome de intestino irritável |
| AU2004229464A1 (en) * | 2003-04-08 | 2004-10-28 | Progenics Pharmaceuticals, Inc. | Combination therapy for constipation comprising a laxative and a peripheral opioid antagonist |
| SI2368553T1 (sl) * | 2003-04-08 | 2015-05-29 | Progenics Pharmaceuticals, Inc. | Farmacevtske formulacije, vsebujoče metilnatrekson |
| EP1620078A2 (en) * | 2003-05-02 | 2006-02-01 | The Board Of Trustees Of The University Of Illinois | Biodegradable nanoparticles comprising an aminoglycoside and a polymer like a polysaccharide |
| CN101171010B (zh) | 2005-03-07 | 2014-09-17 | 芝加哥大学 | 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途 |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| CA2609985A1 (en) | 2005-06-03 | 2007-05-10 | The University Of Chicago | Modulation of cell barrier dysfunction |
| PL116330U1 (en) * | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
| CA2671200A1 (en) * | 2006-07-21 | 2008-01-24 | Lab International Srl | Hydrophilic abuse deterrent delivery system |
| TW200815451A (en) | 2006-08-04 | 2008-04-01 | Wyeth Corp | 6-carboxy-normorphinan derivatives, synthesis and uses thereof |
| US20080113030A1 (en) | 2006-11-09 | 2008-05-15 | Ching-Fen Hsiao | Sustained release tamsulosin formulations |
-
2009
- 2009-06-15 CA CA2729582A patent/CA2729582C/en active Active
- 2009-06-15 AU AU2009265034A patent/AU2009265034B2/en active Active
- 2009-06-15 US US13/001,146 patent/US20110250278A1/en not_active Abandoned
- 2009-06-15 JP JP2011516438A patent/JP5985824B2/ja active Active
- 2009-06-15 ES ES09774028.6T patent/ES2620373T3/es active Active
- 2009-06-15 EP EP09774028.6A patent/EP2306829B1/en active Active
- 2009-06-15 WO PCT/US2009/047372 patent/WO2010002576A1/en not_active Ceased
-
2014
- 2014-12-05 JP JP2014247340A patent/JP2015091825A/ja active Pending
-
2017
- 2017-12-07 US US15/835,181 patent/US10507188B2/en active Active
-
2019
- 2019-12-04 US US16/703,081 patent/US20200101026A1/en not_active Abandoned
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