JP2015091825A5 - - Google Patents

Info

Publication number

JP2015091825A5

JP2015091825A5 JP2014247340A JP2014247340A JP2015091825A5 JP 2015091825 A5 JP2015091825 A5 JP 2015091825A5 JP 2014247340 A JP2014247340 A JP 2014247340A JP 2014247340 A JP2014247340 A JP 2014247340A JP 2015091825 A5 JP2015091825 A5 JP 2015091825A5

Authority

JP

Japan

Prior art keywords

particle

particles

receptor antagonist

opioid receptor

hydrophilic additive

Prior art date

2014-12-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000002245 particle Substances 0.000 claims 35
• 239000000654 additive Substances 0.000 claims 10
• 230000000996 additive effect Effects 0.000 claims 9
• 229940123257 Opioid receptor antagonist Drugs 0.000 claims 6
• 239000003401 opiate antagonist Substances 0.000 claims 6
• 235000019832 sodium triphosphate Nutrition 0.000 claims 4
• UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 claims 4
• 229920001661 Chitosan Polymers 0.000 claims 3
• 230000002378 acidificating effect Effects 0.000 claims 3
• 239000003795 chemical substances by application Substances 0.000 claims 3
• 239000002702 enteric coating Substances 0.000 claims 3
• 238000009505 enteric coating Methods 0.000 claims 3
• 230000007935 neutral effect Effects 0.000 claims 3
• 229940079358 peripheral opioid receptor antagonist Drugs 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 229920000642 polymer Polymers 0.000 claims 3
• 229920003134 Eudragit® polymer Polymers 0.000 claims 2
• VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 2
• 150000002772 monosaccharides Chemical class 0.000 claims 2
• JVLBPIPGETUEET-WIXLDOGYSA-O (3r,4r,4as,7ar,12bs)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one Chemical group C([N@+]1(C)[C@@H]2CC=3C4=C(C(=CC=3)O)O[C@@H]3[C@]4([C@@]2(O)CCC3=O)CC1)C1CC1 JVLBPIPGETUEET-WIXLDOGYSA-O 0.000 claims 1
• PCSQOABIHJXZMR-MGQKVWQSSA-O (4r,4as,7ar,12bs)-4a,9-dihydroxy-3-methyl-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CC[N+](C)(CC=C)[C@@H]3CC5=CC=C4O PCSQOABIHJXZMR-MGQKVWQSSA-O 0.000 claims 1
• HJDWPCLBBHHTIG-NNJWZEOZSA-O (4r,7s,7ar,12bs)-3-methyl-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7,9-diol Chemical compound O([C@H]1[C@H](C=CC23)O)C4=C5[C@@]12CC[N+](C)(CC=C)[C@@H]3CC5=CC=C4O HJDWPCLBBHHTIG-NNJWZEOZSA-O 0.000 claims 1
• 229920000388 Polyphosphate Polymers 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• JVLBPIPGETUEET-GAAHOAFPSA-O methylnaltrexone Chemical compound C[N+]1([C@@H]2CC=3C4=C(C(=CC=3)O)O[C@@H]3[C@]4([C@@]2(O)CCC3=O)CC1)CC1CC1 JVLBPIPGETUEET-GAAHOAFPSA-O 0.000 claims 1
• 229960002921 methylnaltrexone Drugs 0.000 claims 1
• INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical group C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 claims 1
• BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical group O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 1
• 239000001205 polyphosphate Substances 0.000 claims 1
• 235000011176 polyphosphates Nutrition 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 150000003839 salts Chemical group 0.000 claims 1