JP2011526892A5 - - Google Patents
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- JP2011526892A5 JP2011526892A5 JP2011516339A JP2011516339A JP2011526892A5 JP 2011526892 A5 JP2011526892 A5 JP 2011526892A5 JP 2011516339 A JP2011516339 A JP 2011516339A JP 2011516339 A JP2011516339 A JP 2011516339A JP 2011526892 A5 JP2011526892 A5 JP 2011526892A5
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- Prior art keywords
- pharmaceutical composition
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- growth factor
- vascular endothelial
- endothelial growth
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 17
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 15
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 230000011664 signaling Effects 0.000 claims 6
- 108091008605 VEGF receptors Proteins 0.000 claims 5
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 5
- 230000033115 angiogenesis Effects 0.000 claims 5
- 230000001413 cellular effect Effects 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 229940124676 vascular endothelial growth factor receptor Drugs 0.000 claims 5
- 238000002648 combination therapy Methods 0.000 claims 4
- 208000030533 eye disease Diseases 0.000 claims 4
- 208000002780 macular degeneration Diseases 0.000 claims 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 4
- 102000016878 Hypoxia-Inducible Factor 1 Human genes 0.000 claims 3
- 108010028501 Hypoxia-Inducible Factor 1 Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 2
- 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 claims 2
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010029113 Neovascularisation Diseases 0.000 claims 2
- 206010038848 Retinal detachment Diseases 0.000 claims 2
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims 2
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims 2
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims 2
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000004264 retinal detachment Effects 0.000 claims 2
- 230000019491 signal transduction Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- JLTPSDHKZGWXTD-UHFFFAOYSA-N 2-[6-(dicyanomethylidene)naphthalen-2-ylidene]propanedinitrile Chemical compound N#CC(C#N)=C1C=CC2=CC(=C(C#N)C#N)C=CC2=C1 JLTPSDHKZGWXTD-UHFFFAOYSA-N 0.000 claims 1
- 206010000050 Abdominal adhesions Diseases 0.000 claims 1
- 102100025683 Alkaline phosphatase, tissue-nonspecific isozyme Human genes 0.000 claims 1
- 101710161969 Alkaline phosphatase, tissue-nonspecific isozyme Proteins 0.000 claims 1
- 208000003120 Angiofibroma Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000003732 Cat-scratch disease Diseases 0.000 claims 1
- 206010011017 Corneal graft rejection Diseases 0.000 claims 1
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 241000590002 Helicobacter pylori Species 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000851030 Homo sapiens Vascular endothelial growth factor receptor 3 Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022873 Ocular disease Diseases 0.000 claims 1
- 201000010183 Papilledema Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 208000002367 Retinal Perforations Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038886 Retinal oedema Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 101150052863 THY1 gene Proteins 0.000 claims 1
- 206010043189 Telangiectasia Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims 1
- 108010073925 Vascular Endothelial Growth Factor B Proteins 0.000 claims 1
- 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 claims 1
- 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 claims 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims 1
- 102100038217 Vascular endothelial growth factor B Human genes 0.000 claims 1
- 102100038232 Vascular endothelial growth factor C Human genes 0.000 claims 1
- 102100038234 Vascular endothelial growth factor D Human genes 0.000 claims 1
- 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 claims 1
- 208000034698 Vitreous haemorrhage Diseases 0.000 claims 1
- 208000013058 Weber syndrome Diseases 0.000 claims 1
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 201000007293 brain stem infarction Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000011190 diabetic macular edema Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 229940037467 helicobacter pylori Drugs 0.000 claims 1
- 208000031209 hemophilic arthropathy Diseases 0.000 claims 1
- 206010020718 hyperplasia Diseases 0.000 claims 1
- 230000002390 hyperplastic effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000004068 intracellular signaling Effects 0.000 claims 1
- 208000038015 macular disease Diseases 0.000 claims 1
- 208000029233 macular holes Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 201000011195 retinal edema Diseases 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 208000032253 retinal ischemia Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 208000009056 telangiectasis Diseases 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 230000006711 vascular endothelial growth factor production Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13360708P | 2008-06-30 | 2008-06-30 | |
| AU2008903349 | 2008-06-30 | ||
| AU2008903349A AU2008903349A0 (en) | 2008-06-30 | Treatment of eye diseases and excessive neovascularization using combined therapy | |
| US61/133,607 | 2008-06-30 | ||
| PCT/US2009/003902 WO2010005527A1 (en) | 2008-06-30 | 2009-06-29 | Treatment of eye diseases and excessive neovascularization using a combined therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014138345A Division JP2015038059A (ja) | 2008-06-30 | 2014-07-04 | 併用療法を使用した眼疾患及び過剰血管新生の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011526892A JP2011526892A (ja) | 2011-10-20 |
| JP2011526892A5 true JP2011526892A5 (https=) | 2012-08-09 |
Family
ID=41507350
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516339A Withdrawn JP2011526892A (ja) | 2008-06-30 | 2009-06-29 | 併用療法を使用した眼疾患及び過剰血管新生の治療 |
| JP2014138345A Pending JP2015038059A (ja) | 2008-06-30 | 2014-07-04 | 併用療法を使用した眼疾患及び過剰血管新生の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014138345A Pending JP2015038059A (ja) | 2008-06-30 | 2014-07-04 | 併用療法を使用した眼疾患及び過剰血管新生の治療 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20110200612A1 (https=) |
| EP (1) | EP2294184A4 (https=) |
| JP (2) | JP2011526892A (https=) |
| KR (1) | KR20110036101A (https=) |
| CN (1) | CN102076844B (https=) |
| AU (2) | AU2009269149B2 (https=) |
| CA (1) | CA2729303A1 (https=) |
| SG (1) | SG10201510586PA (https=) |
| WO (1) | WO2010005527A1 (https=) |
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| US20090043365A1 (en) | 2005-07-18 | 2009-02-12 | Kolis Scientific, Inc. | Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma |
| US8137390B2 (en) | 2006-05-15 | 2012-03-20 | Tearscience, Inc. | System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction |
| US9314369B2 (en) | 2006-05-15 | 2016-04-19 | Tearscience, Inc. | System for inner eyelid treatment of meibomian gland dysfunction |
| US8128674B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction |
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-
2009
- 2009-06-29 WO PCT/US2009/003902 patent/WO2010005527A1/en not_active Ceased
- 2009-06-29 CN CN2009801249790A patent/CN102076844B/zh not_active Expired - Fee Related
- 2009-06-29 KR KR1020117002350A patent/KR20110036101A/ko not_active Ceased
- 2009-06-29 AU AU2009269149A patent/AU2009269149B2/en not_active Ceased
- 2009-06-29 CA CA2729303A patent/CA2729303A1/en not_active Abandoned
- 2009-06-29 JP JP2011516339A patent/JP2011526892A/ja not_active Withdrawn
- 2009-06-29 US US13/002,229 patent/US20110200612A1/en not_active Abandoned
- 2009-06-29 EP EP09794792A patent/EP2294184A4/en not_active Withdrawn
- 2009-06-29 SG SG10201510586PA patent/SG10201510586PA/en unknown
-
2014
- 2014-07-04 JP JP2014138345A patent/JP2015038059A/ja active Pending
-
2016
- 2016-06-14 AU AU2016203973A patent/AU2016203973A1/en not_active Abandoned
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