JP2011526493A5 - - Google Patents
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- JP2011526493A5 JP2011526493A5 JP2011515664A JP2011515664A JP2011526493A5 JP 2011526493 A5 JP2011526493 A5 JP 2011526493A5 JP 2011515664 A JP2011515664 A JP 2011515664A JP 2011515664 A JP2011515664 A JP 2011515664A JP 2011526493 A5 JP2011526493 A5 JP 2011526493A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- antigen
- encoding
- binding polypeptide
- gene segment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims 81
- 108091007433 antigens Proteins 0.000 claims 81
- 102000036639 antigens Human genes 0.000 claims 81
- 229920001184 polypeptide Polymers 0.000 claims 49
- 108090000765 processed proteins & peptides Proteins 0.000 claims 49
- 102000004196 processed proteins & peptides Human genes 0.000 claims 49
- 108090000623 proteins and genes Proteins 0.000 claims 39
- 239000013604 expression vector Substances 0.000 claims 36
- 238000000034 method Methods 0.000 claims 35
- 239000013598 vector Substances 0.000 claims 23
- 239000002773 nucleotide Substances 0.000 claims 18
- 125000003729 nucleotide group Chemical group 0.000 claims 18
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 15
- 241000894007 species Species 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 238000010367 cloning Methods 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 239000002299 complementary DNA Substances 0.000 claims 4
- 238000012216 screening Methods 0.000 claims 4
- 235000002198 Annona diversifolia Nutrition 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 3
- 241000282842 Lama glama Species 0.000 claims 3
- 241001416177 Vicugna pacos Species 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 210000004602 germ cell Anatomy 0.000 claims 3
- 230000003053 immunization Effects 0.000 claims 3
- 238000002649 immunization Methods 0.000 claims 3
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims 2
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 2
- 241000282828 Camelus bactrianus Species 0.000 claims 2
- 241000282836 Camelus dromedarius Species 0.000 claims 2
- 241000282852 Lama guanicoe Species 0.000 claims 2
- 241001416176 Vicugna Species 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 210000003563 lymphoid tissue Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108700005091 Immunoglobulin Genes Proteins 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000005457 optimization Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7773008P | 2008-07-02 | 2008-07-02 | |
| US61/077,730 | 2008-07-02 | ||
| GB0812120.4 | 2008-07-02 | ||
| GB0812120A GB2461546B (en) | 2008-07-02 | 2008-07-02 | Antigen binding polypeptides |
| US11016108P | 2008-10-31 | 2008-10-31 | |
| US61/110,161 | 2008-10-31 | ||
| PCT/IB2009/006329 WO2010001251A2 (en) | 2008-07-02 | 2009-07-02 | Antigen binding polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015250837A Division JP2016128421A (ja) | 2008-07-02 | 2015-12-24 | ラクダ科動物由来の抗原結合ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011526493A JP2011526493A (ja) | 2011-10-13 |
| JP2011526493A5 true JP2011526493A5 (enExample) | 2012-08-16 |
| JP6216940B2 JP6216940B2 (ja) | 2017-10-25 |
Family
ID=39707916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515664A Active JP6216940B2 (ja) | 2008-07-02 | 2009-07-02 | ラクダ科動物由来の抗原結合ポリペプチド |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP3061768A1 (enExample) |
| JP (1) | JP6216940B2 (enExample) |
| CN (2) | CN107739405A (enExample) |
| AU (1) | AU2009265278B2 (enExample) |
| CA (1) | CA2728076C (enExample) |
| DK (1) | DK2310413T3 (enExample) |
| GB (1) | GB2461546B (enExample) |
| WO (1) | WO2010001251A2 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8444976B2 (en) | 2008-07-02 | 2013-05-21 | Argen-X B.V. | Antigen binding polypeptides |
| GB2476681B (en) * | 2010-01-04 | 2012-04-04 | Argen X Bv | Humanized camelid VH, VK and VL immunoglobulin domains |
| PL2560993T3 (pl) | 2010-04-20 | 2024-11-04 | Genmab A/S | Heterodimeryczne białka zawierające region FC przeciwciała i sposoby ich wytwarzania |
| NZ604003A (en) | 2010-05-27 | 2015-04-24 | Genmab As | Monoclonal antibodies against her2 |
| ES2617446T3 (es) | 2010-09-27 | 2017-06-19 | Morphosys Ag | Anticuerpo anti-cd38 y lenalidomida o bortezomib para el tratamiento del mieloma múltiple y nhl |
| EP3165538A1 (en) | 2010-11-03 | 2017-05-10 | Argen-X Nv | Anti c-met antibodies |
| AU2011352207B2 (en) * | 2010-12-31 | 2016-03-03 | Bioatla, Llc | Comprehensive monoclonal antibody generation |
| CN103596979B (zh) * | 2011-03-16 | 2018-01-26 | 阿尔金-X有限公司 | 针对cd70的抗体 |
| WO2012143523A1 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecifc antibodies against her2 |
| AU2012245116A1 (en) | 2011-04-20 | 2013-11-07 | Genmab A/S | Bispecific antibodies against HER2 and CD3 |
| EP2699260B1 (en) | 2011-04-20 | 2024-11-20 | Genmab A/S | Bispecifc antibodies against her2 |
| SG10201805291TA (en) | 2011-10-27 | 2018-08-30 | Genmab As | Production of heterodimeric proteins |
| EP2773660A2 (en) * | 2011-11-03 | 2014-09-10 | Argen-X B.V. | Chimeric human-camel antigens and their use |
| GB2504139B (en) * | 2012-07-20 | 2014-12-31 | Argen X Bv | Antibodies to highly conserved targets produced by the immunisation of Camelidae species |
| WO2013175276A1 (en) | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
| AU2013310839B2 (en) * | 2012-08-31 | 2017-06-01 | Argenx Bvba | Highly diverse combinatorial antibody libraries |
| WO2014033252A1 (en) * | 2012-08-31 | 2014-03-06 | arGEN-X BV | Method for producing antibody molecules having inter-species, intra-target cross-reactivity |
| MY174813A (en) | 2013-03-15 | 2020-05-16 | Zymeworks Inc | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| NZ717476A (en) | 2013-08-01 | 2022-04-29 | Univ Catholique Louvain | Anti-garp protein and uses thereof |
| KR102122632B1 (ko) | 2013-08-05 | 2020-06-16 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
| EP3447068A1 (en) * | 2013-11-04 | 2019-02-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Synthetic single domain antibody |
| CA2935077C (en) | 2013-12-27 | 2022-03-15 | Geoffrey C. Winters | Sulfonamide-containing linkage systems for drug conjugates |
| US10391168B1 (en) | 2014-08-22 | 2019-08-27 | University Of Bern | Anti-CD70 combination therapy |
| CA2960899C (en) | 2014-09-17 | 2021-08-17 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| RU2609627C2 (ru) | 2014-09-26 | 2017-02-02 | Закрытое Акционерное Общество "Биокад" | Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh |
| WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| EP3350314A4 (en) | 2015-09-18 | 2019-02-06 | Twist Bioscience Corporation | OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF |
| CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
| GB201611123D0 (en) | 2016-06-27 | 2016-08-10 | Euremab Srl | Anti met antibodiesand uses thereof |
| MA45602A (fr) | 2016-07-08 | 2019-05-15 | Staten Biotechnology B V | Anticorps anti-apoc3 et leurs méthodes d'utilisation |
| GB201612337D0 (en) | 2016-07-15 | 2016-08-31 | Argen-X N V | Ant-il-22r antibodies |
| US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
| CN110139952B (zh) * | 2016-12-09 | 2022-11-25 | 深圳华大生命科学研究院 | 骆驼科抗体可变区免疫组库构建的引物组合及应用 |
| SG11201907713WA (en) | 2017-02-22 | 2019-09-27 | Twist Bioscience Corp | Nucleic acid based data storage |
| JP2020517242A (ja) | 2017-04-21 | 2020-06-18 | スターテン・バイオテクノロジー・ベー・フェー | 抗ＡｐｏＣ３抗体およびその使用方法 |
| GB201707484D0 (en) | 2017-05-10 | 2017-06-21 | Argenx Bvba | Method of preparing ph-dependent antibodies |
| GB201707561D0 (en) | 2017-05-11 | 2017-06-28 | Argenx Bvba | GARP-TGF-beta antibodies |
| KR102784398B1 (ko) | 2017-06-12 | 2025-03-19 | 트위스트 바이오사이언스 코포레이션 | 심리스 핵산 어셈블리를 위한 방법 |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| JP2020536504A (ja) | 2017-09-11 | 2020-12-17 | ツイスト バイオサイエンス コーポレーション | Ｇｐｃｒ結合タンパク質およびその合成 |
| KR102889470B1 (ko) | 2017-10-20 | 2025-11-21 | 트위스트 바이오사이언스 코포레이션 | 폴리뉴클레오타이드 합성을 위한 가열된 나노웰 |
| MA50516A (fr) | 2017-10-31 | 2020-09-09 | Staten Biotechnology B V | Anticorps anti-apoc3 et leurs procédés d'utilisation |
| US10538583B2 (en) | 2017-10-31 | 2020-01-21 | Staten Biotechnology B.V. | Anti-APOC3 antibodies and compositions thereof |
| IT201800000535A1 (it) | 2018-01-03 | 2019-07-03 | Procedimenti per la cura del cancro. | |
| WO2019136175A1 (en) | 2018-01-04 | 2019-07-11 | Twist Bioscience Corporation | Dna-based digital information storage |
| GB201800649D0 (en) | 2018-01-16 | 2018-02-28 | Argenx Bvba | CD70 Combination Therapy |
| GB201802487D0 (en) | 2018-02-15 | 2018-04-04 | Argenx Bvba | Cytokine combination therapy |
| CA3094215A1 (en) | 2018-04-13 | 2019-10-17 | Argenx Bvba | Galectin-10 antibodies |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| CN109206511B (zh) * | 2018-09-13 | 2021-03-16 | 东南大学 | 能够特异结合HPVl6-E6蛋白的纳米抗体及其编码序列、制备方法和应用 |
| TWI874341B (zh) | 2018-12-18 | 2025-03-01 | 美商健生生物科技公司 | 產生異二聚體抗體之方法 |
| TWI848030B (zh) | 2018-12-18 | 2024-07-11 | 比利時商阿根思公司 | Ｃｄ７０組合治療 |
| CN119708086A (zh) | 2018-12-26 | 2025-03-28 | 特韦斯特生物科学公司 | 高度准确的从头多核苷酸合成 |
| AU2020227802A1 (en) | 2019-02-26 | 2021-10-14 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
| EP3930753A4 (en) | 2019-02-26 | 2023-03-29 | Twist Bioscience Corporation | VARIANT NUCLEIC ACID LIBRARIES FOR GLP1 RECEPTOR |
| JP2022541697A (ja) * | 2019-02-27 | 2022-09-27 | ジャージャン ナノマブ テクノロジー センター カンパニー リミテッド | 高解像度で広範なエピトープを網羅するために、ラクダ科動物抗体を生成する配列ベースのハイスループット法 |
| WO2020178193A1 (en) | 2019-03-01 | 2020-09-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment of sarcoidosis |
| GB2589049C (en) * | 2019-04-11 | 2024-02-21 | argenx BV | Anti-IgE antibodies |
| CN114729342A (zh) | 2019-06-21 | 2022-07-08 | 特韦斯特生物科学公司 | 基于条形码的核酸序列装配 |
| AU2020355027A1 (en) | 2019-09-23 | 2022-04-21 | Twist Bioscience Corporation | Antibodies that bind CD3 Epsilon |
| WO2021061829A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for crth2 |
| CN110642948B (zh) * | 2019-10-09 | 2021-06-29 | 达石药业(广东)有限公司 | B7-h3纳米抗体、其制备方法及用途 |
| JP7651477B2 (ja) * | 2019-12-27 | 2025-03-26 | 株式会社カネカ | プライマーセット及びそれを用いて標的核酸を検出する方法 |
| GB202003444D0 (en) | 2020-03-10 | 2020-04-22 | argenx BV | Musk agonist antibody |
| CN116284374A (zh) * | 2020-08-14 | 2023-06-23 | 上海洛启生物医药技术有限公司 | 非pH依赖性长效型抗血清白蛋白纳米抗体及其应用 |
| CN114591436B (zh) * | 2020-12-07 | 2022-12-02 | 生物岛实验室 | 胃蛋白酶原i的特异性抗体及其制备方法与应用 |
| CN118696057A (zh) | 2021-06-14 | 2024-09-24 | 阿根思有限公司 | 抗il-9抗体及其使用方法 |
| IL314365A (en) | 2022-01-18 | 2024-09-01 | argenx BV | Nebulization of fab fragments |
| JP2025503707A (ja) | 2022-01-18 | 2025-02-04 | アルジェニクス ビーブイ | ガレクチン－１０抗体 |
| GB202203269D0 (en) | 2022-03-09 | 2022-04-20 | Argenx Iip Bv | TGF-Beta antibodies |
| TW202504921A (zh) * | 2023-02-28 | 2025-02-01 | 中國大陸商禮新醫藥科技（上海）有限公司 | Ceacam5依賴性4-1bb促效性雙特異性抗體 |
| AU2024229974A1 (en) | 2023-02-28 | 2025-09-11 | LaNova Medicines Limited | Ceacam5-dependent 4-1bb-agonistic bispecific antibodies |
| CN117310163B (zh) * | 2023-11-23 | 2024-02-13 | 北京贝思泰生物科技有限公司 | 一种基于重组抗体的呼吸道合胞病毒检测方法 |
| CN117986360B (zh) * | 2024-02-01 | 2024-08-27 | 生物岛实验室 | Il18蛋白的特异性抗体及其制备方法与应用 |
| CN119591719B (zh) * | 2024-11-25 | 2025-10-21 | 江苏集萃崛创生物科技研究所有限公司 | 靶向fap的纳米抗体、car-t细胞及其应用 |
| CN119708213B (zh) * | 2024-12-25 | 2025-12-12 | 河北科技师范学院 | 针对猪流行性腹泻病毒的纳米抗体或抗原结合片段及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE452975T1 (de) * | 1992-08-21 | 2010-01-15 | Univ Bruxelles | Immunoglobuline ohne leichte ketten |
| GB9926084D0 (en) * | 1999-11-03 | 2000-01-12 | King S College London | Recombinant fusion molecules |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20050037420A1 (en) * | 2001-09-14 | 2005-02-17 | Mei-Yun Zhang | Immunoglobulin having particular framework scaffold and methods of making and using |
| ES2694247T3 (es) * | 2005-05-20 | 2018-12-19 | Ablynx N.V. | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| US20070269442A1 (en) * | 2006-05-19 | 2007-11-22 | Robert J. Webber | Chimeric monoclonal antibody recognizing iNOS |
| US8796429B2 (en) * | 2006-05-31 | 2014-08-05 | Lpath, Inc. | Bioactive lipid derivatives, and methods of making and using same |
| US7829674B2 (en) * | 2006-10-27 | 2010-11-09 | Lpath, Inc. | Compositions and methods for binding sphingosine-1-phosphate |
| US7732195B2 (en) * | 2006-11-01 | 2010-06-08 | Facet Biotech Corporation | Tethered vectors for cell surface immunoglobulin display |
| US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
-
2008
- 2008-07-02 GB GB0812120A patent/GB2461546B/en active Active
-
2009
- 2009-07-02 DK DK09772912.3T patent/DK2310413T3/en active
- 2009-07-02 AU AU2009265278A patent/AU2009265278B2/en active Active
- 2009-07-02 CN CN201710747051.4A patent/CN107739405A/zh active Pending
- 2009-07-02 CN CN2009801343928A patent/CN102216328A/zh active Pending
- 2009-07-02 JP JP2011515664A patent/JP6216940B2/ja active Active
- 2009-07-02 EP EP15190638.5A patent/EP3061768A1/en not_active Withdrawn
- 2009-07-02 EP EP09772912.3A patent/EP2310413B1/en active Active
- 2009-07-02 WO PCT/IB2009/006329 patent/WO2010001251A2/en not_active Ceased
- 2009-07-02 CA CA2728076A patent/CA2728076C/en active Active
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