JP2011523697A5 - - Google Patents

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JP2011523697A5
JP2011523697A5 JP2011507650A JP2011507650A JP2011523697A5 JP 2011523697 A5 JP2011523697 A5 JP 2011523697A5 JP 2011507650 A JP2011507650 A JP 2011507650A JP 2011507650 A JP2011507650 A JP 2011507650A JP 2011523697 A5 JP2011523697 A5 JP 2011523697A5
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JP5608914B2 (ja
JP2011523697A (ja
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Priority claimed from US12/112,289 external-priority patent/US7563433B2/en
Priority claimed from US12/343,655 external-priority patent/US7993626B2/en
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JP2011507650A 2008-04-30 2009-04-30 タンパク質、ペプチドおよびその他の分子のf−18標識化のための改良型方法および組成物 Active JP5608914B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/112,289 2008-04-30
US12/112,289 US7563433B2 (en) 2007-01-11 2008-04-30 Methods and compositions for F-18 labeling of proteins, peptides and other molecules
US12/343,655 US7993626B2 (en) 2007-01-11 2008-12-24 Methods and compositions for F-18 labeling of proteins, peptides and other molecules
US12/343,655 2008-12-24
PCT/US2009/042333 WO2009135015A2 (en) 2008-04-30 2009-04-30 Improved methods and compositions for f-18 labeling of proteins, peptides and other molecules

Publications (3)

Publication Number Publication Date
JP2011523697A JP2011523697A (ja) 2011-08-18
JP2011523697A5 true JP2011523697A5 (https=) 2012-05-31
JP5608914B2 JP5608914B2 (ja) 2014-10-22

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JP2011507650A Active JP5608914B2 (ja) 2008-04-30 2009-04-30 タンパク質、ペプチドおよびその他の分子のf−18標識化のための改良型方法および組成物

Country Status (7)

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US (2) US7993626B2 (https=)
EP (1) EP2291678A4 (https=)
JP (1) JP5608914B2 (https=)
CN (1) CN102066974B (https=)
AU (1) AU2009242641B2 (https=)
CA (1) CA2720935C (https=)
WO (1) WO2009135015A2 (https=)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7563433B2 (en) * 2007-01-11 2009-07-21 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
US7597876B2 (en) * 2007-01-11 2009-10-06 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US7993626B2 (en) * 2007-01-11 2011-08-09 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
US8398956B2 (en) * 2007-01-11 2013-03-19 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
US8709382B2 (en) * 2007-01-11 2014-04-29 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US8889100B2 (en) * 2007-01-11 2014-11-18 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US20160045626A1 (en) * 2007-01-11 2016-02-18 Immunomedics, Inc. Methods and Compositions for Improved Labeling of Targeting Peptides
US8545809B2 (en) * 2007-01-11 2013-10-01 Immunomedics, Inc. Methods and compositions for improved 18F labeling of proteins, peptides and other molecules
WO2010011367A2 (en) * 2008-02-22 2010-01-28 Illinois Institute Of Technology Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
US10556873B2 (en) 2008-02-22 2020-02-11 Illinois Institute Of Technology Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
US10189803B2 (en) 2008-02-22 2019-01-29 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US20120165650A1 (en) 2010-12-22 2012-06-28 General Electric Company Her2 binders
AU2010326004B2 (en) * 2009-12-04 2016-04-21 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
CA2814962A1 (en) * 2010-12-02 2012-06-07 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
NZ612161A (en) * 2010-12-22 2015-04-24 Gen Electric Radiolabled her2 binding peptides
KR101142153B1 (ko) 2011-02-01 2012-05-10 서울대학교산학협력단 개선된 플루오르-18 표지를 위한 트리아자노난 유도체 또는 이의 약학적으로 허용가능한 염
EP2675485A4 (en) * 2011-02-15 2014-10-15 Immunomedics Inc ANTI-MUCIN ANTIBODY FOR THE EARLY RECOGNITION AND TREATMENT OF PANCREATIC CANCER
CN102295685B (zh) * 2011-07-03 2013-07-10 江苏省原子医学研究所 一种18f标记的prgd2化合物、其药盒、药盒制备方法及应用
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
CN109966515A (zh) * 2011-12-21 2019-07-05 通用电气健康护理有限公司 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
GB201201062D0 (en) * 2012-01-23 2012-03-07 Ge Healthcare Ltd Radiofluorination method
CN104854126B (zh) 2012-11-30 2018-10-16 国立大学法人京都大学 多肽及成像方法
CN103030689B (zh) * 2012-12-27 2014-09-24 无锡米度生物技术有限公司 一种cart多肽化合物及其制备方法和应用
KR20150131208A (ko) 2013-03-13 2015-11-24 이미지냅 인코포레이티드 Cd8에의 항원 결합 구조체들
WO2015051362A1 (en) 2013-10-04 2015-04-09 Illinois Institute Of Technology Multifunctional chelators, complexes, and compositions thereof, and methods of using same
US20150217006A1 (en) * 2014-02-06 2015-08-06 Immunomedics, Inc. Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer
EP3212610B1 (en) * 2014-10-30 2020-10-28 Katholieke Universiteit Leuven Methods for low temperature fluorine-18 radiolabeling of biomolecules
EP3865139B1 (en) 2015-02-18 2023-05-03 Enlivex Therapeutics Rdo Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11000548B2 (en) 2015-02-18 2021-05-11 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
WO2016170541A1 (en) 2015-04-21 2016-10-27 Enlivex Therapeutics Ltd. Therapeutic pooled blood apoptotic cell preparations and uses thereof
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11596652B2 (en) 2015-02-18 2023-03-07 Enlivex Therapeutics R&D Ltd Early apoptotic cells for use in treating sepsis
CN105277715A (zh) * 2015-05-28 2016-01-27 广州凯拓生物科技开发有限公司 巨噬细胞迁移抑制因子(mif)作为早期阿尔茨海默病血清分子标志物
US11254744B2 (en) 2015-08-07 2022-02-22 Imaginab, Inc. Antigen binding constructs to target molecules
CN109069539A (zh) 2016-02-18 2018-12-21 恩立夫克治疗有限责任公司 用于癌症治疗的联合免疫疗法和细胞因子控制疗法
CN108699108B (zh) * 2016-03-01 2022-04-08 国立大学法人千叶大学 放射性标记药物
WO2017192605A1 (en) * 2016-05-02 2017-11-09 University Of Pittsburgh -Of The Commonwealth System Of Higher Education Dimerization strategies and compounds for molecular imaging and/or radioimmunotherapy
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI651097B (zh) * 2016-10-19 2019-02-21 行政院原子能委員會核能研究所 造影劑前驅物之製備方法
CN107353323B (zh) * 2016-12-26 2021-04-27 南京江原安迪科正电子研究发展有限公司 Al18F标记的PSMA靶向抑制剂及其制备方法与应用
US11266745B2 (en) 2017-02-08 2022-03-08 Imaginab, Inc. Extension sequences for diabodies
EP3773670A4 (en) * 2018-04-05 2022-03-09 Tarveda Therapeutics, Inc. Hsp90-targeting conjugates and formulations thereof
US12427209B2 (en) 2018-12-18 2025-09-30 Provincial Health Services Authority Dual mode 18F-labelled theranostic compounds and uses thereof
US11396535B2 (en) 2019-03-01 2022-07-26 Provincial Health Services Authority Cyclic peptide analogs of melanocortin and amanitin and methods of making such
AU2020257786B2 (en) 2019-04-17 2025-10-23 Provincial Health Services Authority Novel radiolabelled compounds for diagnosis or treatment of prostate-specific membrane antigen-expressing cancer
EP3970208A4 (en) * 2019-05-13 2023-07-26 Shanghai Polaris Biology Co., Ltd. LABEL FOR MARKING BIOMOLECULES
CN113651662B (zh) * 2020-12-31 2023-10-27 复旦大学附属华山医院 一种靶向fgfr的新型肿瘤pet分子探针及其制备方法
CN115433138A (zh) * 2022-10-24 2022-12-06 苏州思萃同位素技术研究所有限公司 一种氘代配体及其制备方法
CN117919452A (zh) * 2023-03-09 2024-04-26 中国科学院宁波材料技术与工程研究所 一种亚细胞器主动靶向成像探针及其制备方法
CN119661643A (zh) * 2024-12-17 2025-03-21 北京肿瘤医院(北京大学肿瘤医院) 一种cd25靶向环状多肽、分子探针及应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1222691A (en) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
FR2604092B1 (fr) 1986-09-19 1990-04-13 Immunotech Sa Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo
US5446147A (en) 1992-04-03 1995-08-29 Trustees Of The University Of Pennsylvania Fluorinated and iodinated dopamine agents
US6187284B1 (en) 1997-09-03 2001-02-13 Immunomedics, Inc. Fluorination of proteins and peptides for F-18 positron emission tomography
US7138103B2 (en) 1998-06-22 2006-11-21 Immunomedics, Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
US6962702B2 (en) 1998-06-22 2005-11-08 Immunomedics Inc. Production and use of novel peptide-based agents for use with bi-specific antibodies
US7387772B1 (en) 1999-06-22 2008-06-17 Immunimedics, Inc. Chimeric, human and humanized anti-CSAP monoclonal antibodies
US6056939A (en) 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
DE19846148C2 (de) 1998-10-01 2002-10-10 Igor Popov Verfahren zur Beurteilung der oxidativen Modifikation proteinhaltiger Stoffe mittels Messung ihrer antiradikalen Aktivität
US6207858B1 (en) 1999-03-03 2001-03-27 Idec Pharmaceuticals Corporation Regioselective synthesis of DTPA derivatives
JP2003531105A (ja) 1999-10-15 2003-10-21 メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ 造影剤および治療薬として有用なコバラミン結合体
US6605615B2 (en) 2000-03-01 2003-08-12 Tularik Inc. Hydrazones and analogs as cholesterol lowering agents
US7011816B2 (en) 2001-12-26 2006-03-14 Immunomedics, Inc. Labeling targeting agents with gallium-68 and gallium-67
CA2478047C (en) * 2002-03-01 2014-01-21 Immunomedics, Inc. Rs7 antibodies
US7081452B2 (en) 2002-06-03 2006-07-25 The United States Of America As Represented By The Department Of Health And Human Services Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same
US7597876B2 (en) 2007-01-11 2009-10-06 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US7563433B2 (en) * 2007-01-11 2009-07-21 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
US7993626B2 (en) * 2007-01-11 2011-08-09 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
FR2841558B1 (fr) * 2002-07-01 2004-08-13 Commissariat Energie Atomique Peptides marques ayant une affinite pour un phospholipide et utilisations
EP1660519B1 (en) 2003-07-29 2014-05-14 Immunomedics, Inc. Conjugates comprising 2-[18F]fluoro-2-deoxy-D-glucose and a peptide molecule
JP2007524677A (ja) * 2004-02-13 2007-08-30 ザ ユニバーシティ オブ ブリティッシュ コロンビア 放射性標識化合物及び組成物、それらの前駆体及びそれらの製造方法
DE102004034517A1 (de) * 2004-07-16 2006-02-16 Covion Organic Semiconductors Gmbh Metallkomplexe
US20060029544A1 (en) * 2004-08-06 2006-02-09 The Regents Of The University Of California Office Of Technology Transfer Receptor-binding cyclic peptides and methods of use
CA2604032C (en) * 2005-04-06 2017-08-22 Ibc Pharmaceuticals, Inc. Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
US7842279B2 (en) * 2005-08-31 2010-11-30 Immunomedics, Inc. F-18 peptides for pre targeted positron emission tomography imaging
EP1884515A1 (en) * 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments
KR20090053863A (ko) * 2006-09-15 2009-05-27 지멘스 메디컬 솔루션즈 유에스에이, 인크. 인테그린에 대한 이미지화제로서 클릭 화학반응-유래된 시클로펩티드 유도체
CN101568352B (zh) 2007-01-11 2013-08-21 免疫医学股份有限公司 用于蛋白质、肽和其他分子的改进的f-18标记的方法和组合物
JP5264913B2 (ja) * 2007-09-11 2013-08-14 ヴォイスエイジ・コーポレーション 話声およびオーディオの符号化における、代数符号帳の高速検索のための方法および装置

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