JP2016513098A5 - - Google Patents
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- Publication number
- JP2016513098A5 JP2016513098A5 JP2015557088A JP2015557088A JP2016513098A5 JP 2016513098 A5 JP2016513098 A5 JP 2016513098A5 JP 2015557088 A JP2015557088 A JP 2015557088A JP 2015557088 A JP2015557088 A JP 2015557088A JP 2016513098 A5 JP2016513098 A5 JP 2016513098A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cancer
- complex
- p2pdox
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361761845P | 2013-02-07 | 2013-02-07 | |
| US61/761,845 | 2013-02-07 | ||
| US201361810002P | 2013-04-09 | 2013-04-09 | |
| US61/810,002 | 2013-04-09 | ||
| PCT/US2014/015253 WO2014124227A1 (en) | 2013-02-07 | 2014-02-07 | Pro-drug form (p2pdox) of the highly potent 2-pyrrolinodoxorubicin conjugated to antibodies for targeted therapy of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016513098A JP2016513098A (ja) | 2016-05-12 |
| JP2016513098A5 true JP2016513098A5 (https=) | 2017-02-09 |
Family
ID=51259378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015557088A Pending JP2016513098A (ja) | 2013-02-07 | 2014-02-07 | 癌の標的治療用抗体と抱合した極めて強力なプロドラック形態の2−ピロリノドキソルビシン(p2pdox) |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US8877202B2 (https=) |
| EP (1) | EP2953645A4 (https=) |
| JP (1) | JP2016513098A (https=) |
| CN (1) | CN105209068A (https=) |
| AU (1) | AU2014214843A1 (https=) |
| CA (1) | CA2895284A1 (https=) |
| IL (1) | IL238543A0 (https=) |
| WO (1) | WO2014124227A1 (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9770517B2 (en) | 2002-03-01 | 2017-09-26 | Immunomedics, Inc. | Anti-Trop-2 antibody-drug conjugates and uses thereof |
| US8361464B2 (en) | 2002-03-01 | 2013-01-29 | Immunomedics, Inc. | Anthracycline-Antibody Conjugates for Cancer Therapy |
| US10058621B2 (en) | 2015-06-25 | 2018-08-28 | Immunomedics, Inc. | Combination therapy with anti-HLA-DR antibodies and kinase inhibitors in hematopoietic cancers |
| US9707302B2 (en) | 2013-07-23 | 2017-07-18 | Immunomedics, Inc. | Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer |
| US20100226884A1 (en) | 2009-01-20 | 2010-09-09 | Immunomedics, Inc. | Novel Class of Monospecific and Bispecific Humanized Antibodies that Target the Insulin-like Growth Factor Type I Receptor (IGF-1R) |
| EP3009455A1 (en) * | 2009-09-16 | 2016-04-20 | Immunomedics Inc. | Class i anti-cea antibodies and uses thereof |
| CN107898791A (zh) | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
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| US10131712B2 (en) | 2012-08-14 | 2018-11-20 | Ibc Pharmaceuticals, Inc. | Combination therapy with T-cell redirecting bispecific antibodies and checkpoint inhibitors |
| JP2016512549A (ja) * | 2013-03-14 | 2016-04-28 | ファーマサイクリックス エルエルシー | ブルトン型チロシンキナーゼ阻害剤及びcyp3a4阻害剤の組み合わせ |
| US11253606B2 (en) | 2013-07-23 | 2022-02-22 | Immunomedics, Inc. | Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, Bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer |
| CA2920113A1 (en) * | 2013-08-20 | 2015-02-26 | Merck Sharp & Dohme Corp. | Treating cancer with a combination of a pd-1 antagonist and dinaciclib |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| AU2015228372B2 (en) | 2014-03-12 | 2018-05-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10278986B2 (en) | 2014-08-14 | 2019-05-07 | The Regents Of The University Of Colorado, A Body Corporate | Antibody-siRNA conjugates and uses therefor |
| GB201416960D0 (en) | 2014-09-25 | 2014-11-12 | Antikor Biopharma Ltd | Biological materials and uses thereof |
| CN117138060A (zh) * | 2014-10-07 | 2023-12-01 | 免疫医疗公司 | 抗体-药物缀合物的新辅助剂用途 |
| CN104357445B (zh) * | 2014-10-23 | 2017-02-15 | 吕海龙 | 一种用于抑制和治疗细粒棘球蚴病的干扰rna及其应用 |
| CN104569373B (zh) * | 2015-01-27 | 2016-08-17 | 苏州博源医疗科技有限公司 | 一种甲氨蝶呤均相酶免疫检测试剂及其制备和检测方法 |
| CN108112254B (zh) | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| WO2016172427A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| US10441644B2 (en) | 2015-05-05 | 2019-10-15 | The Regents Of The University Of California | H3.3 CTL peptides and uses thereof |
| US10195175B2 (en) | 2015-06-25 | 2019-02-05 | Immunomedics, Inc. | Synergistic effect of anti-Trop-2 antibody-drug conjugate in combination therapy for triple-negative breast cancer when used with microtubule inhibitors or PARP inhibitors |
| EP4257134A3 (en) * | 2015-06-25 | 2024-01-24 | Immunomedics, Inc. | Combining anti-hla-dr or anti-trop-2 antibodies with microtubule inhibitors, parp inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer |
| CN114591433A (zh) | 2015-07-13 | 2022-06-07 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
| WO2017020291A1 (en) | 2015-08-06 | 2017-02-09 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel anti-pd-l1 antibodies |
| CN106432501B (zh) * | 2015-08-06 | 2021-07-30 | 基石药业 | 新型抗pd-l1抗体 |
| JP7379795B2 (ja) * | 2016-04-27 | 2023-11-15 | イミューノメディクス、インコーポレイテッド | チェックポイント阻害薬に再発/耐性を示す腫瘍を治療するための抗Trop-2-SN-38抗体薬物複合体の効果 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
| WO2017210246A2 (en) * | 2016-05-31 | 2017-12-07 | Tarveda Therapeutics, Inc. | Penicillamine conjugates and particles and formulations thereof |
| CN107459579B (zh) * | 2016-06-01 | 2021-09-24 | 泰州迈博太科药业有限公司 | 一种靶向egfr和cd47双特异性融合蛋白、制备方法及应用 |
| US11299543B2 (en) * | 2016-06-02 | 2022-04-12 | Bristol-Myers Squibb Company | Use of an anti-PD-1 antibody in combination with an anti-CD30 antibody in cancer treatment |
| US10669338B2 (en) | 2016-06-17 | 2020-06-02 | Immunomedics, Inc. | Anti-PD-1 checkpoint inhibitor antibodies that block binding of PD-L1 to PD-1 |
| TWI639430B (zh) * | 2016-08-27 | 2018-11-01 | 中國醫藥大學 | 醫藥組合物用於製備治療胃癌藥物的用途 |
| CN107773762B (zh) * | 2016-08-31 | 2021-06-15 | 上海干云生物科技有限公司 | 基于pd-l1抗体偶联化疗药物的adc及其制备方法和应用 |
| CN107915777A (zh) * | 2016-10-09 | 2018-04-17 | 泰州迈博太科药业有限公司 | 一种重组免疫细胞因子及其应用 |
| CN108066772B (zh) * | 2016-11-14 | 2021-07-13 | 中国科学院上海药物研究所 | 靶向tacstd2的抗体与药物偶联体(adc)分子 |
| US20180133345A1 (en) * | 2016-11-15 | 2018-05-17 | Nanoco Technologies Ltd. | Nano-Devices for Detection and Treatment of Cancer |
| US11690919B2 (en) | 2017-01-17 | 2023-07-04 | The Texas A&M University System | Endolysosomal targeting conjugates for improved delivery of cargo molecules to the endolysosomal compartment of target cells |
| CN106892980B (zh) * | 2017-01-25 | 2020-08-04 | 长春金赛药业有限责任公司 | 抗vegfr2单克隆抗体及其应用 |
| CN106983738B (zh) * | 2017-04-13 | 2020-03-10 | 深圳市润佳通科技有限公司 | 甲状腺激素及其药学上可接受的盐或前药在制备治疗和/或预防皮肤疾病的药物中的应用 |
| CN107158404A (zh) * | 2017-05-26 | 2017-09-15 | 中国医学科学院生物医学工程研究所 | 一种应用于肝癌化疗联合给药的肝靶向pH敏感性纳米粒子给药系统及其制备方法 |
| JP2020522486A (ja) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | 活性化可能抗pdl1抗体、およびその使用方法 |
| CA3080148A1 (en) | 2017-11-10 | 2019-05-16 | Ngm Biopharmaceuticals, Inc. | Angptl8-binding agents and methods of use thereof |
| CN110028584B (zh) * | 2018-01-12 | 2021-04-06 | 北京科昕生物科技有限公司 | 针对egfr蛋白和met蛋白的双特异性抗体 |
| US20190247560A1 (en) | 2018-02-13 | 2019-08-15 | Gambro Lundia Ab | Extracorporeal devices and methods of treating complement factor related diseases |
| CN109053862A (zh) * | 2018-08-07 | 2018-12-21 | 复旦大学附属肿瘤医院 | 靶向PD-L1的多肽衍生物及其99mTc配合物的制备和应用 |
| WO2020163269A1 (en) * | 2019-02-04 | 2020-08-13 | Xenetic Biosciences, Inc. | Methods of using glycopolysialylated therapeutic proteins |
| CA3129495A1 (en) * | 2019-02-11 | 2020-08-20 | The Heart Research Institute Ltd | Plasma polymer nanoparticles carrying agents |
| KR102735988B1 (ko) | 2019-02-18 | 2024-12-03 | 일라이 릴리 앤드 캄파니 | 치료 항체 제제 |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| CN111534475B (zh) * | 2019-11-28 | 2022-03-15 | 厦门诺康得生物科技有限公司 | 一种细胞表面偶联抗体的方法及其应用 |
| CN111374151A (zh) * | 2020-03-19 | 2020-07-07 | 西南大学 | 一种含taa的杀菌、抗蛋白吸附以及特异性识别多功能材料的制备方法 |
| CN111184740B (zh) * | 2020-03-23 | 2021-10-01 | 中国科学院西北高原生物研究所 | 佐太在制备增强紫杉醇抗癌活性的药物中的应用 |
| CN113372415A (zh) * | 2020-06-18 | 2021-09-10 | 长春理工大学 | 一种人膀胱癌特异性抗原结合肽 |
| CN111850002B (zh) * | 2020-06-22 | 2022-04-19 | 华中农业大学 | 牛支原体分泌蛋白MbovP570的应用 |
| GB202011993D0 (en) | 2020-07-31 | 2020-09-16 | Adc Therapeutics Sa | ANTI-IL 13Ra2 antibodies |
| CN115850483B (zh) * | 2020-10-21 | 2025-09-19 | 北京纽安博生物技术有限公司 | 抗CEACAM6单域抗体、人源化单域抗体及其Fc融合蛋白和应用 |
| CA3201518A1 (en) * | 2020-11-18 | 2022-05-27 | Suzhou Transcenta Therapeutics Co., Ltd. | Bi-functional molecules |
| EP4269447A4 (en) | 2020-12-22 | 2024-07-24 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | ANTI-IL-4R ANTIBODY COMPLEX OR ANTIGEN-BINDING FRAGMENT THEREOF AND ASSOCIATED MEDICAL USE |
| CN114621093A (zh) * | 2022-04-20 | 2022-06-14 | 江苏师范大学 | 一种室温下Pd(II)/Ag(I)组合催化合成二芳基化合物的方法 |
| WO2025237246A1 (en) * | 2024-05-11 | 2025-11-20 | Westlake Laboratory Of Life Sciences And Biomedicine | Novel covalent protein and use thereof |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
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| FI101678B1 (fi) | 1990-12-31 | 1998-08-14 | Akzo Nv | Happolabiileja kytkentämolekyylejä |
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| CN101503732B (zh) * | 2009-03-13 | 2012-04-11 | 浙江东瓯诊断产品有限公司 | 一种葡萄糖氧化酶单一液体测定试剂 |
| CA3159948A1 (en) * | 2010-12-22 | 2012-07-19 | General Electric Company | Radiolabled her2 binding peptides |
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-
2014
- 2014-02-07 CA CA2895284A patent/CA2895284A1/en not_active Abandoned
- 2014-02-07 AU AU2014214843A patent/AU2014214843A1/en not_active Abandoned
- 2014-02-07 WO PCT/US2014/015253 patent/WO2014124227A1/en not_active Ceased
- 2014-02-07 EP EP14749544.4A patent/EP2953645A4/en not_active Withdrawn
- 2014-02-07 US US14/175,089 patent/US8877202B2/en not_active Expired - Fee Related
- 2014-02-07 JP JP2015557088A patent/JP2016513098A/ja active Pending
- 2014-02-07 CN CN201480003456.1A patent/CN105209068A/zh active Pending
- 2014-09-22 US US14/492,312 patent/US9095628B2/en not_active Expired - Fee Related
-
2015
- 2015-04-30 IL IL238543A patent/IL238543A0/en unknown
- 2015-06-24 US US14/748,830 patent/US9283286B2/en not_active Expired - Fee Related
-
2016
- 2016-01-28 US US15/009,346 patent/US9486536B2/en not_active Expired - Fee Related
- 2016-09-20 US US15/270,542 patent/US9694088B2/en not_active Expired - Fee Related
-
2017
- 2017-05-31 US US15/609,829 patent/US20170266310A1/en not_active Abandoned
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