JP2011523643A5 - - Google Patents
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- Publication number
- JP2011523643A5 JP2011523643A5 JP2011510067A JP2011510067A JP2011523643A5 JP 2011523643 A5 JP2011523643 A5 JP 2011523643A5 JP 2011510067 A JP2011510067 A JP 2011510067A JP 2011510067 A JP2011510067 A JP 2011510067A JP 2011523643 A5 JP2011523643 A5 JP 2011523643A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- acceptable salt
- item
- following formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QZDZEQOMUGMANT-HGRCFPFLSA-N CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C(C(C)([C@H](C[C@H]2OC[C@]22OC(C)=O)O)[C@@H]2[C@@]2(C3)OC(c4ccccc4)=O)=O)O)C3(C)[C@@]12O)=O)OC(CCCN1CCN(C)CC1)=O)c1ccccc1)=O Chemical compound CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C(C(C)([C@H](C[C@H]2OC[C@]22OC(C)=O)O)[C@@H]2[C@@]2(C3)OC(c4ccccc4)=O)=O)O)C3(C)[C@@]12O)=O)OC(CCCN1CCN(C)CC1)=O)c1ccccc1)=O QZDZEQOMUGMANT-HGRCFPFLSA-N 0.000 description 1
- UQULALZGMRBUMD-FSBDEDPYSA-N CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CCN1CCCCC1)=O)c1ccccc1)=O Chemical compound CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CCN1CCCCC1)=O)c1ccccc1)=O UQULALZGMRBUMD-FSBDEDPYSA-N 0.000 description 1
- ORTQFODLPLMDGP-DNCPDDFDSA-N CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CN1CCOCC1)=O)c1ccccc1)=O Chemical compound CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](C[C@H]2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)O)C(C)(C)[C@@]14O)=O)OC(CN1CCOCC1)=O)c1ccccc1)=O ORTQFODLPLMDGP-DNCPDDFDSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5592908P | 2008-05-23 | 2008-05-23 | |
| US61/055,929 | 2008-05-23 | ||
| PCT/IB2009/006532 WO2009141738A2 (en) | 2008-05-23 | 2009-05-26 | Modified drugs for use in liposomal nanoparticles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043564A Division JP5744267B2 (ja) | 2008-05-23 | 2014-03-06 | リポソームナノ粒子中で使用するための修飾薬物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523643A JP2011523643A (ja) | 2011-08-18 |
| JP2011523643A5 true JP2011523643A5 (https=) | 2012-07-19 |
| JP5542804B2 JP5542804B2 (ja) | 2014-07-09 |
Family
ID=41340622
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510067A Expired - Fee Related JP5542804B2 (ja) | 2008-05-23 | 2009-05-26 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2014043564A Expired - Fee Related JP5744267B2 (ja) | 2008-05-23 | 2014-03-06 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2014146559A Expired - Fee Related JP5992019B2 (ja) | 2008-05-23 | 2014-07-17 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2016159491A Expired - Fee Related JP6437968B2 (ja) | 2008-05-23 | 2016-08-16 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2018214441A Pending JP2019048851A (ja) | 2008-05-23 | 2018-11-15 | リポソームナノ粒子中で使用するための修飾薬物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043564A Expired - Fee Related JP5744267B2 (ja) | 2008-05-23 | 2014-03-06 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2014146559A Expired - Fee Related JP5992019B2 (ja) | 2008-05-23 | 2014-07-17 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2016159491A Expired - Fee Related JP6437968B2 (ja) | 2008-05-23 | 2016-08-16 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2018214441A Pending JP2019048851A (ja) | 2008-05-23 | 2018-11-15 | リポソームナノ粒子中で使用するための修飾薬物 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US8790691B2 (https=) |
| EP (2) | EP3415151A1 (https=) |
| JP (5) | JP5542804B2 (https=) |
| KR (5) | KR101975843B1 (https=) |
| CN (2) | CN104622809B (https=) |
| CA (3) | CA2989616A1 (https=) |
| ES (1) | ES2694481T3 (https=) |
| IL (2) | IL209419A (https=) |
| WO (1) | WO2009141738A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3415151A1 (en) * | 2008-05-23 | 2018-12-19 | The University of British Columbia | Modified drugs for use in liposomal nanoparticles |
| CN102018672B (zh) * | 2010-11-29 | 2013-09-18 | 广州朗圣药业有限公司 | 一种水溶性药物的脂质体冻干组合物及其制备方法 |
| CN102617517B (zh) * | 2011-01-27 | 2015-11-18 | 李勤耕 | 一类新的7,10-o,o-二甲多西紫杉醇衍生物及其应用 |
| JP2014503582A (ja) * | 2011-01-28 | 2014-02-13 | コーニンクレッカ フィリップス エヌ ヴェ | 親水性プロドラッグの局所放出用担体 |
| US9375484B2 (en) | 2011-05-31 | 2016-06-28 | Regents Of The University Of Minnesota | Taxane silicate prodrugs and nanoparticles |
| WO2014058729A1 (en) * | 2012-10-09 | 2014-04-17 | California Institute Of Technology | In vivo and in vitro carbene insertion and nitrene transfer reactions catalyzed by heme enzymes |
| EP2906518A4 (en) | 2012-10-09 | 2016-07-27 | California Inst Of Techn | CYCLES CATALYZED IN VIVO AND IN VITRO OLEFINCYCLOPROPANATION |
| CN105188675A (zh) * | 2013-03-13 | 2015-12-23 | 马林克罗特有限公司 | 经修饰多西他赛脂质体制剂 |
| GB201315321D0 (en) * | 2013-08-28 | 2013-10-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction Buffer |
| EP3052508A1 (en) | 2013-09-30 | 2016-08-10 | Danmarks Tekniske Universitet | Silicone chain extender |
| US9399762B2 (en) | 2014-02-18 | 2016-07-26 | California Institute Of Technology | Methods and systems for sulfimidation or sulfoximidation of organic molecules |
| CN105085437B (zh) * | 2014-05-23 | 2018-07-03 | 上海交通大学 | 3-(1-叔丁氧羰酰哌嗪-4-yl)丙酸的两亲性衍生物及其用途 |
| CN104368011B (zh) * | 2014-11-27 | 2017-05-10 | 东南大学 | 一种药物甜菜碱缀合物、其药物组合物及应用 |
| US20160250177A1 (en) * | 2015-02-17 | 2016-09-01 | Mallinckrodt Llc | Modified docetaxel liposome formulations and uses thereof |
| TWI678213B (zh) * | 2015-07-22 | 2019-12-01 | 美商史倍壯製藥公司 | 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物 |
| US20180344644A1 (en) * | 2015-09-21 | 2018-12-06 | Mallinckrodt Llc | Improved stability of liposome formulations and uses thereof |
| GB201521101D0 (en) | 2015-11-30 | 2016-01-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction buffer |
| ES2954596T3 (es) * | 2015-12-23 | 2023-11-23 | Univ British Columbia | Profármacos unidos a lípidos |
| WO2018160794A1 (en) | 2017-03-01 | 2018-09-07 | Merrimack Pharmaceuticals, Inc. | Epha2-targeted docetaxel -generating liposomes in combination with an agent that impedes regulatory t cell activity for treating cancer |
| CN109422759B (zh) * | 2017-08-22 | 2021-05-04 | 复旦大学 | 小分子修饰的紫杉烷类水溶性前药及其药用用途 |
| CN111004195B (zh) * | 2019-12-03 | 2022-01-28 | 沈阳药科大学 | 卡巴他赛弱碱性衍生物及其制剂 |
| CN120569223A (zh) * | 2022-07-07 | 2025-08-29 | 薇芯制药有限公司 | 多层囊泡药物制剂 |
| CN117024381B (zh) * | 2023-08-14 | 2025-08-12 | 沈阳药科大学 | 卡巴他赛衍生物及其脂质体制剂 |
| TW202539737A (zh) * | 2024-03-29 | 2025-10-16 | 聖安生醫股份有限公司 | 一種大量提升細胞外囊泡藥物裝載效率的方法以及其方法所製成的醫用製劑 |
| CN118324842B (zh) * | 2024-04-10 | 2025-05-02 | 沈阳药科大学 | 地塞米松弱碱性衍生物及其制剂的制备及应用 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2979518A (en) * | 1956-08-14 | 1961-04-11 | Organon | New steroid alaninates |
| GB1272841A (en) * | 1969-01-23 | 1972-05-03 | Leo Ab | New corticoid steroid compounds of cytostatic interest |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4443440A (en) * | 1982-08-30 | 1984-04-17 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
| US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| ATE92501T1 (de) * | 1984-10-04 | 1993-08-15 | Sandoz Ag | Monoklonale antikoerper gegen zyklosporine. |
| US4975282A (en) * | 1985-06-26 | 1990-12-04 | The Liposome Company, Inc. | Multilamellar liposomes having improved trapping efficiencies |
| US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| JPH01117885A (ja) * | 1987-10-30 | 1989-05-10 | Dai Ichi Seiyaku Co Ltd | 新規ボドフィロトキシン誘導体及びその製造法 |
| ZA886810B (en) * | 1987-12-18 | 1989-08-30 | Bristol Myers Co | Epipodophyllotoxin glucoside 4'-acyl derivatives |
| US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
| IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5457111A (en) * | 1991-09-05 | 1995-10-10 | Abbott Laboratories | Macrocyclic immunomodulators |
| US5534632A (en) * | 1991-09-05 | 1996-07-09 | Abbott Laboratories | Macrocyclic carbamate immunomodulators |
| US5563172A (en) * | 1991-09-05 | 1996-10-08 | Abbott Laboratories | Macrocyclic amide and urea immunomodulators |
| JPH069600A (ja) | 1992-05-06 | 1994-01-18 | Bristol Myers Squibb Co | タクソールのベンゾエート誘導体 |
| US5547981A (en) * | 1993-03-09 | 1996-08-20 | Enzon, Inc. | Taxol-7-carbazates |
| US5475011A (en) * | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| AU8052194A (en) * | 1993-10-20 | 1995-05-08 | Enzon, Inc. | 2'- and/or 7- substituted taxoids |
| US5489589A (en) * | 1994-12-07 | 1996-02-06 | Bristol-Myers Squibb Company | Amino acid derivatives of paclitaxel |
| JPH09110865A (ja) * | 1995-08-15 | 1997-04-28 | Masao Oguro | タキソール誘導体 |
| US6107332A (en) * | 1995-09-12 | 2000-08-22 | The Liposome Company, Inc. | Hydrolysis-promoting hydrophobic taxane derivatives |
| CA2263455C (en) * | 1996-08-23 | 2002-10-29 | Sequus Pharmaceuticals, Inc. | Liposomes containing a cisplatin compound |
| GB9814527D0 (en) * | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
| KR100669053B1 (ko) * | 1999-04-23 | 2007-01-15 | 알자 코포레이션 | 리포좀에 사용하기 위한 절단가능 결합을 갖는 콘쥬게이트 |
| FR2810321B1 (fr) * | 2000-06-20 | 2002-07-26 | Adir | Nouveaux derives de podophyllotoxine carbamate et thiocarbamate, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU9418501A (en) * | 2000-10-04 | 2002-04-15 | Kyowa Hakko Kogyo Kk | Method of coating fine particle with lipid film |
| US6403604B1 (en) * | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| US6855720B2 (en) * | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| AU2002303164A1 (en) * | 2001-03-23 | 2002-10-08 | Protarga, Inc. | Fatty amine drug conjugates |
| PT1389089E (pt) * | 2001-03-27 | 2009-11-30 | Phares Pharm Res Nv | Processo e composição para solubilizar um composto biologicamente activo com uma baixa solubilidade em água |
| GB0111279D0 (en) * | 2001-05-10 | 2001-06-27 | Nycomed Imaging As | Radiolabelled liposomes |
| ITMI20020148A1 (it) * | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
| US20050152962A1 (en) * | 2002-06-12 | 2005-07-14 | Metselaar Josbert M. | Composition for treatment of inflammatory disorders |
| EP1585504A4 (en) * | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | Protein stabilized liposomal formulations of pharmaceutical active ingredients |
| US7342114B2 (en) * | 2003-07-01 | 2008-03-11 | California Pacific Medical Center | Podophyllotoxin derivatives |
| US8173840B2 (en) * | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
| US20050095283A1 (en) | 2003-09-16 | 2005-05-05 | Aphios Corporation | Compositions and methods for topically treating diseases |
| JP2007522094A (ja) | 2003-09-22 | 2007-08-09 | アシドフィル エルエルシー | 小分子組成物、及びその組成物を使用して薬物効率を高めるための方法 |
| EP1537858A1 (en) * | 2003-12-04 | 2005-06-08 | Vectron Therapeutics AG | Drug delivery vehicles and uses thereof |
| NZ548195A (en) * | 2004-01-14 | 2011-01-28 | Gilead Sciences Inc | Lipid-based dispersions useful for drug delivery |
| CA2928387A1 (en) * | 2004-05-03 | 2005-11-17 | Merrimack Pharmaceuticals, Inc. | Drug delivery liposomes containing anionic polyols or anionic sugars |
| US7744920B2 (en) * | 2004-09-09 | 2010-06-29 | Hadasit Medical Research Services & Development Limited | Use of liposomal glucocorticoids for treating inflammatory states |
| EP1811962A2 (en) * | 2004-10-29 | 2007-08-01 | Neopharm, Inc. | Manufacturing process for liposomal preparations |
| JP4504845B2 (ja) * | 2005-03-11 | 2010-07-14 | テスコ・エコライティング株式会社 | 照明器具用下部反射板の取り付け具 |
| JP5700909B2 (ja) * | 2005-05-04 | 2015-04-15 | メディゲーネ アクチエンゲゼルシャフトＭｅｄｉＧｅｎｅ ＡＧ | パクリタキセルを含む陽イオン性リポソーム製剤を投与する方法 |
| ES2462541T3 (es) * | 2005-06-09 | 2014-05-23 | Meda Ab | Método y composición para el tratamiento de trastornos inflamatorios |
| US8653238B2 (en) * | 2006-02-27 | 2014-02-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for transport of molecules with enhanced release properties across biological barriers |
| TWI528976B (zh) * | 2006-12-13 | 2016-04-11 | 斯茹林製藥公司 | 用於醫物傳遞之以環糊精為基之聚合物 |
| CN101029034B (zh) | 2007-03-30 | 2010-05-26 | 浙江大学 | 多烯紫杉醇水溶性衍生物及制备方法和用途 |
| EP3415151A1 (en) * | 2008-05-23 | 2018-12-19 | The University of British Columbia | Modified drugs for use in liposomal nanoparticles |
-
2009
- 2009-05-26 EP EP18185021.5A patent/EP3415151A1/en not_active Withdrawn
- 2009-05-26 JP JP2011510067A patent/JP5542804B2/ja not_active Expired - Fee Related
- 2009-05-26 KR KR1020187032439A patent/KR101975843B1/ko not_active Expired - Fee Related
- 2009-05-26 KR KR1020107028838A patent/KR101659457B1/ko not_active Expired - Fee Related
- 2009-05-26 WO PCT/IB2009/006532 patent/WO2009141738A2/en not_active Ceased
- 2009-05-26 EP EP09750195.1A patent/EP2282724B1/en not_active Not-in-force
- 2009-05-26 CN CN201410836670.7A patent/CN104622809B/zh not_active Expired - Fee Related
- 2009-05-26 KR KR1020167025450A patent/KR101830018B1/ko not_active Expired - Fee Related
- 2009-05-26 CA CA2989616A patent/CA2989616A1/en not_active Abandoned
- 2009-05-26 US US12/993,482 patent/US8790691B2/en not_active Expired - Fee Related
- 2009-05-26 CN CN200980128975.XA patent/CN102105135B/zh not_active Expired - Fee Related
- 2009-05-26 CA CA2910133A patent/CA2910133C/en not_active Expired - Fee Related
- 2009-05-26 KR KR1020197012513A patent/KR20190049930A/ko not_active Ceased
- 2009-05-26 KR KR1020187003893A patent/KR101919093B1/ko not_active Expired - Fee Related
- 2009-05-26 CA CA2725535A patent/CA2725535C/en not_active Expired - Fee Related
- 2009-05-26 ES ES09750195.1T patent/ES2694481T3/es active Active
-
2010
- 2010-11-18 IL IL209419A patent/IL209419A/en active IP Right Grant
-
2012
- 2012-05-08 US US13/467,021 patent/US8324410B2/en not_active Expired - Fee Related
-
2013
- 2013-04-19 US US13/866,956 patent/US8545877B2/en not_active Expired - Fee Related
- 2013-04-19 US US13/866,913 patent/US8568772B2/en not_active Expired - Fee Related
- 2013-04-19 US US13/866,873 patent/US8545876B1/en not_active Expired - Fee Related
- 2013-04-25 IL IL225961A patent/IL225961A/en active IP Right Grant
-
2014
- 2014-03-06 JP JP2014043564A patent/JP5744267B2/ja not_active Expired - Fee Related
- 2014-06-12 US US14/302,537 patent/US9968554B2/en not_active Expired - Fee Related
- 2014-07-17 JP JP2014146559A patent/JP5992019B2/ja not_active Expired - Fee Related
-
2016
- 2016-08-16 JP JP2016159491A patent/JP6437968B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-09 US US15/948,716 patent/US20180221279A1/en not_active Abandoned
- 2018-11-15 JP JP2018214441A patent/JP2019048851A/ja active Pending
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