JP2014515354A5 - - Google Patents
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- Publication number
- JP2014515354A5 JP2014515354A5 JP2014511580A JP2014511580A JP2014515354A5 JP 2014515354 A5 JP2014515354 A5 JP 2014515354A5 JP 2014511580 A JP2014511580 A JP 2014511580A JP 2014511580 A JP2014511580 A JP 2014511580A JP 2014515354 A5 JP2014515354 A5 JP 2014515354A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound according
- hydrogen
- alkyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 24
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- -1 amino, Fmoc Chemical class 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000638 benzylaminocarbonyl group Chemical group C(C1=CC=CC=C1)NC(=O)* 0.000 claims 2
- 229960002173 citrulline Drugs 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 2
- AUDYZXNUHIIGRB-UHFFFAOYSA-N 3-thiophen-2-ylpyrrole-2,5-dione Chemical compound O=C1NC(=O)C(C=2SC=CC=2)=C1 AUDYZXNUHIIGRB-UHFFFAOYSA-N 0.000 claims 1
- 238000006845 Michael addition reaction Methods 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488023P | 2011-05-19 | 2011-05-19 | |
| US61/488,023 | 2011-05-19 | ||
| PCT/US2012/038562 WO2012159027A2 (en) | 2011-05-19 | 2012-05-18 | Osw-1 analogs and conjugates, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014515354A JP2014515354A (ja) | 2014-06-30 |
| JP2014515354A5 true JP2014515354A5 (https=) | 2015-07-09 |
Family
ID=47177654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014511580A Pending JP2014515354A (ja) | 2011-05-19 | 2012-05-18 | Ｏｓｗ−１類似体および抱合体、ならびにそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9790253B2 (https=) |
| EP (1) | EP2710024A4 (https=) |
| JP (1) | JP2014515354A (https=) |
| CN (1) | CN103857689A (https=) |
| WO (1) | WO2012159027A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105056236A (zh) * | 2015-08-13 | 2015-11-18 | 暨南大学 | Orp4l在制备治疗急性髓性白血病产品中的应用 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| WO2020160156A2 (en) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anti-gal3 antibodies and uses thereof |
| CN111159770B (zh) * | 2019-12-31 | 2022-12-13 | 医渡云（北京）技术有限公司 | 文本数据脱敏方法、装置、介质及电子设备 |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| FR3125047B1 (fr) * | 2021-07-06 | 2024-03-15 | Centre Nat Rech Scient | Composé de type 7a,8,9,10,11,11a-hexahydro-1H,7H-pyrano[2,3-c]xanthene, leur procédé de préparation, leurs intermédiaires et leurs applications thérapeutiques. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4318924A1 (de) | 1993-06-03 | 1994-12-08 | Schering Ag | Cephalostatin-Analoga |
| JPH0948794A (ja) | 1995-06-02 | 1997-02-18 | Yutaka Sashita | ステロイド配糖体及びこれを有効成分とする医薬 |
| US7321050B2 (en) | 1999-12-06 | 2008-01-22 | Welichem Biotech Inc. | Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues |
| US6753414B2 (en) | 2001-08-07 | 2004-06-22 | University Of Iowa Research Foundation, Inc. | Process for preparing saponin compounds |
| DK1545613T3 (da) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| US20050004044A1 (en) | 2003-04-07 | 2005-01-06 | Board Of Regents | Use of orsaponin [3beta, 16beta, 17 alpha-trihydroxycholost-5-en-22-one 16-0-(2-0-4-methoxybenzoyl-beta-D-xylopyranosyl)-(1->3)-(2-0-acetyl-alpha-L-arabinopyranoside)] or OSW-1 and its derivatives for cancer therapeutics |
| EP2478912B1 (en) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| US7358377B2 (en) | 2004-03-29 | 2008-04-15 | University Of Iowa Research Foundation | Schweinfurthin analogues |
| CN1844138A (zh) | 2006-05-12 | 2006-10-11 | 中国科学院上海有机化学研究所 | 一种合成虎眼万年青皂甙的脱除保护基的方法 |
| US20110319352A1 (en) * | 2008-12-11 | 2011-12-29 | President And Fellows Of Harvard College | Compounds That Bind Oxysterol Binding Proteins, and Methods of Use Thereof |
-
2012
- 2012-05-18 EP EP12786278.7A patent/EP2710024A4/en not_active Withdrawn
- 2012-05-18 JP JP2014511580A patent/JP2014515354A/ja active Pending
- 2012-05-18 CN CN201280035918.9A patent/CN103857689A/zh active Pending
- 2012-05-18 WO PCT/US2012/038562 patent/WO2012159027A2/en not_active Ceased
- 2012-05-18 US US14/118,589 patent/US9790253B2/en not_active Expired - Fee Related
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