JP2011522835A5 - - Google Patents
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- Publication number
- JP2011522835A5 JP2011522835A5 JP2011512705A JP2011512705A JP2011522835A5 JP 2011522835 A5 JP2011522835 A5 JP 2011522835A5 JP 2011512705 A JP2011512705 A JP 2011512705A JP 2011512705 A JP2011512705 A JP 2011512705A JP 2011522835 A5 JP2011522835 A5 JP 2011522835A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- suppressor
- antibody
- isolated
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims 13
- 210000001821 langerhans cell Anatomy 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 3
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102000001398 Granzyme Human genes 0.000 claims 2
- 108060005986 Granzyme Proteins 0.000 claims 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 229930192851 perforin Natural products 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5964708P | 2008-06-06 | 2008-06-06 | |
| US61/059,647 | 2008-06-06 | ||
| PCT/US2009/046464 WO2009149382A2 (en) | 2008-06-06 | 2009-06-05 | Anti-cd8 antibodies block priming of cytotoxic effectors and lead to generation of regulatory cd8+t cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011522835A JP2011522835A (ja) | 2011-08-04 |
| JP2011522835A5 true JP2011522835A5 (enExample) | 2012-07-19 |
Family
ID=41398905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011512705A Pending JP2011522835A (ja) | 2008-06-06 | 2009-06-05 | 抗ｃｄ８抗体は、細胞傷害性エフェクターのプライミングを遮断し、制御性ｃｄ８＋ｔ細胞の生成を導く |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090304659A1 (enExample) |
| EP (1) | EP2297204A4 (enExample) |
| JP (1) | JP2011522835A (enExample) |
| KR (1) | KR20110025812A (enExample) |
| CN (1) | CN102112491A (enExample) |
| AU (1) | AU2009255999A1 (enExample) |
| BR (1) | BRPI0915582A2 (enExample) |
| CA (1) | CA2728772A1 (enExample) |
| IL (1) | IL209798A0 (enExample) |
| MX (1) | MX2010013265A (enExample) |
| NZ (1) | NZ590197A (enExample) |
| TW (1) | TW201000130A (enExample) |
| WO (1) | WO2009149382A2 (enExample) |
| ZA (1) | ZA201100061B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5825966B2 (ja) * | 2011-10-11 | 2015-12-02 | 株式会社日本バイオセラピー研究所 | Ｃｄ５６陽性ｔ細胞増強方法 |
| US10092597B2 (en) | 2014-01-14 | 2018-10-09 | The University Of Hong Kong | Human CD8+ regulatory T cells inhibit GVHD and preserve general immunity in humanized mice |
| WO2018085897A1 (en) * | 2016-11-14 | 2018-05-17 | Murdoch Childrens Research Institute | Transplant rejection assay |
| KR102880156B1 (ko) * | 2017-07-24 | 2025-11-05 | 리제너론 파마슈티칼스 인코포레이티드 | 항cd8 항체 및 이의 용도 |
| US20220227887A1 (en) | 2019-06-11 | 2022-07-21 | Ono Pharmaceutical Co., Ltd. | Immunosuppressant |
| US20240209089A1 (en) * | 2020-07-21 | 2024-06-27 | Suzhou Smartnuclide Biopharmaceutical Co., Ltd. | Cd8 binding polypeptide and use thereof |
| CN112156110B (zh) * | 2020-09-15 | 2022-10-14 | 上海交通大学医学院 | Cd8+抑制性t细胞在免疫调节中的应用及诱导方法 |
| EP4340866A4 (en) | 2021-05-19 | 2025-05-21 | Asher Biotherapeutics, Inc. | Il-21 polypeptides and targeted constructs |
| CN120569191A (zh) | 2022-11-23 | 2025-08-29 | 乔治亚大学研究基金公司 | 用于增加免疫应答的组合物及其使用方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5178858A (en) * | 1987-12-02 | 1993-01-12 | Reichert Thomas A | Method for prevention of graft versus host disease |
| CA1339840C (en) * | 1988-12-16 | 1998-04-28 | Kenneth Kortright | Method and apparatus for screening cells or formed bodies with populations expressing selected characteristics |
| US5601828A (en) * | 1989-03-15 | 1997-02-11 | Tkb Associates Limited Partnership | CD8 derivatives and methods of use for cellular modulation and enhancement of cellular engraftment |
| GB8912497D0 (en) * | 1989-05-31 | 1989-07-19 | Cobbold Stephen P | Monoclonal antibodies |
| US5690933A (en) * | 1989-05-31 | 1997-11-25 | Glaxo Wellcome Inc. | Monoclonal antibodies for inducing tolerance |
| CA2096530A1 (en) * | 1990-11-23 | 1992-05-24 | Thomas Russell | Method and apparatus for screening microscopic cells utilizing light scatter techniques |
| US5876708A (en) * | 1992-02-19 | 1999-03-02 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
| US6911220B1 (en) * | 1992-02-19 | 2005-06-28 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
| US6335174B1 (en) * | 1996-04-05 | 2002-01-01 | South Alabama Medical Science Foundation | Oncofetal antigen specific t-lymphocyte mediated immune response: manipulation and uses of oncofetal antigen specific CD4, CD8 cytotoxic and suppressor T cells and interleukin-10 |
| JP2001511187A (ja) * | 1997-02-28 | 2001-08-07 | エンゾー セラピュウティクス， インコーポレイテッド | 選択的免疫ダウンレギュレーション（ｓｉｄｒ）を行う新規プロセス |
| US6803036B1 (en) * | 1998-03-03 | 2004-10-12 | University Of Southern California | Use of cytokines, cells and mitogens to inhibit graft versus host disease |
| US20040022761A1 (en) * | 2001-05-11 | 2004-02-05 | Banchereau Jacques F | Compositions and methods for producing antigen-presenting cells |
| JP4344696B2 (ja) * | 2002-09-27 | 2009-10-14 | バイオイー， インコーポレイテッド | 細胞分離組成物および細胞分離法 |
| CA2522380A1 (en) * | 2003-03-19 | 2004-09-30 | Isogenis, Inc. | Specific inhibition of allorejection |
| GB0314461D0 (en) * | 2003-06-20 | 2003-07-23 | Isis Innovation | Suppression of transplant rejection |
| EP1674479A1 (en) * | 2004-12-22 | 2006-06-28 | Memorial Sloan-Kettering Cancer Center | Modulation of Fc Gamma receptors for optimizing immunotherapy |
| WO2008005859A2 (en) * | 2006-06-30 | 2008-01-10 | Baylor Research Institute | Dendritic cells generated using gm-csf and interferon alpha and loaded with heat-treated and killed cancer cells |
-
2009
- 2009-06-05 JP JP2011512705A patent/JP2011522835A/ja active Pending
- 2009-06-05 MX MX2010013265A patent/MX2010013265A/es active IP Right Grant
- 2009-06-05 BR BRPI0915582A patent/BRPI0915582A2/pt not_active IP Right Cessation
- 2009-06-05 AU AU2009255999A patent/AU2009255999A1/en not_active Abandoned
- 2009-06-05 KR KR1020117000123A patent/KR20110025812A/ko not_active Withdrawn
- 2009-06-05 CN CN2009801301198A patent/CN102112491A/zh active Pending
- 2009-06-05 CA CA2728772A patent/CA2728772A1/en not_active Abandoned
- 2009-06-05 WO PCT/US2009/046464 patent/WO2009149382A2/en not_active Ceased
- 2009-06-05 EP EP09759540.9A patent/EP2297204A4/en not_active Withdrawn
- 2009-06-05 US US12/479,349 patent/US20090304659A1/en not_active Abandoned
- 2009-06-05 NZ NZ590197A patent/NZ590197A/xx not_active IP Right Cessation
- 2009-06-06 TW TW098118952A patent/TW201000130A/zh unknown
-
2010
- 2010-12-06 IL IL209798A patent/IL209798A0/en unknown
-
2011
- 2011-01-03 ZA ZA2011/00061A patent/ZA201100061B/en unknown
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