JP2011522835A - 抗ｃｄ８抗体は、細胞傷害性エフェクターのプライミングを遮断し、制御性ｃｄ８＋ｔ細胞の生成を導く - Google Patents
抗ｃｄ８抗体は、細胞傷害性エフェクターのプライミングを遮断し、制御性ｃｄ８＋ｔ細胞の生成を導く Download PDFInfo
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013081428A (ja) * | 2011-10-11 | 2013-05-09 | Biotherapy Institute Of Japan | Ｃｄ５６陽性ｔ細胞増強方法 |
| WO2020250940A1 (ja) | 2019-06-11 | 2020-12-17 | 小野薬品工業株式会社 | 免疫抑制剤 |
| JP2023535708A (ja) * | 2020-07-21 | 2023-08-21 | スーチョウ スマートヌクライド バイオファーマシューティカル カンパニー リミテッド | Ｃｄ８結合ポリペプチドおよびその使用 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10092597B2 (en) | 2014-01-14 | 2018-10-09 | The University Of Hong Kong | Human CD8+ regulatory T cells inhibit GVHD and preserve general immunity in humanized mice |
| WO2018085897A1 (en) * | 2016-11-14 | 2018-05-17 | Murdoch Childrens Research Institute | Transplant rejection assay |
| KR102880156B1 (ko) * | 2017-07-24 | 2025-11-05 | 리제너론 파마슈티칼스 인코포레이티드 | 항cd8 항체 및 이의 용도 |
| CN112156110B (zh) * | 2020-09-15 | 2022-10-14 | 上海交通大学医学院 | Cd8+抑制性t细胞在免疫调节中的应用及诱导方法 |
| EP4340866A4 (en) | 2021-05-19 | 2025-05-21 | Asher Biotherapeutics, Inc. | Il-21 polypeptides and targeted constructs |
| CN120569191A (zh) | 2022-11-23 | 2025-08-29 | 乔治亚大学研究基金公司 | 用于增加免疫应答的组合物及其使用方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04503405A (ja) * | 1988-12-16 | 1992-06-18 | クールター エレクトロニクス インコーポレイテッド | 選択された特性を現わす集団についての細胞または形成体をスクリーニングする方法および装置 |
| WO2004112835A2 (en) * | 2003-06-20 | 2004-12-29 | Isis Innovation Ltd | Suppression of transplant rejection |
| JP2006500932A (ja) * | 2002-09-27 | 2006-01-12 | バイオイー， インコーポレイテッド | 細胞分離組成物および細胞分離法 |
| WO2008005859A2 (en) * | 2006-06-30 | 2008-01-10 | Baylor Research Institute | Dendritic cells generated using gm-csf and interferon alpha and loaded with heat-treated and killed cancer cells |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5178858A (en) * | 1987-12-02 | 1993-01-12 | Reichert Thomas A | Method for prevention of graft versus host disease |
| US5601828A (en) * | 1989-03-15 | 1997-02-11 | Tkb Associates Limited Partnership | CD8 derivatives and methods of use for cellular modulation and enhancement of cellular engraftment |
| GB8912497D0 (en) * | 1989-05-31 | 1989-07-19 | Cobbold Stephen P | Monoclonal antibodies |
| US5690933A (en) * | 1989-05-31 | 1997-11-25 | Glaxo Wellcome Inc. | Monoclonal antibodies for inducing tolerance |
| CA2096530A1 (en) * | 1990-11-23 | 1992-05-24 | Thomas Russell | Method and apparatus for screening microscopic cells utilizing light scatter techniques |
| US5876708A (en) * | 1992-02-19 | 1999-03-02 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
| US6911220B1 (en) * | 1992-02-19 | 2005-06-28 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
| US6335174B1 (en) * | 1996-04-05 | 2002-01-01 | South Alabama Medical Science Foundation | Oncofetal antigen specific t-lymphocyte mediated immune response: manipulation and uses of oncofetal antigen specific CD4, CD8 cytotoxic and suppressor T cells and interleukin-10 |
| JP2001511187A (ja) * | 1997-02-28 | 2001-08-07 | エンゾー セラピュウティクス， インコーポレイテッド | 選択的免疫ダウンレギュレーション（ｓｉｄｒ）を行う新規プロセス |
| US6803036B1 (en) * | 1998-03-03 | 2004-10-12 | University Of Southern California | Use of cytokines, cells and mitogens to inhibit graft versus host disease |
| US20040022761A1 (en) * | 2001-05-11 | 2004-02-05 | Banchereau Jacques F | Compositions and methods for producing antigen-presenting cells |
| CA2522380A1 (en) * | 2003-03-19 | 2004-09-30 | Isogenis, Inc. | Specific inhibition of allorejection |
| EP1674479A1 (en) * | 2004-12-22 | 2006-06-28 | Memorial Sloan-Kettering Cancer Center | Modulation of Fc Gamma receptors for optimizing immunotherapy |
-
2009
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- 2009-06-05 CA CA2728772A patent/CA2728772A1/en not_active Abandoned
- 2009-06-05 WO PCT/US2009/046464 patent/WO2009149382A2/en not_active Ceased
- 2009-06-05 EP EP09759540.9A patent/EP2297204A4/en not_active Withdrawn
- 2009-06-05 US US12/479,349 patent/US20090304659A1/en not_active Abandoned
- 2009-06-05 NZ NZ590197A patent/NZ590197A/xx not_active IP Right Cessation
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2010
- 2010-12-06 IL IL209798A patent/IL209798A0/en unknown
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2011
- 2011-01-03 ZA ZA2011/00061A patent/ZA201100061B/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04503405A (ja) * | 1988-12-16 | 1992-06-18 | クールター エレクトロニクス インコーポレイテッド | 選択された特性を現わす集団についての細胞または形成体をスクリーニングする方法および装置 |
| JP2006500932A (ja) * | 2002-09-27 | 2006-01-12 | バイオイー， インコーポレイテッド | 細胞分離組成物および細胞分離法 |
| WO2004112835A2 (en) * | 2003-06-20 | 2004-12-29 | Isis Innovation Ltd | Suppression of transplant rejection |
| WO2008005859A2 (en) * | 2006-06-30 | 2008-01-10 | Baylor Research Institute | Dendritic cells generated using gm-csf and interferon alpha and loaded with heat-treated and killed cancer cells |
Non-Patent Citations (3)
| Title |
|---|
| JPN6013057688; 病理と臨床 第２４巻，第５号, 2006, ｐ．４７３-４７９ * |
| JPN6013057690; 実験医学 第１８巻，第１５号, 2000, ｐ．２１１６-２１２２ * |
| JPN6013057691; Ａｍｅｒｉｃａｎ Ｊｏｕｒｎａｌ ｏｆ Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ Ｖｏｌ．７， Ｎｏ．５, 2007, ｐ．１０５５-１０６１ * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013081428A (ja) * | 2011-10-11 | 2013-05-09 | Biotherapy Institute Of Japan | Ｃｄ５６陽性ｔ細胞増強方法 |
| WO2020250940A1 (ja) | 2019-06-11 | 2020-12-17 | 小野薬品工業株式会社 | 免疫抑制剤 |
| JP2023535708A (ja) * | 2020-07-21 | 2023-08-21 | スーチョウ スマートヌクライド バイオファーマシューティカル カンパニー リミテッド | Ｃｄ８結合ポリペプチドおよびその使用 |
| JP7688941B2 (ja) | 2020-07-21 | 2025-06-05 | スーチョウ スマートヌクライド バイオファーマシューティカル カンパニー リミテッド | Ｃｄ８結合ポリペプチドおよびその使用 |
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| CN102112491A (zh) | 2011-06-29 |
| WO2009149382A3 (en) | 2010-04-29 |
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| CA2728772A1 (en) | 2009-12-10 |
| US20090304659A1 (en) | 2009-12-10 |
| EP2297204A2 (en) | 2011-03-23 |
| KR20110025812A (ko) | 2011-03-11 |
| WO2009149382A2 (en) | 2009-12-10 |
| IL209798A0 (en) | 2011-02-28 |
| ZA201100061B (en) | 2011-10-26 |
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