JP2011522773A5 - - Google Patents
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- JP2011522773A5 JP2011522773A5 JP2010540875A JP2010540875A JP2011522773A5 JP 2011522773 A5 JP2011522773 A5 JP 2011522773A5 JP 2010540875 A JP2010540875 A JP 2010540875A JP 2010540875 A JP2010540875 A JP 2010540875A JP 2011522773 A5 JP2011522773 A5 JP 2011522773A5
- Authority
- JP
- Japan
- Prior art keywords
- treatment
- cancer
- pharmaceutically acceptable
- acceptable salt
- hedgehog inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000011282 treatment Methods 0.000 claims description 354
- 206010028980 Neoplasm Diseases 0.000 claims description 133
- 201000011510 cancer Diseases 0.000 claims description 120
- 241000289669 Erinaceus europaeus Species 0.000 claims description 103
- 239000003112 inhibitor Substances 0.000 claims description 83
- 150000003839 salts Chemical class 0.000 claims description 74
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 33
- 229960004316 cisplatin Drugs 0.000 claims description 33
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 33
- 229960005277 gemcitabine Drugs 0.000 claims description 33
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 24
- 239000003446 ligand Substances 0.000 claims description 22
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 21
- 229930012538 Paclitaxel Natural products 0.000 claims description 21
- 229960000397 bevacizumab Drugs 0.000 claims description 21
- 229960002949 fluorouracil Drugs 0.000 claims description 21
- 229960001592 paclitaxel Drugs 0.000 claims description 21
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 21
- 239000002246 antineoplastic agent Substances 0.000 claims description 20
- 229940127089 cytotoxic agent Drugs 0.000 claims description 20
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 19
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 19
- 229960004562 carboplatin Drugs 0.000 claims description 19
- 229960003668 docetaxel Drugs 0.000 claims description 19
- 229960004768 irinotecan Drugs 0.000 claims description 19
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims description 19
- 238000011275 oncology therapy Methods 0.000 claims description 15
- 229960005395 cetuximab Drugs 0.000 claims description 14
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 13
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 13
- 201000002528 pancreatic cancer Diseases 0.000 claims description 13
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 13
- 206010009944 Colon cancer Diseases 0.000 claims description 12
- 206010033128 Ovarian cancer Diseases 0.000 claims description 12
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 12
- 208000029742 colonic neoplasm Diseases 0.000 claims description 12
- 229960004679 doxorubicin Drugs 0.000 claims description 12
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical group COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims description 12
- 229960005420 etoposide Drugs 0.000 claims description 12
- 229960005079 pemetrexed Drugs 0.000 claims description 12
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 claims description 12
- 229960000303 topotecan Drugs 0.000 claims description 12
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims description 12
- 238000001959 radiotherapy Methods 0.000 claims description 11
- 206010005003 Bladder cancer Diseases 0.000 claims description 10
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 10
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 10
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 10
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 10
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims description 9
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims description 9
- 229960001904 epirubicin Drugs 0.000 claims description 9
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 8
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 8
- 201000005202 lung cancer Diseases 0.000 claims description 8
- 208000020816 lung neoplasm Diseases 0.000 claims description 8
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 8
- 230000004083 survival effect Effects 0.000 claims description 8
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims description 7
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims description 7
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims description 7
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims description 7
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims description 7
- 229960004117 capecitabine Drugs 0.000 claims description 7
- 229960001433 erlotinib Drugs 0.000 claims description 7
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims description 7
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims description 7
- 235000008191 folinic acid Nutrition 0.000 claims description 7
- 239000011672 folinic acid Substances 0.000 claims description 7
- 229960002584 gefitinib Drugs 0.000 claims description 7
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims description 7
- 229960001691 leucovorin Drugs 0.000 claims description 7
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 7
- 229960001756 oxaliplatin Drugs 0.000 claims description 7
- 229960001972 panitumumab Drugs 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims description 7
- 229960002066 vinorelbine Drugs 0.000 claims description 7
- 230000000306 recurrent effect Effects 0.000 claims description 6
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 5
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 5
- 206010060862 Prostate cancer Diseases 0.000 claims description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 5
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims description 5
- 210000001185 bone marrow Anatomy 0.000 claims description 5
- 229960000485 methotrexate Drugs 0.000 claims description 5
- 229960004857 mitomycin Drugs 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 229960003048 vinblastine Drugs 0.000 claims description 5
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims description 5
- 208000034578 Multiple myelomas Diseases 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
- 238000001574 biopsy Methods 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 2
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims description 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 208000014829 head and neck neoplasm Diseases 0.000 claims 5
- 208000005243 Chondrosarcoma Diseases 0.000 claims 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 201000008968 osteosarcoma Diseases 0.000 claims 4
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 claims 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 241000027355 Ferocactus setispinus Species 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000002825 nitriles Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- DQKIJKCARXABEE-SQELQLCWSA-N C[C@H]1[C@](CC2)(CC(C)C(C3)[C@@H]2C(CC2)[C@H]3[C@@](C)(CCCC3)[C@]23N)OC2[C@H]1NC[C@@H](C)C2 Chemical compound C[C@H]1[C@](CC2)(CC(C)C(C3)[C@@H]2C(CC2)[C@H]3[C@@](C)(CCCC3)[C@]23N)OC2[C@H]1NC[C@@H](C)C2 DQKIJKCARXABEE-SQELQLCWSA-N 0.000 description 3
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 0 C[C@@]1[C@](CCC(C2)(C3C4)[C@](CC5)[C@]4[C@@](*)(CC4)[C@@]5(*)CC4(*)I)(C[C@@]23[Mc])N[C@](C2)[C@]1N(*)C[C@]2[Mc] Chemical compound C[C@@]1[C@](CCC(C2)(C3C4)[C@](CC5)[C@]4[C@@](*)(CC4)[C@@]5(*)CC4(*)I)(C[C@@]23[Mc])N[C@](C2)[C@]1N(*)C[C@]2[Mc] 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- -1 bevacizumab Chemical compound 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1716007P | 2007-12-27 | 2007-12-27 | |
| US61/017,160 | 2007-12-27 | ||
| US11/965,688 US7812164B2 (en) | 2006-12-28 | 2007-12-27 | Cyclopamine analogs |
| US11/965,688 | 2007-12-27 | ||
| US11896908P | 2008-12-01 | 2008-12-01 | |
| US61/118,969 | 2008-12-01 | ||
| PCT/US2008/088222 WO2009086416A1 (en) | 2007-12-27 | 2008-12-23 | Therapeutic cancer treatments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011522773A JP2011522773A (ja) | 2011-08-04 |
| JP2011522773A5 true JP2011522773A5 (OSRAM) | 2012-02-16 |
Family
ID=40824720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540875A Pending JP2011522773A (ja) | 2007-12-27 | 2008-12-23 | 治療剤での癌の処置方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090181997A1 (OSRAM) |
| EP (1) | EP2225254A4 (OSRAM) |
| JP (1) | JP2011522773A (OSRAM) |
| KR (1) | KR20100137416A (OSRAM) |
| CN (1) | CN101918420A (OSRAM) |
| AR (1) | AR070047A1 (OSRAM) |
| AU (1) | AU2008345151A1 (OSRAM) |
| BR (1) | BRPI0821779A2 (OSRAM) |
| CA (1) | CA2710377A1 (OSRAM) |
| CL (1) | CL2008003901A1 (OSRAM) |
| IL (1) | IL206632A0 (OSRAM) |
| MX (1) | MX2010006991A (OSRAM) |
| PE (1) | PE20091180A1 (OSRAM) |
| TW (1) | TW200934784A (OSRAM) |
| WO (1) | WO2009086416A1 (OSRAM) |
| ZA (1) | ZA201004403B (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| ES2610130T3 (es) | 2007-12-27 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Métodos para reducción estereoselectiva |
| US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
| CA2750639A1 (en) * | 2009-01-23 | 2010-07-29 | Cancer Research Technology Limited | Hedgehog pathway inhibitors |
| ES2567134T3 (es) | 2009-08-05 | 2016-04-20 | Infinity Pharmaceuticals, Inc. | Transaminación enzimática de análogos de ciclopamina |
| KR20120053052A (ko) | 2009-08-25 | 2012-05-24 | 아브락시스 바이오사이언스, 엘엘씨 | 헤지호그 억제제 및 탁산의 나노입자 조성물로의 조합 요법 |
| US20110183948A1 (en) * | 2010-01-15 | 2011-07-28 | Infinity Pharmaceuticals, Inc. | Treatment of fibrotic conditions using hedgehog inhibitors |
| US20120010229A1 (en) * | 2010-07-08 | 2012-01-12 | Macdougall John R | Therapeutic regimens for hedgehog-associated cancers |
| US20120010230A1 (en) * | 2010-07-08 | 2012-01-12 | Macdougall John R | Methods and compositions for identification, assessment and treatment of cancers associated with hedgehog signaling |
| US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| RU2492855C2 (ru) * | 2011-02-15 | 2013-09-20 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт онкологии" СО РАМН (ФГБУ "НИИ онкологии" СО РАМН) | Способ комбинированного лечения немелкоклеточного рака легкого ii и iii стадии с пред- и послеоперационной химиотерапией |
| CA2752008A1 (en) | 2011-09-13 | 2013-03-13 | Universite De Montreal | Combination therapy using ribavirin as elf4e inhibitor |
| CA2955384C (en) * | 2014-07-17 | 2024-03-12 | Biocurity Holdings, Inc. | Treatment of cancer with a combination of radiation, cerium oxide nanoparticles, and a chemotherapeutic agent |
| ES3007999T3 (en) * | 2015-04-21 | 2025-03-21 | Genentech Inc | Compositions and methods for prostate cancer analysis |
| BR112017026103B1 (pt) | 2015-06-04 | 2023-10-03 | Sol-Gel Technologies Ltd | Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos |
| CN107137406B (zh) * | 2016-03-01 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 一种Hedgehog信号通路抑制剂在制备治疗EGFR过度表达的癌症的药物中的用途 |
| MX381059B (es) * | 2016-08-10 | 2025-04-01 | Celgene Quanticel Res Inc | Tratamiento de tumores y linfomas no de hodgkin sólidos, reincididos y/o refractarios. |
| AU2018247767B2 (en) | 2017-04-03 | 2025-01-30 | F. Hoffmann-La Roche Ag | Antibodies binding to STEAP-1 |
| MX2020009759A (es) | 2018-07-31 | 2020-10-08 | Ascentage Pharma Suzhou Co Ltd | Efecto antitumoral sinergico de un inhibidor de bcl-2 combinado con rituximab y/o bendamustina o un inhibidor de bcl-2 combinado con chop. |
| CN110772521A (zh) | 2018-07-31 | 2020-02-11 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
| CA3095699A1 (en) | 2018-07-31 | 2020-02-06 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
| AU2019314624B2 (en) | 2018-07-31 | 2022-03-03 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of Bcl-2 inhibitor and MDM2 inhibitor and use thereof in the prevention and/or treatment of diseases |
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- 2008-12-23 BR BRPI0821779A patent/BRPI0821779A2/pt not_active IP Right Cessation
- 2008-12-23 CN CN2008801239807A patent/CN101918420A/zh active Pending
- 2008-12-23 CA CA2710377A patent/CA2710377A1/en not_active Abandoned
- 2008-12-23 AU AU2008345151A patent/AU2008345151A1/en not_active Abandoned
- 2008-12-23 WO PCT/US2008/088222 patent/WO2009086416A1/en not_active Ceased
- 2008-12-23 US US12/343,245 patent/US20090181997A1/en not_active Abandoned
- 2008-12-23 EP EP08868388A patent/EP2225254A4/en not_active Withdrawn
- 2008-12-23 MX MX2010006991A patent/MX2010006991A/es not_active Application Discontinuation
- 2008-12-23 AR ARP080105739A patent/AR070047A1/es not_active Application Discontinuation
- 2008-12-23 JP JP2010540875A patent/JP2011522773A/ja active Pending
- 2008-12-23 KR KR1020107016717A patent/KR20100137416A/ko not_active Withdrawn
- 2008-12-24 CL CL2008003901A patent/CL2008003901A1/es unknown
- 2008-12-26 TW TW097151085A patent/TW200934784A/zh unknown
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2010
- 2010-06-22 ZA ZA2010/04403A patent/ZA201004403B/en unknown
- 2010-06-27 IL IL206632A patent/IL206632A0/en unknown
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