JP2011522515A5 - - Google Patents
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- JP2011522515A5 JP2011522515A5 JP2011504009A JP2011504009A JP2011522515A5 JP 2011522515 A5 JP2011522515 A5 JP 2011522515A5 JP 2011504009 A JP2011504009 A JP 2011504009A JP 2011504009 A JP2011504009 A JP 2011504009A JP 2011522515 A5 JP2011522515 A5 JP 2011522515A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- composition according
- administering
- salinomycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 12
- 229930012538 Paclitaxel Natural products 0.000 claims 4
- KQXDHUJYNAXLNZ-XQSDOZFQSA-N Salinomycin Chemical compound O1[C@@H]([C@@H](CC)C(O)=O)CC[C@H](C)[C@@H]1[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@@H]1[C@@H](C)C[C@@H](C)[C@@]2(C=C[C@@H](O)[C@@]3(O[C@@](C)(CC3)[C@@H]3O[C@@H](C)[C@@](O)(CC)CC3)O2)O1 KQXDHUJYNAXLNZ-XQSDOZFQSA-N 0.000 claims 4
- 239000004189 Salinomycin Substances 0.000 claims 4
- 229960001592 paclitaxel Drugs 0.000 claims 4
- 229960001548 salinomycin Drugs 0.000 claims 4
- 235000019378 salinomycin Nutrition 0.000 claims 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000009956 adenocarcinoma Diseases 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 208000017572 squamous cell neoplasm Diseases 0.000 claims 2
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 201000009051 Embryonal Carcinoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 201000010208 Seminoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- 208000003362 bronchogenic carcinoma Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000002445 cystadenocarcinoma Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000025189 neoplasm of testis Diseases 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000004019 papillary adenocarcinoma Diseases 0.000 claims 1
- 208000018964 sebaceous gland cancer Diseases 0.000 claims 1
- 208000011581 secondary neoplasm Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 201000008759 sweat gland cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4394808P | 2008-04-10 | 2008-04-10 | |
| US61/043,948 | 2008-04-10 | ||
| US5356308P | 2008-05-15 | 2008-05-15 | |
| US61/053,563 | 2008-05-15 | ||
| PCT/US2009/002254 WO2009126310A2 (en) | 2008-04-10 | 2009-04-10 | Methods for identification and use of agents targeting cancer stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014079322A Division JP2014128294A (ja) | 2008-04-10 | 2014-04-08 | 癌幹細胞を標的とする薬剤を同定する方法およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011522515A JP2011522515A (ja) | 2011-08-04 |
| JP2011522515A5 true JP2011522515A5 (https=) | 2013-08-15 |
Family
ID=41162467
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011504009A Pending JP2011522515A (ja) | 2008-04-10 | 2009-04-10 | 癌幹細胞を標的とする薬剤を同定する方法およびその使用 |
| JP2014079322A Pending JP2014128294A (ja) | 2008-04-10 | 2014-04-08 | 癌幹細胞を標的とする薬剤を同定する方法およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014079322A Pending JP2014128294A (ja) | 2008-04-10 | 2014-04-08 | 癌幹細胞を標的とする薬剤を同定する方法およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20110191868A1 (https=) |
| EP (2) | EP2274617A4 (https=) |
| JP (2) | JP2011522515A (https=) |
| CN (1) | CN102144163A (https=) |
| CA (1) | CA2723648A1 (https=) |
| WO (1) | WO2009126310A2 (https=) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2579909T3 (es) | 2009-02-03 | 2016-08-17 | Koninklijke Nederlandse Akademie Van Wetenschappen | Medio de cultivo para células madre epiteliales y organoides que comprenden dichas células madre |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| US20120295346A1 (en) * | 2009-07-22 | 2012-11-22 | Tufts University | Methods and compositions for modulating membrane potential to influence cell behavior |
| EP2322927A1 (en) * | 2009-11-16 | 2011-05-18 | Deutsches Krebsforschungszentrum | Compounds inhibiting CD95 signaling for the treatment of pancreatic cancer |
| US8815581B2 (en) | 2010-02-03 | 2014-08-26 | Samsung Life Public Welfare Foundation | Method for proliferating stem cells by activating c-MET/HGF signaling and notch signaling |
| EP2561356B1 (en) | 2010-04-18 | 2016-08-03 | Yeda Research and Development Co. Ltd. | MOLECULES AND METHODS OF USING SAME FOR TREATING ErbB/ErbB LIGANDS ASSOCIATED DISEASES |
| US10095842B2 (en) * | 2010-05-28 | 2018-10-09 | Salgomed, Inc. | Methods for artificial combinatorial control of biological systems |
| US20110293525A1 (en) * | 2010-05-29 | 2011-12-01 | Board Of Trustees Of The University Of Illinois | Tumor stem cells |
| WO2012018857A2 (en) * | 2010-08-02 | 2012-02-09 | The Broad Institute Of Mit And Harvard | Prediction of and monitoring cancer therapy response based on gene expression profiling |
| JP2013536689A (ja) | 2010-09-01 | 2013-09-26 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | Emtを調節するための組成物および方法ならびにその使用 |
| US9778264B2 (en) | 2010-09-03 | 2017-10-03 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
| EP2611463A2 (en) | 2010-09-03 | 2013-07-10 | Stem Centrx, Inc. | Identification and enrichment of cell subpopulations |
| GB201100180D0 (en) * | 2011-01-06 | 2011-02-23 | Capsant Neurotechnologies Ltd | Tumour cell and tissue culture |
| FR2970179B1 (fr) | 2011-01-11 | 2013-01-18 | Centre Nat Rech Scient | Moyens pour reduire ou eradiquer le pouvoir tumoral de cellules souches cancereuses et/ou metastasiques |
| WO2013105985A1 (en) | 2011-02-28 | 2013-07-18 | Philadelphia Health & Education Corporation | Small molecule inhibitors of rad51 recombinase and methods thereof |
| US20130331381A1 (en) | 2011-02-28 | 2013-12-12 | Mcmaster University | Treatment of Cancer WIth Dopamine Receptor Antagonists |
| ES2586599T3 (es) * | 2011-03-24 | 2016-10-17 | The Rogosin Institute | Ensayo para cribar compuestos que disminuyen selectivamente el número de células madre de cáncer |
| CN103562723B (zh) * | 2011-03-27 | 2017-04-26 | 欧恩克斯特姆诊断学(毛里求斯)私人有限公司 | 用于识别肿瘤细胞的标记、方法及其试剂盒 |
| WO2012150543A1 (en) | 2011-05-02 | 2012-11-08 | Universite De Geneve | Macrocyclic lactones and use thereof |
| WO2012167101A1 (en) * | 2011-06-03 | 2012-12-06 | The General Hospital Corporation | Ovarian cancer stem cells and methods of isolation and uses thereof |
| DK2729806T3 (en) | 2011-07-08 | 2017-05-15 | Sloan-Kettering Inst For Cancer Res | APPLICATIONS OF MARKED HSP90 INHIBITORS |
| WO2013032907A1 (en) * | 2011-08-26 | 2013-03-07 | The Broad Institute, Inc. | Compounds and methods for the treatment of cancer stem cells |
| WO2013063229A1 (en) * | 2011-10-25 | 2013-05-02 | The Regents Of The University Of Michigan | Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells |
| WO2013071247A1 (en) | 2011-11-10 | 2013-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Gene expression signatures of neoplasm responsiveness to theraphy |
| WO2013071066A1 (en) * | 2011-11-11 | 2013-05-16 | The Broad Institute, Inc. | Signatures associated with the response to cancer therapy |
| CN103127052A (zh) * | 2011-12-05 | 2013-06-05 | 维瑞斯特姆有限公司 | 治疗组合物和相关使用方法 |
| CN103193841A (zh) | 2012-01-06 | 2013-07-10 | 维瑞斯特姆有限公司 | 治疗性化合物及相关使用方法 |
| US9534058B2 (en) | 2012-02-08 | 2017-01-03 | Abbvie Stemcentrx Llc | Anti-CD324 monoclonal antibodies and uses thereof |
| CN103243074B (zh) * | 2012-02-14 | 2014-10-01 | 中国科学院动物研究所 | 一种人结直肠癌肿瘤细胞系及其制备方法和应用 |
| US20150017134A1 (en) * | 2012-03-01 | 2015-01-15 | Whitehead Institute For Biomedical Research | Emt-inducing transcription factors cooperate with sox9 |
| JP6429191B2 (ja) * | 2012-03-06 | 2018-11-28 | セレクト バイオセラピューティクス リミテッド | アポトーシスシグナル伝達抵抗性細胞を選択する装置および方法ならびにその使用 |
| US9080154B1 (en) * | 2012-04-02 | 2015-07-14 | Bowling Green State University | Cancer stem cell survivor lines |
| KR101463183B1 (ko) | 2012-06-05 | 2014-11-21 | 연세대학교 산학협력단 | 암 줄기세포 특성에 기초한 암의 신규한 치료용 타겟 및 바이오마커 |
| CN110079580B (zh) | 2012-06-22 | 2022-12-06 | 真蒂奥姆责任有限公司 | 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法 |
| WO2014009245A2 (en) * | 2012-07-09 | 2014-01-16 | Qithera Gmbh | Novel drug target indentification methods |
| NZ727295A (en) * | 2012-08-09 | 2018-06-29 | Celgene Corp | Treatment of immune-related and inflammatory diseases |
| US20150038511A1 (en) | 2012-08-09 | 2015-02-05 | Celgene Corporation | Treatment of immune-related and inflammatory diseases |
| WO2014074805A1 (en) | 2012-11-08 | 2014-05-15 | Whitehead Institute For Biomedical Research | Selective targeting of cancer stem cells |
| US9551036B2 (en) | 2013-02-25 | 2017-01-24 | Whitehead Institute For Biomedical Research | Metabolic gene mesenchymal signatures and uses thereof |
| GB2513299A (en) | 2013-03-12 | 2014-10-29 | Cellact Pharma Gmbh Biomedizinzentrum | Compounds for targeting cancer stem cells |
| EP2972381A2 (en) * | 2013-03-14 | 2016-01-20 | Galapagos NV | Molecular targets and compounds, and methods to identify the same, useful in the treatment of diseases associated with epithelial mesenchymal transition |
| CN104840961B (zh) * | 2014-02-14 | 2016-03-23 | 马立伟 | 癌症干细胞敏感剂在制备抗癌症干细胞试剂盒中的应用 |
| KR102353589B1 (ko) * | 2014-03-17 | 2022-01-19 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 핵 인자-κB 전위에 근거하여 화합물의 독성을 예측하는 방법 |
| WO2015140296A2 (en) * | 2014-03-20 | 2015-09-24 | Centre National De La Recherche Scientifique (Cnrs) | Use of compounds inhibiting apelin / apj / gp130 signaling for treating cancer |
| EP2921855A1 (en) * | 2014-03-20 | 2015-09-23 | Centre National de la Recherche Scientifique (CNRS) | Use of compounds inhibiting apelin / apj / gp130 signaling for treating cancer |
| WO2015168255A1 (en) | 2014-04-29 | 2015-11-05 | Whitehead Institute For Biomedical Research | Methods and compositions for targeting cancer stem cells |
| WO2015171339A1 (en) * | 2014-05-06 | 2015-11-12 | The Board Of Regents Of The University Of Texas System | Identification and isolation of neural stem cells and neurosphere initiating cells |
| AU2015261380B2 (en) | 2014-05-16 | 2021-04-15 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method for organoids |
| US10245266B2 (en) | 2014-05-19 | 2019-04-02 | Celgene Corporation | 3-(4-((4-morpholinomethyl-benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione for the treatment of systemic lupus erythematosus |
| JP6277894B2 (ja) * | 2014-07-08 | 2018-02-14 | 株式会社島津製作所 | 上皮間葉転換の有無を判別する方法 |
| WO2016047688A1 (ja) * | 2014-09-24 | 2016-03-31 | 国立研究開発法人国立がん研究センター | 扁平上皮がんに対する化学放射線療法の有効性を評価するための方法 |
| US20170304251A1 (en) * | 2014-10-09 | 2017-10-26 | Paul Anthony Spagnuolo | Avocado-derived lipids for use in treating leukemia |
| EP3026122A1 (en) * | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| GB201421094D0 (en) * | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201421092D0 (en) * | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| WO2016098041A1 (en) * | 2014-12-18 | 2016-06-23 | Saarum Sciences Private Ltd | Establishment and use of an in vitro platform for emt |
| CN104725511B (zh) * | 2015-02-16 | 2018-01-12 | 华南农业大学 | 一种猪肠道干细胞的分离培养方法 |
| EP3415149A1 (en) * | 2015-05-14 | 2018-12-19 | NuCana plc | Cancer treatments |
| JP2019515643A (ja) * | 2015-09-23 | 2019-06-13 | ミネルバ バイオテクノロジーズ コーポレーション | 幹細胞分化剤のスクリーニング方法 |
| GB201603569D0 (en) | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
| GB201609600D0 (en) | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Cancer treatments |
| CN106701886B (zh) * | 2016-12-16 | 2021-06-22 | 管晓翔 | 一种三阴性乳腺癌细胞上皮间质转换过程中对内皮细胞分泌功能影响的检测方法 |
| US11957739B2 (en) * | 2017-11-08 | 2024-04-16 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating cancer using RHOA dominant negative forms |
| GB201721615D0 (en) | 2017-12-21 | 2018-02-07 | Koninklijke Nederlandse Akademie Van Wetenschappen | Immune cell organoid co-cultures |
| EP3502700A1 (en) * | 2017-12-21 | 2019-06-26 | Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron | Methods based on the detection of rad51 foci in tumor cells |
| CN108410986B (zh) * | 2018-02-26 | 2021-06-22 | 中国人民解放军总医院 | Cdh6促进骨肉瘤生长和转移 |
| US10146914B1 (en) * | 2018-03-01 | 2018-12-04 | Recursion Pharmaceuticals, Inc. | Systems and methods for evaluating whether perturbations discriminate an on target effect |
| GB201819224D0 (en) | 2018-11-26 | 2019-01-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Hepatocyte expansion methods |
| CN109512833B (zh) * | 2018-12-04 | 2020-10-30 | 天津医科大学总医院 | E2f6抑制剂的功能与用途 |
| CN110082536B (zh) * | 2019-04-17 | 2022-06-10 | 广州医科大学附属肿瘤医院 | 一种乳腺癌细胞标志物细胞因子群及其应用 |
| WO2021188849A1 (en) * | 2020-03-20 | 2021-09-23 | University Of Houston System | Methods and compositions for treating inflammatory and fibrotic pulmonary disorders |
| US12116637B2 (en) | 2020-07-24 | 2024-10-15 | The Regents Of The University Of Michigan | Compositions and methods for detecting and treating high grade subtypes of uterine cancer |
| CN116783487A (zh) * | 2020-08-05 | 2023-09-19 | 乔斯林糖尿病中心公司 | 终末期肾病生物标记物组 |
| WO2022059026A1 (en) * | 2020-09-21 | 2022-03-24 | Mestastop Solutions Private Limited | Systems and methods for predicting cancer metastasis and screening of drugs |
| CN112730840B (zh) * | 2021-01-29 | 2023-10-17 | 章毅 | 鉴别cd44和cd24分子表型的方法 |
| CN113125689B (zh) * | 2021-03-29 | 2022-02-22 | 创芯国际生物科技(广州)有限公司 | 一种新型mtt细胞活力检测试剂盒及其应用 |
| CN114181102B (zh) * | 2021-11-10 | 2023-06-23 | 深圳市检验检疫科学研究院 | 己雷琐辛半抗原、人工抗原、抗体及其合成方法和应用 |
| CN116286658A (zh) * | 2022-09-26 | 2023-06-23 | 南通大学 | Traf5抑制剂在制备人恶性黑色素瘤治疗药物中的应用 |
| CN115992240A (zh) * | 2022-10-28 | 2023-04-21 | 中山大学附属第三医院 | E2f转录因子2作为治疗靶点在制备预防和/或治疗多发性骨髓瘤的药物中的应用 |
| CN115948558B (zh) * | 2023-01-19 | 2025-04-11 | 重庆医科大学 | 乳腺癌肺特异性转移的标志物及其药物组合物与应用 |
| CN117347621B (zh) * | 2023-08-25 | 2024-03-12 | 广东省农业科学院农业生物基因研究中心 | 一种用蛋白模拟抗原-纳米抗体检测黄曲霉毒素b1的方法 |
| WO2025170878A1 (en) * | 2024-02-05 | 2025-08-14 | Exvivo Labs Inc | Methods for high-throughput drug screens at clonal resolution |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| EP0336248A1 (de) | 1988-03-31 | 1989-10-11 | Hoechst Aktiengesellschaft | Am F-Ring substituierte Nigericinderivate, Verfahren zu deren Herstellung, diese enthaltende Mittel und Verwendung derselben als antiviral wirksam und antibakteriell wirksame Substanzen |
| EP0346760A2 (de) | 1988-06-14 | 1989-12-20 | Hoechst Aktiengesellschaft | Nigericinderivate, Verfahren zu deren Herstellung, diese enthaltende Mittel und Verwendung derselben |
| DE3829450A1 (de) | 1988-08-31 | 1990-03-01 | Hoechst Ag | Nigericinderivate, verfahren zu deren herstellung, diese enthaltende mittel und verwendung derselben |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5211657A (en) | 1988-11-07 | 1993-05-18 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5407686A (en) | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
| US5229415A (en) | 1992-03-24 | 1993-07-20 | Merck & Co., Inc. | Alkylthio alkyl avermectins are active antiparasitic agents |
| GB9312154D0 (en) | 1993-06-12 | 1993-07-28 | Pfizer Ltd | Antiparasitic agents |
| US20020042079A1 (en) * | 1994-02-01 | 2002-04-11 | Sanford M. Simon | Methods and agents for measuring and controlling multidrug resistance |
| EP0804249A2 (en) | 1994-03-15 | 1997-11-05 | Brown University Research Foundation | Polymeric gene delivery system |
| US6190657B1 (en) | 1995-06-07 | 2001-02-20 | Yale University | Vectors for the diagnosis and treatment of solid tumors including melanoma |
| US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US7122623B2 (en) | 1996-07-12 | 2006-10-17 | Adherex Technologies, Inc. | Compounds and methods for modulating cell adhesion |
| DK1001962T3 (da) | 1997-07-23 | 2002-12-16 | Pfizer | Fremstilling af avermectinforbindelser |
| US8334238B2 (en) | 1998-04-17 | 2012-12-18 | Rigel, Inc. | Multiparameter FACS assays to detect alterations in cellular parameters and to screen small molecule libraries |
| US20040101936A1 (en) | 2000-02-24 | 2004-05-27 | Hirofumi Endo | Process for producing avermectin derivative |
| US20050209310A1 (en) * | 2000-12-22 | 2005-09-22 | Chaplin David J | Methods for modulating tumor growth and metastasis |
| SE0102168D0 (sv) * | 2001-06-19 | 2001-06-19 | Karolinska Innovations Ab | New use and new compounds |
| CA2464311A1 (en) | 2001-10-26 | 2003-05-01 | Centre National De La Recherche Scientifique | Derivatives of etoposide and analogs, and pharmaceutical compositions containing them |
| TW200300416A (en) | 2001-11-27 | 2003-06-01 | Bristol Myers Squibb Co | Method of synthesizing a paclitaxel derivative |
| WO2003048166A1 (en) | 2001-12-03 | 2003-06-12 | Universitätsklinikum Charite Der Humboldt-Universität Zu Berlin Technologie Transferstelle | Podophyllotoxins as antiproliferative agents |
| US6566393B1 (en) | 2002-06-21 | 2003-05-20 | The University Of North Carolina At Chapel Hill | Etoposide analogs and methods of use thereof |
| US7176236B2 (en) | 2002-06-21 | 2007-02-13 | University Of North Carolina At Chapel Hill | Water-soluble etoposide analogs and methods of use thereof |
| US20050026866A1 (en) | 2002-08-02 | 2005-02-03 | Pawelek John M. | Agents and methods for treatment of disease by oligosaccharide targeting agents |
| EP1732911A2 (en) | 2004-02-24 | 2006-12-20 | Chatham Biotec Ltd. | Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel |
| EP2803357B1 (en) * | 2004-06-25 | 2020-11-18 | The Johns-Hopkins University | Angiogenesis inhibitors |
| US20060040980A1 (en) * | 2004-08-20 | 2006-02-23 | Lind Stuart E | Ionophores as cancer chemotherapeutic agents |
| CA2601157A1 (en) * | 2005-03-16 | 2006-09-28 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors |
| EP1907858A4 (en) * | 2005-06-13 | 2009-04-08 | Univ Michigan | COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER |
| WO2007005611A2 (en) | 2005-06-30 | 2007-01-11 | Whitehead Institute | Progenitor cells and uses thereof |
| US8653083B2 (en) * | 2005-08-22 | 2014-02-18 | The Johns Hopkins University | Hedgehog pathway antagonists to treat disease |
| AU2006292278B2 (en) * | 2005-09-20 | 2012-03-08 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| DE102007007750A1 (de) | 2006-08-17 | 2008-02-21 | Bayer Cropscience Ag | Avermectinderivate |
| FR2906465B1 (fr) | 2006-09-28 | 2008-11-28 | Galderma Sa | Utilisation de composes de la famille des avermectines pour le traitement de desordres dermatologiques chez l'homme |
| CA2676292C (en) * | 2007-02-01 | 2017-09-19 | Dana-Farber Cancer Institute, Inc. | Cell co-culture systems and uses thereof |
| WO2009025854A1 (en) * | 2007-08-22 | 2009-02-26 | Burnham Institute For Medical Research | Smips: small molecule inhibitors of p27 depletion in cancers and other proliferative diseases |
| US20100162416A1 (en) * | 2008-09-29 | 2010-06-24 | Stemlifeline, Inc. | Multi-stage stem cell carcinogenesis |
-
2009
- 2009-04-10 EP EP20090729661 patent/EP2274617A4/en not_active Withdrawn
- 2009-04-10 CN CN2009801219225A patent/CN102144163A/zh active Pending
- 2009-04-10 CA CA2723648A patent/CA2723648A1/en not_active Abandoned
- 2009-04-10 US US12/937,070 patent/US20110191868A1/en not_active Abandoned
- 2009-04-10 WO PCT/US2009/002254 patent/WO2009126310A2/en not_active Ceased
- 2009-04-10 EP EP11158438A patent/EP2385370A1/en not_active Withdrawn
- 2009-04-10 JP JP2011504009A patent/JP2011522515A/ja active Pending
-
2013
- 2013-10-28 US US14/065,311 patent/US20140294729A1/en not_active Abandoned
-
2014
- 2014-04-08 JP JP2014079322A patent/JP2014128294A/ja active Pending
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