JP2011521930A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011521930A5 JP2011521930A5 JP2011511053A JP2011511053A JP2011521930A5 JP 2011521930 A5 JP2011521930 A5 JP 2011521930A5 JP 2011511053 A JP2011511053 A JP 2011511053A JP 2011511053 A JP2011511053 A JP 2011511053A JP 2011521930 A5 JP2011521930 A5 JP 2011521930A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- natural
- modified
- protected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0802928A FR2931824B1 (fr) | 2008-05-29 | 2008-05-29 | Procede de synthese d'arn par voie chimique. |
| FR0802928 | 2008-05-29 | ||
| PCT/FR2009/000624 WO2009144418A1 (fr) | 2008-05-29 | 2009-05-28 | Procede de synthese d'arn par voie chimique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521930A JP2011521930A (ja) | 2011-07-28 |
| JP2011521930A5 true JP2011521930A5 (enExample) | 2014-07-24 |
| JP5689054B2 JP5689054B2 (ja) | 2015-03-25 |
Family
ID=39712442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511053A Expired - Fee Related JP5689054B2 (ja) | 2008-05-29 | 2009-05-28 | Ｒｎａ化学合成方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8536318B2 (enExample) |
| EP (1) | EP2303905B1 (enExample) |
| JP (1) | JP5689054B2 (enExample) |
| BR (1) | BRPI0910689A2 (enExample) |
| CA (1) | CA2726260C (enExample) |
| FR (1) | FR2931824B1 (enExample) |
| WO (1) | WO2009144418A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011028218A1 (en) | 2009-09-02 | 2011-03-10 | Alnylam Pharmaceuticals, Inc. | Process for triphosphate oligonucleotide synthesis |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| HUE069586T2 (hu) | 2010-10-01 | 2025-03-28 | Modernatx Inc | Módosított nukleozidok, nukleotidok és nukleinsavak, valamint ezek felhasználása |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DK3682905T3 (da) | 2011-10-03 | 2022-02-28 | Modernatx Inc | Modificerede nukleosider, nukleotider og nukleinsyrer og anvendelser deraf |
| HRP20220717T1 (hr) | 2011-12-16 | 2022-07-22 | Modernatx, Inc. | Modificirani pripravci mrna |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| JP6189415B2 (ja) | 2012-04-02 | 2017-08-30 | モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． | 細胞質および細胞骨格タンパク質の産生のための修飾ポリヌクレオチド |
| US9303056B2 (en) | 2012-07-25 | 2016-04-05 | Kochi University | Monomer for synthesis of RNA, method for producing same, and method for producing RNA |
| EP2922554B1 (en) | 2012-11-26 | 2022-02-23 | ModernaTX, Inc. | Terminally modified rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| PL221806B1 (pl) * | 2013-03-21 | 2016-05-31 | Inst Chemii Bioorg Polskiej Akademii Nauk | Sposób wprowadzania acetalowych i acetaloestrowych grup ochronnych oraz związki do realizacji tego sposobu |
| JP2016530294A (ja) | 2013-09-03 | 2016-09-29 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | キメラポリヌクレオチド |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| WO2015062738A1 (en) | 2013-11-01 | 2015-05-07 | Curevac Gmbh | Modified rna with decreased immunostimulatory properties |
| EP3542802A1 (en) | 2013-11-01 | 2019-09-25 | CureVac AG | Modified rna with decreased immunostimulatory properties |
| CA2955250A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| CN118317970B (zh) * | 2021-11-29 | 2025-12-23 | 兆维生物科技公司 | 2'乙酰基-酯保护的核苷的合成 |
| CN114685572B (zh) * | 2022-06-02 | 2022-08-30 | 上海百力格生物技术有限公司 | 用于mgb核酸探针合成的氧化剂组合物及探针的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| EP1386925A1 (en) * | 2002-07-31 | 2004-02-04 | Girindus AG | Method for preparing oligonucleotides |
| CN100484949C (zh) * | 2005-07-18 | 2009-05-06 | 张必良 | 用于rna寡核苷酸合成中的核苷亚磷酰胺及其合成方法 |
-
2008
- 2008-05-29 FR FR0802928A patent/FR2931824B1/fr active Active
-
2009
- 2009-04-28 BR BRPI0910689A patent/BRPI0910689A2/pt not_active IP Right Cessation
- 2009-05-28 EP EP09754068A patent/EP2303905B1/fr active Active
- 2009-05-28 JP JP2011511053A patent/JP5689054B2/ja not_active Expired - Fee Related
- 2009-05-28 US US12/995,001 patent/US8536318B2/en active Active
- 2009-05-28 CA CA2726260A patent/CA2726260C/fr active Active
- 2009-05-28 WO PCT/FR2009/000624 patent/WO2009144418A1/fr not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011521930A5 (enExample) | ||
| JP5689054B2 (ja) | Ｒｎａ化学合成方法 | |
| JP7492829B2 (ja) | 多重カップリングおよび酸化の方法 | |
| CN112533892B (zh) | 烷氧基苯基衍生物、核苷保护体和核苷酸保护体、寡核苷酸制造方法以及取代基除去方法 | |
| FI3794012T3 (fi) | Koostumuksia ja menetelmiä pintaan sitoutuneiden oligonukleotidien kemiallista pilkkomista ja suojauksen poistoa varten | |
| JP5925383B2 (ja) | 光クロスリンク能を有する光応答性ヌクレオチドアナログ | |
| CN106255697A (zh) | 磷保护基团及其制备方法和用途 | |
| CN110719912B (zh) | 在可见光区能进行光交联的光响应性核苷酸类似物 | |
| JP2011184318A (ja) | リボヌクレシドｈ−ボラノホスホネート | |
| CN1997658A (zh) | 合成被保护的3′－氨基核苷单体 | |
| JPWO2017218454A5 (enExample) | ||
| JP7004480B2 (ja) | ソホスブビルの調製のための改善された製造方法 | |
| AU2018298658B2 (en) | Improved process for preparing imetelstat | |
| US7166718B2 (en) | Calix[4]arene-nucleoside and calix[4]oligonucleotide hybrids | |
| CN113166185A (zh) | 作为立体限定的寡核苷酸合成中的活化剂的吡啶鎓盐 | |
| JPH069682A (ja) | レトロウイルス感染用治療薬としてのポリヌクレオチドホスホロジチオエート | |
| CA2685515A1 (en) | Synthesis of oligonucleotides | |
| JP2020132604A (ja) | 核酸合成用固相担体及びそれを用いた核酸の製造方法 | |
| KR20070101870A (ko) | 올리고뉴클레오티드의 정제 | |
| Nukaga et al. | Chemical Synthesis of Boranophosphate Deoxy-ribonucleotides | |
| JP2018184351A (ja) | ヌクレオシド又はそのヌクレオチドの誘導体、それを構成単位として含むｒｎａ誘導体、核酸医薬、及びｒｎａ誘導体若しくはｒｎａの製造方法 | |
| CN118632854A (zh) | 亚磷酰胺单体 | |
| CN119173522A (zh) | 方法和化合物 | |
| WO2024143276A1 (ja) | オリゴヌクレオチドの製造方法 | |
| JP2025536748A (ja) | 標的化リガンドコンジュゲート化ヌクレオチドホスホラミダイトを合成する方法 |