FR2931824B1 - Procede de synthese d'arn par voie chimique. - Google Patents

Procede de synthese d'arn par voie chimique.

Info

Publication number
FR2931824B1
FR2931824B1 FR0802928A FR0802928A FR2931824B1 FR 2931824 B1 FR2931824 B1 FR 2931824B1 FR 0802928 A FR0802928 A FR 0802928A FR 0802928 A FR0802928 A FR 0802928A FR 2931824 B1 FR2931824 B1 FR 2931824B1
Authority
FR
France
Prior art keywords
chemical
rna synthesis
rna
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR0802928A
Other languages
English (en)
French (fr)
Other versions
FR2931824A1 (fr
Inventor
Francoise Debart
Jean Jacques Vasseur
Thomas Lavergne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ChemGenes Corp
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR0802928A priority Critical patent/FR2931824B1/fr
Priority to BRPI0910689A priority patent/BRPI0910689A2/pt
Priority to PCT/FR2009/000624 priority patent/WO2009144418A1/fr
Priority to US12/995,001 priority patent/US8536318B2/en
Priority to JP2011511053A priority patent/JP5689054B2/ja
Priority to EP09754068A priority patent/EP2303905B1/fr
Priority to CA2726260A priority patent/CA2726260C/fr
Publication of FR2931824A1 publication Critical patent/FR2931824A1/fr
Application granted granted Critical
Publication of FR2931824B1 publication Critical patent/FR2931824B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0802928A 2008-05-29 2008-05-29 Procede de synthese d'arn par voie chimique. Active FR2931824B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0802928A FR2931824B1 (fr) 2008-05-29 2008-05-29 Procede de synthese d'arn par voie chimique.
BRPI0910689A BRPI0910689A2 (pt) 2008-05-29 2009-04-28 processo de síntese de rna por via química
US12/995,001 US8536318B2 (en) 2008-05-29 2009-05-28 Chemical RNA synthesis method
JP2011511053A JP5689054B2 (ja) 2008-05-29 2009-05-28 Ｒｎａ化学合成方法
PCT/FR2009/000624 WO2009144418A1 (fr) 2008-05-29 2009-05-28 Procede de synthese d'arn par voie chimique
EP09754068A EP2303905B1 (fr) 2008-05-29 2009-05-28 Procede de synthese d'arn par voie chimique
CA2726260A CA2726260C (fr) 2008-05-29 2009-05-28 Procede de synthese d'arn par voie chimique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0802928A FR2931824B1 (fr) 2008-05-29 2008-05-29 Procede de synthese d'arn par voie chimique.

Publications (2)

Publication Number Publication Date
FR2931824A1 FR2931824A1 (fr) 2009-12-04
FR2931824B1 true FR2931824B1 (fr) 2014-11-28

Family

ID=39712442

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0802928A Active FR2931824B1 (fr) 2008-05-29 2008-05-29 Procede de synthese d'arn par voie chimique.

Country Status (7)

Country Link
US (1) US8536318B2 (enExample)
EP (1) EP2303905B1 (enExample)
JP (1) JP5689054B2 (enExample)
BR (1) BRPI0910689A2 (enExample)
CA (1) CA2726260C (enExample)
FR (1) FR2931824B1 (enExample)
WO (1) WO2009144418A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011028218A1 (en) 2009-09-02 2011-03-10 Alnylam Pharmaceuticals, Inc. Process for triphosphate oligonucleotide synthesis
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
ES3005233T3 (en) 2010-10-01 2025-03-14 Modernatx Inc Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2763701B1 (en) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
JP2015501844A (ja) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
WO2013151663A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of membrane proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
JP5757641B2 (ja) 2012-07-25 2015-07-29 国立大学法人高知大学 Ｒｎａ合成用モノマー、その製造方法、およびｒｎａの製造方法
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
PL221806B1 (pl) 2013-03-21 2016-05-31 Inst Chemii Bioorg Polskiej Akademii Nauk Sposób wprowadzania acetalowych i acetaloestrowych grup ochronnych oraz związki do realizacji tego sposobu
US20160194625A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Chimeric polynucleotides
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
ES2806575T3 (es) 2013-11-01 2021-02-18 Curevac Ag ARN modificado con propiedades inmunoestimuladoras disminuidas
EP3542802A1 (en) 2013-11-01 2019-09-25 CureVac AG Modified rna with decreased immunostimulatory properties
EP3169693B1 (en) 2014-07-16 2022-03-09 ModernaTX, Inc. Chimeric polynucleotides
EP4441066A1 (en) * 2021-11-29 2024-10-09 Hongene Biotech Corporation Synthesis of 2' acetyl-ester protected nucleosides
CN114685572B (zh) * 2022-06-02 2022-08-30 上海百力格生物技术有限公司 用于mgb核酸探针合成的氧化剂组合物及探针的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
EP1386925A1 (en) * 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
CN100484949C (zh) * 2005-07-18 2009-05-06 张必良 用于rna寡核苷酸合成中的核苷亚磷酰胺及其合成方法

Also Published As

Publication number Publication date
WO2009144418A1 (fr) 2009-12-03
US8536318B2 (en) 2013-09-17
JP2011521930A (ja) 2011-07-28
BRPI0910689A2 (pt) 2016-11-01
US20110275793A1 (en) 2011-11-10
CA2726260C (fr) 2017-04-04
FR2931824A1 (fr) 2009-12-04
EP2303905B1 (fr) 2012-11-28
CA2726260A1 (fr) 2009-12-03
JP5689054B2 (ja) 2015-03-25
EP2303905A1 (fr) 2011-04-06

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