BR112012010591A2 - "conjugado de moléculas, ácido nucleico e método pe produção de conjugado de móleculas" - Google Patents
"conjugado de moléculas, ácido nucleico e método pe produção de conjugado de móleculas"Info
- Publication number
- BR112012010591A2 BR112012010591A2 BR112012010591A BR112012010591A BR112012010591A2 BR 112012010591 A2 BR112012010591 A2 BR 112012010591A2 BR 112012010591 A BR112012010591 A BR 112012010591A BR 112012010591 A BR112012010591 A BR 112012010591A BR 112012010591 A2 BR112012010591 A2 BR 112012010591A2
- Authority
- BR
- Brazil
- Prior art keywords
- molecule conjugate
- nucleic acid
- producing
- conjugate
- molecule
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09013887 | 2009-11-05 | ||
| PCT/EP2010/006728 WO2011054519A1 (en) | 2009-11-05 | 2010-11-04 | Glycosylated repeat-motif-molecule conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012010591A2 true BR112012010591A2 (pt) | 2016-11-29 |
Family
ID=41821255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012010591A BR112012010591A2 (pt) | 2009-11-05 | 2010-11-04 | "conjugado de moléculas, ácido nucleico e método pe produção de conjugado de móleculas" |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10280214B2 (pt) |
| EP (1) | EP2496603B1 (pt) |
| JP (1) | JP5735972B2 (pt) |
| KR (1) | KR101528392B1 (pt) |
| CN (2) | CN106977598A (pt) |
| AR (1) | AR078882A1 (pt) |
| BR (1) | BR112012010591A2 (pt) |
| CA (1) | CA2778203C (pt) |
| IL (2) | IL218911A0 (pt) |
| MX (1) | MX2012004680A (pt) |
| MY (1) | MY162320A (pt) |
| NZ (1) | NZ599081A (pt) |
| TW (1) | TW201120210A (pt) |
| WO (1) | WO2011054519A1 (pt) |
| ZA (1) | ZA201202807B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201120210A (en) | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
| CA2864872C (en) * | 2012-02-24 | 2022-07-05 | Alteogen Inc. | Modified antibody in which motif comprising cysteine residue is bound |
| RU2014150224A (ru) * | 2012-06-28 | 2016-08-20 | Молекьюлар Партнерс Аг | Сконструированный белок с анкириновым повтором, связывающийся с фактором роста тромбоцитов |
| US10093740B2 (en) * | 2012-10-15 | 2018-10-09 | Universitat Zurich | Bispecific HER2 ligands for cancer therapy |
| EP2738180A1 (en) * | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| WO2014131694A1 (en) * | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| PL3146057T3 (pl) * | 2014-05-19 | 2020-12-14 | F. Hoffmann-La Roche Ag | Sposób wytwarzania polipeptydów |
| WO2020231930A1 (en) * | 2019-05-11 | 2020-11-19 | The Texas A&M University System | Protein inhibitors of clostridium difficile toxin b |
| WO2020263943A1 (en) * | 2019-06-24 | 2020-12-30 | University Of Georgia Research Foundation, Inc. | Dual drug antibody-drug conjugates |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US5582996A (en) | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
| GB9222931D0 (en) | 1992-11-02 | 1992-12-16 | Sandoz Ltd | Organic compounds |
| CA2126967A1 (en) * | 1992-11-04 | 1994-05-11 | Anna M. Wu | Novel antibody construct |
| US5512473A (en) | 1993-01-29 | 1996-04-30 | Brent; Roger | Max-interacting proteins and related molecules and methods |
| US5443953A (en) | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| CA2305680A1 (en) | 1998-08-04 | 2000-02-17 | Immunex Corporation | Death associated kinase containing ankyrin repeats (dakar) |
| AU2001285252A1 (en) | 2000-08-25 | 2002-03-13 | Gendaq, Ltd. | Analysis of binding interactions |
| CA2421447C (en) | 2000-09-08 | 2012-05-08 | Universitat Zurich | Collections of repeat proteins comprising repeat modules |
| TWI329129B (en) * | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
| US20030143612A1 (en) | 2001-07-18 | 2003-07-31 | Pointilliste, Inc. | Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening |
| AR038568A1 (es) * | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| EP1403282A1 (en) | 2002-09-26 | 2004-03-31 | Cellzome Ag | Protein complexes of the Tumor necrosis factor-alpha (TNF-alpha) signalling pathway |
| US7348004B2 (en) * | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| WO2005000899A2 (en) * | 2003-06-27 | 2005-01-06 | Biogen Idec Ma Inc. | Modified binding molecules comprising connecting peptides |
| PT1718677E (pt) | 2003-12-19 | 2012-07-18 | Genentech Inc | Fragmentos de anticorpo monovalentes úteis como agentes terapêuticos |
| CN101160064A (zh) | 2004-02-06 | 2008-04-09 | 麦克考米克有限公司 | 风味物质基质合成物,其制备方法,其使用方法和由其制备的食物 |
| DK1773872T3 (en) | 2004-05-21 | 2017-05-08 | Uab Res Found | VARIABLE Lymphocyte Receptors, Associated Polypeptides and Nucleic Acids, and Uses thereof |
| US20080206201A1 (en) | 2004-11-12 | 2008-08-28 | Rudolf Beier | Recombinant Newcastle Disease Virus |
| JP2008520207A (ja) | 2004-11-16 | 2008-06-19 | アヴィディア リサーチ インスティテュート | タンパク質骨格およびその使用 |
| DE102005002978B4 (de) | 2005-01-21 | 2013-04-25 | Merz Pharma Gmbh & Co. Kgaa | Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form |
| DE602006021335D1 (de) * | 2005-10-21 | 2011-05-26 | Hoffmann La Roche | Methode zur rekombinanten expression eines polyeptids |
| KR20080082629A (ko) * | 2005-11-10 | 2008-09-11 | 리셉터 바이오로직스 인크 | 간세포 성장인자 인트론 융합 단백질 |
| US20100015661A1 (en) | 2006-04-21 | 2010-01-21 | Mab-Factory Gmbh | Antibody-rnase-conjugate |
| TW200817438A (en) * | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
| US8106166B2 (en) | 2007-03-16 | 2012-01-31 | Stowers Institute For Medical Research | Antibodies that bind specifically to phosphorylated β-catenin |
| DK2152736T3 (en) | 2007-05-03 | 2017-09-18 | Lysomab Gmbh | Complement factor H-derived short-consensus repeat (SCR) antibody constructs |
| NZ581395A (en) * | 2007-05-14 | 2012-08-31 | Biogen Idec Inc | Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto |
| WO2008154226A1 (en) * | 2007-06-06 | 2008-12-18 | Boehringer Ingelheim International Gmbh | Natriuretic fusion proteins |
| CN101323643B (zh) * | 2007-06-15 | 2010-12-01 | 烟台荣昌生物工程有限公司 | 优化的TACI-Fc融合蛋白 |
| EP2195028A2 (en) * | 2007-09-18 | 2010-06-16 | The Jackson Laboratory | Antibodies and fc fusion protein modifications with enhanced persistence or pharmacokinetic stability in vivo and methods of use thereof |
| AU2008328726B2 (en) * | 2007-11-30 | 2014-06-12 | Glaxo Group Limited | Antigen-binding constructs |
| TW201120210A (en) | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
-
2010
- 2010-11-02 TW TW099137689A patent/TW201120210A/zh unknown
- 2010-11-03 AR ARP100104063A patent/AR078882A1/es not_active Application Discontinuation
- 2010-11-04 MX MX2012004680A patent/MX2012004680A/es active IP Right Grant
- 2010-11-04 JP JP2012537323A patent/JP5735972B2/ja active Active
- 2010-11-04 MY MYPI2012001943A patent/MY162320A/en unknown
- 2010-11-04 KR KR1020127011563A patent/KR101528392B1/ko active IP Right Grant
- 2010-11-04 NZ NZ599081A patent/NZ599081A/en not_active IP Right Cessation
- 2010-11-04 CN CN201710255569.6A patent/CN106977598A/zh active Pending
- 2010-11-04 BR BR112012010591A patent/BR112012010591A2/pt not_active Application Discontinuation
- 2010-11-04 CN CN2010800500661A patent/CN102597000A/zh active Pending
- 2010-11-04 EP EP10779694.8A patent/EP2496603B1/en active Active
- 2010-11-04 CA CA2778203A patent/CA2778203C/en not_active Expired - Fee Related
- 2010-11-04 WO PCT/EP2010/006728 patent/WO2011054519A1/en active Application Filing
-
2012
- 2012-03-28 IL IL218911A patent/IL218911A0/en unknown
- 2012-04-17 ZA ZA2012/02807A patent/ZA201202807B/en unknown
- 2012-05-04 US US13/464,878 patent/US10280214B2/en active Active
-
2018
- 2018-05-16 IL IL259430A patent/IL259430B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN106977598A (zh) | 2017-07-25 |
| ZA201202807B (en) | 2018-11-28 |
| CA2778203C (en) | 2018-09-11 |
| CA2778203A1 (en) | 2011-05-12 |
| JP2013509868A (ja) | 2013-03-21 |
| MY162320A (en) | 2017-05-31 |
| NZ599081A (en) | 2014-05-30 |
| CN102597000A (zh) | 2012-07-18 |
| IL259430A (en) | 2018-07-31 |
| KR20120089487A (ko) | 2012-08-10 |
| IL259430B (en) | 2019-01-31 |
| US20190135901A9 (en) | 2019-05-09 |
| KR101528392B1 (ko) | 2015-06-11 |
| EP2496603A1 (en) | 2012-09-12 |
| EP2496603B1 (en) | 2018-07-18 |
| AU2010314450A1 (en) | 2012-04-26 |
| MX2012004680A (es) | 2012-06-14 |
| TW201120210A (en) | 2011-06-16 |
| RU2012122869A (ru) | 2013-12-10 |
| AR078882A1 (es) | 2011-12-07 |
| US20120309940A1 (en) | 2012-12-06 |
| WO2011054519A1 (en) | 2011-05-12 |
| JP5735972B2 (ja) | 2015-06-17 |
| US10280214B2 (en) | 2019-05-07 |
| IL218911A0 (en) | 2012-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |