JP2011519967A5 - - Google Patents
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- Publication number
- JP2011519967A5 JP2011519967A5 JP2011508995A JP2011508995A JP2011519967A5 JP 2011519967 A5 JP2011519967 A5 JP 2011519967A5 JP 2011508995 A JP2011508995 A JP 2011508995A JP 2011508995 A JP2011508995 A JP 2011508995A JP 2011519967 A5 JP2011519967 A5 JP 2011519967A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- release component
- coated
- sustained
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 14
- 238000013268 sustained release Methods 0.000 claims 10
- 239000012730 sustained-release form Substances 0.000 claims 10
- 239000001856 Ethyl cellulose Substances 0.000 claims 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229920001249 ethyl cellulose Polymers 0.000 claims 5
- 235000019325 ethyl cellulose Nutrition 0.000 claims 5
- 239000003513 alkali Substances 0.000 claims 4
- 206010018364 Glomerulonephritis Diseases 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 3
- 239000003246 corticosteroid Substances 0.000 claims 3
- 230000003111 delayed effect Effects 0.000 claims 3
- 210000000936 intestine Anatomy 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 2
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 241000255925 Diptera Species 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 229960004436 budesonide Drugs 0.000 claims 1
- 239000007963 capsule composition Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000007931 coated granule Substances 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 229940126701 oral medication Drugs 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 238000013269 sustained drug release Methods 0.000 claims 1
- 229960002622 triacetin Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0808537.5 | 2008-05-12 | ||
| GBGB0808537.5A GB0808537D0 (en) | 2008-05-12 | 2008-05-12 | Compositions |
| PCT/GB2009/001150 WO2009138716A1 (en) | 2008-05-12 | 2009-05-07 | Compositions for the oral delivery of corticosteroids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519967A JP2011519967A (ja) | 2011-07-14 |
| JP2011519967A5 true JP2011519967A5 (https=) | 2012-06-21 |
| JP5608641B2 JP5608641B2 (ja) | 2014-10-15 |
Family
ID=39571149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011508995A Active JP5608641B2 (ja) | 2008-05-12 | 2009-05-07 | 副腎皮質ステロイドの経口送達のための組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8491932B2 (https=) |
| EP (1) | EP2278958B1 (https=) |
| JP (1) | JP5608641B2 (https=) |
| CN (1) | CN102088962B (https=) |
| DK (1) | DK2278958T3 (https=) |
| ES (1) | ES2452265T3 (https=) |
| GB (1) | GB0808537D0 (https=) |
| PL (1) | PL2278958T3 (https=) |
| WO (1) | WO2009138716A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2419443C1 (ru) * | 2009-12-08 | 2011-05-27 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" | Способ лечения больных язвенным колитом |
| EP3187171B1 (en) | 2012-04-30 | 2024-09-25 | Tillotts Pharma AG | A delayed release drug formulation |
| US10799515B2 (en) | 2013-10-29 | 2020-10-13 | Tillotts Pharma Ag | Delayed release drug formulation |
| CN104257669A (zh) * | 2014-09-25 | 2015-01-07 | 合肥平光制药有限公司 | 一种用于向肠道递送水杨酸类药物的口服给药组合物 |
| US9707182B2 (en) | 2015-09-11 | 2017-07-18 | Sun Pharmaceutical Industries Ltd. | Oral pharmaceutical dosage forms of budesonide |
| EP3257501A1 (en) * | 2016-06-14 | 2017-12-20 | Tillotts Pharma AG | Multiple unit dosage form comprising a core with individual core units covered by a mucoadhesive material, and an enteric core coating |
| JP2020513280A (ja) | 2016-12-14 | 2020-05-14 | プロジェニティ， インコーポレイテッド | 消化管疾病の免疫抑制剤による治療 |
| WO2018111326A1 (en) * | 2016-12-14 | 2018-06-21 | Progenity Inc. | Methods and ingestible devices for the regio-specific release of immunosuppressants at the site of gastrointestinal tract disease |
| CN110869007B (zh) | 2017-06-23 | 2022-10-14 | 太阳医药高级研究有限公司 | 防滥用的口服固体剂型 |
| EP3613414A1 (de) | 2018-08-24 | 2020-02-26 | Dr. Falk Pharma Gmbh | Pellets mit mehrschichtiger struktur zur verzögerten freisetzung des wirkstoffs im distalen kolon |
| CN110200947A (zh) * | 2019-06-27 | 2019-09-06 | 深圳市泛谷药业股份有限公司 | 一种安非他酮肠溶缓释微丸胶囊及其制备方法 |
| CN112999229B (zh) * | 2019-12-19 | 2023-01-24 | 江苏恒瑞医药股份有限公司 | 一种包含布地奈德的口服药物组合物 |
| TW202302116A (zh) * | 2021-04-20 | 2023-01-16 | 大陸商江蘇恒瑞醫藥股份有限公司 | 口服腸溶皮質類固醇的藥物組合物 |
| US20240197639A1 (en) * | 2021-04-20 | 2024-06-20 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Capsule for specific drug delivery and preparation method therefor |
| US11896719B2 (en) * | 2022-01-24 | 2024-02-13 | Calliditas Therapeutics Ab | Pharmaceutical compositions |
| EP4554566A1 (en) | 2022-07-15 | 2025-05-21 | Synthon B.V. | Budesonide two layers capsule formulation |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4123403A (en) * | 1977-06-27 | 1978-10-31 | The Dow Chemical Company | Continuous process for preparing aqueous polymer microsuspensions |
| US4502888A (en) * | 1982-12-13 | 1985-03-05 | The Dow Chemical Company | Aqueous dispersions of plasticized polymer particles |
| SE8903914D0 (sv) | 1989-11-22 | 1989-11-22 | Draco Ab | Oral composition for the treatment of inflammatory bowel diseases |
| US5142906A (en) * | 1990-07-09 | 1992-09-01 | Westinghouse Electric Corp. | Apparatus for measuring valve stem loads in a motor operated valve assembly |
| DE69425453T2 (de) * | 1993-04-23 | 2001-04-12 | Novartis Ag, Basel | Wirkstoffabgabevorrichtung mit gesteuerter Freigabe |
| DE4332394A1 (de) * | 1993-09-23 | 1995-03-30 | Falk Pharma Gmbh | Budesonid-Pellets mit kontrolliertem Freigabeprofil und Verfahren zu ihrer Herstellung |
| GB9412394D0 (en) | 1994-06-21 | 1994-08-10 | Danbiosyst Uk | Colonic drug delivery composition |
| DE4446891A1 (de) * | 1994-12-27 | 1996-07-04 | Falk Pharma Gmbh | Stabile wäßrige Budesonid-Lösung |
| JP3185206B2 (ja) * | 1995-07-20 | 2001-07-09 | 田辺製薬株式会社 | 消化管下部放出型被覆カプセル製剤 |
| SG80553A1 (en) | 1995-07-20 | 2001-05-22 | Tanabe Seiyaku Co | Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract |
| GB9516268D0 (en) * | 1995-08-08 | 1995-10-11 | Danbiosyst Uk | Compositiion for enhanced uptake of polar drugs from the colon |
| GB9722426D0 (en) | 1997-10-23 | 1997-12-24 | Univ London Pharmacy | Controlled release formulations |
| US6239120B1 (en) * | 1998-03-17 | 2001-05-29 | Pharmalink Ab | Method and means for treating glomerulonephritis |
| SE514128C2 (sv) * | 1998-03-17 | 2001-01-08 | Pharmalink Ab | Användning av en glukokortikoid för framställning av ett läkemedel för behandling av glomerulonefrit |
| ITRM20010614A1 (it) | 2001-10-16 | 2003-04-16 | Italchimici S P A | Preparazione farmaceutica di una soluzione idro/propilenica di budesonide e suo procedimento di preparazione. |
| JP2003201256A (ja) * | 2001-12-28 | 2003-07-18 | Hisamitsu Pharmaceut Co Inc | 大腸送達性経口医薬製剤、大腸癌治療用経口医薬製剤および大腸炎治療用経口医薬製剤 |
| DE10214002A1 (de) * | 2002-03-27 | 2003-10-09 | Roehm Gmbh | Pharmazeutische Formulierung für den Wirkstoff Budesonid |
| AR041873A1 (es) | 2003-10-30 | 2005-06-01 | Pablo Cassara Srl Lab | Una formulacion farmaceutica en aerosol adecuada para la inhalacion oral o nasal que contienen glucocorticoides en solucion estable al almacenamiento; un metodo para estabilzar formulaciones y uso de un agente estabilizante |
| US20090004281A1 (en) * | 2007-06-26 | 2009-01-01 | Biovail Laboratories International S.R.L. | Multiparticulate osmotic delivery system |
| JP2011506607A (ja) * | 2007-12-17 | 2011-03-03 | ザリカス インコーポレイティッド | 免疫炎症性障害の処置のための治療法 |
-
2008
- 2008-05-12 GB GBGB0808537.5A patent/GB0808537D0/en not_active Ceased
-
2009
- 2009-05-07 WO PCT/GB2009/001150 patent/WO2009138716A1/en not_active Ceased
- 2009-05-07 JP JP2011508995A patent/JP5608641B2/ja active Active
- 2009-05-07 ES ES09746033.1T patent/ES2452265T3/es active Active
- 2009-05-07 CN CN2009801272725A patent/CN102088962B/zh active Active
- 2009-05-07 PL PL09746033T patent/PL2278958T3/pl unknown
- 2009-05-07 US US12/992,182 patent/US8491932B2/en active Active
- 2009-05-07 EP EP09746033.1A patent/EP2278958B1/en active Active
- 2009-05-07 DK DK09746033.1T patent/DK2278958T3/da active
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