JP2011519863A5 - - Google Patents
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- Publication number
- JP2011519863A5 JP2011519863A5 JP2011507632A JP2011507632A JP2011519863A5 JP 2011519863 A5 JP2011519863 A5 JP 2011519863A5 JP 2011507632 A JP2011507632 A JP 2011507632A JP 2011507632 A JP2011507632 A JP 2011507632A JP 2011519863 A5 JP2011519863 A5 JP 2011519863A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- fluoro
- phenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GYZKKKIFYYBYSB-UHFFFAOYSA-N CC(Cc1c2)C=Cc1ncc2-c(cc1)nc2c1C=CCC2NC(c1ccccc1)=O Chemical compound CC(Cc1c2)C=Cc1ncc2-c(cc1)nc2c1C=CCC2NC(c1ccccc1)=O GYZKKKIFYYBYSB-UHFFFAOYSA-N 0.000 description 1
- KMZSRRANCBLSIZ-UHFFFAOYSA-N COCC1C=CC(CNC(c(cccc2cc3)c2nc3-c2ccccc2)=O)=CC1 Chemical compound COCC1C=CC(CNC(c(cccc2cc3)c2nc3-c2ccccc2)=O)=CC1 KMZSRRANCBLSIZ-UHFFFAOYSA-N 0.000 description 1
- PUJQPIUTUFMOES-UHFFFAOYSA-N COc(cc1)ccc1S(Nc1cccc(nc2)c1nc2-c1ccncc1)(=O)=O Chemical compound COc(cc1)ccc1S(Nc1cccc(nc2)c1nc2-c1ccncc1)(=O)=O PUJQPIUTUFMOES-UHFFFAOYSA-N 0.000 description 1
- UOBCRIAKAHFLDZ-UHFFFAOYSA-N COc1ccc(CNC(C(CCC=C2C=C3)=C2N=C3c(cc2)ccc2OC)=O)cc1 Chemical compound COc1ccc(CNC(C(CCC=C2C=C3)=C2N=C3c(cc2)ccc2OC)=O)cc1 UOBCRIAKAHFLDZ-UHFFFAOYSA-N 0.000 description 1
- FBNHXCOGKZBJCL-UHFFFAOYSA-N O=C(c1ccccc1)Nc1cccc2ccc(-c3nc(cccc4)c4cc3)nc12 Chemical compound O=C(c1ccccc1)Nc1cccc2ccc(-c3nc(cccc4)c4cc3)nc12 FBNHXCOGKZBJCL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12611208P | 2008-05-01 | 2008-05-01 | |
| US61/126,112 | 2008-05-01 | ||
| PCT/US2009/042255 WO2009134973A1 (en) | 2008-05-01 | 2009-04-30 | Quenolines and related analogs as sirtuin modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519863A JP2011519863A (ja) | 2011-07-14 |
| JP2011519863A5 true JP2011519863A5 (OSRAM) | 2012-06-21 |
| JP5425891B2 JP5425891B2 (ja) | 2014-02-26 |
Family
ID=41255415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507632A Expired - Fee Related JP5425891B2 (ja) | 2008-05-01 | 2009-04-30 | サーチュイン調節薬としてのキノリンおよび関連する類似体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8685970B2 (OSRAM) |
| EP (1) | EP2273992B1 (OSRAM) |
| JP (1) | JP5425891B2 (OSRAM) |
| KR (1) | KR20110007235A (OSRAM) |
| CN (1) | CN102083438B (OSRAM) |
| AU (1) | AU2009243006B2 (OSRAM) |
| BR (1) | BRPI0912356A2 (OSRAM) |
| CA (1) | CA2723135A1 (OSRAM) |
| EA (1) | EA021938B1 (OSRAM) |
| ES (1) | ES2586459T3 (OSRAM) |
| IL (1) | IL208997A0 (OSRAM) |
| MX (1) | MX2010012010A (OSRAM) |
| SG (1) | SG190603A1 (OSRAM) |
| WO (1) | WO2009134973A1 (OSRAM) |
| ZA (1) | ZA201007677B (OSRAM) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011000079A (es) | 2008-07-03 | 2011-03-02 | Sirtris Pharmaceuticals Inc | Bencimidazoles y analogos relacionados como moduladores de sirtuin. |
| CA2738794C (en) | 2008-09-29 | 2016-01-05 | Sirtris Pharmaceuticals, Inc. | Chromenone analogs as sirtuin modulators |
| US8592415B2 (en) * | 2009-02-11 | 2013-11-26 | Reaction Biology Corp. | Selective kinase inhibitors |
| CA2754058A1 (en) * | 2009-03-02 | 2010-09-10 | Sirtris Pharmaceuticals, Inc. | 8-substituted quinolines and related analogs as sirtuin modulators |
| WO2011059839A1 (en) | 2009-10-29 | 2011-05-19 | Sirtris Pharmaceuticals, Inc. | Bicyclic pyridines and analogs as sirtuin modulators |
| CN101723894B (zh) * | 2009-12-03 | 2011-12-28 | 南京大学 | N-喹啉酰胺类衍生物及其制法与用途 |
| US20120214803A1 (en) * | 2011-02-18 | 2012-08-23 | Vifor (International) Ag | Novel Sulfonaminoquinoline Hepcidin Antagonists |
| WO2012122534A2 (en) | 2011-03-10 | 2012-09-13 | The Trustees Of Columbia University In The City Of New York | N-quinolin-benzensulfonamides and related compounds for the treatment of cancer, autoimmune disorders and inflammation |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013178591A1 (en) | 2012-05-31 | 2013-12-05 | F. Hoffmann-La Roche Ag | Aminoquinazoline and pyridopyrimidine derivatives |
| JP6374384B2 (ja) | 2012-08-07 | 2018-08-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体 |
| WO2016081692A2 (en) * | 2014-11-19 | 2016-05-26 | Glaxosmithkline Llc | Substituted bridged urea analogs as sirtuin modulators |
| RU2015153061A (ru) | 2013-05-13 | 2017-06-15 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Замещенные связанные мостиковой связью мочевинные аналоги в качестве модуляторов сиртуина |
| US10207995B2 (en) * | 2013-06-13 | 2019-02-19 | Monsanto Technology Llc | Acetyl CoA carboxylase modulators |
| US9844218B2 (en) | 2013-06-13 | 2017-12-19 | Monsanto Technology Llc | Acetyl-CoA carboxylase modulators |
| MX2016015997A (es) | 2014-06-02 | 2017-04-05 | Glaxosmithkline Intellectual Property (No 2) Ltd | Preparacion y uso de beta-d-nicotinamida ribosido cristalina. |
| CN106715455A (zh) | 2014-06-06 | 2017-05-24 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 烟酰胺核苷类似物及其药物组合物和用途 |
| US20200347038A1 (en) | 2014-08-29 | 2020-11-05 | Russell Dahl | Quinolines that modulate serca and their use for treating disease |
| WO2016032569A1 (en) * | 2014-08-29 | 2016-03-03 | Celladon Corporation | Quinolines and their use for treating endoplasmic reticulum stress-caused diseases |
| ES2958391T3 (es) | 2014-11-06 | 2024-02-08 | Bial R&D Invest S A | Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos |
| CA2966581A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| DK3215511T3 (da) | 2014-11-06 | 2024-05-13 | Bial R&D Invest S A | Substituerede pyrazolo(1,5-a)pyrimidiner og deres anvendelse i behandlingen af medicinske lidelser |
| WO2017091681A1 (en) | 2015-11-24 | 2017-06-01 | Aclaris Therapeutics, Inc. | Selective kinase inhibitors |
| US10383868B2 (en) * | 2015-11-28 | 2019-08-20 | Russell Dahl | Quinoline containing compounds and their use for treating endoplasmic reticulum stress-related diseases |
| EP4006038A1 (en) | 2015-12-09 | 2022-06-01 | Cadent Therapeutics, Inc. | Thienopyrimidinone nmda receptor modulators and uses thereof |
| HRP20201522T1 (hr) | 2015-12-09 | 2020-12-11 | Cadent Therapeutics, Inc. | Heteroaromatski nmda receptor modulatori i njihove uporabe |
| JP7046827B2 (ja) | 2016-04-06 | 2022-04-04 | リソソーマル・セラピューティクス・インコーポレイテッド | イミダゾ［１，５－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用 |
| WO2017176960A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| WO2017176962A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics, Inc. | Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| EP3452480A4 (en) * | 2016-05-05 | 2019-11-06 | Lysosomal Therapeutics Inc. | SUBSTITUTED PYRROLO [1,2-] TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| US11345698B2 (en) | 2016-05-05 | 2022-05-31 | Bial—R&D Investments, S.A. | Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders |
| BR112018072552A8 (pt) | 2016-05-05 | 2023-03-14 | Lysosomal Therapeutics Inc | Compostos de imidazo [1,2-b]piridazinas e imidazo [1,5-b] piridazinas substituídas, composição farmacêutica que os compreende e seu uso no tratamento de distúrbios médicos |
| CN109689664B (zh) | 2016-07-14 | 2022-04-15 | 百时美施贵宝公司 | 作为par4抑制剂的三环杂芳基取代的喹啉和氮杂喹啉化合物 |
| WO2018013774A1 (en) | 2016-07-14 | 2018-01-18 | Bristol-Myers Squibb Company | Bicyclic heteroaryl substituted compounds |
| JP6990228B2 (ja) | 2016-07-14 | 2022-01-13 | ブリストル－マイヤーズ スクイブ カンパニー | 二環式ヘテロアリール置換の化合物 |
| EP3558318B1 (en) | 2016-12-22 | 2023-12-20 | Novartis AG | Nmda receptor modulators and uses thereof |
| KR20200051646A (ko) | 2017-08-17 | 2020-05-13 | 이케나 온콜로지, 인코포레이티드 | Ahr 억제제 및 이의 용도 |
| WO2019057053A1 (zh) * | 2017-09-20 | 2019-03-28 | 北京加科思益新药研发有限公司 | 用作fgfr4抑制剂的稠环衍生物 |
| ES2946632T7 (es) | 2018-02-06 | 2025-03-04 | Ideaya Biosciences Inc | Moduladores de AhR |
| CU24647B1 (es) | 2018-08-03 | 2023-02-13 | Cadent Therapeutics Inc | Moduladores del receptor nmda heteroaromático |
| CN113101295A (zh) * | 2020-03-20 | 2021-07-13 | 上海疆云医疗健康科技有限公司 | 二苯乙烯类似物在治疗糖尿病肾脏疾病中的用途 |
| US11730729B2 (en) | 2020-07-20 | 2023-08-22 | Neurodon Corporation | Quinolines that modulate SERCA and their use for treating disease |
| WO2022173727A1 (en) * | 2021-02-09 | 2022-08-18 | Celgene Corporation | Sulfonamides and their use for treatment of helminthic infections and diseases |
| CN112939955B (zh) * | 2021-03-05 | 2022-10-21 | 朗捷睿(苏州)生物科技有限公司 | 一种8-(吡啶酰胺)取代香豆素类化合物及其制备方法和应用 |
| AU2022380979A1 (en) | 2021-11-02 | 2024-06-06 | Flare Therapeutics Inc. | Pparg inverse agonists and uses thereof |
| WO2024026423A1 (en) * | 2022-07-27 | 2024-02-01 | Black Diamond Therapeutics, Inc. | Substituted quinoline derivatives as pi3k inhibitors |
Family Cites Families (50)
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|---|---|---|---|---|
| JPS5838449B2 (ja) * | 1979-04-17 | 1983-08-23 | カネボウ株式会社 | 微粉末状絹フィプロインの製造法 |
| NZ212525A (en) * | 1985-06-24 | 1989-02-24 | Dfc New Zealand Ltd Formerly D | Nitrogen-containing heterocyclic compounds, and pharmaceutical compositions containing such |
| JP2002363169A (ja) | 2001-06-08 | 2002-12-18 | Fujiyakuhin Co Ltd | 抗腫瘍活性を有する複素環化合物 |
| JP2004043457A (ja) | 2002-05-22 | 2004-02-12 | Kyorin Pharmaceut Co Ltd | ２−置換キノリン−８−カルボン酸アミド誘導体 |
| FR2864535B1 (fr) * | 2003-12-24 | 2006-12-22 | Merck Sante Sas | Derives acides de quinoline et leurs applications en therapeutique |
| GB0428475D0 (en) * | 2004-12-30 | 2005-02-02 | 4 Aza Bioscience Nv | Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
| WO2006094209A2 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N-benzimidazolylalkyl-substituted amide sirtuin modulators |
| AU2006218404A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N-phenyl benzamide derivatives as sirtuin modulators |
| WO2006094248A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Aryl-substituted cyclic sirtuin modulators |
| AU2006218407B2 (en) | 2005-03-03 | 2012-11-15 | Sirtris Pharmaceuticals, Inc. | Fluorescence polarization assays for acetyltransferase/deacetylase activity |
| WO2006094246A2 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N-arylmethyl benzamide sirtuin modulators |
| WO2006094210A2 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Tetrahydroquinoxalinone sirtuin modulators |
| WO2006094233A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N,n'-dicyclic isothiourea sirtuin modulators |
| EP1856099A2 (en) * | 2005-03-03 | 2007-11-21 | Sirtris Pharmaceuticals, Inc. | Acridine and quinoline derivatives as sirtuin modulators |
| US20070014833A1 (en) | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
| US20060229265A1 (en) | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| WO2006127987A2 (en) | 2005-05-25 | 2006-11-30 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
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| ES2389111T3 (es) | 2005-12-02 | 2012-10-23 | Sirtris Pharmaceuticals, Inc. | Ensayos de espectrometría de masas para la actividad acetiltransferasa/desacetilasa |
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| US20080249130A1 (en) | 2007-02-09 | 2008-10-09 | Sirtris Pharmaceuticals, Inc. | Gut microsomal triglyceride transport protein inhibitors |
| WO2008100376A2 (en) | 2007-02-15 | 2008-08-21 | Sirtris Pharmaceuticals, Inc. | Truncation variants of sirt1 and methods of use thereof |
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| WO2009058348A1 (en) | 2007-11-01 | 2009-05-07 | Sirtris Pharmaceuticals, Inc. | Amide derivatives as sirtuin modulators |
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| AU2009282076A1 (en) | 2008-08-12 | 2010-02-18 | Sirtris Pharmaceuticals, Inc. | Benzoxazoles, benzthiazoles and related analogs as sirtuin modulators |
| CA2738794C (en) | 2008-09-29 | 2016-01-05 | Sirtris Pharmaceuticals, Inc. | Chromenone analogs as sirtuin modulators |
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| BRPI0922435A2 (pt) | 2008-12-19 | 2018-09-11 | Sirtris Pharmaceuticals Inc | "composto de tiazolopiridina moduladores de sirtuina, composição farmacêutica compreendendo o mesmo e seu uso." |
| WO2010088574A1 (en) | 2009-01-30 | 2010-08-05 | Sirtris Pharmaceuticals, Inc. | Azabenzimidazoles and related analogs as sirtuin modulators |
| CA2754058A1 (en) | 2009-03-02 | 2010-09-10 | Sirtris Pharmaceuticals, Inc. | 8-substituted quinolines and related analogs as sirtuin modulators |
| WO2011116176A1 (en) | 2010-03-17 | 2011-09-22 | Sirtris Pharmaceuticals Inc. | 3-substitued imidazo (4, 5-b) pyridines and analogs as sirtuin modulators |
-
2009
- 2009-04-30 CA CA2723135A patent/CA2723135A1/en not_active Abandoned
- 2009-04-30 BR BRPI0912356A patent/BRPI0912356A2/pt not_active IP Right Cessation
- 2009-04-30 AU AU2009243006A patent/AU2009243006B2/en not_active Ceased
- 2009-04-30 JP JP2011507632A patent/JP5425891B2/ja not_active Expired - Fee Related
- 2009-04-30 WO PCT/US2009/042255 patent/WO2009134973A1/en not_active Ceased
- 2009-04-30 US US12/990,339 patent/US8685970B2/en not_active Expired - Fee Related
- 2009-04-30 EP EP09739775.6A patent/EP2273992B1/en active Active
- 2009-04-30 MX MX2010012010A patent/MX2010012010A/es not_active Application Discontinuation
- 2009-04-30 CN CN200980125767.4A patent/CN102083438B/zh not_active Expired - Fee Related
- 2009-04-30 SG SG2013032677A patent/SG190603A1/en unknown
- 2009-04-30 ES ES09739775.6T patent/ES2586459T3/es active Active
- 2009-04-30 EA EA201071263A patent/EA021938B1/ru not_active IP Right Cessation
- 2009-04-30 KR KR1020107026866A patent/KR20110007235A/ko not_active Ceased
-
2010
- 2010-10-27 ZA ZA2010/07677A patent/ZA201007677B/en unknown
- 2010-10-28 IL IL208997A patent/IL208997A0/en unknown
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