JP2011518562A5 - - Google Patents
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- JP2011518562A5 JP2011518562A5 JP2011506407A JP2011506407A JP2011518562A5 JP 2011518562 A5 JP2011518562 A5 JP 2011518562A5 JP 2011506407 A JP2011506407 A JP 2011506407A JP 2011506407 A JP2011506407 A JP 2011506407A JP 2011518562 A5 JP2011518562 A5 JP 2011518562A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- concentration
- tissue culture
- extracellular matrix
- culture substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 15
- 206010021143 Hypoxia Diseases 0.000 claims 14
- 230000001146 hypoxic effect Effects 0.000 claims 14
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 11
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 11
- 210000002744 extracellular matrix Anatomy 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 239000000758 substrate Substances 0.000 claims 11
- 210000001519 tissue Anatomy 0.000 claims 11
- 210000001900 endoderm Anatomy 0.000 claims 7
- 239000003550 marker Substances 0.000 claims 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 3
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 3
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- -1 Mix11 Proteins 0.000 claims 2
- 108010023082 activin A Proteins 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 108010059616 Activins Proteins 0.000 claims 1
- 102000005606 Activins Human genes 0.000 claims 1
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 1
- 101100257359 Caenorhabditis elegans sox-2 gene Proteins 0.000 claims 1
- 108010069241 Connexin 43 Proteins 0.000 claims 1
- 102000001045 Connexin 43 Human genes 0.000 claims 1
- 102100039290 Gap junction gamma-1 protein Human genes 0.000 claims 1
- 102000009094 Hepatocyte Nuclear Factor 3-beta Human genes 0.000 claims 1
- 108010087745 Hepatocyte Nuclear Factor 3-beta Proteins 0.000 claims 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 1
- 101000976622 Homo sapiens Zinc finger protein 42 homolog Proteins 0.000 claims 1
- 102000013013 Member 2 Subfamily G ATP Binding Cassette Transporter Human genes 0.000 claims 1
- 108010090306 Member 2 Subfamily G ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 101100013973 Mus musculus Gata4 gene Proteins 0.000 claims 1
- 101100310648 Mus musculus Sox17 gene Proteins 0.000 claims 1
- 101100257363 Mus musculus Sox2 gene Proteins 0.000 claims 1
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 claims 1
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 101001029301 Xenopus tropicalis Forkhead box protein D3 Proteins 0.000 claims 1
- 102100023550 Zinc finger protein 42 homolog Human genes 0.000 claims 1
- 239000000488 activin Substances 0.000 claims 1
- 108010015426 connexin 45 Proteins 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000007959 normoxia Effects 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 239000011669 selenium Substances 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/108,872 | 2008-04-24 | ||
| US12/108,872 US7939322B2 (en) | 2008-04-24 | 2008-04-24 | Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm |
| PCT/US2009/041348 WO2009132063A2 (en) | 2008-04-24 | 2009-04-22 | Pluripotent cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011518562A JP2011518562A (ja) | 2011-06-30 |
| JP2011518562A5 true JP2011518562A5 (enExample) | 2012-05-24 |
| JP5763524B2 JP5763524B2 (ja) | 2015-08-12 |
Family
ID=41129142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506407A Active JP5763524B2 (ja) | 2008-04-24 | 2009-04-22 | 多能性細胞 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7939322B2 (enExample) |
| EP (3) | EP2283113B1 (enExample) |
| JP (1) | JP5763524B2 (enExample) |
| KR (3) | KR102057056B1 (enExample) |
| CN (1) | CN102083965B (enExample) |
| AU (1) | AU2009239442B2 (enExample) |
| BR (1) | BRPI0911599A2 (enExample) |
| CA (2) | CA2722619C (enExample) |
| ES (2) | ES2633455T3 (enExample) |
| MX (1) | MX2010011739A (enExample) |
| PL (2) | PL2283113T3 (enExample) |
| RU (1) | RU2553538C2 (enExample) |
| WO (1) | WO2009132063A2 (enExample) |
| ZA (1) | ZA201008391B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090203141A1 (en) * | 2003-05-15 | 2009-08-13 | Shi-Lung Lin | Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant RNA agents |
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CA3114827C (en) | 2007-07-31 | 2023-09-05 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| CA2954431C (en) | 2007-11-27 | 2021-08-24 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| RU2551772C2 (ru) | 2008-02-21 | 2015-05-27 | Сентокор Орто Байотек Инк. | Способы, поверхностно-модифицированные носители и композиции для иммобилизации, культивирования и открепления клеток |
| AU2009267137A1 (en) | 2008-06-30 | 2010-01-07 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
| MX2011004565A (es) | 2008-10-31 | 2011-07-28 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| MX2011004563A (es) | 2008-10-31 | 2011-06-01 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| BRPI0921996A2 (pt) | 2008-11-20 | 2015-08-18 | Centocor Ortho Biotech Inc | Métodos e composições para cultura e ligação de células em substratos planos. |
| EP3260534A1 (en) | 2008-11-20 | 2017-12-27 | Janssen Biotech, Inc. | Pluripotent stem cell culture on micro-carriers |
| EP2456862A4 (en) | 2009-07-20 | 2013-02-27 | Janssen Biotech Inc | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS |
| BR112012017761A2 (pt) | 2009-12-23 | 2015-09-15 | Centocor Ortho Biotech Inc | diferenciação das células-tronco embrionárias humanas |
| PH12012501254A1 (en) * | 2009-12-23 | 2012-11-05 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| US9969981B2 (en) | 2010-03-01 | 2018-05-15 | Janssen Biotech, Inc. | Methods for purifying cells derived from pluripotent stem cells |
| RU2663339C1 (ru) | 2010-05-12 | 2018-08-03 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| CA2809300A1 (en) | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| JP6133776B2 (ja) | 2010-08-31 | 2017-05-24 | ヤンセン バイオテツク，インコーポレーテツド | 多能性幹細胞の分化 |
| KR101836850B1 (ko) | 2010-08-31 | 2018-03-09 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| ES2902650T3 (es) | 2011-06-21 | 2022-03-29 | Novo Nordisk As | Inducción eficiente de endodermo definitivo a partir de células madre pluripotentes |
| AU2012355698B2 (en) | 2011-12-22 | 2018-11-29 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| NZ627835A (en) * | 2012-02-14 | 2016-05-27 | Univ Washington State | Feeder-free method for culture of bovine and porcine spermatogonial stem cells |
| WO2013131012A1 (en) * | 2012-03-01 | 2013-09-06 | University Of Miami | Isolation and use of pluripotent stem cell population from adult neural crest-derived tissues |
| RU2018128383A (ru) | 2012-03-07 | 2019-03-14 | Янссен Байотек, Инк. | Среда определенного состава для размножения и обновления плюрипотентных стволовых клеток |
| US9334475B2 (en) * | 2012-04-06 | 2016-05-10 | Kyoto University | Method for inducing erythropoietin-producing cell |
| AR090970A1 (es) * | 2012-05-07 | 2014-12-17 | Janssen Biotech Inc | Diferenciacion de celulas madre humanas embrionarias en endodermo pancreatico |
| RU2018108850A (ru) | 2012-06-08 | 2019-02-26 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
| SG11201408150UA (en) * | 2012-06-14 | 2015-01-29 | Janssen Biotech Inc | Treatment of pluripotent cells |
| GB2504996A (en) * | 2012-08-17 | 2014-02-19 | Univ Keele | Embryonic stem cell culture method |
| JP6470687B2 (ja) | 2012-09-03 | 2019-02-13 | ノヴォ ノルディスク アー／エス | 小分子を用いた多能性幹細胞からの膵臓内胚葉の作製 |
| MX2015008577A (es) | 2012-12-31 | 2015-09-07 | Janssen Biotech Inc | Cultivo de celulas madre embrionarias humanas en la interfase aire-liquido para la diferenciacion en celulas endocrinas pancreaticas. |
| SG10201707811XA (en) | 2012-12-31 | 2017-11-29 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators |
| EP4039798A1 (en) | 2012-12-31 | 2022-08-10 | Janssen Biotech, Inc. | Suspension and clustering of human pluripotent cells |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| US10266807B2 (en) * | 2013-04-03 | 2019-04-23 | FUJIFILM Cellular Dynamics, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| GB201317869D0 (en) * | 2013-10-09 | 2013-11-20 | Cambridge Entpr Ltd | In vitro production of foregut stem cells |
| KR102162138B1 (ko) | 2014-05-16 | 2020-10-06 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 세포에서 mafa 발현을 향상시키기 위한 소분자의 용도 |
| US10494608B2 (en) | 2015-04-24 | 2019-12-03 | University Of Copenhagen | Isolation of bona fide pancreatic progenitor cells |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| NL2017670B1 (en) * | 2016-10-25 | 2018-05-04 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Molecular indicators for predicting response to hormonal therapy in breast cancer |
| JP7088564B2 (ja) | 2016-11-10 | 2022-06-21 | ヴィアサイト，インコーポレイテッド | 細胞送達装置におけるｐｄｘ１膵臓内胚葉細胞及びその方法 |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
| CN111213057A (zh) * | 2017-07-17 | 2020-05-29 | 美天施生物科技有限两合公司 | 用于底板中脑多巴胺能祖细胞的单细胞蛋白质表达谱分析的方法 |
| CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
| US10724052B2 (en) | 2018-09-07 | 2020-07-28 | Crispr Therapeutics Ag | Universal donor cells |
| EP3975926A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates, Inc. | A biocompatible membrane composite |
| AU2020283056B2 (en) | 2019-05-31 | 2023-06-08 | Viacyte, Inc. | A biocompatible membrane composite |
| CA3139591C (en) | 2019-05-31 | 2024-01-16 | Timothy M. BRUHN | A biocompatible membrane composite |
| EP3976237A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
| US11118195B2 (en) | 2019-09-05 | 2021-09-14 | Crispr Therapeutics Ag | Universal donor cells |
| AU2020340622A1 (en) | 2019-09-05 | 2022-03-03 | Crispr Therapeutics Ag | Universal donor cells |
| AU2021414405A1 (en) | 2020-12-31 | 2023-08-10 | Crispr Therapeutics Ag | Universal donor cells |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US583308A (en) * | 1897-05-25 | m miehle | ||
| US5834308A (en) | 1994-04-28 | 1998-11-10 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of Langerhans |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| EP1025204A4 (en) | 1997-10-23 | 2001-02-28 | Geron Corp | Methods and materials for the growth of primate-derived primordial stem cells |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US6610540B1 (en) * | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| EP1144597A2 (en) | 1999-01-21 | 2001-10-17 | Vitro Diagnostics, Inc. | Immortalized cell lines and methods of making the same |
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| AU778155B2 (en) | 1999-12-13 | 2004-11-18 | Scripps Research Institute, The | Markers for identification and isolation of pancreatic islet alpha and beta cell progenitors |
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| GB2399823B (en) | 2001-12-07 | 2006-02-15 | Geron Corp | Islet cells from primate pluripotent stem cells |
| US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
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| ITRM20030395A1 (it) | 2003-08-12 | 2005-02-13 | Istituto Naz Per Le Malattie Infettive Lazz | Terreno di coltura per il mantenimento, la proliferazione e il differenziamento di cellule di mammifero. |
| US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| KR101221302B1 (ko) * | 2003-12-23 | 2013-01-11 | 비아싸이트, 인크. | 완전 내배엽 |
| WO2005065354A2 (en) | 2003-12-31 | 2005-07-21 | The Burnham Institute | Defined media for pluripotent stem cell culture |
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| ES2751095T3 (es) | 2004-04-27 | 2020-03-30 | Viacyte Inc | Endodermo que expresa pdx1 |
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| BRPI0814425A2 (pt) | 2007-07-18 | 2014-10-21 | Lifescan Inc | Diferenciação de células-tronco embrionárias humanas |
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| US8623648B2 (en) * | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
-
2008
- 2008-04-24 US US12/108,872 patent/US7939322B2/en not_active Ceased
-
2009
- 2009-04-22 EP EP09734026.9A patent/EP2283113B1/en active Active
- 2009-04-22 WO PCT/US2009/041348 patent/WO2009132063A2/en not_active Ceased
- 2009-04-22 EP EP13163321.6A patent/EP2669366B1/en active Active
- 2009-04-22 KR KR1020187005114A patent/KR102057056B1/ko active Active
- 2009-04-22 BR BRPI0911599-4A patent/BRPI0911599A2/pt not_active IP Right Cessation
- 2009-04-22 ES ES09734026.9T patent/ES2633455T3/es active Active
- 2009-04-22 ES ES13163321.6T patent/ES2663421T3/es active Active
- 2009-04-22 PL PL09734026T patent/PL2283113T3/pl unknown
- 2009-04-22 MX MX2010011739A patent/MX2010011739A/es active IP Right Grant
- 2009-04-22 CN CN200980124667.XA patent/CN102083965B/zh active Active
- 2009-04-22 CA CA2722619A patent/CA2722619C/en active Active
- 2009-04-22 PL PL13163321T patent/PL2669366T3/pl unknown
- 2009-04-22 CA CA2948488A patent/CA2948488A1/en not_active Abandoned
- 2009-04-22 KR KR1020107025916A patent/KR101690773B1/ko not_active Expired - Fee Related
- 2009-04-22 AU AU2009239442A patent/AU2009239442B2/en active Active
- 2009-04-22 KR KR1020167036048A patent/KR101832902B1/ko active Active
- 2009-04-22 RU RU2010147817/10A patent/RU2553538C2/ru active
- 2009-04-22 EP EP18150288.1A patent/EP3327114B1/en active Active
- 2009-04-22 JP JP2011506407A patent/JP5763524B2/ja active Active
-
2010
- 2010-11-23 ZA ZA2010/08391A patent/ZA201008391B/en unknown
-
2012
- 2012-02-14 US US13/372,641 patent/USRE43876E1/en active Active
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