JP5763524B2 - 多能性細胞 - Google Patents
多能性細胞 Download PDFInfo
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- JP5763524B2 JP5763524B2 JP2011506407A JP2011506407A JP5763524B2 JP 5763524 B2 JP5763524 B2 JP 5763524B2 JP 2011506407 A JP2011506407 A JP 2011506407A JP 2011506407 A JP2011506407 A JP 2011506407A JP 5763524 B2 JP5763524 B2 JP 5763524B2
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- cells
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- embryonic stem
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/108,872 US7939322B2 (en) | 2008-04-24 | 2008-04-24 | Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm |
| US12/108,872 | 2008-04-24 | ||
| PCT/US2009/041348 WO2009132063A2 (en) | 2008-04-24 | 2009-04-22 | Pluripotent cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011518562A JP2011518562A (ja) | 2011-06-30 |
| JP2011518562A5 JP2011518562A5 (enExample) | 2012-05-24 |
| JP5763524B2 true JP5763524B2 (ja) | 2015-08-12 |
Family
ID=41129142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506407A Active JP5763524B2 (ja) | 2008-04-24 | 2009-04-22 | 多能性細胞 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7939322B2 (enExample) |
| EP (3) | EP3327114B1 (enExample) |
| JP (1) | JP5763524B2 (enExample) |
| KR (3) | KR101832902B1 (enExample) |
| CN (1) | CN102083965B (enExample) |
| AU (1) | AU2009239442B2 (enExample) |
| BR (1) | BRPI0911599A2 (enExample) |
| CA (2) | CA2722619C (enExample) |
| ES (2) | ES2663421T3 (enExample) |
| MX (1) | MX2010011739A (enExample) |
| PL (2) | PL2283113T3 (enExample) |
| RU (1) | RU2553538C2 (enExample) |
| WO (1) | WO2009132063A2 (enExample) |
| ZA (1) | ZA201008391B (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090203141A1 (en) * | 2003-05-15 | 2009-08-13 | Shi-Lung Lin | Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant RNA agents |
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| RU2473685C2 (ru) | 2007-07-31 | 2013-01-27 | Лайфскен, Инк. | Дифференцировка человеческих эмбриональных стволовых клеток |
| CN107574142B (zh) | 2007-11-27 | 2021-07-06 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
| BRPI0908033A2 (pt) | 2008-02-21 | 2015-08-04 | Centocor Ortho Biotech Inc | Método placas de superfície modificada e composições para adesão, cultura e desprendimento de célula |
| CA2729121C (en) | 2008-06-30 | 2019-04-09 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
| EP2346988B1 (en) | 2008-10-31 | 2017-05-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
| JP2012507289A (ja) | 2008-10-31 | 2012-03-29 | ヤンセン バイオテツク,インコーポレーテツド | ヒト胚性幹細胞の膵内分泌系への分化 |
| CA2744227C (en) | 2008-11-20 | 2018-10-02 | Centocor Ortho Biotech Inc. | Methods and compositions for cell attachment and cultivation on planar substrates |
| MX2011005288A (es) | 2008-11-20 | 2011-06-01 | Centocor Ortho Biotech Inc | Celulas madre pluripotentes en microportadores. |
| EP2456862A4 (en) | 2009-07-20 | 2013-02-27 | Janssen Biotech Inc | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS |
| DK2516625T3 (da) | 2009-12-23 | 2024-09-09 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller |
| RU2664864C1 (ru) * | 2009-12-23 | 2018-08-23 | Янссен Байотек, Инк. | Способы увеличения экспрессии ngn3 и nkx6.1 в эндокринных клетках поджелудочной железы |
| AU2011223900A1 (en) | 2010-03-01 | 2012-09-13 | Janssen Biotech, Inc. | Methods for purifying cells derived from pluripotent stem cells |
| AU2011250912A1 (en) | 2010-05-12 | 2012-11-22 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| CN103221536B (zh) | 2010-08-31 | 2016-08-31 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| KR101836850B1 (ko) | 2010-08-31 | 2018-03-09 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| WO2012030540A2 (en) | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| WO2012175633A1 (en) | 2011-06-21 | 2012-12-27 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
| RU2705001C2 (ru) | 2011-12-22 | 2019-11-01 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека в одногормональные инсулинположительные клетки |
| MX357280B (es) * | 2012-02-14 | 2018-07-03 | Univ Washington State | Método sin alimentadoras para cultivo de células madre espermatogonias de bovino y porcino. |
| WO2013131012A1 (en) * | 2012-03-01 | 2013-09-06 | University Of Miami | Isolation and use of pluripotent stem cell population from adult neural crest-derived tissues |
| MX354775B (es) | 2012-03-07 | 2018-03-20 | Janssen Biotech Inc | Medios definidos para la expansion y el mantenimiento de celulas madre pluripotentes. |
| US9334475B2 (en) * | 2012-04-06 | 2016-05-10 | Kyoto University | Method for inducing erythropoietin-producing cell |
| US20140162359A1 (en) * | 2012-05-07 | 2014-06-12 | Janssen Biotech, Inc. | Differentiation of Human Embryonic Stem Cells into Pancreatic Endoderm |
| CN104334719B (zh) | 2012-06-08 | 2018-02-13 | 詹森生物科技公司 | 人胚胎干细胞向胰腺内分泌细胞的分化 |
| RU2015100900A (ru) * | 2012-06-14 | 2016-08-10 | Янссен Байотек, Инк. | Обработка плюрипотентных клеток |
| GB2504996A (en) * | 2012-08-17 | 2014-02-19 | Univ Keele | Embryonic stem cell culture method |
| EP2893000B1 (en) | 2012-09-03 | 2019-04-10 | Novo Nordisk A/S | Generation of pancreatic endoderm from pluripotent stem cells using small molecules |
| DK2938722T3 (da) | 2012-12-31 | 2022-02-14 | Janssen Biotech Inc | Suspension og klyngedannelse af humane pluripotente celler til differentiering til endokrine pankreasceller |
| KR102084561B1 (ko) | 2012-12-31 | 2020-03-04 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 세포로의 분화를 위한 공기-액체 계면에서의 인간 배아 줄기세포의 배양 |
| MX2015008578A (es) | 2012-12-31 | 2015-09-07 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9. |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| WO2014165663A1 (en) * | 2013-04-03 | 2014-10-09 | Cellular Dynamics International, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| GB201317869D0 (en) * | 2013-10-09 | 2013-11-20 | Cambridge Entpr Ltd | In vitro production of foregut stem cells |
| SG11201609473XA (en) | 2014-05-16 | 2016-12-29 | Janssen Biotech Inc | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
| ES2840076T3 (es) | 2015-04-24 | 2021-07-06 | Univ Copenhagen | Aislamiento de células progenitoras pancreáticas bona fide |
| WO2017180361A1 (en) | 2016-04-14 | 2017-10-19 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells to intestinal midgut endoderm cells |
| NL2017670B1 (en) * | 2016-10-25 | 2018-05-04 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Molecular indicators for predicting response to hormonal therapy in breast cancer |
| EP4595951A3 (en) | 2016-11-10 | 2025-08-27 | ViaCyte, Inc. | Pdx1 pancreatic endoderm cells in cell delivery devices |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
| EP3655774B1 (en) * | 2017-07-17 | 2024-09-25 | Miltenyi Biotec B.V. & Co. KG | A method for single cell protein expression profiling of floorplate mesencephalic dopaminergic progenitor cells |
| CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
| US12378572B2 (en) | 2018-09-07 | 2025-08-05 | Crispr Therapeutics Ag | Universal donor cells |
| EP3953451A1 (en) | 2019-04-08 | 2022-02-16 | Novo Nordisk A/S | Generation of pancreatic endoderm from stem cell derived definitive endoderm |
| EP3975926A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates, Inc. | A biocompatible membrane composite |
| AU2020282355B2 (en) | 2019-05-31 | 2023-11-02 | Viacyte, Inc. | A biocompatible membrane composite |
| US12310830B2 (en) | 2019-05-31 | 2025-05-27 | W. L. Gore & Associates, Inc. | Biocompatible membrane composite |
| CA3257300A1 (en) | 2019-05-31 | 2025-06-12 | W. L. Gore & Associates, Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
| US11116798B2 (en) | 2019-09-05 | 2021-09-14 | Crispr Therapeutics Ag | Universal donor cells |
| US11104918B2 (en) | 2019-09-05 | 2021-08-31 | Crispr Therapeutics Ag | Universal donor cells |
| US11566230B2 (en) | 2020-12-31 | 2023-01-31 | Crispr Therapeutics Ag | Universal donor cells |
| EP4506466A4 (en) * | 2022-04-02 | 2026-02-25 | Iregene Therapeutics Co Ltd | APPLICATION OF MARKER GENES IN THE DETECTION OF MULTIPOTENC STEM CELL RESIDUES, DETECTION METHOD AND KIT |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US583308A (en) * | 1897-05-25 | m miehle | ||
| US5834308A (en) | 1994-04-28 | 1998-11-10 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of Langerhans |
| US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| WO1999020740A2 (en) * | 1997-10-23 | 1999-04-29 | Geron Corporation | Methods and materials for the growth of primate-derived primordial stem cells |
| US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US6610540B1 (en) * | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| US6458593B1 (en) * | 1999-01-21 | 2002-10-01 | Vitro Diagnostics, Inc. | Immortalized cell lines and methods of making the same |
| US20030082155A1 (en) * | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| JP2003517592A (ja) * | 1999-12-13 | 2003-05-27 | ザ スクリプス リサーチ インスティチュート | 膵島αおよびβ前駆体の同定ならびに単離のためのマーカー |
| US7005252B1 (en) * | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| US7439064B2 (en) * | 2000-03-09 | 2008-10-21 | Wicell Research Institute, Inc. | Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium |
| US6458589B1 (en) | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| US7432104B2 (en) * | 2001-08-06 | 2008-10-07 | Bresgen Inc. | Methods for the culture of human embryonic stem cells on human feeder cells |
| GB2399823B (en) * | 2001-12-07 | 2006-02-15 | Geron Corp | Islet cells from primate pluripotent stem cells |
| US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| WO2003102171A1 (en) | 2002-05-28 | 2003-12-11 | Becton, Dickinson And Company | Expansion and transdifferentiation of human acinar cells |
| US6877147B2 (en) * | 2002-07-22 | 2005-04-05 | Broadcom Corporation | Technique to assess timing delay by use of layout quality analyzer comparison |
| EP1539930A4 (en) | 2002-07-29 | 2006-08-09 | Es Cell Int Pte Ltd | METHOD IN MULTIPLE STAGES OF DIFFERENTIATION OF POSITIVE INSULIN-SENSITIVE CELLS, GLUCOSE |
| US20060194315A1 (en) | 2003-03-31 | 2006-08-31 | Condie Brian G | Compositions and methods for the control, differentiaton and/or manipulation of pluripotent cells through a gamma-secretase signaling pathway |
| ITRM20030395A1 (it) | 2003-08-12 | 2005-02-13 | Istituto Naz Per Le Malattie Infettive Lazz | Terreno di coltura per il mantenimento, la proliferazione e il differenziamento di cellule di mammifero. |
| US20050266554A1 (en) * | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| EP2722387B1 (en) * | 2003-12-23 | 2019-12-11 | Viacyte, Inc. | Definitive endoderm |
| US20050233446A1 (en) * | 2003-12-31 | 2005-10-20 | Parsons Xuejun H | Defined media for stem cell culture |
| US20090155218A1 (en) | 2004-03-10 | 2009-06-18 | Alberto Hayek | Compositions and methods for growth of embryonic stem cells |
| CN103103158B (zh) | 2004-04-27 | 2016-08-03 | 韦尔赛特公司 | 细胞培养基 |
| CA2966883A1 (en) | 2004-07-09 | 2006-02-16 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| US8187878B2 (en) | 2004-08-13 | 2012-05-29 | University Of Georgia Research Foundation, Inc. | Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors |
| PL1860950T3 (pl) | 2005-03-04 | 2017-09-29 | Lifescan, Inc. | Dojrzałe komórki podścieliska pochodzenia trzustkowego |
| WO2007027157A1 (en) | 2005-09-02 | 2007-03-08 | Agency For Science, Technology And Research | Method of deriving progenitor cell line |
| WO2007030870A1 (en) | 2005-09-12 | 2007-03-22 | Es Cell International Pte Ltd | Cardiomyocyte production |
| WO2007082963A1 (es) | 2006-01-18 | 2007-07-26 | Fundación Instituto Valenciano De Infertilidad | Líneas de células madre embrionarias humanas y métodos para usar las mismas |
| NZ571427A (en) | 2006-03-02 | 2012-07-27 | Viacyte Inc | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| GB2452186B (en) * | 2006-05-02 | 2011-01-26 | Wisconsin Alumni Res Found | Method of differentiating stem cells into cells of the endoderm and pancreatic lineage |
| WO2007139929A2 (en) | 2006-05-25 | 2007-12-06 | The Burnham Institute For Medical Research | Methods for culture and production of single cell populations of human embryonic stem cells |
| US20080003676A1 (en) | 2006-06-26 | 2008-01-03 | Millipore Corporation | Growth of embryonic stem cells |
| WO2009012428A2 (en) | 2007-07-18 | 2009-01-22 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| RU2473685C2 (ru) * | 2007-07-31 | 2013-01-27 | Лайфскен, Инк. | Дифференцировка человеческих эмбриональных стволовых клеток |
| US8623648B2 (en) * | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
-
2008
- 2008-04-24 US US12/108,872 patent/US7939322B2/en not_active Ceased
-
2009
- 2009-04-22 CN CN200980124667.XA patent/CN102083965B/zh active Active
- 2009-04-22 EP EP18150288.1A patent/EP3327114B1/en active Active
- 2009-04-22 MX MX2010011739A patent/MX2010011739A/es active IP Right Grant
- 2009-04-22 ES ES13163321.6T patent/ES2663421T3/es active Active
- 2009-04-22 JP JP2011506407A patent/JP5763524B2/ja active Active
- 2009-04-22 KR KR1020167036048A patent/KR101832902B1/ko active Active
- 2009-04-22 EP EP09734026.9A patent/EP2283113B1/en active Active
- 2009-04-22 KR KR1020187005114A patent/KR102057056B1/ko active Active
- 2009-04-22 RU RU2010147817/10A patent/RU2553538C2/ru active
- 2009-04-22 PL PL09734026T patent/PL2283113T3/pl unknown
- 2009-04-22 AU AU2009239442A patent/AU2009239442B2/en active Active
- 2009-04-22 PL PL13163321T patent/PL2669366T3/pl unknown
- 2009-04-22 BR BRPI0911599-4A patent/BRPI0911599A2/pt not_active IP Right Cessation
- 2009-04-22 KR KR1020107025916A patent/KR101690773B1/ko not_active Expired - Fee Related
- 2009-04-22 CA CA2722619A patent/CA2722619C/en active Active
- 2009-04-22 EP EP13163321.6A patent/EP2669366B1/en active Active
- 2009-04-22 ES ES09734026.9T patent/ES2633455T3/es active Active
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