JP2011518191A5 - - Google Patents

Download PDF

Info

Publication number
JP2011518191A5
JP2011518191A5 JP2011505259A JP2011505259A JP2011518191A5 JP 2011518191 A5 JP2011518191 A5 JP 2011518191A5 JP 2011505259 A JP2011505259 A JP 2011505259A JP 2011505259 A JP2011505259 A JP 2011505259A JP 2011518191 A5 JP2011518191 A5 JP 2011518191A5
Authority
JP
Japan
Prior art keywords
compound
pharmaceutically acceptable
hydrogen
present
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011505259A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011518191A (ja
JP5529851B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/041172 external-priority patent/WO2009129546A1/en
Publication of JP2011518191A publication Critical patent/JP2011518191A/ja
Publication of JP2011518191A5 publication Critical patent/JP2011518191A5/ja
Application granted granted Critical
Publication of JP5529851B2 publication Critical patent/JP5529851B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011505259A 2008-04-18 2009-04-20 抗酸化炎症モジュレーター:c−17においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体 Active JP5529851B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4634208P 2008-04-18 2008-04-18
US61/046,342 2008-04-18
US11126908P 2008-11-04 2008-11-04
US61/111,269 2008-11-04
PCT/US2009/041172 WO2009129546A1 (en) 2008-04-18 2009-04-20 Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17

Publications (3)

Publication Number Publication Date
JP2011518191A JP2011518191A (ja) 2011-06-23
JP2011518191A5 true JP2011518191A5 (cg-RX-API-DMAC7.html) 2012-06-07
JP5529851B2 JP5529851B2 (ja) 2014-06-25

Family

ID=40833485

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011505259A Active JP5529851B2 (ja) 2008-04-18 2009-04-20 抗酸化炎症モジュレーター:c−17においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体

Country Status (25)

Country Link
US (10) US8124799B2 (cg-RX-API-DMAC7.html)
EP (1) EP2276493B1 (cg-RX-API-DMAC7.html)
JP (1) JP5529851B2 (cg-RX-API-DMAC7.html)
KR (1) KR101735807B1 (cg-RX-API-DMAC7.html)
CN (2) CN104177468B (cg-RX-API-DMAC7.html)
AU (1) AU2009237579C1 (cg-RX-API-DMAC7.html)
CA (1) CA2721838C (cg-RX-API-DMAC7.html)
CO (1) CO6311071A2 (cg-RX-API-DMAC7.html)
CY (1) CY1121586T1 (cg-RX-API-DMAC7.html)
DK (1) DK2276493T3 (cg-RX-API-DMAC7.html)
EA (1) EA019263B1 (cg-RX-API-DMAC7.html)
ES (1) ES2703274T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20182060T1 (cg-RX-API-DMAC7.html)
HU (1) HUE041221T2 (cg-RX-API-DMAC7.html)
IL (1) IL208758A (cg-RX-API-DMAC7.html)
LT (1) LT2276493T (cg-RX-API-DMAC7.html)
MX (1) MX2010011438A (cg-RX-API-DMAC7.html)
NZ (1) NZ588710A (cg-RX-API-DMAC7.html)
PL (1) PL2276493T3 (cg-RX-API-DMAC7.html)
PT (1) PT2276493T (cg-RX-API-DMAC7.html)
RS (1) RS58392B1 (cg-RX-API-DMAC7.html)
SI (1) SI2276493T1 (cg-RX-API-DMAC7.html)
TW (1) TWI453023B (cg-RX-API-DMAC7.html)
WO (1) WO2009129546A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201007586B (cg-RX-API-DMAC7.html)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
DE602006021142D1 (de) 2005-02-03 2011-05-19 Gen Hospital Corp Verfahren zur behandlung von gefitinib-resistentem krebs
PE20070763A1 (es) 2005-11-04 2007-08-08 Wyeth Corp COMBINACIONES ANTINEOPLASICAS DE UN INHIBIDOR DE mTOR, TRASTUZUMAB Y/O HKI-272
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
EP3492077A1 (en) 2008-01-11 2019-06-05 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
ES2326065B1 (es) * 2008-03-28 2010-07-08 Consejo Superior De Investigaciones Cientificas (Csic) Utilizacion de un triterpeno pentaciclico para la preparacion de una composicion farmaceutica destinada al tratamiento de la esclerosis multiple.
TW201004627A (en) 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
AU2009251437B2 (en) * 2008-04-18 2014-10-30 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
AU2009237578C1 (en) 2008-04-18 2014-12-04 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
WO2009129546A1 (en) 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
KR101782020B1 (ko) 2008-04-18 2017-09-26 리타 파마슈티컬스 잉크. 산화방지성 염증 조절제 c-17 일치된 올레아놀산 유도체
ES2692769T3 (es) 2008-06-17 2018-12-05 Wyeth Llc Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina
ES2449396T3 (es) 2008-07-22 2014-03-19 Trustees Of Dartmouth College Cianoenonas monocíclicas y métodos de uso de las mismas
CN109464445A (zh) 2008-08-04 2019-03-15 惠氏有限责任公司 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合
LT3000467T (lt) 2009-04-06 2023-04-11 Wyeth Llc Krūties vėžio gydymo schema naudojant neratinibą
ME03713B (me) 2010-04-12 2021-01-20 Reata Pharmaceuticals Inc Bardoksolon meтil za lečenje gojaznosтi
EA025568B1 (ru) 2010-12-17 2017-01-30 Рита Фармасьютикалз, Инк. Пиразолильные и пиримидинильные трициклические еноны в качестве антиоксидантных модуляторов воспаления
BR112013023174B1 (pt) 2011-03-11 2021-09-21 Reata Pharmaceuticals, Inc Compostos derivados de triterpenoide de c4-monometila e composição farmacêutica compreendendo os referidos compostos
US9943522B2 (en) * 2011-05-16 2018-04-17 Bayer Intellectual Property Gmbh Use of cathepsin K inhibition for the treatment and/or prophylaxis of pulmonary hypertension and/or heart failure
WO2013079024A1 (zh) * 2011-12-01 2013-06-06 杭州本生药业有限公司 齐墩果酸酰胺化衍生物、及其制备方法和应用
MX357060B (es) * 2012-04-27 2018-06-25 Reata Pharmaceuticals Inc Derivados de 2,2-difluoropropionamida de bardoxolon metilo, formas polimorficas y metodo para su uso de los mismos.
US8981144B2 (en) 2012-05-08 2015-03-17 Trustees Of Dartmouth College Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
WO2013188818A1 (en) 2012-06-15 2013-12-19 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
UY35023A (es) 2012-09-10 2014-03-31 Reata Pharmaceuticals Inc Derivados c17-alcandiilo y alquendiilo del ácido oleanólico y sus métodos de uso
CA2884400A1 (en) * 2012-09-10 2014-03-13 Abbvie Inc. Glycyrrhetinic acid derivatives and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
WO2014040073A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
WO2014040056A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
TW201514192A (zh) 2013-03-19 2015-04-16 Daiichi Sankyo Co Ltd 萜類衍生物
UY39092A (es) 2013-04-24 2021-03-26 Abbvie Inc Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso
IL285832B2 (en) 2013-08-23 2024-01-01 Reata Pharmaceuticals Inc Methods for the treatment and prevention of impaired functioning of the endothelium using brodoxolone methyl or its analogs
CN104861028A (zh) * 2014-02-24 2015-08-26 上海兰蒂斯生物医药科技有限公司 新型熊果酸衍生物、其制备方法及其应用
CN104861027A (zh) * 2014-02-24 2015-08-26 上海兰蒂斯生物医药科技有限公司 新型齐墩果酸衍生物、其制备方法及其应用
WO2016033132A1 (en) 2014-08-26 2016-03-03 Trustees Of Dartmouth College Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
US10189791B2 (en) 2014-08-26 2019-01-29 Trustees Of Dartmouth College Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
US10208082B2 (en) 2014-09-10 2019-02-19 Daiichi Sankyo Company, Limited Sustained-release pharmaceutical composition for treatment and prevention of eye disease
US20170333450A1 (en) * 2014-10-31 2017-11-23 The Regents Of The University Of California Compositions and methods for treating hiv-associated cognitive dysfunction
AU2016219109B2 (en) 2015-02-12 2020-05-14 Reata Pharmaceuticals, Inc. Imidazolyl tricyclic enones as antioxidant iflammation modulators
CA2998681C (en) 2015-09-23 2024-02-06 Reata Pharmaceuticals, Inc. C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses
EP3387151A1 (en) * 2015-12-10 2018-10-17 Universität für Bodenkultur Wien Compositions and methods for the diagnosis and treatment of bone fractures and disorders
CN105820207A (zh) * 2016-03-24 2016-08-03 庄立 一种茴拉西坦的药物组合物及其抗氧化作用
BR112019009256A2 (pt) 2016-11-08 2019-07-16 Reata Pharmaceuticals Inc métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制RORγ及其他用途的嘧啶三環烯酮衍生物
AU2018334467B2 (en) 2017-09-14 2022-10-20 Phoenix Biotechnology, Inc. Method and improved neuroprotective composition for treating neurological conditions
MX2020002883A (es) 2017-09-14 2020-10-05 Phoenix Biotechnology Inc Método y composiciones para tratar la infección viral.
IL322405A (en) 2018-06-15 2025-09-01 Reata Pharmaceuticals Inc Decahydro-2h-naphth[1,2-d]imidazole compounds for inhibition of IL-17 and ROR-gamma
US12060340B2 (en) 2018-06-20 2024-08-13 Reata Pharmaceuticals, Inc Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith
JP2022501445A (ja) * 2018-09-28 2022-01-06 スーチョワン ハイスコ ファーマスーティカル カンパニー リミテッドSichuan Haisco Pharmaceutical Co., Ltd. テルペノイド誘導体及びその用途
CN114641483B (zh) 2019-07-19 2024-12-06 里亚塔医药公司 C17极性的-取代的杂芳族合成三萜类化合物及其使用方法
JP7711059B2 (ja) * 2019-11-27 2025-07-22 ▲魯▼南制▲薬▼集▲団▼股▲フン▼有限公司 オレアナンシンナムアミド誘導体及びその製造方法と用途
CR20220345A (es) * 2019-12-19 2023-01-12 Reata Pharmaceuticals Inc Triterpenoides sintéticos con sustituyentes a base de nitrógeno en c-17 y métodos de uso de los mismos
RU2020130238A (ru) 2020-03-31 2022-03-14 Феникс Байотекнолоджи, Инк. Способ и композиции для лечения коронавирусной инфекции
EP4295854A3 (en) 2020-03-31 2024-04-03 Phoenix Biotechnology, Inc. Method and compositions for treating coronavirus infection
IL298008A (en) 2020-05-09 2023-01-01 Reata Pharmaceuticals Holdings Llc Methods for treating covid-19 with the help of bardoxolone methyl or its analogs
WO2022126129A1 (en) 2020-12-11 2022-06-16 Reata Pharmaceuticals, Inc. Synthetic triterpenoids for use in therapy
AU2022208727A1 (en) 2021-01-18 2023-08-03 Reata Pharmaceuticals, Inc. Synthetic ursolic acid derivatives and methods of use thereof
CN113603743B (zh) * 2021-08-06 2022-07-15 南通大学 一类具有联合治疗作用的cddo/川芎嗪醇杂合物及其制备方法和用途
CN117050134A (zh) * 2022-05-05 2023-11-14 中国科学院上海有机化学研究所 酰胺化合物的合成及其用途
KR20240118918A (ko) 2023-01-27 2024-08-06 (주)내츄럴코리아 올레아놀산 및 유청 단백질 가수분해산물을 포함하는 항산화 화장료 조성물
WO2025029691A1 (en) 2023-07-28 2025-02-06 Reata Pharmaceuticals Holdings, LLC Methods for producing triterpenoid derivatives
CN117343122B (zh) * 2023-09-08 2025-09-02 安徽医科大学 一种治疗炎症免疫性疾病的齐墩果酸酰胺衍生物、其制备方法及其用途

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5555153Y2 (cg-RX-API-DMAC7.html) 1975-03-19 1980-12-20
NZ191586A (en) 1978-10-10 1981-10-19 Sterling Drug Inc Cyanoketones derived from glycyrrhetinic acid and pharmaceutical compositions
US4395423A (en) 1978-10-10 1983-07-26 Sterling Drug Inc. Polycyclic cyanoketones
US4526988A (en) 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
ATE92499T1 (de) 1984-12-04 1993-08-15 Lilly Co Eli Tumorbehandlung bei saeugetieren.
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
IL84842A0 (en) 1986-12-24 1988-06-30 Lilly Co Eli Immunoglobulin conjugates
ES2075040T3 (es) 1988-02-16 1995-10-01 Lilly Co Eli 2',3'-dideoxi-2',2'-difluoronucleosidos.
US5064823A (en) 1988-08-24 1991-11-12 Research Triangle Institute Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers
CA2004695C (en) 1988-12-12 1999-08-10 Rosanne Bonjouklian Phospholipid nucleosides
JPH05505815A (ja) 1990-04-04 1993-08-26 ニユコメド・イメージング・アクシエセルカペト ヌクレオシド誘導体
SE502569C2 (sv) 1991-05-31 1995-11-13 British Tech Group Användning av en immunologiskt inert matris av en sterol och saponiner som kan bilda sfäriska nanopartiklar med snäv storleksfördelning som läkemedelsbärare, partiklar, komposition samt kit
US5401838A (en) 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
YU43193A (sh) 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
US5606048A (en) 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5426183A (en) 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
UA41261C2 (uk) 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
DE4308042C2 (de) 1993-03-13 2000-10-12 Alstom Energy Syst Gmbh Wälzmühle
US6025395A (en) 1994-04-15 2000-02-15 Duke University Method of preventing or delaying the onset and progression of Alzheimer's disease and related disorders
US5972703A (en) 1994-08-12 1999-10-26 The Regents Of The University Of Michigan Bone precursor cells: compositions and methods
US5521294A (en) 1995-01-18 1996-05-28 Eli Lilly And Company 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides
DE69724964T2 (de) 1996-07-03 2004-07-22 Pharmacia & Upjohn Co., Kalamazoo Zielgerichte arzneimittel abgabe für zulphonamide-derivate
NZ336676A (en) 1997-01-24 2000-01-28 Norsk Hydro As Gemcitabine esters or amides useful as anti-cancer and anti-viral agents
US20050276836A1 (en) 1997-06-11 2005-12-15 Michelle Wilson Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents
US5965119A (en) 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US6369101B1 (en) * 1999-02-26 2002-04-09 Regents Of The University Of Minnesota Therapeutic method to treat herpes virus infection
US6485756B1 (en) 1999-04-06 2002-11-26 Collaborative Technologies, Inc. Stable, homogeneous natural product extracts containing polar and apolar fractions
ATE370928T1 (de) 1999-05-14 2007-09-15 Nereus Pharmaceuticals Inc Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren
JP3737968B2 (ja) 1999-06-25 2006-01-25 ロシュ ダイアグノスティックス コーポレーション 酵素阻害イムノアッセイ
US6649654B1 (en) 1999-11-23 2003-11-18 The Regents Of The University Of California Methods for identifying and using IKK inhibitors
JP2001240573A (ja) * 2000-03-01 2001-09-04 Meiji Seika Kaisha Ltd トリテルペン誘導体及び肝疾患治療剤
WO2002003996A1 (en) 2000-07-12 2002-01-17 RAJKUMAR, Sujatha Use of dammarane-type tritepenoid saporins
WO2002026762A1 (en) * 2000-09-29 2002-04-04 Regents Of The University Of Minnesota Triterpenes having antibacterial activity
US6951847B2 (en) * 2000-09-29 2005-10-04 Regents Of The University Of Minnesota Methods of treating fungal infections using lupeol
EP1322661A1 (en) * 2000-09-29 2003-07-02 Regents Of The University Of Minnesota Triterpenes having fungicidal activity against yeast
US6878751B1 (en) 2000-10-19 2005-04-12 Imperial College Of Science Technology And Medicine Administration of resveratrol to treat inflammatory respiratory disorders
WO2002047611A2 (en) 2000-11-28 2002-06-20 Board Of Regents, The University Of Texas System Cddo-compounds and combination therapies thereof
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
AU2002308701A1 (en) 2001-05-14 2002-11-25 University Of Maryland, Baltimore Novel alanine transaminase enzyme and methods of use
EP1492523A2 (en) 2001-11-23 2005-01-05 Chugai Seiyaku Kabushiki Kaisha Method for identification of tumor targeting enzymes
EP1465615B1 (en) 2002-01-15 2012-08-01 Trustees of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
MXPA04006953A (es) 2002-01-18 2005-06-20 Univ Minnesota Sales cuaternarias de triperpeno como surfactantes biologicamente activos.
CA2485565A1 (en) * 2002-05-13 2004-08-05 Trustees Of Dartmouth College Inhibitors and methods of use thereof
EP1567169A4 (en) 2002-11-04 2009-10-21 Xenoport Inc GEMCITABINE PROMOTERS, THEIR PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
WO2004089357A2 (en) 2003-04-02 2004-10-21 Regents Of The University Of Minnesota Anti-fungal formulation of triterpene and essential oil
US20050208151A1 (en) 2003-10-30 2005-09-22 Entelos, Inc. Treatment of rheumatoid arthritis with FLIP antagonists
US8288439B2 (en) 2003-11-04 2012-10-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for the inhibition of HIV-1 replication
PL1803468T3 (pl) 2003-12-22 2012-05-31 Novartis Ag Środki do leczenia retinopatii jaskrowej i neuropatii wzrokowej
US20060258752A1 (en) 2004-02-12 2006-11-16 Vander Jagt David L Method and compounds for cancer treatment utilizing NFkB as a direct or ultimate target for small molecule inhibitors
JP2005314381A (ja) 2004-03-30 2005-11-10 Anges Mg Inc 増殖性腎疾患の予防・治療・改善剤
CN1272340C (zh) * 2004-07-14 2006-08-30 中国药科大学 齐墩果酸偶联衍生物及其药物用途
JP5087400B2 (ja) 2004-09-07 2012-12-05 パシフィック アロー リミテッド アンゲロイル基を有する抗腫瘍化合物
CN101235071B (zh) * 2004-12-29 2013-02-06 浙江大学 一类双烯齐墩果酸五环三萜类衍生物及用途
JP2006347952A (ja) * 2005-06-16 2006-12-28 Yoshihiro Futamura リパーゼ活性化作用を呈するアントラキノン誘導体、それからなる抗肥満薬、食品製剤及び化粧品
WO2007005879A2 (en) 2005-07-01 2007-01-11 The Johns Hopkins University Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
DE102005041613A1 (de) 2005-09-01 2007-03-08 Ergonex Pharma Gmbh Pharmazeutische Zusammensetzungen zur Behandlung von Karzinoid-Syndrom
NZ569078A (en) 2005-12-12 2012-01-12 Mosamedix Bv Annexin derivatives suitable for pretargeting in therapy and diagnosis
JP2009530405A (ja) 2006-03-23 2009-08-27 アドバンスト ライフ サイエンシズ インコーポレイテッド 合成五環性トリテルペノイド、ならびにベツリン酸およびベツリンの誘導体
WO2007127791A2 (en) 2006-04-25 2007-11-08 The Administrators Of The Tulane Educational Fund New pharmacological method for treatment of neuropathic pain
WO2008000070A1 (en) 2006-06-27 2008-01-03 Wellington Laboratories Inc. Glycyrrhetinic acid derivatives
CN101117348B (zh) * 2006-08-01 2010-12-29 浙江海正药业股份有限公司 A环和c环多氧化取代的五环三萜及其制备方法和用途
JP2008110962A (ja) 2006-08-02 2008-05-15 Santen Pharmaceut Co Ltd Nrf2活性化物質を有効成分として含む角結膜障害の予防または治療剤
WO2008016095A1 (en) 2006-08-02 2008-02-07 Santen Pharmaceutical Co., Ltd. PREVENTIVE OR REMEDY FOR KERATOCONJUNCTIVAL DISORDERS CONTAINING Nrf2 ACTIVATOR AS THE ACTIVE INGREDIENT
US20090203661A1 (en) 2006-10-12 2009-08-13 Safe Stephen H Betulinic acid, derivatives and analogs thereof and uses therefor
WO2008064132A2 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
JP2010510243A (ja) 2006-11-17 2010-04-02 トラスティーズ オブ ダートマス カレッジ 三環系−ビス−エノン(tbe)の合成および生物学的活性
DK2629097T1 (da) 2007-02-08 2022-05-30 Biogen Ma Inc NRF2-screeningsassays og relaterede fremgangsmåder og sammensætninger
JP2008247898A (ja) 2007-03-08 2008-10-16 Santen Pharmaceut Co Ltd トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤
US20080254055A1 (en) 2007-04-11 2008-10-16 John Erich Oblong Compositions for Regulation of Hair Growth
WO2008136838A1 (en) 2007-05-04 2008-11-13 Trustees Of Dartmouth College Novel amide derivatives of cddo and methods of use thereof
US8088824B2 (en) 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
WO2009023845A2 (en) 2007-08-15 2009-02-19 The Board Of Regents Of The University Of Texas System Combination therapy with synthetic triterpenoids and gemcitabine
US9012439B2 (en) 2007-10-29 2015-04-21 University Of Rochester Use of electrophilic compounds for inducing platelet production or maintaining platelet function
EP3492077A1 (en) 2008-01-11 2019-06-05 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
KR101782020B1 (ko) 2008-04-18 2017-09-26 리타 파마슈티컬스 잉크. 산화방지성 염증 조절제 c-17 일치된 올레아놀산 유도체
WO2009129546A1 (en) 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
AU2009251437B2 (en) 2008-04-18 2014-10-30 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
TW201004627A (en) 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
AU2009237578C1 (en) 2008-04-18 2014-12-04 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
JP2010016572A (ja) * 2008-07-02 2010-01-21 Fujitsu Ltd 無線通信装置及びシステム
ES2449396T3 (es) 2008-07-22 2014-03-19 Trustees Of Dartmouth College Cianoenonas monocíclicas y métodos de uso de las mismas
WO2010053817A1 (en) 2008-11-04 2010-05-14 Trustees Of Dartmouth College Betulinic acid derivatives and methods of use thereof
HUE035013T2 (en) 2009-02-13 2018-05-02 Reata Pharmaceuticals Inc Delayed release, oral dosage compositions that contain amorphous cddo-me
EP3028707A1 (en) 2009-05-01 2016-06-08 Ophthotech Corporation Methods for treating or preventing ophthalmological diseases
ME03713B (me) 2010-04-12 2021-01-20 Reata Pharmaceuticals Inc Bardoksolon meтil za lečenje gojaznosтi
WO2011140078A1 (en) 2010-05-04 2011-11-10 Concert Pharmaceuticals, Inc. Synthetic triterpenoid derivatives
CN102070697A (zh) 2010-12-09 2011-05-25 中国药科大学 一种齐墩果酸衍生物、其制备方法及用途
EA025568B1 (ru) 2010-12-17 2017-01-30 Рита Фармасьютикалз, Инк. Пиразолильные и пиримидинильные трициклические еноны в качестве антиоксидантных модуляторов воспаления
EP2670765B1 (en) 2011-01-31 2017-10-18 Viiv Healthcare Uk (No. 4) Limited C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity
BR112013023174B1 (pt) 2011-03-11 2021-09-21 Reata Pharmaceuticals, Inc Compostos derivados de triterpenoide de c4-monometila e composição farmacêutica compreendendo os referidos compostos
WO2012154554A1 (en) 2011-05-06 2012-11-15 Catabasis Pharmaceuticals, Inc. Fatty acid triterpene derivatives and their uses
MX357060B (es) 2012-04-27 2018-06-25 Reata Pharmaceuticals Inc Derivados de 2,2-difluoropropionamida de bardoxolon metilo, formas polimorficas y metodo para su uso de los mismos.
WO2013169740A2 (en) 2012-05-08 2013-11-14 Trustees Of Dartmouth College Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US8981144B2 (en) 2012-05-08 2015-03-17 Trustees Of Dartmouth College Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof
PT2855435T (pt) 2012-05-29 2018-07-03 Parion Sciences Inc Aminoamidas do tipo dendrímeros possuindo atividade bloqueadora de canais de sódio para o tratamento do olho seco e outras doenças das mucosas
WO2013188818A1 (en) 2012-06-15 2013-12-19 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
WO2014040056A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
WO2014040073A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
CA2884400A1 (en) 2012-09-10 2014-03-13 Abbvie Inc. Glycyrrhetinic acid derivatives and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
UY35023A (es) 2012-09-10 2014-03-31 Reata Pharmaceuticals Inc Derivados c17-alcandiilo y alquendiilo del ácido oleanólico y sus métodos de uso
KR101545068B1 (ko) 2012-09-28 2015-08-17 베이징 즈지엔진루이 셩우이야오 커지 요우시엔공스 Cddo 에틸 에스테르의 다형체 및 이의 용도
CN102887936A (zh) 2012-10-24 2013-01-23 苏州晶云药物科技有限公司 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯晶型
CN103788166A (zh) 2012-10-30 2014-05-14 中国药科大学 △13(18)-cddo衍生物、其制备方法与在制药中的用途
UY39092A (es) 2013-04-24 2021-03-26 Abbvie Inc Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso
IL285832B2 (en) 2013-08-23 2024-01-01 Reata Pharmaceuticals Inc Methods for the treatment and prevention of impaired functioning of the endothelium using brodoxolone methyl or its analogs
TWI670263B (zh) 2014-01-24 2019-09-01 美商瑞塔醫藥有限責任公司 作為抗氧化發炎調節劑之經芳基及芳基烷基取代之吡唑及嘧啶三環烯酮
AU2016219109B2 (en) 2015-02-12 2020-05-14 Reata Pharmaceuticals, Inc. Imidazolyl tricyclic enones as antioxidant iflammation modulators
CA2998681C (en) 2015-09-23 2024-02-06 Reata Pharmaceuticals, Inc. C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses
BR112019009256A2 (pt) 2016-11-08 2019-07-16 Reata Pharmaceuticals Inc métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制RORγ及其他用途的嘧啶三環烯酮衍生物
CN114641483B (zh) 2019-07-19 2024-12-06 里亚塔医药公司 C17极性的-取代的杂芳族合成三萜类化合物及其使用方法
CR20220345A (es) 2019-12-19 2023-01-12 Reata Pharmaceuticals Inc Triterpenoides sintéticos con sustituyentes a base de nitrógeno en c-17 y métodos de uso de los mismos

Similar Documents

Publication Publication Date Title
JP2011518191A5 (cg-RX-API-DMAC7.html)
JP2011518193A5 (cg-RX-API-DMAC7.html)
JP2011518192A5 (cg-RX-API-DMAC7.html)
JP2011518190A5 (cg-RX-API-DMAC7.html)
ES2860676T3 (es) Sales o cocristales de 3- (3-dimetilamino-1-etil-2-metil-propil) -fenol
TWI239942B (en) N-arylphenylacetamide derivative and pharmaceutical composition containing the same
AU2016200953B2 (en) Novel Compounds And Compositions For Targeting Cancer Stem Cells
RS65536B1 (sr) Novi postupci za ciljanje matičnih ćelija kancera
JP2019512474A (ja) シアノ置換インドール化合物およびlsd1阻害剤としてのその使用
JP5993390B2 (ja) がん幹細胞を標的とするための新規の化合物および組成物
CN115052588B (zh) 衣康酸酯和衣康酸甲酯的前药
AU2015218436B9 (en) Novel Methods For Targeting Cancer Stem Cells
WO2011106721A1 (en) Flurbiprofen analogs and methods of use in treating cancer
WO2011028571A1 (en) Taxane analogues, their use, pharmaceutical compositions containing them, and processes for their preparation
EP2814480A1 (en) METHOD FOR PREPARING AQUEOUS MANO PARTICLE SUSPENSIONS OF DERIVATIVES OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURAN ALIPHATIC ACID ESTERS
CN119564657A (zh) 衣康酸酯及其衍生物/类似物诱导毛发生长的用途
TWI684581B (zh) 與泛素化-蛋白酶體系統有關之化合物及醫藥組合物
AU2016278040B2 (en) Drug delivery and imaging chemical conjugate, formulations and methods of use thereof
US10058618B2 (en) PAK1-blocking 1,2,3-triazolyl esters
US20140371165A1 (en) Identification of NSC23925 Isomers to Reverse Multidrug Resistance in Human Cancers
RU2020121153A (ru) Сульфонамидные соединения и их применение
HK1239527A1 (en) Novel compounds and compositions for targeting cancer stem cells