JP2011516497A5 - - Google Patents
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- Publication number
- JP2011516497A5 JP2011516497A5 JP2011503214A JP2011503214A JP2011516497A5 JP 2011516497 A5 JP2011516497 A5 JP 2011516497A5 JP 2011503214 A JP2011503214 A JP 2011503214A JP 2011503214 A JP2011503214 A JP 2011503214A JP 2011516497 A5 JP2011516497 A5 JP 2011516497A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- botulinum toxin
- liposome
- bladder
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 25
- 238000009472 formulation Methods 0.000 claims description 22
- 108030001720 Bontoxilysin Proteins 0.000 claims description 13
- 229940053031 botulinum toxin Drugs 0.000 claims description 13
- 239000002502 liposome Substances 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 3
- 150000002632 lipids Chemical class 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002577 cryoprotective agent Substances 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 206010020853 Hypertonic bladder Diseases 0.000 description 2
- 206010071289 Lower urinary tract symptoms Diseases 0.000 description 2
- 208000009722 Overactive Urinary Bladder Diseases 0.000 description 2
- 208000020629 overactive bladder Diseases 0.000 description 2
- 210000000436 anus Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4253608P | 2008-04-04 | 2008-04-04 | |
| US61/042,536 | 2008-04-04 | ||
| US11026608P | 2008-10-31 | 2008-10-31 | |
| US61/110,266 | 2008-10-31 | ||
| PCT/US2009/039489 WO2009139984A2 (en) | 2008-04-04 | 2009-04-03 | Method of treatment for bladder dysfunction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000235A Division JP2014062125A (ja) | 2008-04-04 | 2014-01-06 | リポソームボツリヌス毒素を使用する膀胱機能障害の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011516497A JP2011516497A (ja) | 2011-05-26 |
| JP2011516497A5 true JP2011516497A5 (https=) | 2011-12-08 |
| JP5538359B2 JP5538359B2 (ja) | 2014-07-02 |
Family
ID=41319235
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011503214A Expired - Fee Related JP5538359B2 (ja) | 2008-04-04 | 2009-04-03 | リポソームボツリヌス毒素を使用する膀胱機能障害の治療 |
| JP2014000235A Withdrawn JP2014062125A (ja) | 2008-04-04 | 2014-01-06 | リポソームボツリヌス毒素を使用する膀胱機能障害の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000235A Withdrawn JP2014062125A (ja) | 2008-04-04 | 2014-01-06 | リポソームボツリヌス毒素を使用する膀胱機能障害の治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20120093920A1 (https=) |
| EP (2) | EP2599476A1 (https=) |
| JP (2) | JP5538359B2 (https=) |
| KR (1) | KR20100131471A (https=) |
| CN (1) | CN102065841A (https=) |
| AU (1) | AU2009246834B2 (https=) |
| BR (1) | BRPI0911098A2 (https=) |
| CA (1) | CA2720523C (https=) |
| MX (1) | MX2010010635A (https=) |
| WO (1) | WO2009139984A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2649985A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
| EP2649983A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (II) |
| EP2836193B1 (en) | 2012-04-13 | 2018-01-31 | Lubrizol Advanced Materials, Inc. | Compounds which inhibit neuronal exocytosis (ii) |
| EP2649984A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis |
| SG11201501424SA (en) | 2012-08-31 | 2015-03-30 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of bladder cancer comprising oxaliplatin |
| MX367070B (es) | 2012-08-31 | 2019-08-05 | Taris Biomedical Llc | Sistemas de administracion de farmaco y metodos para el tratamiento de la prostata. |
| AU2014340137B2 (en) | 2013-10-22 | 2020-02-13 | Lipella Pharmaceuticals Inc. | Delivery of agents using metastable liposomes |
| LT4124339T (lt) | 2014-03-06 | 2025-11-10 | Vaisto įvedimo sistemos ir būdai šlapimo pūslės vėžiui gydyti gemcitabinu | |
| US20160045623A1 (en) | 2015-04-03 | 2016-02-18 | Lipella Pharmaceuticals, Inc. | Systems and Methods to Image Intercellular and Intercompartmental Defects with Magnetic Resonance Imaging (MRI) |
| BR112020000832A2 (pt) | 2017-07-25 | 2020-07-21 | Taris Biomedical Llc | métodos para tratar metástase tumoral |
| EP3675900A4 (en) | 2017-08-28 | 2021-05-05 | Revance Therapeutics, Inc. | Transmucosal botulinum toxin compositions, kits, and methods for treating bladder disorders |
| JOP20200124A1 (ar) | 2017-11-08 | 2020-05-20 | Taris Biomedical Llc | طُرق لعلاج سرطان المثانة باستخدام جيمسيتابين وعلاج مدوامة لذلك |
| KR102398743B1 (ko) * | 2020-09-03 | 2022-05-16 | 충남대학교병원 | 초음파유도 마이크로버블을 포함하는 배뇨장애 치료제 조성물 |
| TWI760996B (zh) * | 2020-12-25 | 2022-04-11 | 姜秉均 | 含有疏水性物質的奈米組成物及其製備方法與用途 |
| CN117883383A (zh) * | 2023-12-26 | 2024-04-16 | 中国康复研究中心 | 一种作为A型肉毒素载体的TiO2纳米粒子及制备方法 |
| US12272439B1 (en) | 2024-05-06 | 2025-04-08 | Immunitybio, Inc. | Distributed ledger for medicament administration tracking |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3693209B2 (ja) * | 1996-04-11 | 2005-09-07 | 三菱化学株式会社 | 閉鎖小胞の製造方法 |
| US7063860B2 (en) * | 2001-08-13 | 2006-06-20 | University Of Pittsburgh | Application of lipid vehicles and use for drug delivery |
| WO2003101483A1 (en) * | 2002-05-31 | 2003-12-11 | Solux Corporation | Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use |
| US20040067235A1 (en) * | 2002-07-29 | 2004-04-08 | Rajiv Doshi | Methods for the use of neurotoxin in the treatment of urologic disorders |
| EP1585504A4 (en) * | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | Protein stabilized liposomal formulations of pharmaceutical active ingredients |
| EP1933813A4 (en) * | 2005-10-11 | 2013-02-27 | Univ Pittsburgh | SPHINGOMYELIN LIPOSOME FOR THE TREATMENT OF HYPERACTIVE BLADDER DISORDER |
-
2009
- 2009-04-03 CA CA2720523A patent/CA2720523C/en not_active Expired - Fee Related
- 2009-04-03 BR BRPI0911098A patent/BRPI0911098A2/pt not_active IP Right Cessation
- 2009-04-03 WO PCT/US2009/039489 patent/WO2009139984A2/en not_active Ceased
- 2009-04-03 MX MX2010010635A patent/MX2010010635A/es not_active Application Discontinuation
- 2009-04-03 AU AU2009246834A patent/AU2009246834B2/en not_active Ceased
- 2009-04-03 JP JP2011503214A patent/JP5538359B2/ja not_active Expired - Fee Related
- 2009-04-03 CN CN2009801204554A patent/CN102065841A/zh active Pending
- 2009-04-03 EP EP13156622.6A patent/EP2599476A1/en not_active Withdrawn
- 2009-04-03 KR KR1020107022175A patent/KR20100131471A/ko not_active Ceased
- 2009-04-03 EP EP09747070A patent/EP2273976A2/en not_active Withdrawn
-
2011
- 2011-12-09 US US13/315,861 patent/US20120093920A1/en not_active Abandoned
-
2014
- 2014-01-06 JP JP2014000235A patent/JP2014062125A/ja not_active Withdrawn
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