JP2011516497A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011516497A5 JP2011516497A5 JP2011503214A JP2011503214A JP2011516497A5 JP 2011516497 A5 JP2011516497 A5 JP 2011516497A5 JP 2011503214 A JP2011503214 A JP 2011503214A JP 2011503214 A JP2011503214 A JP 2011503214A JP 2011516497 A5 JP2011516497 A5 JP 2011516497A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- botulinum toxin
- liposome
- bladder
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 25
- 238000009472 formulation Methods 0.000 claims description 22
- 108030001720 Bontoxilysin Proteins 0.000 claims description 13
- 229940053031 botulinum toxin Drugs 0.000 claims description 13
- 239000002502 liposome Substances 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 3
- 150000002632 lipids Chemical class 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002577 cryoprotective agent Substances 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 206010020853 Hypertonic bladder Diseases 0.000 description 2
- 206010071289 Lower urinary tract symptoms Diseases 0.000 description 2
- 208000009722 Overactive Urinary Bladder Diseases 0.000 description 2
- 208000020629 overactive bladder Diseases 0.000 description 2
- 210000000436 anus Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4253608P | 2008-04-04 | 2008-04-04 | |
| US61/042,536 | 2008-04-04 | ||
| US11026608P | 2008-10-31 | 2008-10-31 | |
| US61/110,266 | 2008-10-31 | ||
| PCT/US2009/039489 WO2009139984A2 (en) | 2008-04-04 | 2009-04-03 | Method of treatment for bladder dysfunction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000235A Division JP2014062125A (ja) | 2008-04-04 | 2014-01-06 | リポソームボツリヌス毒素を使用する膀胱機能障害の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011516497A JP2011516497A (ja) | 2011-05-26 |
| JP2011516497A5 true JP2011516497A5 (https=) | 2011-12-08 |
| JP5538359B2 JP5538359B2 (ja) | 2014-07-02 |
Family
ID=41319235
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011503214A Expired - Fee Related JP5538359B2 (ja) | 2008-04-04 | 2009-04-03 | リポソームボツリヌス毒素を使用する膀胱機能障害の治療 |
| JP2014000235A Withdrawn JP2014062125A (ja) | 2008-04-04 | 2014-01-06 | リポソームボツリヌス毒素を使用する膀胱機能障害の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000235A Withdrawn JP2014062125A (ja) | 2008-04-04 | 2014-01-06 | リポソームボツリヌス毒素を使用する膀胱機能障害の治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20120093920A1 (https=) |
| EP (2) | EP2273976A2 (https=) |
| JP (2) | JP5538359B2 (https=) |
| KR (1) | KR20100131471A (https=) |
| CN (1) | CN102065841A (https=) |
| AU (1) | AU2009246834B2 (https=) |
| BR (1) | BRPI0911098A2 (https=) |
| CA (1) | CA2720523C (https=) |
| MX (1) | MX2010010635A (https=) |
| WO (1) | WO2009139984A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2649984A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis |
| EP2649983A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (II) |
| CA2869599C (en) | 2012-04-13 | 2021-07-27 | Lubrizol Advanced Materials, Inc. | Compounds which inhibit neuronal exocytosis (ii) |
| EP2649985A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
| JP6463266B2 (ja) | 2012-08-31 | 2019-01-30 | タリス バイオメディカル エルエルシー | 膀胱癌の治療のためのオキサリプラチンを含む薬物送達システム及び方法 |
| AU2013308465B2 (en) | 2012-08-31 | 2018-05-17 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of prostate disease comprising gemicitabine |
| ES2952675T3 (es) | 2013-10-22 | 2023-11-03 | Lipella Pharmaceuticals Inc | Administración de agentes mediante el uso de liposomas metaestables |
| US20150250717A1 (en) | 2014-03-06 | 2015-09-10 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine |
| US20160045623A1 (en) | 2015-04-03 | 2016-02-18 | Lipella Pharmaceuticals, Inc. | Systems and Methods to Image Intercellular and Intercompartmental Defects with Magnetic Resonance Imaging (MRI) |
| SG10201913998YA (en) | 2017-07-25 | 2020-03-30 | Taris Biomedical Llc | Methods of treating tumor metastasis |
| WO2019046311A1 (en) | 2017-08-28 | 2019-03-07 | Revance Therapeutics, Inc. | TRANSMUCOSAL COMPOSITIONS OF BOTULINUM TOXIN, KITS AND METHODS FOR TREATING BLADDER DISORDERS |
| IL302714B1 (en) | 2017-11-08 | 2026-01-01 | Taris Biomedical Llc | Methods for treating and maintaining bladder cancer using gemcitabine |
| KR102398743B1 (ko) * | 2020-09-03 | 2022-05-16 | 충남대학교병원 | 초음파유도 마이크로버블을 포함하는 배뇨장애 치료제 조성물 |
| TWI760996B (zh) * | 2020-12-25 | 2022-04-11 | 姜秉均 | 含有疏水性物質的奈米組成物及其製備方法與用途 |
| CN117883383A (zh) * | 2023-12-26 | 2024-04-16 | 中国康复研究中心 | 一种作为A型肉毒素载体的TiO2纳米粒子及制备方法 |
| US12272439B1 (en) | 2024-05-06 | 2025-04-08 | Immunitybio, Inc. | Distributed ledger for medicament administration tracking |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3693209B2 (ja) * | 1996-04-11 | 2005-09-07 | 三菱化学株式会社 | 閉鎖小胞の製造方法 |
| AU2002323151A1 (en) | 2001-08-13 | 2003-03-03 | University Of Pittsburgh | Application of lipid vehicles and use for drug delivery |
| US20030224020A1 (en) * | 2002-05-31 | 2003-12-04 | Zabudkin Alexander F. | Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use |
| US20040067235A1 (en) * | 2002-07-29 | 2004-04-08 | Rajiv Doshi | Methods for the use of neurotoxin in the treatment of urologic disorders |
| EP1585504A4 (en) * | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | Protein stabilized liposomal formulations of pharmaceutical active ingredients |
| JP5815915B2 (ja) * | 2005-10-11 | 2015-11-17 | ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 過活動膀胱障害の治療のためのスフィンゴミエリンリポソーム |
-
2009
- 2009-04-03 WO PCT/US2009/039489 patent/WO2009139984A2/en not_active Ceased
- 2009-04-03 CN CN2009801204554A patent/CN102065841A/zh active Pending
- 2009-04-03 MX MX2010010635A patent/MX2010010635A/es not_active Application Discontinuation
- 2009-04-03 KR KR1020107022175A patent/KR20100131471A/ko not_active Ceased
- 2009-04-03 AU AU2009246834A patent/AU2009246834B2/en not_active Ceased
- 2009-04-03 CA CA2720523A patent/CA2720523C/en not_active Expired - Fee Related
- 2009-04-03 BR BRPI0911098A patent/BRPI0911098A2/pt not_active IP Right Cessation
- 2009-04-03 JP JP2011503214A patent/JP5538359B2/ja not_active Expired - Fee Related
- 2009-04-03 EP EP09747070A patent/EP2273976A2/en not_active Withdrawn
- 2009-04-03 EP EP13156622.6A patent/EP2599476A1/en not_active Withdrawn
-
2011
- 2011-12-09 US US13/315,861 patent/US20120093920A1/en not_active Abandoned
-
2014
- 2014-01-06 JP JP2014000235A patent/JP2014062125A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011516497A5 (https=) | ||
| ES2821098T3 (es) | Preparaciones de hidrogel térmico reversible para su uso en el tratamiento de trastornos del urotelio | |
| JP2008044951A5 (https=) | ||
| CN101829036B (zh) | 口腔喷雾剂 | |
| Chang et al. | Prevention and repair of circulatory shock and cerebral ischemia/injury by various agents in experimental heatstroke | |
| JP2002507548A (ja) | 上気道状態を治療するためのキシリトール調合物 | |
| MX2008011823A (es) | Forma de dosificacion solida que contiene un agente activo de sabor encubierto. | |
| CO6260019A2 (es) | Metodos para el tratamiento de desordenes gastrointestinales independientes de la ingesta de alimento | |
| JP2015513309A5 (https=) | ||
| ATE511847T1 (de) | Pharmazeutische zubereitung für die behandlung entzündlicher erkrankungen des urogenitaltraktes | |
| JP2010513487A5 (https=) | ||
| AR070835A1 (es) | Nueva dosificacion y formulacion de aclidinio para el tratamiento de trastornos respiratorios | |
| WO2020043185A1 (zh) | 氨基酸类营养素的应用以及包含它的药物组合物 | |
| CA2738070C (en) | Novel compounds for the treatment or alleviation of edema, and methods for their use | |
| CA2902852A1 (en) | Pharmaceutical compositions for rectal administration | |
| PT106094A (pt) | Administração por inalação de formulações com dose elevada | |
| FI20095600A7 (fi) | Koostumus ihosairauksien hoitoa varten | |
| JP2009522376A5 (https=) | ||
| JP2009503097A5 (https=) | ||
| CN102648279A (zh) | 用于治疗药物诱发的手足综合征的组合物与方法 | |
| WO2008051527A3 (en) | Sustained release of agents for localized pain management | |
| Bowe et al. | Therapeutic update: acne | |
| ES2645339T3 (es) | Usos de n-butilidenftalida en el tratamiento de una lesión hepática y en la mejora de la función hepática | |
| JP2015518000A5 (https=) | ||
| CN101897720B (zh) | 一种治疗呼吸道疾病的药物组合物 |