JP2011515091A5 - - Google Patents
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- Publication number
- JP2011515091A5 JP2011515091A5 JP2011501069A JP2011501069A JP2011515091A5 JP 2011515091 A5 JP2011515091 A5 JP 2011515091A5 JP 2011501069 A JP2011501069 A JP 2011501069A JP 2011501069 A JP2011501069 A JP 2011501069A JP 2011515091 A5 JP2011515091 A5 JP 2011515091A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- fusion transcript
- mitochondrial fusion
- mtdna
- mitochondrial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000004927 fusion Effects 0.000 claims 17
- 230000002438 mitochondrial effect Effects 0.000 claims 17
- 108020005196 Mitochondrial DNA Proteins 0.000 claims 14
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 13
- 239000000523 sample Substances 0.000 claims 11
- 241000124008 Mammalia Species 0.000 claims 6
- 238000003556 assay Methods 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 5
- 238000009396 hybridization Methods 0.000 claims 5
- 238000012216 screening Methods 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 238000002059 diagnostic imaging Methods 0.000 claims 2
- 238000002493 microarray Methods 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 208000030381 cutaneous melanoma Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000010208 microarray analysis Methods 0.000 claims 1
- 230000008707 rearrangement Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 238000012360 testing method Methods 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4061608P | 2008-03-28 | 2008-03-28 | |
| US61/040,616 | 2008-03-28 | ||
| PCT/CA2009/000351 WO2009117811A1 (en) | 2008-03-28 | 2009-03-27 | Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011515091A JP2011515091A (ja) | 2011-05-19 |
| JP2011515091A5 true JP2011515091A5 (cg-RX-API-DMAC7.html) | 2012-05-31 |
| JP5938690B2 JP5938690B2 (ja) | 2016-06-22 |
Family
ID=41112880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501069A Expired - Fee Related JP5938690B2 (ja) | 2008-03-28 | 2009-03-27 | 異常型ミトコンドリアｄｎａ、関連融合転写物およびそのハイブリダイゼーションプローブ |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20110172113A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2274426B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5938690B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101819852B1 (cg-RX-API-DMAC7.html) |
| CN (3) | CN107011428B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009227935B2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2719718C (cg-RX-API-DMAC7.html) |
| NZ (2) | NZ602175A (cg-RX-API-DMAC7.html) |
| SG (3) | SG192453A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009117811A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2719718C (en) * | 2008-03-28 | 2019-07-02 | Mitomics, Inc. | Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor |
| EP3272871B1 (en) * | 2009-03-27 | 2020-01-15 | MDNA Life Sciences Inc. | Aberrant mitochondrial dna, associated fusion transcripts and translation products and hybridization probes therefor |
| CN104946676A (zh) * | 2010-03-01 | 2015-09-30 | 米托米克斯公司 | Uv相关联的mtrna融合转录体及其方法和用途 |
| US9518087B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| CN106456743A (zh) | 2014-02-21 | 2017-02-22 | 洛桑聚合联合学院 | 糖靶向性治疗剂 |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| AU2017280210A1 (en) * | 2016-06-22 | 2019-01-24 | Degen Zhuo | Method and kit for detecting fusion transcripts |
| US11978535B2 (en) * | 2017-02-01 | 2024-05-07 | The Translational Genomics Research Institute | Methods of detecting somatic and germline variants in impure tumors |
| EP3638296A1 (en) | 2017-06-16 | 2020-04-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| WO2019191079A1 (en) * | 2018-03-26 | 2019-10-03 | The University Of Chicago | Methods and compositions for targeting liver and lymph node sinusoidal endothelial cell c-type lectin (lsectin) |
| KR20210010879A (ko) | 2018-05-09 | 2021-01-28 | 더 유니버서티 오브 시카고 | 면역 관용 관여 조성물 및 방법 |
| KR20210107719A (ko) * | 2018-12-22 | 2021-09-01 | 엠디엔에이 라이프 사이언시즈 인코퍼레이티드 | 자궁내막증과 연관된 미토콘드리아 dna 결실 |
| CN117384269B (zh) * | 2023-09-21 | 2024-06-18 | 南方医科大学南方医院 | 短肽mfrlp及其在制备动脉重塑相关疾病药物中的应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) * | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) * | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) * | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) * | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) * | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4366241A (en) * | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US5807522A (en) * | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US6605433B1 (en) * | 1998-08-20 | 2003-08-12 | The Johns Hopkins University | Mitochondrial dosimeter |
| US6203990B1 (en) * | 1998-11-06 | 2001-03-20 | Mitokor | Method and system for pattern analysis, such as for analyzing oligonucleotide primer extension assay products |
| US6933120B2 (en) * | 2000-06-20 | 2005-08-23 | Michael D. Seidman | Method of determining biological/molecular age |
| WO2002101086A2 (en) * | 2001-06-11 | 2002-12-19 | 1304854 Ontario Ltd. | Complete mitochondrial genome sequences as a diagnostic tool for the health sciences |
| US20050026167A1 (en) * | 2001-06-11 | 2005-02-03 | Mark Birch-Machin | Complete mitochondrial genome sequences as a diagnostic tool for the health sciences |
| US20030162174A1 (en) * | 2001-06-11 | 2003-08-28 | Sutherland John W. | Detecting nucleic acid deletion sequences |
| GB2380194B (en) * | 2001-10-01 | 2005-06-22 | Roger Michael Marchbanks | A mitochondrial mutation associated with schizophrenia and increased oxidative stress |
| US20060051796A1 (en) * | 2004-09-09 | 2006-03-09 | Inga Boell | Real time PCR with the addition of pyrophosphatase |
| DK1877559T3 (da) * | 2005-04-18 | 2011-02-07 | Mitomics Inc | Mitochondrial mutationer og omarrangeringer som et diagnostisk værktøj for detektion af soleksponering, prostatacancer og andre cancertyper |
| US20070134678A1 (en) * | 2005-12-12 | 2007-06-14 | Rees Dianne M | Comparative genome hybridization of organelle genomes |
| NZ584815A (en) | 2007-09-26 | 2012-07-27 | Mitomics Inc | 3.4 kb mitochondrial dna deletion for use in the detection of cancer |
| CA2719718C (en) * | 2008-03-28 | 2019-07-02 | Mitomics, Inc. | Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor |
| EP3272871B1 (en) | 2009-03-27 | 2020-01-15 | MDNA Life Sciences Inc. | Aberrant mitochondrial dna, associated fusion transcripts and translation products and hybridization probes therefor |
| CN104946676A (zh) * | 2010-03-01 | 2015-09-30 | 米托米克斯公司 | Uv相关联的mtrna融合转录体及其方法和用途 |
-
2009
- 2009-03-27 CA CA2719718A patent/CA2719718C/en not_active Expired - Fee Related
- 2009-03-27 KR KR1020167036800A patent/KR101819852B1/ko not_active Expired - Fee Related
- 2009-03-27 CA CA3044262A patent/CA3044262C/en active Active
- 2009-03-27 CN CN201710183734.1A patent/CN107011428B/zh active Active
- 2009-03-27 EP EP09725638.2A patent/EP2274426B1/en not_active Not-in-force
- 2009-03-27 US US12/935,181 patent/US20110172113A1/en not_active Abandoned
- 2009-03-27 NZ NZ602175A patent/NZ602175A/en not_active IP Right Cessation
- 2009-03-27 JP JP2011501069A patent/JP5938690B2/ja not_active Expired - Fee Related
- 2009-03-27 NZ NZ588658A patent/NZ588658A/xx not_active IP Right Cessation
- 2009-03-27 CN CN200980114773.XA patent/CN102016039B/zh not_active Expired - Fee Related
- 2009-03-27 SG SG2013050448A patent/SG192453A1/en unknown
- 2009-03-27 WO PCT/CA2009/000351 patent/WO2009117811A1/en not_active Ceased
- 2009-03-27 KR KR1020107024109A patent/KR101693387B1/ko not_active Expired - Fee Related
- 2009-03-27 AU AU2009227935A patent/AU2009227935B2/en not_active Ceased
-
2010
- 2010-03-29 SG SG10201400985RA patent/SG10201400985RA/en unknown
- 2010-03-29 SG SG2011068467A patent/SG174514A1/en unknown
- 2010-03-29 US US13/260,497 patent/US8715960B2/en not_active Expired - Fee Related
- 2010-03-29 CN CN201080014122.6A patent/CN102388140B/zh not_active Expired - Fee Related
-
2015
- 2015-02-20 US US14/627,755 patent/US10266899B2/en active Active
-
2019
- 2019-04-17 US US16/386,381 patent/US20190382846A1/en not_active Abandoned
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