JP2011514144A5 - - Google Patents
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- Publication number
- JP2011514144A5 JP2011514144A5 JP2010544817A JP2010544817A JP2011514144A5 JP 2011514144 A5 JP2011514144 A5 JP 2011514144A5 JP 2010544817 A JP2010544817 A JP 2010544817A JP 2010544817 A JP2010544817 A JP 2010544817A JP 2011514144 A5 JP2011514144 A5 JP 2011514144A5
- Authority
- JP
- Japan
- Prior art keywords
- crei
- chain
- meganuclease
- crei meganuclease
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010050663 endodeoxyribonuclease CreI Proteins 0.000 claims 28
- 230000035772 mutation Effects 0.000 claims 9
- 108020004414 DNA Proteins 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 210000004899 c-terminal region Anatomy 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 101100467529 Homo sapiens RAG1 gene Proteins 0.000 claims 1
- 102220527183 Immunoglobulin heavy joining 1_R51E_mutation Human genes 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 102220602177 Synaptotagmin-3_F54A_mutation Human genes 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000010353 genetic engineering Methods 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 102220223852 rs1060502978 Human genes 0.000 claims 1
- 102200081526 rs121913583 Human genes 0.000 claims 1
- 102200155456 rs35947557 Human genes 0.000 claims 1
- 102220122845 rs767335346 Human genes 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2008/001331 WO2009095742A1 (en) | 2008-01-31 | 2008-01-31 | New i-crei derived single-chain meganuclease and uses thereof |
| PCT/IB2009/000439 WO2009095793A1 (en) | 2008-01-31 | 2009-02-02 | New i-crei derived single-chain meganuclease and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011514144A JP2011514144A (ja) | 2011-05-06 |
| JP2011514144A5 true JP2011514144A5 (https=) | 2012-03-08 |
Family
ID=39884323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544817A Pending JP2011514144A (ja) | 2008-01-31 | 2009-02-02 | 新しいＩ−ＣｒｅＩ由来単鎖メガヌクレアーゼ及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8927247B2 (https=) |
| EP (1) | EP2245147A1 (https=) |
| JP (1) | JP2011514144A (https=) |
| CN (1) | CN101970649B (https=) |
| AU (1) | AU2009208732A1 (https=) |
| CA (1) | CA2729124A1 (https=) |
| WO (2) | WO2009095742A1 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009095742A1 (en) | 2008-01-31 | 2009-08-06 | Cellectis | New i-crei derived single-chain meganuclease and uses thereof |
| AU2003215869B2 (en) † | 2002-03-15 | 2008-04-24 | Cellectis | Hybrid and single chain meganucleases and use thereof |
| EP1863909B2 (en) | 2005-03-15 | 2014-09-10 | Cellectis | I-crei meganuclease variants with modified specificity, method of preparation and uses thereof |
| WO2007060495A1 (en) * | 2005-10-25 | 2007-05-31 | Cellectis | I-crei homing endonuclease variants having novel cleavage specificity and use thereof |
| WO2009019528A1 (en) * | 2007-08-03 | 2009-02-12 | Cellectis | Meganuclease variants cleaving a dna target sequence from the human interleukin-2 receptor gamma chain gene and uses thereof |
| EP2215223B1 (en) | 2007-10-31 | 2013-05-01 | Precision Biosciences, Inc. | Rationally-designed single-chain meganucleases with non-palindromic recognition sequences |
| WO2009074842A1 (en) * | 2007-12-13 | 2009-06-18 | Cellectis | Improved chimeric meganuclease enzymes and uses thereof |
| CN102177235A (zh) * | 2008-09-08 | 2011-09-07 | 赛莱克蒂斯公司 | 切割来自谷氨酰胺合成酶基因的dna靶序列的大范围核酸酶变体及其用途 |
| EP2180058A1 (en) | 2008-10-23 | 2010-04-28 | Cellectis | Meganuclease recombination system |
| US20110239315A1 (en) | 2009-01-12 | 2011-09-29 | Ulla Bonas | Modular dna-binding domains and methods of use |
| US12612435B2 (en) | 2009-01-12 | 2026-04-28 | Ulla Bonas | Modular DNA-binding domains and methods of use |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| US20120171191A1 (en) | 2009-05-26 | 2012-07-05 | Cellectis | Meganuclease variants cleaving the genome of a pathogenic non-integrating virus and uses thereof |
| US8586526B2 (en) | 2010-05-17 | 2013-11-19 | Sangamo Biosciences, Inc. | DNA-binding proteins and uses thereof |
| WO2011021062A1 (en) * | 2009-08-21 | 2011-02-24 | Cellectis | Meganuclease variants cleaving a dna target sequence from the human lysosomal acid alpha-glucosidase gene and uses thereof |
| EP2480659A2 (en) | 2009-09-24 | 2012-08-01 | Cellectis | Meganuclease reagents of uses thereof for treating genetic diseases caused by frame shift/non sense mutations |
| WO2011072246A2 (en) | 2009-12-10 | 2011-06-16 | Regents Of The University Of Minnesota | Tal effector-mediated dna modification |
| WO2011104382A1 (en) | 2010-02-26 | 2011-09-01 | Cellectis | Use of endonucleases for inserting transgenes into safe harbor loci |
| US20130183282A1 (en) | 2010-05-12 | 2013-07-18 | Cellectis | Meganuclease variants cleaving a DNA target sequence from the rhodopsin gene and uses thereof |
| CA2799095A1 (en) | 2010-05-12 | 2011-11-17 | Cellectis | Meganuclease variants cleaving a dna target sequence from the dystrophin gene and uses thereof |
| US20130189759A1 (en) * | 2010-07-07 | 2013-07-25 | Cellectis | Meganucleases variants cleaving a dna target sequence in the nanog gene and uses thereof |
| WO2012010976A2 (en) | 2010-07-15 | 2012-01-26 | Cellectis | Meganuclease variants cleaving a dna target sequence in the tert gene and uses thereof |
| WO2012007848A2 (en) | 2010-07-16 | 2012-01-19 | Cellectis | Meganuclease variants cleaving a dna target sequence in the was gene and uses thereof |
| WO2012017329A2 (en) | 2010-08-02 | 2012-02-09 | Cellectis S.A. | Method for targeted genomic events in algae |
| US20130337454A1 (en) * | 2010-10-27 | 2013-12-19 | Philippe Duchateau | Method for increasing the efficiency of double-strand break-induced mutagenesis |
| US9044492B2 (en) | 2011-02-04 | 2015-06-02 | Cellectis Sa | Method for modulating the efficiency of double-strand break-induced mutagenesis |
| WO2012138901A1 (en) | 2011-04-05 | 2012-10-11 | Cellectis Sa | Method for enhancing rare-cutting endonuclease efficiency and uses thereof |
| CA3111953C (en) | 2011-04-05 | 2023-10-24 | Cellectis | Method for the generation of compact tale-nucleases and uses thereof |
| AU2012249390B2 (en) | 2011-04-27 | 2017-03-30 | Amyris, Inc. | Methods for genomic modification |
| WO2012158778A1 (en) * | 2011-05-16 | 2012-11-22 | Cellectis S.A. | Doubly secure transgenic algae or cyanobacteria strains to prevent their establishment and spread in natural ecosystems |
| EP2714936B1 (en) | 2011-06-01 | 2018-12-12 | Precision Biosciences, Inc. | Methods and products for producing engineered mammalian cell lines with amplified transgenes |
| US20150225734A1 (en) | 2012-06-19 | 2015-08-13 | Regents Of The University Of Minnesota | Gene targeting in plants using dna viruses |
| EP2877488B1 (en) | 2012-07-24 | 2021-02-24 | Cellectis | New modular base-specific nucleic acid binding domains from burkholderia rhizoxinica proteins |
| JP6450683B2 (ja) | 2012-11-01 | 2019-01-09 | セレクティス | 治療用タンパク質の生産のための植物 |
| CA2891510C (en) | 2012-11-16 | 2022-10-18 | Transposagen Biopharmaceuticals, Inc. | Site-specific enzymes and methods of use |
| CN105121649A (zh) | 2012-11-16 | 2015-12-02 | 赛莱蒂克斯公司 | 靶向修饰藻基因组的方法 |
| US10513698B2 (en) | 2012-12-21 | 2019-12-24 | Cellectis | Potatoes with reduced cold-induced sweetening |
| WO2014102688A1 (en) | 2012-12-27 | 2014-07-03 | Cellectis | New design matrix for improvement of homology-directed gene targeting |
| US10113162B2 (en) | 2013-03-15 | 2018-10-30 | Cellectis | Modifying soybean oil composition through targeted knockout of the FAD2-1A/1B genes |
| EP3083958B1 (en) | 2013-12-19 | 2019-04-17 | Amyris, Inc. | Methods for genomic integration |
| WO2015164748A1 (en) | 2014-04-24 | 2015-10-29 | Sangamo Biosciences, Inc. | Engineered transcription activator like effector (tale) proteins |
| CA2952906A1 (en) | 2014-06-20 | 2015-12-23 | Cellectis | Potatoes with reduced granule-bound starch synthase |
| US11473082B2 (en) | 2015-06-17 | 2022-10-18 | Poseida Therapeutics, Inc. | Compositions and methods for directing proteins to specific loci in the genome |
| US10837024B2 (en) | 2015-09-17 | 2020-11-17 | Cellectis | Modifying messenger RNA stability in plant transformations |
| WO2017134601A1 (en) | 2016-02-02 | 2017-08-10 | Cellectis | Modifying soybean oil composition through targeted knockout of the fad3a/b/c genes |
| ES2907837T3 (es) | 2016-04-27 | 2022-04-26 | Univ Puerto Rico | 1,2,3-triazoles 1,5-disustituidos son inhibidores de las GTPasas Rac/Cdc42 |
| DK3452583T3 (da) * | 2016-05-03 | 2022-01-10 | Prec Biosciences Inc | Konstruerede nukleaser, der er nyttige til behandling af hæmofili a |
| US11293033B2 (en) | 2016-05-18 | 2022-04-05 | Amyris, Inc. | Compositions and methods for genomic integration of nucleic acids into exogenous landing pads |
| WO2018022619A1 (en) * | 2016-07-25 | 2018-02-01 | Bluebird Bio, Inc. | Bcl11a homing endonuclease variants, compositions, and methods of use |
| CA3042857A1 (en) | 2016-11-16 | 2018-05-24 | Cellectis | Methods for altering amino acid content in plants through frameshift mutations |
| CA3060622A1 (en) | 2017-04-25 | 2018-11-01 | Cellectis | Alfalfa with reduced lignin composition |
| MA48797A (fr) * | 2017-05-25 | 2020-04-08 | Bluebird Bio Inc | Variants de l'endonucléase cblb , compositions et procédés d'utilisation |
| WO2019089913A1 (en) | 2017-11-01 | 2019-05-09 | Precision Biosciences, Inc. | Engineered nucleases that target human and canine factor viii genes as a treatment for hemophilia a |
| WO2019126578A1 (en) | 2017-12-20 | 2019-06-27 | Poseida Therapeutics, Inc. | Compositions and methods for directing proteins to specific loci in the genome |
| WO2019126558A1 (en) * | 2017-12-20 | 2019-06-27 | Bluebird Bio, Inc. | Ahr homing endonuclease variants, compositions, and methods of use |
| DK3806903T5 (da) | 2018-06-14 | 2024-08-19 | 2Seventy Bio Inc | Cd79a kimæriske antigenreceptorer |
| WO2020072059A1 (en) | 2018-10-04 | 2020-04-09 | Bluebird Bio, Inc. | Cblb endonuclease variants, compositions, and methods of use |
| NL2022714B1 (en) | 2019-03-11 | 2020-09-18 | Academisch Ziekenhuis Leiden | Optimised RAG1 deficient SCID Gene Therapy |
| WO2024236547A1 (en) | 2023-05-18 | 2024-11-21 | Inceptor Bio, Llc | Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof |
| WO2025046513A1 (en) | 2023-08-29 | 2025-03-06 | Inceptor Bio, Llc | Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof |
| WO2025101946A1 (en) * | 2023-11-08 | 2025-05-15 | Precision Biosciences, Inc. | Polypeptide linkers for use in engineered meganucleases |
| WO2026047626A1 (en) | 2024-08-30 | 2026-03-05 | Inceptor Bio, Llc | Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy |
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| WO2008149176A1 (en) | 2007-06-06 | 2008-12-11 | Cellectis | Meganuclease variants cleaving a dna target sequence from the mouse rosa26 locus and uses thereof |
| EP2215223B1 (en) | 2007-10-31 | 2013-05-01 | Precision Biosciences, Inc. | Rationally-designed single-chain meganucleases with non-palindromic recognition sequences |
| CN102177235A (zh) | 2008-09-08 | 2011-09-07 | 赛莱克蒂斯公司 | 切割来自谷氨酰胺合成酶基因的dna靶序列的大范围核酸酶变体及其用途 |
-
2008
- 2008-01-31 WO PCT/IB2008/001331 patent/WO2009095742A1/en not_active Ceased
-
2009
- 2009-02-02 AU AU2009208732A patent/AU2009208732A1/en not_active Abandoned
- 2009-02-02 EP EP09705925A patent/EP2245147A1/en not_active Withdrawn
- 2009-02-02 JP JP2010544817A patent/JP2011514144A/ja active Pending
- 2009-02-02 US US12/864,998 patent/US8927247B2/en not_active Expired - Fee Related
- 2009-02-02 CN CN200980109080.1A patent/CN101970649B/zh not_active Expired - Fee Related
- 2009-02-02 CA CA2729124A patent/CA2729124A1/en not_active Abandoned
- 2009-02-02 WO PCT/IB2009/000439 patent/WO2009095793A1/en not_active Ceased
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