CN101970649B - 新的衍生自I-CreI的单链大范围核酸酶及其用途 - Google Patents

新的衍生自I-CreI的单链大范围核酸酶及其用途 Download PDF

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CN101970649B
CN101970649B CN200980109080.1A CN200980109080A CN101970649B CN 101970649 B CN101970649 B CN 101970649B CN 200980109080 A CN200980109080 A CN 200980109080A CN 101970649 B CN101970649 B CN 101970649B
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crei
sequence
meganuclease
target
strand
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CN101970649A (zh
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西尔韦斯特·格里佐
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Cellectis SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Virology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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CN200980109080.1A 2008-01-31 2009-02-02 新的衍生自I-CreI的单链大范围核酸酶及其用途 Expired - Fee Related CN101970649B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/IB2008/001331 WO2009095742A1 (en) 2008-01-31 2008-01-31 New i-crei derived single-chain meganuclease and uses thereof
WOPCT/IB2008/001331 2008-01-31
PCT/IB2009/000439 WO2009095793A1 (en) 2008-01-31 2009-02-02 New i-crei derived single-chain meganuclease and uses thereof

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CN101970649A CN101970649A (zh) 2011-02-09
CN101970649B true CN101970649B (zh) 2014-02-12

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US (1) US8927247B2 (https=)
EP (1) EP2245147A1 (https=)
JP (1) JP2011514144A (https=)
CN (1) CN101970649B (https=)
AU (1) AU2009208732A1 (https=)
CA (1) CA2729124A1 (https=)
WO (2) WO2009095742A1 (https=)

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CN101970649A (zh) 2011-02-09
CA2729124A1 (en) 2009-08-06
US8927247B2 (en) 2015-01-06
WO2009095793A1 (en) 2009-08-06
EP2245147A1 (en) 2010-11-03
WO2009095742A1 (en) 2009-08-06
JP2011514144A (ja) 2011-05-06
AU2009208732A1 (en) 2009-08-06
US20110179506A1 (en) 2011-07-21

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