JP2011513476A5 - - Google Patents
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- JP2011513476A5 JP2011513476A5 JP2010550262A JP2010550262A JP2011513476A5 JP 2011513476 A5 JP2011513476 A5 JP 2011513476A5 JP 2010550262 A JP2010550262 A JP 2010550262A JP 2010550262 A JP2010550262 A JP 2010550262A JP 2011513476 A5 JP2011513476 A5 JP 2011513476A5
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- Japan
- Prior art keywords
- disease
- independently
- nhr
- ring atoms
- dementia
- Prior art date
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- 125000006413 ring segment Chemical group 0.000 claims 20
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 7
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
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- VODWXIYHKVUFBI-UHFFFAOYSA-N [5-[2-[4-(1-hydroxyethyl)anilino]pyrimidin-4-yl]thiophen-3-yl]-piperidin-1-ylmethanone Chemical compound C1=CC(C(O)C)=CC=C1NC1=NC=CC(C=2SC=C(C=2)C(=O)N2CCCCC2)=N1 VODWXIYHKVUFBI-UHFFFAOYSA-N 0.000 claims 2
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| US7803806B2 (en) * | 2005-11-03 | 2010-09-28 | Sgx Pharmaceuticals, Inc. | Pyrimidinyl-thiophene kinase modulators |
| BRPI0710479A2 (pt) | 2006-01-18 | 2012-08-14 | Hoffmann La Roche | composto, processo para sua preparaÇço, composiÇço farmacÊutica, uso de um composto e mÉtodo de tratamento de doenÇa ou desosrdem metabàlica. |
| ES2362949T3 (es) | 2006-06-08 | 2011-07-15 | Eli Lilly And Company | Carboxamidas substituidas como antagonistas del receptor metabotrópico de grupo i. |
| AU2007275301A1 (en) | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1 |
| GB0724251D0 (en) | 2007-12-12 | 2008-02-06 | Univ Edinburgh | Therapeutic compounds and their use |
| US20100022590A1 (en) | 2008-01-17 | 2010-01-28 | Biovitrum Ab (Publ.) | Novel compounds |
| GB0804685D0 (en) | 2008-03-13 | 2008-04-16 | Univ Edinburgh | Therapeutic compounds and their use |
| CA2735204C (en) | 2008-08-25 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| WO2010146338A1 (en) | 2009-06-15 | 2010-12-23 | The University Of Edinburgh | Amido-isothiazole compounds and their use as inhibitors of 11beta-hsd1 for the treatment of metabolic syndrome and related disorders |
| US8642621B2 (en) | 2009-09-16 | 2014-02-04 | The University Of Edinburgh | (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and their use |
| AU2011247116B2 (en) | 2010-04-29 | 2015-12-03 | The University Of Edinburgh | 3, 3 -disubstituted- ( 8 - aza - bicyclo [3.2.1] oct- 8 - yl) -[5- (1H - pyrazol - 4 -yl) -thiophen-3 -yl] methanones as inhibitors of 11 (beta) -HSD1 |
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2008
- 2008-03-13 GB GBGB0804685.6A patent/GB0804685D0/en not_active Ceased
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2009
- 2009-03-13 US US12/920,774 patent/US8299063B2/en active Active
- 2009-03-13 CA CA2716679A patent/CA2716679C/en active Active
- 2009-03-13 KR KR1020107022050A patent/KR101626627B1/ko active Active
- 2009-03-13 WO PCT/GB2009/000686 patent/WO2009112845A1/en not_active Ceased
- 2009-03-13 EP EP09718896.5A patent/EP2283004B1/en active Active
- 2009-03-13 AU AU2009224017A patent/AU2009224017B2/en active Active
- 2009-03-13 ES ES09718896.5T patent/ES2545489T3/es active Active
- 2009-03-13 DK DK09718896.5T patent/DK2283004T3/en active
- 2009-03-13 JP JP2010550262A patent/JP5570435B2/ja active Active
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