JP2011511845A - アルファ７（α７）ニコチン作動薬と抗精神病薬との組合せ物 - Google Patents
アルファ７（α７）ニコチン作動薬と抗精神病薬との組合せ物 Download PDFInfo
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- JP2011511845A JP2011511845A JP2010546920A JP2010546920A JP2011511845A JP 2011511845 A JP2011511845 A JP 2011511845A JP 2010546920 A JP2010546920 A JP 2010546920A JP 2010546920 A JP2010546920 A JP 2010546920A JP 2011511845 A JP2011511845 A JP 2011511845A
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- pyridinyl
- methyl
- azabicyclo
- oct
- carboxamide
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- 239000000181 nicotinic agonist Substances 0.000 title claims abstract description 63
- 230000000561 anti-psychotic effect Effects 0.000 title claims abstract description 43
- 239000011885 synergistic combination Substances 0.000 claims abstract description 3
- -1 2-((3-pyridinyl) methyl) -1-azabicyclo [2.2.2] oct-3-yl Chemical group 0.000 claims description 133
- 201000000980 schizophrenia Diseases 0.000 claims description 114
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- 239000003814 drug Substances 0.000 claims description 64
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- 238000011282 treatment Methods 0.000 claims description 51
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 42
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- 208000028017 Psychotic disease Diseases 0.000 claims description 36
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- NTJOBXMMWNYJFB-UHFFFAOYSA-N amisulpride Chemical compound CCN1CCCC1CNC(=O)C1=CC(S(=O)(=O)CC)=C(N)C=C1OC NTJOBXMMWNYJFB-UHFFFAOYSA-N 0.000 claims description 6
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- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 6
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- HDOZVRUNCMBHFH-UHFFFAOYSA-N zotepine Chemical compound CN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12 HDOZVRUNCMBHFH-UHFFFAOYSA-N 0.000 claims description 6
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 5
- 125000005842 heteroatom Chemical group 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 5
- RGCVKNLCSQQDEP-UHFFFAOYSA-N Perphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 RGCVKNLCSQQDEP-UHFFFAOYSA-N 0.000 claims description 4
- 208000019568 Shared Paranoid disease Diseases 0.000 claims description 4
- 208000028810 Shared psychotic disease Diseases 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 125000006269 biphenyl-2-yl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(*)C([H])=C([H])C([H])=C1[H] 0.000 claims description 4
- 125000006268 biphenyl-3-yl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(*)=C([H])C([H])=C1[H] 0.000 claims description 4
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 claims description 4
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- 125000003342 alkenyl group Chemical group 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 3
- OXKRFEWMSWPKKV-UHFFFAOYSA-N n-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Chemical compound C=1C2=CC=CC=C2OC=1C(=O)NC1C(CC2)CCN2C1CC1=CC=CN=C1 OXKRFEWMSWPKKV-UHFFFAOYSA-N 0.000 claims description 3
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- STUXELCGSPOOKH-UHFFFAOYSA-N 1-(1-benzothiophen-3-yl)-3-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]urea Chemical compound C=1SC2=CC=CC=C2C=1NC(=O)NC1C(CC2)CCN2C1CC1=CC=CN=C1 STUXELCGSPOOKH-UHFFFAOYSA-N 0.000 claims description 2
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- PLBRJYVRNDEBQU-UHFFFAOYSA-N 1-[4-(dimethylamino)phenyl]-3-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]urea Chemical compound C1=CC(N(C)C)=CC=C1NC(=O)NC1C(CC=2C=NC=CC=2)N2CCC1CC2 PLBRJYVRNDEBQU-UHFFFAOYSA-N 0.000 claims description 2
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- JBLCIQZBAQAMME-UHFFFAOYSA-N 1-naphthalen-1-yl-3-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]urea Chemical compound C=1C=CC2=CC=CC=C2C=1NC(=O)NC1C(CC2)CCN2C1CC1=CC=CN=C1 JBLCIQZBAQAMME-UHFFFAOYSA-N 0.000 claims description 2
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- QUUZVLSBZNXIKV-UHFFFAOYSA-N 4-phenoxy-n-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Chemical compound C=1C=C(OC=2C=CC=CC=2)C=CC=1C(=O)NC1C(CC2)CCN2C1CC1=CC=CN=C1 QUUZVLSBZNXIKV-UHFFFAOYSA-N 0.000 claims description 2
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| JP2017195862A (ja) * | 2016-04-29 | 2017-11-02 | 国立大学法人秋田大学 | クロザピン又はその誘導体の血中薬剤濃度上昇リスク判定方法及び薬剤投与量判定方法 |
| JP2024502470A (ja) * | 2021-01-08 | 2024-01-19 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
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| EP2619205B1 (en) | 2010-09-23 | 2017-05-17 | AbbVie Bahamas Ltd. | Monohydrate of an azaadamantane derivative |
| EP2665478A1 (en) * | 2011-01-18 | 2013-11-27 | Targacept, Inc. | Treatment of cognitive dysfunction in schizophrenia |
| US9139576B2 (en) | 2011-05-03 | 2015-09-22 | Merck Sharp & Dohme Corp. | Aminomethyl biaryl benzotriazole derivatives |
| MX2015004285A (es) * | 2012-10-02 | 2015-08-06 | Sumitomo Dainippon Pharma Co Ltd | Derivado de imidazol. |
| CN110087641B (zh) | 2016-12-20 | 2024-03-12 | 罗曼治疗系统股份公司 | 含有阿塞那平和聚硅氧烷或聚异丁烯的透皮治疗系统 |
| PL3338768T3 (pl) | 2016-12-20 | 2020-05-18 | Lts Lohmann Therapie-Systeme Ag | Transdermalny system terapeutyczny zawierający asenapinę |
| CN108727416B (zh) * | 2017-04-20 | 2021-03-09 | 北京大学 | 三环杂芳香体系酰胺衍生物及其制备和用途 |
| JP2020525545A (ja) | 2017-06-26 | 2020-08-27 | エルテーエス ローマン テラピー−ジステーメ アーゲー | アセナピンおよびシリコーンアクリルハイブリッドポリマーを含有する経皮治療システム |
| CN107469087A (zh) * | 2017-09-10 | 2017-12-15 | 孙永丽 | 用于治疗精神病的制剂 |
| CN118806732A (zh) | 2018-06-20 | 2024-10-22 | 罗曼治疗系统股份公司 | 含有阿塞那平的透皮治疗系统 |
| BR112020026099A2 (pt) | 2018-06-20 | 2021-03-23 | Lts Lohmann Therapie-Systeme Ag | sistema terapêutico transdérmico que contém asenapina |
| JP2024502474A (ja) | 2021-01-08 | 2024-01-19 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための、尿素を有するヘテロ二環式化合物または類似体およびその組成物 |
| DE102022114269A1 (de) | 2022-06-07 | 2023-12-07 | Rational Aktiengesellschaft | Gargerät mit einem Selbstreinigungssystem sowie ein Verfahren zum Ändern von Reinigungsparametern für das Gargerät |
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| JP2024502470A (ja) * | 2021-01-08 | 2024-01-19 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
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| WO2009102962A2 (en) | 2009-08-20 |
| CN101977628A (zh) | 2011-02-16 |
| PL2254598T3 (pl) | 2013-12-31 |
| EP2254598B1 (en) | 2013-07-10 |
| IL207389A0 (en) | 2010-12-30 |
| PT2254598E (pt) | 2013-10-16 |
| SG188144A1 (en) | 2013-03-28 |
| CO6290706A2 (es) | 2011-06-20 |
| ES2430622T3 (es) | 2013-11-21 |
| RS52941B (sr) | 2014-02-28 |
| WO2009102962A3 (en) | 2009-10-08 |
| HRP20130749T1 (en) | 2013-10-11 |
| AU2009214625A1 (en) | 2009-08-20 |
| SI2254598T1 (sl) | 2013-10-30 |
| RU2010137787A (ru) | 2012-03-20 |
| EP2254598A2 (en) | 2010-12-01 |
| ZA201005999B (en) | 2011-05-25 |
| NZ587312A (en) | 2011-12-22 |
| KR20100113163A (ko) | 2010-10-20 |
| ECSP10010471A (es) | 2010-10-30 |
| MX2010008875A (es) | 2010-08-31 |
| DK2254598T3 (da) | 2013-07-29 |
| CA2715268A1 (en) | 2009-08-20 |
| BRPI0907570A2 (pt) | 2019-09-24 |
| CN103143023A (zh) | 2013-06-12 |
| HK1147954A1 (en) | 2011-08-26 |
| RU2481123C2 (ru) | 2013-05-10 |
| US20110059947A1 (en) | 2011-03-10 |
| EP2633868A1 (en) | 2013-09-04 |
| CY1114492T1 (el) | 2016-10-05 |
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