JP2011511076A - 治療用ペプチド模倣大環状分子 - Google Patents
治療用ペプチド模倣大環状分子 Download PDFInfo
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- JP2011511076A JP2011511076A JP2010545895A JP2010545895A JP2011511076A JP 2011511076 A JP2011511076 A JP 2011511076A JP 2010545895 A JP2010545895 A JP 2010545895A JP 2010545895 A JP2010545895 A JP 2010545895A JP 2011511076 A JP2011511076 A JP 2011511076A
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- peptidomimetic macrocycle
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- 229960000241 vandetanib Drugs 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07K7/64—Cyclic peptides containing only normal peptide links
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- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1761—Apoptosis related proteins, e.g. Apoptotic protease-activating factor-1 (APAF-1), Bax, Bax-inhibitory protein(s)(BI; bax-I), Myeloid cell leukemia associated protein (MCL-1), Inhibitor of apoptosis [IAP] or Bcl-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Oncology (AREA)
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- Marine Sciences & Fisheries (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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| PCT/US2009/000837 WO2009099677A2 (en) | 2008-02-08 | 2009-02-09 | Therapeutic peptidomimetic macrocycles |
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| JP2014244169A Division JP2015078208A (ja) | 2008-02-08 | 2014-12-02 | 治療用ペプチド模倣大環状分子 |
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| EP (2) | EP2242503A4 (enExample) |
| JP (2) | JP2011511076A (enExample) |
| KR (1) | KR20100126361A (enExample) |
| CN (2) | CN101980718A (enExample) |
| BR (1) | BRPI0907754A2 (enExample) |
| CA (1) | CA2714251C (enExample) |
| DE (1) | DE112009000300T5 (enExample) |
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| IL (2) | IL207421A0 (enExample) |
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| ZA (1) | ZA201005741B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015526410A (ja) * | 2012-06-26 | 2015-09-10 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| JP2017513826A (ja) * | 2014-04-02 | 2017-06-01 | ユニバーシティー オブ ロチェスター | アルファヘリックスを模倣した大環状ペプチドミメティック |
| JP2018511594A (ja) * | 2015-03-18 | 2018-04-26 | マサチューセッツ インスティテュート オブ テクノロジー | 選択的ｍｃｌ−１結合ペプチド |
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| BRPI0918838A2 (pt) * | 2008-09-22 | 2015-12-08 | Aileron Therapeutics Inc | processos para preparação de composições de polipeptídeos purificados |
| AU2009294877C1 (en) * | 2008-09-22 | 2015-05-07 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
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| WO2012051405A1 (en) | 2010-10-13 | 2012-04-19 | Bristol-Myers Squibb Company | Methods for preparing macrocycles and macrocycle stabilized peptides |
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- 2009-02-09 CN CN201410541607.0A patent/CN104474529A/zh active Pending
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2010
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2012
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015526410A (ja) * | 2012-06-26 | 2015-09-10 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| JP2018087205A (ja) * | 2012-06-26 | 2018-06-07 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| JP2017513826A (ja) * | 2014-04-02 | 2017-06-01 | ユニバーシティー オブ ロチェスター | アルファヘリックスを模倣した大環状ペプチドミメティック |
| JP2018511594A (ja) * | 2015-03-18 | 2018-04-26 | マサチューセッツ インスティテュート オブ テクノロジー | 選択的ｍｃｌ−１結合ペプチド |
Also Published As
| Publication number | Publication date |
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| EP2242503A4 (en) | 2012-04-25 |
| CN101980718A (zh) | 2011-02-23 |
| US8808694B2 (en) | 2014-08-19 |
| JP2015078208A (ja) | 2015-04-23 |
| EP2926827A3 (en) | 2015-11-04 |
| US20150038430A1 (en) | 2015-02-05 |
| US20120149648A1 (en) | 2012-06-14 |
| ZA201005741B (en) | 2018-11-28 |
| IL243240A (en) | 2016-11-30 |
| WO2009099677A3 (en) | 2009-12-17 |
| AU2009210682A1 (en) | 2009-08-13 |
| DE112009000300T5 (de) | 2011-01-20 |
| CA2714251A1 (en) | 2009-08-13 |
| BRPI0907754A2 (pt) | 2015-07-21 |
| GB2471588A (en) | 2011-01-05 |
| US20090275519A1 (en) | 2009-11-05 |
| GB201014734D0 (en) | 2010-10-20 |
| KR20100126361A (ko) | 2010-12-01 |
| EP2926827A2 (en) | 2015-10-07 |
| CN104474529A (zh) | 2015-04-01 |
| IL207421A0 (en) | 2010-12-30 |
| WO2009099677A2 (en) | 2009-08-13 |
| CA2714251C (en) | 2017-08-15 |
| US20190071469A1 (en) | 2019-03-07 |
| EP2242503A2 (en) | 2010-10-27 |
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