KR20100126361A - 치료용 펩티드유사 거대고리 - Google Patents

치료용 펩티드유사 거대고리 Download PDF

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Publication number
KR20100126361A
KR20100126361A KR1020107020028A KR20107020028A KR20100126361A KR 20100126361 A KR20100126361 A KR 20100126361A KR 1020107020028 A KR1020107020028 A KR 1020107020028A KR 20107020028 A KR20107020028 A KR 20107020028A KR 20100126361 A KR20100126361 A KR 20100126361A
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South Korea
Prior art keywords
peptide
amino acid
cancer
macrocycle
polypeptide
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KR1020107020028A
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English (en)
Korean (ko)
Inventor
휴 엠 네쉬
데이빗 앨렌 애니스
로사나 카펠러-리베르만
토미 케이 소이어
노리유키 가와하타
지아웬 한
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에일러론 테라퓨틱스 인코포레이티드
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Publication of KR20100126361A publication Critical patent/KR20100126361A/ko
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1761Apoptosis related proteins, e.g. Apoptotic protease-activating factor-1 (APAF-1), Bax, Bax-inhibitory protein(s)(BI; bax-I), Myeloid cell leukemia associated protein (MCL-1), Inhibitor of apoptosis [IAP] or Bcl-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020107020028A 2008-02-08 2009-02-09 치료용 펩티드유사 거대고리 Ceased KR20100126361A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2732608P 2008-02-08 2008-02-08
US61/027,326 2008-02-08
US12038008P 2008-12-05 2008-12-05
US61/120,380 2008-12-05

Publications (1)

Publication Number Publication Date
KR20100126361A true KR20100126361A (ko) 2010-12-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107020028A Ceased KR20100126361A (ko) 2008-02-08 2009-02-09 치료용 펩티드유사 거대고리

Country Status (12)

Country Link
US (4) US20090275519A1 (enExample)
EP (2) EP2242503A4 (enExample)
JP (2) JP2011511076A (enExample)
KR (1) KR20100126361A (enExample)
CN (2) CN104474529A (enExample)
BR (1) BRPI0907754A2 (enExample)
CA (1) CA2714251C (enExample)
DE (1) DE112009000300T5 (enExample)
GB (1) GB2471588A (enExample)
IL (2) IL207421A0 (enExample)
WO (1) WO2009099677A2 (enExample)
ZA (1) ZA201005741B (enExample)

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Publication number Publication date
CN101980718A (zh) 2011-02-23
EP2926827A2 (en) 2015-10-07
IL243240A (en) 2016-11-30
GB2471588A (en) 2011-01-05
JP2011511076A (ja) 2011-04-07
DE112009000300T5 (de) 2011-01-20
US8808694B2 (en) 2014-08-19
CN104474529A (zh) 2015-04-01
EP2242503A2 (en) 2010-10-27
CA2714251A1 (en) 2009-08-13
EP2926827A3 (en) 2015-11-04
US20190071469A1 (en) 2019-03-07
CA2714251C (en) 2017-08-15
BRPI0907754A2 (pt) 2015-07-21
IL207421A0 (en) 2010-12-30
US20120149648A1 (en) 2012-06-14
WO2009099677A2 (en) 2009-08-13
JP2015078208A (ja) 2015-04-23
GB201014734D0 (en) 2010-10-20
ZA201005741B (en) 2018-11-28
US20090275519A1 (en) 2009-11-05
WO2009099677A3 (en) 2009-12-17
US20150038430A1 (en) 2015-02-05
AU2009210682A1 (en) 2009-08-13
EP2242503A4 (en) 2012-04-25

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