JP2011509700A - 生体分子でコーティングされた減圧式ドレッシング材の改良 - Google Patents
生体分子でコーティングされた減圧式ドレッシング材の改良 Download PDFInfo
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Abstract
【選択図】 図1
Description
Claims (24)
- 生体分子でコーティングされる減圧式ドレッシング材であって、
高分子材料層と、
止血剤と、抗酸化剤と、一酸化窒素のプロモータとからなる群から選択される少なくとも1の生体分子と、
を含み、当該少なくとも1の生体分子が前記高分子材料層の一部に吸収されることを特徴とする、生体分子でコーティングされる減圧式ドレッシング材。 - 請求項1に記載の生体分子でコーティングされる減圧式ドレッシング材が、止血剤と、抗酸化剤と、一酸化窒素のプロモータとからなる群から選択される更なる生体分子層を更に具え、前記少なくとも1の生体分子は前記高分子材料層の外面に適用されることを特徴とする、生体分子でコーティングされる減圧式ドレッシング材。
- 請求項2に記載の生体分子でコーティングされる減圧式ドレッシング材が、前記高分子層と前記更なる生体分子層との間に実質的に散在する不活性層を更に具えることを特徴とする、生体分子でコーティングされる減圧式ドレッシング材。
- 請求項1に記載の生体分子でコーティングされる減圧式ドレッシング材において、前記高分子材料層がポリ乳酸(PLA)(L−ラクチド及びDL−ラクチドの双方)と、ポリ(L−ラクチド−DL−ラクチド)の共重合体と、ポリグリコール酸(PGA)と、アルファエステルと、飽和エステルと、不飽和エステルと、オルトエステルと、カーボネートと、無水物と、エーテルと、アミドと、サッカライドと、ポリエステルと、ポリカーボネートと、ポリカプロラクトン(PCL)と、ポリトリメチレンカーボネート(PTMC)と、ポリジオキサノン(PDO)と、ポリヒドロキシブチレートと、ポリヒドロキシバレレートと、ポリジオキサノンと、ポリオルトエステルと、ポリフォスファーゼンと、ポリウレタンと、コラーゲンと、ヒアルロン酸と、キトサンと、ヒドロキシアパタイト、コラリンアパタイト、リン酸カルシウム、硫酸カルシウム、硫酸カルシウム、炭酸カルシウム、カーボネート、バイオガラス、同種移植片、及び自家移植片のうちの少なくとも1又はそれ以上を取り込む高分子と、これらの化合物の混合物及び/又は共重合体とからなる群から選択される生体反復吸収性材料であることを特徴とする、生体分子でコーティングされる減圧式ドレッシング材。
- 請求項1に記載の生体分子でコーティングされる減圧式ドレッシング材において、前記第1の材料層及び前記第2の材料層が約1mmないし約100mmの厚さを有することを特徴とする、生体分子でコーティングされる減圧式ドレッシング材。
- 請求項1に記載の生体分子でコーティングされる減圧式ドレッシング材において、前記高分子層が約250ミクロンないし約600ミクロンの孔径を有することを特徴とする、生体分子でコーティングされる減圧式ドレッシング材。
- 請求項1に記載の生体分子でコーティングされる減圧式ドレッシング材において、前記止血剤がポリN−アセチルグルコサミン、トロンビン、フィブリノーゲン、あるいは、非酸性、水溶性、又は水膨潤性の高分子の水溶液中に構成されるフィブリンからなる群から選択され、限定しないがメチルセルロースと、ヒドロキシアルキルセルロースと、ケラチン硫酸と、水溶性キトサンと、N−アセチルラクトサミン合成酵素と、カルボシキメチルカルボシキエチルセルロースの塩と、キチンと、ヒアルロン酸の塩と、アルギナートと、アルギン酸プロピレングリコールと、グリコーゲンと、デキストランと、カラゲナンと、キトサンと、デンプンと、アミロースと、アルデヒド酸化されたその誘導体とを含むことを特徴とする、生体分子でコーティングされる減圧式ドレッシング材。
- 請求項1に記載の生体分子でコーティングされる減圧式ドレッシング材において、前記抗酸化剤がグルタチオンと、リポ酸と、ビタミンEと、アスコルビン酸と、トロロクスと、トコフェロールと、トコトリエノールとからなる群から選択されることを特徴とする、生体分子でコーティングされる減圧式ドレッシング材。
- 請求項1に記載の生体分子でコーティングされる減圧式ドレッシング材において、前記一酸化窒素のプロモータが一酸化窒素と、一酸化窒素ドナー化合物と、一酸化窒素前駆体化合物と、一酸化窒素化合物の上方制御因子と、L−アルギニンと、一酸化窒素合成酵素と、ニトロプルシドとからなる群から選択されることを特徴とする、生体分子でコーティングされる減圧式ドレッシング材。
- 減圧治療を組織部位に適用するための減圧治療システムであって、
高分子材料層と、
止血剤と、抗酸化剤と、一酸化窒素のプロモータとからなる群から選択され、前記高分子材料層の一部に吸収される少なくとも1の生体分子と、
前記組織部位と連結して前記高分子層の上方に実質的に配置されるマニホルド層と、
減圧を前記組織部位に送達すべく、前記マニホルド層に流体連結される減圧送達管と、
を具えることを特徴とする減圧治療システム。 - 請求項10に記載の減圧送達システムが前記第1の材料層と前記第2の材料層とのうちの1つと隣接して配置される、前記生体反復吸収性ミクロスフェア層と、前記生体反復吸収性ファイバ層とのうちの1つから選択される更なる材料層を更に具えることを特徴とする減圧送達システム。
- 請求項10に記載の減圧送達システムにおいて、前記高分子材料層がポリウレタンと、セルロースと、カルボシキル化されたブタジエン−スチレンゴムと、発泡ポリエステル樹脂と、親水性の発泡エポキシ樹脂と、ポリアクリラートと、GranuFoam(登録商標)と、WhiteFoam(商標)とからなる群から選択されることを特徴とする減圧送達システム。
- 請求項10に記載の減圧送達システムにおいて、前記高分子材料層がポリ乳酸(PLA)(L−ラクチド及びDL−ラクチドの双方)と、ポリ(L−ラクチド−DL−ラクチド)の共重合体と、ポリグリコール酸(PGA)と、アルファエステルと、飽和エステルと、不飽和エステルと、オルトエステルと、カーボネートと、無水物と、エーテルと、アミドと、サッカライドと、ポリエステルと、ポリカーボネートと、ポリカプロラクトン(PCL)と、ポリトリメチレンカーボネート(PTMC)と、ポリジオキサノン(PDO)と、ポリヒドロキシブチレートと、ポリヒドロキシバレレートと、ポリジオキサノンと、ポリオルトエステルと、ポリフォスファーゼンと、ポリウレタンと、コラーゲンと、ヒアルロン酸と、キトサンと、ヒドロキシアパタイト、コラリンアパタイト、リン酸カルシウム、硫酸カルシウム、硫酸カルシウム、炭酸カルシウム、カーボネート、バイオガラス、同種移植片、及び自家移植片のうちの少なくとも1又はそれ以上を取り込む高分子と、これらの化合物の混合物及び/又は共重合体とから生成されうる生体反復吸収性材料からなる群から選択されることを特徴とする減圧送達システム。
- 請求項10に記載の減圧送達システムにおいて、前記高分子材料層が前記少なくとも1の生体分子を共有結合に供するように化学修飾されることを特徴とする減圧送達システム。
- 請求項10に記載の減圧送達システムにおいて、前記高分子材料層が前記少なくとも1の生体分子をイオン結合に供するように化学修飾されることを特徴とする減圧送達システム。
- 請求項10に記載の減圧送達システムが、少なくとも2の生体分子を更に含み、第1の前記少なくとも2の生体分子が前記高分子層の第1の部分に吸収され、第2の前記少なくとも2の生体分子が前記高分子層の第2の部分に吸収されることを特徴とする減圧送達システム。
- 請求項10に記載の減圧送達システムにおいて、前記止血剤がポリN−アセチルグルコサミン、トロンビン、フィブリノーゲン、あるいは、非酸性、水溶性、又は水膨潤性の高分子の水溶液中に構成されるフィブリンからなる群から選択され、限定しないがメチルセルロースと、ヒドロキシアルキルセルロースと、ケラチン硫酸と、水溶性キトサンと、N−アセチルラクトサミン合成酵素と、カルボシキメチルカルボシキエチルセルロースの塩と、キチンと、ヒアルロン酸の塩と、アルギナートと、アルギン酸プロピレングリコールと、グリコーゲンと、デキストランと、カラゲナンと、キトサンと、デンプンと、アミロースと、アルデヒド酸化されたその誘導体とを含むことを特徴とする減圧送達システム。
- 請求項10に記載の減圧送達システムにおいて、前記抗酸化剤がグルタチオンと、リポ酸と、ビタミンEと、アスコルビン酸と、トロロクスと、トコフェロールと、トコトリエノールとからなる群から選択されることを特徴とする減圧送達システム。
- 請求項10に記載の減圧送達システムにおいて、前記一酸化窒素のプロモータが一酸化窒素と、一酸化窒素ドナー化合物と、一酸化窒素前駆体化合物と、一酸化窒素化合物の上方制御因子と、L−アルギニンと、一酸化窒素合成酵素と、ニトロプルシドとからなる群から選択されることを特徴とする減圧送達システム。
- 生体分子でコーティングされる減圧式ドレッシング材を生成する方法であって、
止血剤と、抗酸化剤と、一酸化窒素のプロモータとからなる群から選択される少なくとも1の生体分子を調製するステップと、
高分子材料層を調製するステップと、
前記少なくとも1の生体分子を前記高分子材料層の第1の部分に吸収するステップと、
前記生体分子でコーティングされる減圧式ドレッシング材を完成するステップと、
を具えることを特徴とする、生体分子でコーティングされる減圧式ドレッシング材を生成する方法。 - 請求項20に記載の生体分子でコーティングされる減圧式ドレッシング材を生成する方法が、過剰な前記少なくとも1の生体分子を前記高分子層から除去するステップを更に具えることを特徴とする、生体分子でコーティングされる減圧式ドレッシング材を生成する方法。
- 請求項20に記載の生体分子でコーティングされる減圧式ドレッシング材を生成する方法が、前記高分子層に吸収される前記少なくとも1の生体分子を乾燥させるステップを更に具えることを特徴とする、生体分子でコーティングされる減圧式ドレッシング材を生成する方法。
- 請求項20に記載の生体分子でコーティングされる減圧式ドレッシング材を生成する方法が、別の前記少なくとも1の生体分子を前記高分子材料層の第2の部分に吸収するステップを更に具えることを特徴とする、生体分子でコーティングされる減圧式ドレッシング材を生成する方法。
- 請求項20に記載の生体分子でコーティングされる減圧式ドレッシング材を生成する方法において、前記生体分子でコーティングされる減圧式ドレッシング材を完成するステップが、整形、調整、切削、形成、滅菌、及びパッケージングのうちの少なくとも1つによって、前記生体分子でコーティングされる減圧式ドレッシング材を処理するステップを具えることを特徴とする、生体分子でコーティングされる減圧式ドレッシング材を生成する方法。
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2008
- 2008-01-04 US US12/006,721 patent/US20090177133A1/en not_active Abandoned
- 2008-12-31 EP EP08869720A patent/EP2224966A4/en not_active Withdrawn
- 2008-12-31 JP JP2010541538A patent/JP5483365B2/ja not_active Expired - Fee Related
- 2008-12-31 CA CA2710864A patent/CA2710864A1/en not_active Abandoned
- 2008-12-31 WO PCT/US2008/088636 patent/WO2009088926A1/en active Application Filing
- 2008-12-31 TW TW097151871A patent/TW200938235A/zh unknown
- 2008-12-31 AU AU2008347285A patent/AU2008347285B2/en not_active Ceased
-
2010
- 2010-07-16 ZA ZA2010/05063A patent/ZA201005063B/en unknown
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2013
- 2013-10-18 JP JP2013217422A patent/JP2014036882A/ja active Pending
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CN109550071A (zh) * | 2018-12-05 | 2019-04-02 | 中国科学院深圳先进技术研究院 | 聚氨酯海绵材料及其制备方法、应用和聚氨酯海绵制品 |
CN109550071B (zh) * | 2018-12-05 | 2021-08-24 | 中国科学院深圳先进技术研究院 | 聚氨酯海绵材料及其制备方法、应用和聚氨酯海绵制品 |
Also Published As
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WO2009088926A1 (en) | 2009-07-16 |
JP2014036882A (ja) | 2014-02-27 |
JP2015131128A (ja) | 2015-07-23 |
AU2008347285A1 (en) | 2009-07-16 |
EP2224966A1 (en) | 2010-09-08 |
US20090177133A1 (en) | 2009-07-09 |
AU2008347285B2 (en) | 2013-02-28 |
JP5483365B2 (ja) | 2014-05-07 |
ZA201005063B (en) | 2011-03-30 |
EP2224966A4 (en) | 2013-01-02 |
TW200938235A (en) | 2009-09-16 |
CA2710864A1 (en) | 2009-07-16 |
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