JP2011507903A5 - - Google Patents

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Publication number
JP2011507903A5
JP2011507903A5 JP2010539882A JP2010539882A JP2011507903A5 JP 2011507903 A5 JP2011507903 A5 JP 2011507903A5 JP 2010539882 A JP2010539882 A JP 2010539882A JP 2010539882 A JP2010539882 A JP 2010539882A JP 2011507903 A5 JP2011507903 A5 JP 2011507903A5
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JP
Japan
Prior art keywords
bmp
protein
amino acid
modified
wild
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Application number
JP2010539882A
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English (en)
Japanese (ja)
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JP5529754B2 (ja
JP2011507903A (ja
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Priority claimed from PCT/US2008/087720 external-priority patent/WO2009086131A1/en
Publication of JP2011507903A publication Critical patent/JP2011507903A/ja
Publication of JP2011507903A5 publication Critical patent/JP2011507903A5/ja
Application granted granted Critical
Publication of JP5529754B2 publication Critical patent/JP5529754B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010539882A 2007-12-21 2008-12-19 Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体 Expired - Fee Related JP5529754B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US875407P 2007-12-21 2007-12-21
US61/008,754 2007-12-21
PCT/US2008/087720 WO2009086131A1 (en) 2007-12-21 2008-12-19 Bmp mutants with decreased susceptibility to noggin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014056688A Division JP2014121334A (ja) 2007-12-21 2014-03-19 Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体

Publications (3)

Publication Number Publication Date
JP2011507903A JP2011507903A (ja) 2011-03-10
JP2011507903A5 true JP2011507903A5 (https=) 2013-01-17
JP5529754B2 JP5529754B2 (ja) 2014-06-25

Family

ID=40424155

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010539882A Expired - Fee Related JP5529754B2 (ja) 2007-12-21 2008-12-19 Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体
JP2014056688A Pending JP2014121334A (ja) 2007-12-21 2014-03-19 Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014056688A Pending JP2014121334A (ja) 2007-12-21 2014-03-19 Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体

Country Status (6)

Country Link
US (2) US20110039773A1 (https=)
EP (1) EP2222696A1 (https=)
JP (2) JP5529754B2 (https=)
AU (1) AU2008345689B2 (https=)
CA (1) CA2708549C (https=)
WO (1) WO2009086131A1 (https=)

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Publication number Priority date Publication date Assignee Title
EP1698691A1 (en) * 2005-03-04 2006-09-06 Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH Growth factor mutants with improved biological activity
JP5529754B2 (ja) * 2007-12-21 2014-06-25 ストライカー コーポレイション Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体
CN102369212B (zh) * 2009-03-12 2015-12-16 哈瑟投资公司 具有降低的bmp拮抗剂敏感性的骨形成蛋白2(bmp2)变体
WO2011087768A1 (en) * 2009-12-22 2011-07-21 Stryker Corporation Bmp-7 variants with reduced immunogenicity
US9856305B2 (en) 2010-08-20 2018-01-02 Wyeth Llc Designer osteogenic proteins
CN105198981B (zh) * 2010-08-20 2019-07-16 惠氏有限责任公司 经设计的成骨蛋白
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
AU2015202418B2 (en) * 2010-08-20 2017-02-02 Wyeth Llc Designer osteogenic proteins
US9359417B2 (en) 2013-01-25 2016-06-07 Warsaw Orthopedic, Inc. Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5)
US9169308B2 (en) 2013-01-25 2015-10-27 Warsaw Orthopedic, Inc. Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies
US8956829B2 (en) 2013-01-25 2015-02-17 Warsaw Orthopedic, Inc. Human recombinant growth and differentiaton factor-5 (rhGDF-5)
US9051389B2 (en) 2013-01-25 2015-06-09 Warsaw Orthopedic, Inc. Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5)
US8945872B2 (en) 2013-01-25 2015-02-03 Warsaw Orthopedic, Inc. Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein
EP2784083A1 (en) * 2013-03-28 2014-10-01 Charité - Universitätsmedizin Berlin Bone Morphogenetic Protein (BMP) variants with highly reduced antagonist sensitivity and enhanced specific biological activity
JP6666899B2 (ja) 2014-07-21 2020-03-18 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニヴァーシティー オブ アリゾナ Ａｎｇ−（１−７）誘導体オリゴペプチド、ならびにそれを使用および作製するための方法
US10183055B2 (en) 2014-07-21 2019-01-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications
CA2976376A1 (en) 2015-02-13 2016-08-18 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
US10508134B2 (en) 2015-05-01 2019-12-17 Onl Therapeutics, Inc. Peptide compositions and methods of use
IL308824A (en) 2016-08-17 2024-01-01 Factor Bioscience Inc Nucleic acid products and methods of administration thereof
JP7308151B2 (ja) * 2017-04-27 2023-07-13 イーライ リリー アンド カンパニー ヒトｂｍｐ７タンパク質のバリアント

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026713A1 (de) * 2000-05-30 2001-12-06 Walter Sebald Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
CA2561809A1 (en) * 2004-03-31 2005-10-20 Xencor, Inc. Bmp-7 variants with improved properties
AU2005250441A1 (en) * 2004-05-27 2005-12-15 Acceleron Pharma Inc. TGF derepressors and uses related thereto
WO2008051526A2 (en) * 2006-10-23 2008-05-02 Stryker Corporation Bone morphogenetic proteins
JP5529754B2 (ja) * 2007-12-21 2014-06-25 ストライカー コーポレイション Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体

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