JP2011506941A5 - - Google Patents
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- Publication number
- JP2011506941A5 JP2011506941A5 JP2010537302A JP2010537302A JP2011506941A5 JP 2011506941 A5 JP2011506941 A5 JP 2011506941A5 JP 2010537302 A JP2010537302 A JP 2010537302A JP 2010537302 A JP2010537302 A JP 2010537302A JP 2011506941 A5 JP2011506941 A5 JP 2011506941A5
- Authority
- JP
- Japan
- Prior art keywords
- seprase
- cancer
- esophagus
- colon
- stomach
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 15
- 108010072257 fibroblast activation protein alpha Proteins 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 13
- 229920001184 polypeptide Polymers 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 10
- 208000026900 bile duct neoplasm Diseases 0.000 claims 10
- 210000001072 colon Anatomy 0.000 claims 10
- 210000003238 esophagus Anatomy 0.000 claims 10
- 210000003128 head Anatomy 0.000 claims 10
- 210000004072 lung Anatomy 0.000 claims 10
- 210000003739 neck Anatomy 0.000 claims 10
- 230000000694 effects Effects 0.000 claims 6
- 108010036226 antigen CYFRA21.1 Proteins 0.000 claims 5
- 210000000013 bile duct Anatomy 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 5
- 208000014829 head and neck neoplasm Diseases 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 210000002784 stomach Anatomy 0.000 claims 5
- 201000000498 stomach carcinoma Diseases 0.000 claims 5
- 206010004593 Bile duct cancer Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 4
- 206010017758 gastric cancer Diseases 0.000 claims 4
- 208000026037 malignant tumor of neck Diseases 0.000 claims 4
- 201000011549 stomach cancer Diseases 0.000 claims 4
- 101000603202 Homo sapiens Nicotinamide N-methyltransferase Proteins 0.000 claims 3
- 102100038951 Nicotinamide N-methyltransferase Human genes 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- NJHLGKJQFKUSEA-UHFFFAOYSA-N n-[2-(4-hydroxyphenyl)ethyl]-n-methylnitrous amide Chemical compound O=NN(C)CCC1=CC=C(O)C=C1 NJHLGKJQFKUSEA-UHFFFAOYSA-N 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07023897.7 | 2007-12-10 | ||
| EP07023897A EP2071337A1 (en) | 2007-12-10 | 2007-12-10 | Seprase as a marker for cancer |
| EP08015310 | 2008-08-29 | ||
| EP08015310.9 | 2008-08-29 | ||
| PCT/EP2008/010385 WO2009074275A1 (en) | 2007-12-10 | 2008-12-08 | Seprase as a marker for cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506941A JP2011506941A (ja) | 2011-03-03 |
| JP2011506941A5 true JP2011506941A5 (https=) | 2011-10-06 |
| JP5563988B2 JP5563988B2 (ja) | 2014-07-30 |
Family
ID=40373548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010537302A Expired - Fee Related JP5563988B2 (ja) | 2007-12-10 | 2008-12-08 | 癌のマーカーとしてのセプラーゼ |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8980573B2 (https=) |
| EP (1) | EP2223115B1 (https=) |
| JP (1) | JP5563988B2 (https=) |
| KR (1) | KR101202220B1 (https=) |
| CN (1) | CN101896818B (https=) |
| AT (1) | ATE524740T1 (https=) |
| AU (1) | AU2008335855B2 (https=) |
| BR (1) | BRPI0820793A2 (https=) |
| CA (1) | CA2706115A1 (https=) |
| DK (1) | DK2223115T3 (https=) |
| ES (1) | ES2372442T3 (https=) |
| MX (1) | MX2010004671A (https=) |
| PL (1) | PL2223115T3 (https=) |
| WO (1) | WO2009074275A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8213005B2 (en) | 2003-07-22 | 2012-07-03 | King Saud University | Method for discriminating between benign and malignant prostate tumors |
| CA2728153C (en) * | 2008-07-03 | 2015-01-27 | F. Hoffmann-La Roche Ag | Asc as a marker for lung cancer |
| JP5763098B2 (ja) | 2009-12-20 | 2015-08-12 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| PT2666872T (pt) | 2010-02-05 | 2016-07-08 | Astute Medical Inc | Processos e composições para o diagnóstico e o prognóstico de lesões renais e de insuficiência renal |
| AU2011316986A1 (en) * | 2010-10-20 | 2013-06-06 | Rush University Medical Center | Lung cancer tests |
| EP2684051B1 (en) | 2011-03-11 | 2016-04-27 | Roche Diagniostics GmbH | Asc as marker for chronic obstructive pulmonary disease (copd) |
| JP2014509736A (ja) * | 2011-03-11 | 2014-04-21 | エフ．ホフマン−ラ ロシュ アーゲー | 慢性閉塞性肺疾患（ｃｏｐｄ）のマーカーとしてのセプラーゼ |
| CN102435748B (zh) * | 2011-11-25 | 2014-07-16 | 广东药学院 | 一种双抗夹心酶联免疫检测试剂盒及其制备方法 |
| ES2734494T3 (es) | 2011-12-08 | 2019-12-10 | Astute Medical Inc | Métodos y usos para el diagnóstico de una lesión renal y de una insuficiencia renal |
| CA2877721A1 (en) | 2012-06-27 | 2014-01-03 | Berg Llc | Use of markers in the diagnosis and treatment of prostate cancer |
| CA2891028C (en) | 2012-11-09 | 2017-02-07 | F. Hoffmann-La Roche Ag | In vitro capture and analysis of circulating tumor cells |
| SG11201504241QA (en) * | 2012-11-30 | 2015-06-29 | Applied Proteomics Inc | Method for evaluation of presence of or risk of colon tumors |
| TR201807542T4 (tr) | 2013-01-17 | 2018-06-21 | Astute Medical Inc | Böbrek hasarı ve böbrek yetmezliği teşhisi ve prognozuna yönelik metotlar ve bileşimler. |
| US9753037B2 (en) | 2013-03-15 | 2017-09-05 | Rush University Medical Center | Biomarker panel for detecting lung cancer |
| CN103267852B (zh) * | 2013-05-15 | 2015-03-25 | 中国医学科学院北京协和医院 | 成纤维激活蛋白α在制备胰腺癌预后试剂盒中的用途 |
| KR101619122B1 (ko) | 2013-08-14 | 2016-05-10 | 연세대학교 산학협력단 | 탈메틸화 의존적 ａｓｃ 발현을 촉진시켜서 대장암 종양세포의 사멸감수성을 증진시키는 항암제 병용 투여용 후보물질의 스크리닝 방법 |
| EP3080299B1 (en) | 2013-12-09 | 2020-09-30 | Rush University Medical Center | Biomarkers of rapid progression in advanced non-small cell lung cancer |
| PL230661B1 (pl) * | 2014-01-29 | 2018-11-30 | Centrum Onkologii Inst Im Marii Sklodowskiej Curie Oddzial W Gliwicach | Metoda predykcyjna in vitro do przewidywania i/lub wykluczenia obecnosci raka pluc, zastosowanie in vitro metody predykcyjnej oraz zestaw testowy do wykrywania in vitro raka pluc |
| EP2916134B1 (en) * | 2014-03-05 | 2017-08-16 | Roche Diagnostics GmbH | Use of Seprase for differential diagnosis of acute dyspnea |
| US10539566B2 (en) | 2014-12-08 | 2020-01-21 | Berg Llc | Use of markers including filamin A in the diagnosis and treatment of prostate cancer |
| WO2016146174A1 (en) * | 2015-03-17 | 2016-09-22 | Biontech Ag | Compositions and methods for diagnosis and treatment of cancer |
| WO2016164815A1 (en) | 2015-04-10 | 2016-10-13 | Applied Proteomics, Inc. | Protein biomarker panels for detecting colorectal cancer and advanced adenoma |
| JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ | 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用 |
| WO2018020530A1 (ja) * | 2016-07-25 | 2018-02-01 | 静岡県 | 肝外胆管癌、肝内胆管癌、又は胆嚢癌の診断用バイオマーカー |
| CN116474108A (zh) | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| DE102017010455A1 (de) * | 2017-06-13 | 2018-12-13 | Forschungszentrum Jülich GmbH | Verfahren zum Nachweis von Aggregaten biotherapeutischer Substanzen in einer Probe |
| CA3074684A1 (en) * | 2017-09-05 | 2019-03-14 | Oncotag Diagnostics Co., Ltd. | Method for diagnosing pancreatic cancer using methionyl-trna synthetase, and pancreatic cancer diagnostic kit using same |
| CN112540176B (zh) * | 2020-07-08 | 2021-09-28 | 深圳霁因生物医药转化研究院 | 用于诊断fap表达异常相关疾病的试剂盒、方法及计算机可读存储介质 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0953639A1 (en) * | 1998-04-30 | 1999-11-03 | Boehringer Ingelheim International GmbH | FAPalpha-specific antibody with improved producibility |
| CN1922304A (zh) | 2003-10-31 | 2007-02-28 | 维特克公司 | 用于检测循环肿瘤和内皮细胞的血液测试样机和方法 |
| CN101048426A (zh) * | 2004-10-22 | 2007-10-03 | 金克克国际有限公司 | 分离人抗体 |
| EP1760076A1 (en) * | 2005-09-02 | 2007-03-07 | Ferring B.V. | FAP Inhibitors |
| JP5270369B2 (ja) * | 2005-12-19 | 2013-08-21 | タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ | ソフトプロテアーゼ抑制剤およびそのプロソフト型 |
-
2008
- 2008-12-08 CN CN200880119930.1A patent/CN101896818B/zh active Active
- 2008-12-08 BR BRPI0820793-3A patent/BRPI0820793A2/pt not_active IP Right Cessation
- 2008-12-08 DK DK08859952.7T patent/DK2223115T3/da active
- 2008-12-08 CA CA2706115A patent/CA2706115A1/en not_active Abandoned
- 2008-12-08 WO PCT/EP2008/010385 patent/WO2009074275A1/en not_active Ceased
- 2008-12-08 ES ES08859952T patent/ES2372442T3/es active Active
- 2008-12-08 AT AT08859952T patent/ATE524740T1/de active
- 2008-12-08 PL PL08859952T patent/PL2223115T3/pl unknown
- 2008-12-08 EP EP08859952A patent/EP2223115B1/en active Active
- 2008-12-08 KR KR1020107012678A patent/KR101202220B1/ko not_active Expired - Fee Related
- 2008-12-08 MX MX2010004671A patent/MX2010004671A/es active IP Right Grant
- 2008-12-08 AU AU2008335855A patent/AU2008335855B2/en not_active Ceased
- 2008-12-08 JP JP2010537302A patent/JP5563988B2/ja not_active Expired - Fee Related
-
2010
- 2010-06-02 US US12/791,946 patent/US8980573B2/en active Active
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