JP2011506447A - 損傷した創傷治癒組成物および治療 - Google Patents

損傷した創傷治癒組成物および治療 Download PDF

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Publication number
JP2011506447A
JP2011506447A JP2010537971A JP2010537971A JP2011506447A JP 2011506447 A JP2011506447 A JP 2011506447A JP 2010537971 A JP2010537971 A JP 2010537971A JP 2010537971 A JP2010537971 A JP 2010537971A JP 2011506447 A JP2011506447 A JP 2011506447A
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connexin
wound
polynucleotide
agent
seq
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JP2011506447A5 (enExample
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ブラッドフォード ジェイ. ダフト,
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コーダ セラピューティクス, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/31Combination therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010537971A 2007-12-11 2008-12-11 損傷した創傷治癒組成物および治療 Withdrawn JP2011506447A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US726207P 2007-12-11 2007-12-11
PCT/US2008/013656 WO2009075882A2 (en) 2007-12-11 2008-12-11 Impaired wound healing compositions and treatments

Related Child Applications (1)

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JP2014097425A Division JP2014144976A (ja) 2007-12-11 2014-05-09 損傷した創傷治癒組成物および治療

Publications (2)

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JP2011506447A true JP2011506447A (ja) 2011-03-03
JP2011506447A5 JP2011506447A5 (enExample) 2013-01-31

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Family Applications (3)

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JP2010537971A Withdrawn JP2011506447A (ja) 2007-12-11 2008-12-11 損傷した創傷治癒組成物および治療
JP2014097425A Withdrawn JP2014144976A (ja) 2007-12-11 2014-05-09 損傷した創傷治癒組成物および治療
JP2016082856A Pending JP2016135799A (ja) 2007-12-11 2016-04-18 損傷した創傷治癒組成物および治療

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JP2014097425A Withdrawn JP2014144976A (ja) 2007-12-11 2014-05-09 損傷した創傷治癒組成物および治療
JP2016082856A Pending JP2016135799A (ja) 2007-12-11 2016-04-18 損傷した創傷治癒組成物および治療

Country Status (8)

Country Link
US (1) US20100279921A1 (enExample)
EP (1) EP2245158A2 (enExample)
JP (3) JP2011506447A (enExample)
CN (2) CN102920996A (enExample)
AU (2) AU2008335718A1 (enExample)
CA (1) CA2709153A1 (enExample)
WO (1) WO2009075882A2 (enExample)
ZA (1) ZA201004998B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011507860A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 異常瘢痕または過剰瘢痕の治療のための抗コネキシンポリヌクレオチドおよび抗コネキシンペプチドの使用
JP2011507855A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 外科的癒着の治療のための、単独のまたは抗コネキシンポリヌクレオチドと組み合わせた抗コネキシンペプチドの使用
JP2011507599A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 改良医療デバイス

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* Cited by examiner, † Cited by third party
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EP2510938A1 (en) 2005-02-03 2012-10-17 Coda Therapeutics Limited Anti-connexin antisense compounds and use thereof for treating vascular disorders
AU2007333535B2 (en) 2006-12-11 2014-04-17 Coda Therapeutics, Inc. Anticonnexin polynucleotides as impaired wound healing compositions
AU2008343756A1 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin polypeptide agent in combination with anti-connexin polynucleotide agent for the treatment of fibrotic conditions
JP2011507858A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 整形外科状態の治療のための、単独のまたは抗コネキシンポリヌクレオチドと組み合わせた、抗コネキシンペプチドの使用
JP2011507857A (ja) 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 線維症性の状態の処置のためのコネキシン43の阻害剤の使用
CA2710227A1 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Treatment of surgical adhesions
WO2013131040A1 (en) 2012-03-01 2013-09-06 Firststring Research, Inc. Topical gels containing alpha connexin c-terminal (act) peptides
US20140031753A1 (en) * 2012-07-25 2014-01-30 Neil T. Winthrop Thoracostomy devices and methods of use
US9156896B2 (en) 2013-03-15 2015-10-13 Coda Therapeutics, Inc. Wound healing compositions and treatments
EP3110455A4 (en) * 2014-02-25 2017-10-11 CoDa Therapeutics, Inc. Treatment of resistant lesions
CN107109410B (zh) 2014-08-22 2021-11-02 奥克兰联合服务有限公司 通道调节剂
BR112017015618A2 (pt) * 2015-01-20 2018-04-10 Miragen Therapeutics Inc inibidores de mir-92 e usos destes.
CN111201247A (zh) 2017-04-28 2020-05-26 奥克兰联合服务有限公司 治疗方法和新颖构建体
CN109513037B (zh) * 2018-11-14 2021-09-17 华中科技大学同济医学院附属协和医院 一种负载介孔生物玻璃的小肠粘膜下层创面敷料
EP4073253A4 (en) * 2019-12-09 2024-01-24 Cage Bio Inc. TOPICAL ADMINISTRATION OF RNA INTERFERENCE AGENT USING IONIC LIQUID
CN111214694B (zh) * 2020-03-31 2022-04-22 山东大鱼生物技术有限公司 一种具有止血和加速伤口愈合功能的敷料及其制备方法
IL302262A (en) 2020-10-22 2023-06-01 Xequel Bio Inc Peptide Formulations and Ophthalmic Uses Thereof

Citations (2)

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JP2002535377A (ja) * 1999-01-27 2002-10-22 ユニバーシテイ・カレツジ・ロンドン コネキシンに対するアンチセンスヌクレオチドを含む配合物
WO2006134494A2 (en) * 2005-02-03 2006-12-21 Coda Therapeutics Limited Anti-connexin compounds and therapeutic uses thereof

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US20050119211A1 (en) * 2001-05-18 2005-06-02 Sirna Therapeutics, Inc. RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA)
CA2474788A1 (en) * 2002-01-29 2003-08-07 Wyeth Compositions and methods for modulating connexin hemichannels
PL2289535T3 (pl) * 2004-12-21 2018-12-31 Musc Foundation For Research Development Kompozycje i sposoby wspomagania gojenia ran oraz regeneracji tkanek
US8247384B2 (en) * 2006-11-15 2012-08-21 Coda Therapeutics, Inc. Methods and compositions for wound healing
AU2007333535B2 (en) * 2006-12-11 2014-04-17 Coda Therapeutics, Inc. Anticonnexin polynucleotides as impaired wound healing compositions
CN107080845A (zh) * 2007-12-11 2017-08-22 科达治疗公司 受损伤口愈合的组合物和治疗
JP2011507858A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 整形外科状態の治療のための、単独のまたは抗コネキシンポリヌクレオチドと組み合わせた、抗コネキシンペプチドの使用
AU2008343756A1 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin polypeptide agent in combination with anti-connexin polynucleotide agent for the treatment of fibrotic conditions
WO2009085268A2 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of surgical adhesions
JP2011507862A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 異常瘢痕または過剰瘢痕の治療のための抗コネキシン43ポリヌクレオチドの使用
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011507860A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 異常瘢痕または過剰瘢痕の治療のための抗コネキシンポリヌクレオチドおよび抗コネキシンペプチドの使用
JP2011507855A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 外科的癒着の治療のための、単独のまたは抗コネキシンポリヌクレオチドと組み合わせた抗コネキシンペプチドの使用
JP2011507599A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 改良医療デバイス

Also Published As

Publication number Publication date
CN101970663A (zh) 2011-02-09
WO2009075882A3 (en) 2009-07-30
JP2016135799A (ja) 2016-07-28
JP2014144976A (ja) 2014-08-14
US20100279921A1 (en) 2010-11-04
EP2245158A2 (en) 2010-11-03
CN102920996A (zh) 2013-02-13
WO2009075882A9 (en) 2009-09-17
CA2709153A1 (en) 2009-06-18
ZA201004998B (en) 2011-06-29
AU2008335718A1 (en) 2009-06-18
AU2015200904A1 (en) 2015-03-12
WO2009075882A2 (en) 2009-06-18

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