JP2011506447A5 - - Google Patents

Info

Publication number

JP2011506447A5

JP2011506447A5 JP2010537971A JP2010537971A JP2011506447A5 JP 2011506447 A5 JP2011506447 A5 JP 2011506447A5 JP 2010537971 A JP2010537971 A JP 2010537971A JP 2010537971 A JP2010537971 A JP 2010537971A JP 2011506447 A5 JP2011506447 A5 JP 2011506447A5

Authority

JP

Japan

Prior art keywords

connexin

agent

polynucleotide

pharmaceutical composition

item

Prior art date

2008-12-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 239000003795 chemical substances by application Substances 0.000 claims description 64
• 238000000034 method Methods 0.000 claims description 56
• 108091033319 polynucleotide Proteins 0.000 claims description 56
• 239000002157 polynucleotide Substances 0.000 claims description 56
• 102000040430 polynucleotide Human genes 0.000 claims description 56
• 230000000692 anti-sense effect Effects 0.000 claims description 44
• 239000000203 mixture Substances 0.000 claims description 41
• 239000008194 pharmaceutical composition Substances 0.000 claims description 39
• 206010052428 Wound Diseases 0.000 claims description 27
• 208000027418 Wounds and injury Diseases 0.000 claims description 27
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 25
• 239000003814 drug Substances 0.000 claims description 24
• 230000001684 chronic effect Effects 0.000 claims description 17
• 239000000816 peptidomimetic Substances 0.000 claims description 17
• 241001465754 Metazoa Species 0.000 claims description 16
• 102000001045 Connexin 43 Human genes 0.000 claims description 12
• 108010069241 Connexin 43 Proteins 0.000 claims description 12
• 241000124008 Mammalia Species 0.000 claims description 12
• 108020004999 messenger RNA Proteins 0.000 claims description 12
• 239000002773 nucleotide Substances 0.000 claims description 12
• 125000003729 nucleotide group Chemical group 0.000 claims description 12
• 208000025865 Ulcer Diseases 0.000 claims description 8
• 231100000397 ulcer Toxicity 0.000 claims description 8
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
• 108091030071 RNAI Proteins 0.000 claims description 6
• 108020004459 Small interfering RNA Proteins 0.000 claims description 6
• 230000000295 complement effect Effects 0.000 claims description 6
• 238000002844 melting Methods 0.000 claims description 6
• 230000008018 melting Effects 0.000 claims description 6
• 230000004962 physiological condition Effects 0.000 claims description 6
• 230000029663 wound healing Effects 0.000 claims description 6
• 206010011985 Decubitus ulcer Diseases 0.000 claims description 4
• 206010056340 Diabetic ulcer Diseases 0.000 claims description 4
• 208000004210 Pressure Ulcer Diseases 0.000 claims description 4
• 208000000558 Varicose Ulcer Diseases 0.000 claims description 4
• 230000036573 scar formation Effects 0.000 claims description 4
• 238000011200 topical administration Methods 0.000 claims description 4
• 230000003156 vasculitic effect Effects 0.000 claims description 4
• 244000144972 livestock Species 0.000 claims description 3
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
• 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
• 230000007547 defect Effects 0.000 claims description 2
• 239000005022 packaging material Substances 0.000 claims description 2
• 230000002085 persistent effect Effects 0.000 claims description 2
• 229920001983 poloxamer Polymers 0.000 claims description 2
• 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 2
• 230000001737 promoting effect Effects 0.000 claims description 2
• 238000013268 sustained release Methods 0.000 claims description 2
• 239000012730 sustained-release form Substances 0.000 claims description 2
• 230000017423 tissue regeneration Effects 0.000 claims description 2
• 229940079593 drug Drugs 0.000 claims 8
• 102000010970 Connexin Human genes 0.000 claims 1
• 108050001175 Connexin Proteins 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1