JP2013515009A5 - - Google Patents
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- Publication number
- JP2013515009A5 JP2013515009A5 JP2012544948A JP2012544948A JP2013515009A5 JP 2013515009 A5 JP2013515009 A5 JP 2013515009A5 JP 2012544948 A JP2012544948 A JP 2012544948A JP 2012544948 A JP2012544948 A JP 2012544948A JP 2013515009 A5 JP2013515009 A5 JP 2013515009A5
- Authority
- JP
- Japan
- Prior art keywords
- hmb
- composition
- muscle
- acid
- grams
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- AXFYFNCPONWUHW-UHFFFAOYSA-N 3-hydroxyisovaleric acid Chemical compound CC(C)(O)CC(O)=O AXFYFNCPONWUHW-UHFFFAOYSA-N 0.000 claims 75
- 239000002253 acid Substances 0.000 claims 10
- 210000003205 muscle Anatomy 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 208000029549 Muscle injury Diseases 0.000 claims 6
- 159000000007 calcium salts Chemical class 0.000 claims 5
- 230000036470 plasma concentration Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 230000014759 maintenance of location Effects 0.000 claims 3
- 230000004220 muscle function Effects 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28785709P | 2009-12-18 | 2009-12-18 | |
| US61/287,857 | 2009-12-18 | ||
| PCT/US2010/061367 WO2011075741A1 (en) | 2009-12-18 | 2010-12-20 | Improved method of administering beta-hydroxy-beta-methylbutyrate (hmb) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015188107A Division JP2016026181A (ja) | 2009-12-18 | 2015-09-25 | β−ヒドロキシ−β−メチル酪酸塩（ＨＭＢ）の改善された投与方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515009A JP2013515009A (ja) | 2013-05-02 |
| JP2013515009A5 true JP2013515009A5 (enExample) | 2013-09-26 |
| JP6077857B2 JP6077857B2 (ja) | 2017-02-08 |
Family
ID=44167737
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012544948A Active JP6077857B2 (ja) | 2009-12-18 | 2010-12-20 | β−ヒドロキシ−β−メチル酪酸塩（ＨＭＢ）の改善された投与方法 |
| JP2015188107A Pending JP2016026181A (ja) | 2009-12-18 | 2015-09-25 | β−ヒドロキシ−β−メチル酪酸塩（ＨＭＢ）の改善された投与方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015188107A Pending JP2016026181A (ja) | 2009-12-18 | 2015-09-25 | β−ヒドロキシ−β−メチル酪酸塩（ＨＭＢ）の改善された投与方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20120053240A1 (enExample) |
| EP (1) | EP2512236B1 (enExample) |
| JP (2) | JP6077857B2 (enExample) |
| CN (1) | CN102762097B (enExample) |
| CA (1) | CA2784836C (enExample) |
| DK (1) | DK2512236T3 (enExample) |
| ES (1) | ES2608483T3 (enExample) |
| HU (1) | HUE032486T2 (enExample) |
| PL (1) | PL2512236T3 (enExample) |
| PT (1) | PT2512236T (enExample) |
| WO (1) | WO2011075741A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12014500198A1 (en) * | 2011-07-15 | 2017-02-10 | Nusirt Sciences Inc | Compositions and methods for modulating metabolic pathways |
| AU2013312113B2 (en) * | 2012-09-10 | 2018-08-02 | Metabolic Technologies, LLC | Composition of HMB and ATP and methods of use |
| HK1220391A1 (zh) | 2013-03-14 | 2017-05-05 | Abbott Laboratories | 与长期体力活动不足有关的胰岛素抗性的治疗 |
| US20140272000A1 (en) * | 2013-03-14 | 2014-09-18 | Metabolic Technologies, Inc. | Liquids and Foodstuffs Containing beta-hydroxy-beta-methylbutyrate (HMB) in the Free Acid Form and Methods of Manufacturing or Producing the Same |
| EP2993994A4 (en) * | 2013-03-14 | 2016-11-23 | Metabolic Technologies Inc | LIQUIDS AND FOODS WITH BETA-HYDROXY-BETA-METHYLBUTYRATE (HMB) IN A FREE ACID FORM |
| AU2014386220B2 (en) * | 2013-03-14 | 2018-04-26 | Metabolic Technologies, Inc. | Liquids and foodstuffs containing beta-hydroxy-beta-methylbutyrate (HMB) in free acid form |
| BR112015022757A2 (pt) * | 2013-03-15 | 2017-07-18 | Abbott Lab | composições nutricionais que incluem beta-hidróxi-beta-metilbutirato de cálcio, fosfopeptídeo de caseína, e proteína |
| US20150057350A1 (en) * | 2013-08-23 | 2015-02-26 | Abbott Laboratories | Fibrosis biomarkers and methods of using same |
| US10188611B2 (en) * | 2013-12-18 | 2019-01-29 | Capsugel Belguim NV | Stable liquid filled hard capsule comprising beta-hydroxy-beta methylbutyric acid |
| WO2015105981A2 (en) * | 2014-01-09 | 2015-07-16 | Abbott Laboratories | Conditional essentiality of hmb |
| WO2015116714A1 (en) | 2014-01-28 | 2015-08-06 | The Methodist Hospital | Single-cell pipette assembly comprising single-cell pipette handle and single-cell pipette tip |
| JP6309287B2 (ja) * | 2014-01-29 | 2018-04-11 | 協和発酵バイオ株式会社 | ３−ヒドロキシ−３−メチル酪酸カルシウム含有飲料 |
| US20160184248A1 (en) * | 2014-12-15 | 2016-06-30 | University Of Central Florida Research Foundation Inc. | Compositions and methods of use of -hydroxy-methylbutyrate (hmb) resulting in an acute endocrine response |
| US20160346238A1 (en) * | 2015-06-01 | 2016-12-01 | Metabolic Technologies, Inc. | Compositions and Methods of Use of -hydroxy--methylbutyrate (HMB) for Decreasing Fat Mass |
| US12208073B2 (en) | 2015-09-16 | 2025-01-28 | Metabolic Technologies, LLC | Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (HMB) for enhancing recovery from soft tissue trauma |
| PL3349745T3 (pl) | 2015-09-16 | 2024-05-20 | Metabolic Technologies, LLC | Kompozycje i sposoby stosowania beta-hydroksy-beta-metylomaślanu (hmb) w celu poprawy regeneracji po urazach tkanek miękkich |
| US20170127673A1 (en) | 2015-11-10 | 2017-05-11 | Metabolic Technologies, Inc. | Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (hmb) as an animal feed additive |
| MX386153B (es) * | 2016-01-13 | 2025-03-18 | Metabolic Tech Inc | COMPOSICIONES Y MÉTODOS DE USO DE ß-HIDROXI-ß-METILBUTIRATO (HMB) PARA ESTABILIDAD DE ARTICULACIÓN. |
| BR112018014920A2 (en) | 2016-01-21 | 2018-12-18 | Metabolic Technologies, Inc. | methods of modulating autophagy, treating or reducing the likelihood of onset of an autophagy-mediated condition, treating, inhibiting, reducing, decreasing, or preventing an age-related disorder, modulating the expression or activity of at least one factor transcription, treatment, prevention, reduction, inhibition or reduction of a pathological condition attributable to a state of nutrient excess, promoting longevity by modulating autophagy, increasing the length of time a mammal can lead a lifestyle active without suffering from conditions associated with aging and extending the health of a mammal. |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US12521378B2 (en) | 2016-04-19 | 2026-01-13 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US20230346721A1 (en) | 2018-04-18 | 2023-11-02 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US12533346B2 (en) | 2016-04-19 | 2026-01-27 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
| US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| EP3463327B1 (en) * | 2016-05-25 | 2024-04-17 | TSI Group Co., Ltd. | Stabilization of beta-hydroxyisovaleric acid formulations in soft gel capsules |
| US10588877B2 (en) | 2016-07-21 | 2020-03-17 | Savind, Inc. | Compositions comprising β-hydroxybutyric acid and salt, and methods of using the same |
| PL3528801T3 (pl) | 2016-10-21 | 2025-02-03 | Metabolic Technologies, LLC | Kompozycje i sposoby zastosowania beta-hydroksy-beta-metylomaślanu (hmb) i probiotyków |
| US12370159B2 (en) * | 2016-10-21 | 2025-07-29 | Metabolic Technologies, LLC | Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (HMB) and probiotics |
| JP7022420B2 (ja) * | 2017-06-30 | 2022-02-18 | 株式会社東洋新薬 | 経口組成物 |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| MX2020007008A (es) * | 2018-01-05 | 2021-04-28 | Texas Tech Univ Office Of Research Commercialization | COMPOSICIONES Y MÉTODOS DE USO DE ß- HIDROXI-ß-METILBUTIRATO (HMB) ASOCIADO CON AYUNO INTERMITENTE. |
| US11419836B2 (en) | 2019-02-13 | 2022-08-23 | Axcess Global Sciences, Llc | Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions |
| US10888576B2 (en) | 2018-10-08 | 2021-01-12 | Metabolic Technologies, Inc. | Composition of HMB and ATP and methods of use |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12186297B2 (en) * | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4857552A (en) * | 1988-06-08 | 1989-08-15 | E. I. Du Pont De Nemours And Co. | Stable pharmaceutical composition |
| US5087472A (en) * | 1990-01-30 | 1992-02-11 | Iowa State University Research Foundation, Inc. | Feed compositions for domestics animals containing hydroxymethylbutyrate |
| US5028440A (en) * | 1990-01-30 | 1991-07-02 | Iowa State University Research Foundation, Inc. | Method of raising meat producing animals to increase lean tissue development |
| US4992470A (en) * | 1990-02-08 | 1991-02-12 | Iowa State University Research Foundation, Inc. | Method of enhancing immune response of mammals |
| US5348979A (en) * | 1992-12-23 | 1994-09-20 | Iowa State University Research Foundation Inc. | Method of promoting nitrogen retention in humans |
| US6103764A (en) * | 1997-11-07 | 2000-08-15 | Iowa State University Research Foundation, Inc. | Method for increasing the aerobic capacity of muscle |
| US6031000A (en) * | 1998-06-23 | 2000-02-29 | Iowa State University Research Foundation, Inc. | Composition comprising β-hydroxy-β-methylbutyric acid and at least one amino acid and methods of use |
| US20010008641A1 (en) * | 1998-11-25 | 2001-07-19 | R. Douglas Krotzer | Nutritionally active composition for bodybuilding |
| EP1429602B1 (en) * | 2001-08-31 | 2009-12-16 | Rutgers, The State University Of New Jersey | Methods for treating disorders using plant extracts |
| DE10215007A1 (de) * | 2002-04-05 | 2003-10-16 | Degussa Bioactives Deutschland | Verwendung von Kreatinpyruvat zur Steigerung der Ausdauer bei hochintensiven körperlichen Intervallbelastungen |
| US20040220266A1 (en) * | 2002-09-09 | 2004-11-04 | Wiley David B. | Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives |
| EP1750527A1 (en) * | 2004-03-11 | 2007-02-14 | Wiley Organics, Inc. | Compositions and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives |
| US20050215640A1 (en) * | 2004-03-26 | 2005-09-29 | Baxter Jeffrey H | HMB compositions and uses thereof |
| EP1973426A2 (en) * | 2005-11-03 | 2008-10-01 | Southwest Immunology Inc. | Compositions for preventing and reducing delayed onset muscle soreness |
| EP2381784B1 (en) * | 2008-12-09 | 2018-07-11 | Metabolic Technologies, Inc. | Nutritional intervention for improving muscular function and strength |
| JP2009155336A (ja) * | 2009-03-31 | 2009-07-16 | Tsujido Chemical Corp | 治療剤 |
-
2010
- 2010-12-20 PT PT108383555T patent/PT2512236T/pt unknown
- 2010-12-20 CA CA2784836A patent/CA2784836C/en active Active
- 2010-12-20 US US12/973,803 patent/US20120053240A1/en not_active Abandoned
- 2010-12-20 ES ES10838355.5T patent/ES2608483T3/es active Active
- 2010-12-20 HU HUE10838355A patent/HUE032486T2/en unknown
- 2010-12-20 WO PCT/US2010/061367 patent/WO2011075741A1/en not_active Ceased
- 2010-12-20 JP JP2012544948A patent/JP6077857B2/ja active Active
- 2010-12-20 EP EP10838355.5A patent/EP2512236B1/en active Active
- 2010-12-20 CN CN201080064031.3A patent/CN102762097B/zh active Active
- 2010-12-20 PL PL10838355T patent/PL2512236T3/pl unknown
- 2010-12-20 DK DK10838355.5T patent/DK2512236T3/en active
-
2015
- 2015-09-25 JP JP2015188107A patent/JP2016026181A/ja active Pending
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