JP2013526611A5 - - Google Patents
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- Publication number
- JP2013526611A5 JP2013526611A5 JP2013512175A JP2013512175A JP2013526611A5 JP 2013526611 A5 JP2013526611 A5 JP 2013526611A5 JP 2013512175 A JP2013512175 A JP 2013512175A JP 2013512175 A JP2013512175 A JP 2013512175A JP 2013526611 A5 JP2013526611 A5 JP 2013526611A5
- Authority
- JP
- Japan
- Prior art keywords
- oral formulation
- extract
- sinensis
- subject
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 109
- 238000009472 formulation Methods 0.000 claims description 108
- 229940109529 pomegranate extract Drugs 0.000 claims description 38
- 230000014509 gene expression Effects 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 32
- 235000020710 ginseng extract Nutrition 0.000 claims description 31
- 230000000694 effects Effects 0.000 claims description 26
- 244000269722 Thea sinensis Species 0.000 claims description 12
- -1 chewables Substances 0.000 claims description 10
- 230000007423 decrease Effects 0.000 claims description 10
- 241001416980 Paecilomyces hepiali Species 0.000 claims description 9
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 9
- 235000013824 polyphenols Nutrition 0.000 claims description 9
- 210000005013 brain tissue Anatomy 0.000 claims description 8
- UFNDONGOJKNAES-UHFFFAOYSA-N Ginsenoside Rb1 Natural products CC(=CCCC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CC(O)C45C)C UFNDONGOJKNAES-UHFFFAOYSA-N 0.000 claims description 7
- YURJSTAIMNSZAE-UHFFFAOYSA-N UNPD89172 Natural products C1CC(C2(CC(C3C(C)(C)C(O)CCC3(C)C2CC2O)OC3C(C(O)C(O)C(CO)O3)O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O YURJSTAIMNSZAE-UHFFFAOYSA-N 0.000 claims description 7
- 230000032683 aging Effects 0.000 claims description 7
- 239000002552 dosage form Substances 0.000 claims description 7
- GZYPWOGIYAIIPV-JBDTYSNRSA-N ginsenoside Rb1 Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)O[C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(CC[C@H]4C(C)(C)[C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)CC[C@]4(C)[C@H]3C[C@H]2O)C)(C)CC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GZYPWOGIYAIIPV-JBDTYSNRSA-N 0.000 claims description 7
- TXEWRVNOAJOINC-UHFFFAOYSA-N ginsenoside Rb2 Natural products CC(=CCCC(OC1OC(COC2OCC(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C)C TXEWRVNOAJOINC-UHFFFAOYSA-N 0.000 claims description 7
- YURJSTAIMNSZAE-HHNZYBFYSA-N ginsenoside Rg1 Chemical compound O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YURJSTAIMNSZAE-HHNZYBFYSA-N 0.000 claims description 7
- CBEHEBUBNAGGKC-UHFFFAOYSA-N ginsenoside Rg1 Natural products CC(=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5CC(OC6OC(CO)C(O)C(O)C6O)C34C)C CBEHEBUBNAGGKC-UHFFFAOYSA-N 0.000 claims description 7
- 210000003205 muscle Anatomy 0.000 claims description 7
- 235000020934 caloric restriction Nutrition 0.000 claims description 6
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 5
- RZALONVQKUWRRY-FYZOBXCZSA-N 2,3-dihydroxybutanedioic acid;(3r)-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound OC(=O)C(O)C(O)C(O)=O.C[N+](C)(C)C[C@H](O)CC([O-])=O RZALONVQKUWRRY-FYZOBXCZSA-N 0.000 claims description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 244000042430 Rhodiola rosea Species 0.000 claims description 5
- 235000003713 Rhodiola rosea Nutrition 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 239000013543 active substance Substances 0.000 claims description 5
- 239000000654 additive Substances 0.000 claims description 5
- 230000000996 additive effect Effects 0.000 claims description 5
- 235000021028 berry Nutrition 0.000 claims description 5
- 235000013361 beverage Nutrition 0.000 claims description 5
- 239000000090 biomarker Substances 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 5
- 239000008298 dragée Substances 0.000 claims description 5
- 239000006196 drop Substances 0.000 claims description 5
- 230000037149 energy metabolism Effects 0.000 claims description 5
- 239000000499 gel Substances 0.000 claims description 5
- 229940038487 grape extract Drugs 0.000 claims description 5
- 239000000787 lecithin Substances 0.000 claims description 5
- 235000010445 lecithin Nutrition 0.000 claims description 5
- 229940067606 lecithin Drugs 0.000 claims description 5
- 239000007937 lozenge Substances 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 230000035936 sexual power Effects 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- 229960001866 silicon dioxide Drugs 0.000 claims description 5
- 239000006188 syrup Substances 0.000 claims description 5
- 235000020357 syrup Nutrition 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- 210000001519 tissue Anatomy 0.000 claims description 5
- 235000012431 wafers Nutrition 0.000 claims description 5
- 230000003679 aging effect Effects 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000013355 food flavoring agent Nutrition 0.000 claims description 3
- 235000002791 Panax Nutrition 0.000 claims 1
- 241000208343 Panax Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34778910P | 2010-05-24 | 2010-05-24 | |
| US61/347,789 | 2010-05-24 | ||
| PCT/US2011/037797 WO2011149981A2 (en) | 2010-05-24 | 2011-05-24 | Oral formulations for counteracting effects of aging |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015204980A Division JP2016020387A (ja) | 2010-05-24 | 2015-10-16 | 加齢の影響を防止するための経口処方物 |
| JP2017158000A Division JP2017200957A (ja) | 2010-05-24 | 2017-08-18 | 加齢の影響を防止するための経口処方物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013526611A JP2013526611A (ja) | 2013-06-24 |
| JP2013526611A5 true JP2013526611A5 (enExample) | 2014-07-03 |
| JP6226744B2 JP6226744B2 (ja) | 2017-11-08 |
Family
ID=45004730
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013512175A Active JP6226744B2 (ja) | 2010-05-24 | 2011-05-24 | 加齢の影響を防止するための経口処方物 |
| JP2015204980A Pending JP2016020387A (ja) | 2010-05-24 | 2015-10-16 | 加齢の影響を防止するための経口処方物 |
| JP2017158000A Withdrawn JP2017200957A (ja) | 2010-05-24 | 2017-08-18 | 加齢の影響を防止するための経口処方物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015204980A Pending JP2016020387A (ja) | 2010-05-24 | 2015-10-16 | 加齢の影響を防止するための経口処方物 |
| JP2017158000A Withdrawn JP2017200957A (ja) | 2010-05-24 | 2017-08-18 | 加齢の影響を防止するための経口処方物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9072780B2 (enExample) |
| EP (1) | EP2575839B1 (enExample) |
| JP (3) | JP6226744B2 (enExample) |
| KR (2) | KR101993009B1 (enExample) |
| CN (2) | CN103153320B (enExample) |
| WO (1) | WO2011149981A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6226744B2 (ja) * | 2010-05-24 | 2017-11-08 | エヌエスイー プロダクツ インコーポレイテッド | 加齢の影響を防止するための経口処方物 |
| SG193370A1 (en) * | 2011-03-14 | 2013-10-30 | Nse Products Inc | Oral formulations for promoting cellular purification |
| CN103445151B (zh) * | 2012-10-08 | 2014-12-24 | 李津龙 | 北虫草口服液及其制备方法 |
| CN103083384A (zh) * | 2013-01-31 | 2013-05-08 | 李耀华 | 一种冬虫夏草菌粉保健组合物及其制备工艺 |
| CN104825710A (zh) * | 2015-04-30 | 2015-08-12 | 张美洲 | 一种舒缓肌筋膏 |
| US12440465B2 (en) | 2016-08-31 | 2025-10-14 | Nse Products, Inc. | Nutritional compositions and associated methods |
| US10806764B2 (en) * | 2018-05-25 | 2020-10-20 | Nuliv Science Usa, Inc. | Anti-aging method and composition |
| TW202017577A (zh) * | 2018-11-13 | 2020-05-16 | 大江生醫股份有限公司 | 冬蟲夏草的萃取物用於提升端粒酶反轉錄酶基因及端粒酶ｒｎａ組分基因的表現量及抗老化之用途 |
| JP7366496B2 (ja) * | 2019-09-09 | 2023-10-23 | 株式会社ノエビア | ミトコンドリア活性化剤 |
| BE1029965B1 (nl) * | 2021-11-26 | 2023-06-27 | Dormouse Bv | Anti-verouderingssupplement |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1185908A (zh) * | 1996-12-27 | 1998-07-01 | 李江 | 一组功能型虫草奶、虫草奶制品及其制备方法 |
| JPH10245340A (ja) * | 1997-03-04 | 1998-09-14 | Meiji Milk Prod Co Ltd | 強壮強精組成物 |
| US7611738B2 (en) * | 2005-05-24 | 2009-11-03 | Pom Wonderful, Llc | Processes for extracting phytochemicals from pomegranate solids and compositions and methods of use thereof |
| WO2001012851A2 (en) | 1999-08-12 | 2001-02-22 | Wisconsin Alumni Research Foundation | Identification of genetic markers of biological age and metabolism |
| CN1286051A (zh) * | 1999-08-26 | 2001-03-07 | 侯维祥 | 虫草灵芝(菌)茶 |
| JP2001139483A (ja) * | 1999-08-30 | 2001-05-22 | Japan Science & Technology Corp | 薬用人蔘からなる脳細胞または神経細胞保護剤 |
| CN1355048A (zh) * | 2000-11-23 | 2002-06-26 | 成都迪康药物研究所 | 一种抗疲劳和调节免疫功能的植物制剂 |
| JP2002275086A (ja) * | 2001-03-15 | 2002-09-25 | Fancl Corp | 虚弱体質改善用組成物 |
| CA2441086A1 (en) | 2001-03-19 | 2002-09-26 | Wisconsin Alumni Research Foundation | Identification of gene expression alterations underlying the aging process in mammals |
| US20060073197A1 (en) * | 2004-05-20 | 2006-04-06 | Ramaekers Joseph C | Encapsulated transfer factor compositions and methods of use |
| KR20030055950A (ko) * | 2001-12-27 | 2003-07-04 | 나드리화장품주식회사 | 석류 추출물을 함유하는 노화 방지용 화장료 조성물 |
| JP2003274888A (ja) | 2002-03-26 | 2003-09-30 | Takara Holdings Inc | 果実の磨砕物及び飲食品 |
| JP2003292429A (ja) | 2002-04-01 | 2003-10-15 | Noevir Co Ltd | 皮膚外用剤 |
| JP2004300104A (ja) * | 2003-04-01 | 2004-10-28 | Nasu Bio Farm:Kk | 女性ホルモン不足症治療剤 |
| KR100525994B1 (ko) | 2003-05-12 | 2005-11-08 | 한불화장품주식회사 | 복방 생약 추출물을 함유하는 화장료 조성물 |
| KR20040101694A (ko) * | 2003-05-26 | 2004-12-03 | (주)헬스마스터 | 갱년기 여성용 감마리놀렌산 가공식품 |
| CN1704469A (zh) * | 2004-05-31 | 2005-12-07 | 沈南英 | 一种中国冬虫夏草真菌的生产方法 |
| EP1835818B1 (en) * | 2004-12-09 | 2011-08-10 | Eurark, LLC | Product and method for producing a vehicle for oral administration of nutraceuticals |
| JP2006312594A (ja) | 2005-05-06 | 2006-11-16 | Univ Nihon | 学習・記憶障害予防用組成物 |
| JP2008201749A (ja) * | 2007-02-21 | 2008-09-04 | Okayama Univ | 肝細胞増殖因子産生誘導剤及びその医薬品組成物 |
| KR20080104600A (ko) | 2007-05-28 | 2008-12-03 | (주)아모레퍼시픽 | 인삼 열매 추출물을 함유하는 혈행촉진, 혈관신생촉진, 및허혈성 심질환 치료용 조성물 |
| CN101142956B (zh) * | 2007-11-09 | 2010-12-29 | 北京中科雍和医药技术有限公司 | 一种保健袋泡茶及其生产工艺 |
| JP2009143886A (ja) | 2007-12-18 | 2009-07-02 | Lion Corp | 成長ホルモン分泌促進剤 |
| US20090252758A1 (en) | 2008-04-07 | 2009-10-08 | Mazed Mohammad A | Nutritional supplement for the prevention of cardiovascular disease, alzheimer's disease, diabetes, and regulation and reduction of blood sugar and insulin resistance |
| US20090291156A1 (en) | 2008-05-20 | 2009-11-26 | Sagittarius Life Science Corp. | Herbal composition for skin care |
| US7923044B2 (en) * | 2008-07-15 | 2011-04-12 | Paradise Herbs & Essentials, Inc. | Composition for high-ORAC value dietary supplement |
| CN101361896B (zh) | 2008-09-16 | 2010-10-06 | 陈月明 | 一种治疗人体脏腑炎症的中药组合物 |
| CA2743002A1 (en) | 2008-11-12 | 2010-05-20 | June Jacobs Laboratories, Llc | Antioxidant compositions for the cleansing and conditioning of skin |
| JP6226744B2 (ja) * | 2010-05-24 | 2017-11-08 | エヌエスイー プロダクツ インコーポレイテッド | 加齢の影響を防止するための経口処方物 |
-
2011
- 2011-05-24 JP JP2013512175A patent/JP6226744B2/ja active Active
- 2011-05-24 WO PCT/US2011/037797 patent/WO2011149981A2/en not_active Ceased
- 2011-05-24 CN CN201180035847.8A patent/CN103153320B/zh not_active Expired - Fee Related
- 2011-05-24 KR KR1020127032339A patent/KR101993009B1/ko active Active
- 2011-05-24 KR KR1020187000785A patent/KR101944441B1/ko active Active
- 2011-05-24 EP EP11787279.6A patent/EP2575839B1/en active Active
- 2011-05-24 CN CN201610653182.1A patent/CN106511415A/zh active Pending
- 2011-05-24 US US13/115,027 patent/US9072780B2/en active Active
-
2015
- 2015-07-07 US US14/793,612 patent/US9795645B2/en active Active
- 2015-10-16 JP JP2015204980A patent/JP2016020387A/ja active Pending
-
2017
- 2017-08-18 JP JP2017158000A patent/JP2017200957A/ja not_active Withdrawn
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