JP2011506447A - 損傷した創傷治癒組成物および治療 - Google Patents

損傷した創傷治癒組成物および治療 Download PDF

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Publication number
JP2011506447A
JP2011506447A JP2010537971A JP2010537971A JP2011506447A JP 2011506447 A JP2011506447 A JP 2011506447A JP 2010537971 A JP2010537971 A JP 2010537971A JP 2010537971 A JP2010537971 A JP 2010537971A JP 2011506447 A JP2011506447 A JP 2011506447A
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connexin
wound
polynucleotide
agent
seq
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JP2011506447A5 (OSRAM
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ブラッドフォード ジェイ. ダフト,
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コーダ セラピューティクス, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/31Combination therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010537971A 2007-12-11 2008-12-11 損傷した創傷治癒組成物および治療 Withdrawn JP2011506447A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US726207P 2007-12-11 2007-12-11
PCT/US2008/013656 WO2009075882A2 (en) 2007-12-11 2008-12-11 Impaired wound healing compositions and treatments

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014097425A Division JP2014144976A (ja) 2007-12-11 2014-05-09 損傷した創傷治癒組成物および治療

Publications (2)

Publication Number Publication Date
JP2011506447A true JP2011506447A (ja) 2011-03-03
JP2011506447A5 JP2011506447A5 (OSRAM) 2013-01-31

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Family Applications (3)

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JP2010537971A Withdrawn JP2011506447A (ja) 2007-12-11 2008-12-11 損傷した創傷治癒組成物および治療
JP2014097425A Withdrawn JP2014144976A (ja) 2007-12-11 2014-05-09 損傷した創傷治癒組成物および治療
JP2016082856A Pending JP2016135799A (ja) 2007-12-11 2016-04-18 損傷した創傷治癒組成物および治療

Family Applications After (2)

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JP2014097425A Withdrawn JP2014144976A (ja) 2007-12-11 2014-05-09 損傷した創傷治癒組成物および治療
JP2016082856A Pending JP2016135799A (ja) 2007-12-11 2016-04-18 損傷した創傷治癒組成物および治療

Country Status (8)

Country Link
US (1) US20100279921A1 (OSRAM)
EP (1) EP2245158A2 (OSRAM)
JP (3) JP2011506447A (OSRAM)
CN (2) CN101970663A (OSRAM)
AU (2) AU2008335718A1 (OSRAM)
CA (1) CA2709153A1 (OSRAM)
WO (1) WO2009075882A2 (OSRAM)
ZA (1) ZA201004998B (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011507860A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 異常瘢痕または過剰瘢痕の治療のための抗コネキシンポリヌクレオチドおよび抗コネキシンペプチドの使用
JP2011507855A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 外科的癒着の治療のための、単独のまたは抗コネキシンポリヌクレオチドと組み合わせた抗コネキシンペプチドの使用
JP2011507599A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 改良医療デバイス

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150004906A (ko) 2005-02-03 2015-01-13 코다 테라퓨틱스 (엔지) 리미티드 항-코넥신 화합물 및 그의 용도
RU2521329C2 (ru) 2006-12-11 2014-06-27 Коуда Терапьютикс, Инк. Композиции и способы лечения плохо заживающих ран
AU2008343756A1 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin polypeptide agent in combination with anti-connexin polynucleotide agent for the treatment of fibrotic conditions
JP2011507859A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 外科的癒着の治療のための抗コネキシンポリヌクレオチドの使用
US8975237B2 (en) 2007-12-21 2015-03-10 Coda Therapeutics, Inc. Treatment of fibrotic conditions
AU2008343842A1 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of orthopedic conditions
KR102038948B1 (ko) 2012-03-01 2019-11-26 퍼스트스트링 리서치 인코포레이티드 알파 코넥신 c-말단 (act) 펩타이드를 포함하는 국소 겔
US20140031753A1 (en) * 2012-07-25 2014-01-30 Neil T. Winthrop Thoracostomy devices and methods of use
US9156896B2 (en) * 2013-03-15 2015-10-13 Coda Therapeutics, Inc. Wound healing compositions and treatments
EP3110455A4 (en) * 2014-02-25 2017-10-11 CoDa Therapeutics, Inc. Treatment of resistant lesions
EP4491184A3 (en) 2014-08-22 2025-03-26 Auckland Uniservices Limited Channel modulators
SG11201705907XA (en) * 2015-01-20 2017-08-30 Miragen Therapeutics Inc Mir-92 inhibitors and uses thereof
CA3061738A1 (en) 2017-04-28 2018-11-01 Auckland Uniservices Limited Methods of treatment and novel constructs
CN109513037B (zh) * 2018-11-14 2021-09-17 华中科技大学同济医学院附属协和医院 一种负载介孔生物玻璃的小肠粘膜下层创面敷料
WO2021119198A1 (en) * 2019-12-09 2021-06-17 Cage Bio, Inc. Topical delivery of rna interference agents using ionic liquid
CN111214694B (zh) * 2020-03-31 2022-04-22 山东大鱼生物技术有限公司 一种具有止血和加速伤口愈合功能的敷料及其制备方法
MX2023004631A (es) 2020-10-22 2023-07-20 Xequel Bio Inc Formulaciones peptidicas y usos oftalmicos de las mismas.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535377A (ja) * 1999-01-27 2002-10-22 ユニバーシテイ・カレツジ・ロンドン コネキシンに対するアンチセンスヌクレオチドを含む配合物
WO2006134494A2 (en) * 2005-02-03 2006-12-21 Coda Therapeutics Limited Anti-connexin compounds and therapeutic uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0539594Y2 (OSRAM) * 1988-08-05 1993-10-07
US5166195A (en) * 1990-05-11 1992-11-24 Isis Pharmaceuticals, Inc. Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides
US7250397B2 (en) * 2000-02-23 2007-07-31 Zealand Pharma A/S Antiarrhythmic peptides
US20050119211A1 (en) * 2001-05-18 2005-06-02 Sirna Therapeutics, Inc. RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA)
CN1939529A (zh) * 2002-01-29 2007-04-04 Wyeth公司 用于调节连接蛋白半通道的组合物和方法
HUE038099T2 (hu) * 2004-12-21 2018-09-28 Musc Found For Res Dev Kompozíciók és módszerek sebgyógyulás és szöveti regeneráció elõsegítésére
KR20150072458A (ko) * 2006-11-15 2015-06-29 코다 테라퓨틱스, 인크. 상처 치유를 위한 개선 방법 및 조성물
RU2521329C2 (ru) * 2006-12-11 2014-06-27 Коуда Терапьютикс, Инк. Композиции и способы лечения плохо заживающих ран
AU2008335717A1 (en) * 2007-12-11 2009-06-18 Coda Therapeutics, Inc. Impaired wound healing compositions and treatments
AU2008343758A1 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin 43 polynucleotides for the treatment of abnormal or excessive scars
JP2011507855A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 外科的癒着の治療のための、単独のまたは抗コネキシンポリヌクレオチドと組み合わせた抗コネキシンペプチドの使用
AU2008343756A1 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin polypeptide agent in combination with anti-connexin polynucleotide agent for the treatment of fibrotic conditions
AU2008343842A1 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of orthopedic conditions
US20110038920A1 (en) * 2008-01-07 2011-02-17 Ryoichi Mori Wound healing compositions and treatments

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535377A (ja) * 1999-01-27 2002-10-22 ユニバーシテイ・カレツジ・ロンドン コネキシンに対するアンチセンスヌクレオチドを含む配合物
WO2006134494A2 (en) * 2005-02-03 2006-12-21 Coda Therapeutics Limited Anti-connexin compounds and therapeutic uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN7013002160; Journal of Cell Science Vol.119, 2006, p.5193-5203 *
JPN7013002161; Diabetes Vol.56, 200711, p.2809-2817 *
JPN7013002162; Annals of the New York Academy of Sciences Vol.1080, 2006, p.49-62 *
JPN7013002163; Journal of Investigative Dermatology Vol.128, 200710, p.1039-1049 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011507860A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 異常瘢痕または過剰瘢痕の治療のための抗コネキシンポリヌクレオチドおよび抗コネキシンペプチドの使用
JP2011507855A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 外科的癒着の治療のための、単独のまたは抗コネキシンポリヌクレオチドと組み合わせた抗コネキシンペプチドの使用
JP2011507599A (ja) * 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 改良医療デバイス

Also Published As

Publication number Publication date
CN102920996A (zh) 2013-02-13
AU2008335718A1 (en) 2009-06-18
WO2009075882A2 (en) 2009-06-18
ZA201004998B (en) 2011-06-29
EP2245158A2 (en) 2010-11-03
WO2009075882A9 (en) 2009-09-17
US20100279921A1 (en) 2010-11-04
CA2709153A1 (en) 2009-06-18
CN101970663A (zh) 2011-02-09
JP2014144976A (ja) 2014-08-14
WO2009075882A3 (en) 2009-07-30
AU2015200904A1 (en) 2015-03-12
JP2016135799A (ja) 2016-07-28

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