JP2011506436A5 - - Google Patents

Info

Publication number

JP2011506436A5

JP2011506436A5 JP2010537941A JP2010537941A JP2011506436A5 JP 2011506436 A5 JP2011506436 A5 JP 2011506436A5 JP 2010537941 A JP2010537941 A JP 2010537941A JP 2010537941 A JP2010537941 A JP 2010537941A JP 2011506436 A5 JP2011506436 A5 JP 2011506436A5

Authority

JP

Japan

Prior art keywords

ctla4

antibody against

thymosin peptide

use according

alpha thymosin

Prior art date

2008-12-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 39
• 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 39
• 238000000034 method Methods 0.000 claims description 26
• 108010046075 Thymosin Proteins 0.000 claims description 23
• 108010078233 Thymalfasin Proteins 0.000 claims description 20
• 102400000800 Thymosin alpha-1 Human genes 0.000 claims description 20
• NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 claims description 20
• 229960004231 thymalfasin Drugs 0.000 claims description 20
• 201000001441 melanoma Diseases 0.000 claims description 11
• 238000011282 treatment Methods 0.000 claims description 8
• 229960005386 ipilimumab Drugs 0.000 claims description 7
• 229940034982 antineoplastic agent Drugs 0.000 claims description 6
• 239000002246 antineoplastic agent Substances 0.000 claims description 6
• FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims description 4
• 206010027476 Metastases Diseases 0.000 claims description 4
• 238000002648 combination therapy Methods 0.000 claims description 4
• 230000009401 metastasis Effects 0.000 claims description 4
• 230000037396 body weight Effects 0.000 claims description 2
• 229960003901 dacarbazine Drugs 0.000 claims description 2
• 238000011269 treatment regimen Methods 0.000 claims description 2
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 239000002295 alkylating antineoplastic agent Substances 0.000 claims 1