JP2009538916A5 - - Google Patents
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- Publication number
- JP2009538916A5 JP2009538916A5 JP2009513264A JP2009513264A JP2009538916A5 JP 2009538916 A5 JP2009538916 A5 JP 2009538916A5 JP 2009513264 A JP2009513264 A JP 2009513264A JP 2009513264 A JP2009513264 A JP 2009513264A JP 2009538916 A5 JP2009538916 A5 JP 2009538916A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- chimeric anti
- seq
- stx2
- stx1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims description 12
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims description 12
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims description 12
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims description 12
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims description 12
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims description 12
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims description 12
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims description 12
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims description 12
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims description 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
- 108010079723 Shiga Toxin Proteins 0.000 claims description 6
- 238000001802 infusion Methods 0.000 claims description 6
- 238000001990 intravenous administration Methods 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims 14
- 238000000034 method Methods 0.000 description 11
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80946406P | 2006-05-31 | 2006-05-31 | |
| PCT/US2007/012797 WO2007143004A2 (en) | 2006-05-31 | 2007-05-31 | Methods, compositions, and kits for treating shiga toxin associated conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009538916A JP2009538916A (ja) | 2009-11-12 |
| JP2009538916A5 true JP2009538916A5 (enExample) | 2011-05-12 |
Family
ID=38802032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009513264A Pending JP2009538916A (ja) | 2006-05-31 | 2007-05-31 | 志賀毒素関連病状を治療するための方法、組成物、およびキット |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120195891A1 (enExample) |
| EP (2) | EP2545936A3 (enExample) |
| JP (1) | JP2009538916A (enExample) |
| AU (1) | AU2007254950A1 (enExample) |
| CA (1) | CA2652999A1 (enExample) |
| WO (1) | WO2007143004A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8969529B2 (en) | 2009-01-23 | 2015-03-03 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods and compositions based on shiga toxin type 2 protein |
| WO2011028961A2 (en) | 2009-09-04 | 2011-03-10 | Xoma Technology Ltd. | Anti-botulism antibody coformulations |
| EP2793941A1 (en) * | 2011-12-23 | 2014-10-29 | F.Hoffmann-La Roche Ag | Articles of manufacture and methods for co-administration of antibodies |
| SI3589661T1 (sl) | 2017-03-02 | 2024-03-29 | Genentech, Inc. | Adjuvansno zdravljenje her2 pozitivnega raka dojke |
| RU2732155C1 (ru) * | 2019-09-24 | 2020-09-11 | Открытое акционерное общество "Всероссийский научный Центр молекулярной диагностики и лечения" (ОАО ВНЦМДЛ) | Гуманизированное антитело или его антигенсвязывающий фрагмент (Fab) против шига-токсинов первого и/или второго типов (варианты), композиция для лечения токсических состояний, вызванных энтерогеморрагической кишечной палочкой, содержащая указанные антитела и/или Fab |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| JPWO2006030883A1 (ja) * | 2004-09-17 | 2008-05-15 | 財団法人浜松科学技術研究振興会 | モノクローナル抗体の製造方法 |
| WO2007098201A2 (en) * | 2006-02-16 | 2007-08-30 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Shiga toxoid chimeric proteins |
-
2007
- 2007-05-31 EP EP12165151A patent/EP2545936A3/en not_active Withdrawn
- 2007-05-31 WO PCT/US2007/012797 patent/WO2007143004A2/en not_active Ceased
- 2007-05-31 CA CA002652999A patent/CA2652999A1/en not_active Abandoned
- 2007-05-31 AU AU2007254950A patent/AU2007254950A1/en not_active Abandoned
- 2007-05-31 JP JP2009513264A patent/JP2009538916A/ja active Pending
- 2007-05-31 EP EP07795522A patent/EP2035037A4/en not_active Ceased
-
2012
- 2012-03-06 US US13/412,735 patent/US20120195891A1/en not_active Abandoned
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