JP2011501656A5 - - Google Patents

Info

Publication number

JP2011501656A5

JP2011501656A5 JP2010527128A JP2010527128A JP2011501656A5 JP 2011501656 A5 JP2011501656 A5 JP 2011501656A5 JP 2010527128 A JP2010527128 A JP 2010527128A JP 2010527128 A JP2010527128 A JP 2010527128A JP 2011501656 A5 JP2011501656 A5 JP 2011501656A5

Authority

JP

Japan

Prior art keywords

antibody

sequence

seq

chain variable

variable domain

Prior art date

2008-09-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000003814 drug Substances 0.000 claims 12
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 8
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 8
• 239000005557 antagonist Substances 0.000 claims 8
• 238000006467 substitution reaction Methods 0.000 claims 5
• 229940127089 cytotoxic agent Drugs 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 230000033115 angiogenesis Effects 0.000 claims 3
• 239000002246 antineoplastic agent Substances 0.000 claims 3
• 230000002401 inhibitory effect Effects 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 229940124597 therapeutic agent Drugs 0.000 claims 3
• 230000008728 vascular permeability Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
• 229960000397 bevacizumab Drugs 0.000 claims 2
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• 239000002254 cytotoxic agent Substances 0.000 claims 2
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• 102220494895 Stromal cell-derived factor 2-like protein 1_T46L_mutation Human genes 0.000 claims 1
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