JP2011501656A5 - - Google Patents
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- JP2011501656A5 JP2011501656A5 JP2010527128A JP2010527128A JP2011501656A5 JP 2011501656 A5 JP2011501656 A5 JP 2011501656A5 JP 2010527128 A JP2010527128 A JP 2010527128A JP 2010527128 A JP2010527128 A JP 2010527128A JP 2011501656 A5 JP2011501656 A5 JP 2011501656A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- sequence
- seq
- chain variable
- variable domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 8
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 8
- 239000005557 antagonist Substances 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 5
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000033115 angiogenesis Effects 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 230000008728 vascular permeability Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 229960000397 bevacizumab Drugs 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102220499814 Carbonic anhydrase 2_N62A_mutation Human genes 0.000 claims 1
- 238000012286 ELISA Assay Methods 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102220536901 PRKC apoptosis WT1 regulator protein_L69I_mutation Human genes 0.000 claims 1
- 102220480127 Protein-tyrosine sulfotransferase 1_N60A_mutation Human genes 0.000 claims 1
- 102220494895 Stromal cell-derived factor 2-like protein 1_T46L_mutation Human genes 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 102000058223 human VEGFA Human genes 0.000 claims 1
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 102200094891 rs121913566 Human genes 0.000 claims 1
- 102200074783 rs144422014 Human genes 0.000 claims 1
- 102220008795 rs193922245 Human genes 0.000 claims 1
- 102200096229 rs387906796 Human genes 0.000 claims 1
- 102220040412 rs587778307 Human genes 0.000 claims 1
- 102200124875 rs59151893 Human genes 0.000 claims 1
- 102200153731 rs7122277 Human genes 0.000 claims 1
- 102220061206 rs786203134 Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97547107P | 2007-09-26 | 2007-09-26 | |
| PCT/US2008/077622 WO2009042746A1 (en) | 2007-09-26 | 2008-09-25 | Novel antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011501656A JP2011501656A (ja) | 2011-01-13 |
| JP2011501656A5 true JP2011501656A5 (enExample) | 2011-11-10 |
Family
ID=40329277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527128A Pending JP2011501656A (ja) | 2007-09-26 | 2008-09-25 | 新規抗体 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US7973138B2 (enExample) |
| EP (1) | EP2200700B1 (enExample) |
| JP (1) | JP2011501656A (enExample) |
| KR (1) | KR20100065162A (enExample) |
| CN (1) | CN101888878B (enExample) |
| AR (1) | AR066170A1 (enExample) |
| AU (1) | AU2008304452B2 (enExample) |
| BR (1) | BRPI0816049A2 (enExample) |
| CA (1) | CA2698609A1 (enExample) |
| CL (1) | CL2008002856A1 (enExample) |
| CO (1) | CO6260094A2 (enExample) |
| DK (1) | DK2200700T3 (enExample) |
| HR (1) | HRP20160308T1 (enExample) |
| HU (1) | HUE027911T2 (enExample) |
| MX (1) | MX2010003325A (enExample) |
| MY (1) | MY151191A (enExample) |
| NZ (1) | NZ584838A (enExample) |
| PE (1) | PE20091029A1 (enExample) |
| RU (1) | RU2490277C2 (enExample) |
| SI (1) | SI2200700T1 (enExample) |
| TW (1) | TWI547503B (enExample) |
| WO (1) | WO2009042746A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI547503B (zh) | 2007-09-26 | 2016-09-01 | 建南德克公司 | 抗α5β1抗體、編碼其之核酸、包含其之組合物及其製造及使用方法 |
| AU2010229479B2 (en) | 2009-03-25 | 2013-03-28 | Genentech, Inc. | Novel anti-alpha5beta1 antibodies and uses thereof |
| CA2665956A1 (en) * | 2009-05-07 | 2010-11-07 | Samir Patel | Combination treatment for ocular diseases |
| CN102875677A (zh) | 2009-05-08 | 2013-01-16 | 霍夫曼-拉罗奇有限公司 | 人源化抗egfl7抗体及其使用方法 |
| US8956600B2 (en) | 2009-08-10 | 2015-02-17 | Taiwan Liposome Co. Ltd. | Ophthalmic drug delivery system containing phospholipid and cholesterol |
| WO2012154983A2 (en) | 2011-05-10 | 2012-11-15 | Biocare Medical, Llc | Systems and methods for anti-pax8 antibodies |
| US20130058926A1 (en) * | 2011-08-30 | 2013-03-07 | Shiseido Company, Ltd. | Method for alleviating and/or preventing skin reddening |
| US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
| US9494597B2 (en) * | 2012-04-02 | 2016-11-15 | Ab Biosciences, Inc. | Human control antibodies and uses therefor |
| CA2872908C (en) | 2012-05-10 | 2023-11-14 | Gerhard Frey | Multi-specific monoclonal antibodies |
| DK2900265T3 (en) | 2012-09-27 | 2018-08-20 | Biocare Medical Llc | Anti-Uroplakin II Antibodies, Systems and Methods |
| WO2014100220A2 (en) | 2012-12-18 | 2014-06-26 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| JP6502856B2 (ja) * | 2012-12-26 | 2019-04-17 | オンコシナジー インコーポレイテッド | 抗インテグリンβ１抗体組成物及びその使用方法 |
| WO2014114298A1 (en) | 2013-01-23 | 2014-07-31 | Syddansk Universitet | Mfap4 binding antibodies blocking the interaction between mfap4 and integrin receptors |
| ES2667420T3 (es) * | 2013-02-05 | 2018-05-10 | Engmab Sàrl | Anticuerpos biespecíficos contra cd3epsilon y bcma |
| DK2962113T3 (da) | 2013-02-28 | 2019-07-01 | Biocare Medical Llc | Systemer og fremgangsmåder med anti-p40-antistoffer |
| ES2765423T3 (es) | 2013-10-03 | 2020-06-09 | Biocare Medical Llc | Sistemas y procedimientos de anticuerpos anti-SOX10 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| BR112018013407A2 (en) | 2015-12-30 | 2018-12-18 | Kodiak Sciences Inc. | antibodies and conjugates thereof |
| SG11202008242XA (en) | 2018-03-02 | 2020-09-29 | Kodiak Sciences Inc | Il-6 antibodies and fusion constructs and conjugates thereof |
| CN108693004B (zh) * | 2018-05-24 | 2020-08-04 | 中国农业科学院农业质量标准与检测技术研究所 | 一种检测菜籽粕中是否掺杂抗生素滤渣的方法 |
| KR20210009421A (ko) | 2018-06-14 | 2021-01-26 | 바이오아트라, 엘엘씨 | 다중 특이적 항체 구조체 |
| US11384146B2 (en) * | 2019-04-01 | 2022-07-12 | Curia Ip Holdings, Llc | BTLA-binding antibodies for modulating immune response and treating disease |
| US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN114688461B (zh) * | 2020-12-31 | 2025-02-28 | 青岛海尔施特劳斯水设备有限公司 | 一种漏水检测方法及系统 |
| CN113133431A (zh) * | 2021-02-25 | 2021-07-20 | 中南大学 | 慢性高眼压合并长眼轴动物模型的建立方法、模型及应用 |
| CN114073996B (zh) * | 2021-11-24 | 2023-04-14 | 中山大学 | 一种嵌套式微井阵列芯片及其制备方法 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5540933A (en) | 1985-05-31 | 1996-07-30 | La Jolla Cancer Research Foundation | Isolation and use of fibronectin receptor |
| EP0330506A3 (en) | 1988-02-26 | 1990-06-20 | Dana Farber Cancer Institute | Vla proteins |
| US20020146410A1 (en) | 1992-05-22 | 2002-10-10 | Helmut Eckert | Monoclonal antibodies and their use |
| US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| US5627263A (en) | 1993-11-24 | 1997-05-06 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| DK0719859T3 (da) | 1994-12-20 | 2003-10-20 | Merck Patent Gmbh | Anti-alfa V-integrin monoklonalt antistof |
| ATE322508T1 (de) | 1998-01-23 | 2006-04-15 | Merck Patent Gmbh | Verwendung des antikörpers 271.14d9.f8 (dsm acc2331) um die bindung zwischen alphavbeta6- integrin und fibronectin in vitro zu hemmen |
| US6852318B1 (en) | 1998-05-08 | 2005-02-08 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
| PT1075277E (pt) | 1998-05-08 | 2009-05-08 | Univ California | Métodos para detectar e inibir a angiogénese |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| GB9909392D0 (en) | 1999-04-24 | 1999-06-23 | Imp Cancer Res Tech | Treatment, imaging and diagnosis of disease |
| US20020015970A1 (en) | 1999-08-11 | 2002-02-07 | Richard Murray | Novel methods of diagnosis of angiogenesis, compositions, and methods of screening for angiogenesis modulators |
| US20040009494A1 (en) | 1999-08-11 | 2004-01-15 | Richard Murray | Novel methods of diagnosis of angiogenesis and other conditions, compositions, and the methods of screening for modulators |
| US20020019330A1 (en) | 1999-08-11 | 2002-02-14 | Richard Murray | Novel methods of diagnosis of angiogenesis, compositions, and methods of screening for angiogenesis modulators |
| EP1204764A2 (en) | 1999-08-11 | 2002-05-15 | EOS Biotechnology, Inc. | Methods of screening for angiogenesis modulators |
| US20030152926A1 (en) | 1999-08-11 | 2003-08-14 | Eos Biotechnology, Inc. | Novel methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators |
| US20040259152A1 (en) | 2000-02-22 | 2004-12-23 | Richard Murray | Novel methods of diagnosing and screening for modulators of tissue remodeling and treating related diseases |
| CA2438030A1 (en) | 2001-02-14 | 2002-10-10 | Protein Design Labs | Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators |
| JP2005527180A (ja) | 2001-04-18 | 2005-09-15 | プロテイン デザイン ラブス， インコーポレイテッド | 肺がんの診断方法、肺がんの修飾因子の組成及びスクリーニングの方法 |
| AU2002314901A1 (en) | 2001-06-04 | 2002-12-16 | Eos Biotechnology, Inc. | Methods of diagnosis and treatment of androgen-dependent prostate cancer, prostate cancer undergoing androgen-withdrawal, and androgen-independent prostate cancer |
| AU2002347428A1 (en) | 2001-06-18 | 2003-01-02 | Eos Biotechnology Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| US7189507B2 (en) | 2001-06-18 | 2007-03-13 | Pdl Biopharma, Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| US20040076955A1 (en) | 2001-07-03 | 2004-04-22 | Eos Biotechnology, Inc. | Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer |
| US20040033495A1 (en) | 2001-08-03 | 2004-02-19 | Eos Biotechnology, Inc. | Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators |
| US20030124579A1 (en) | 2001-09-05 | 2003-07-03 | Eos Biotechnology, Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| WO2003025138A2 (en) | 2001-09-17 | 2003-03-27 | Protein Design Labs, Inc. | Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer |
| US20070042360A1 (en) | 2001-09-17 | 2007-02-22 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| WO2003042661A2 (en) | 2001-11-13 | 2003-05-22 | Protein Design Labs, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| US20030232350A1 (en) | 2001-11-13 | 2003-12-18 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| WO2004001384A2 (en) | 2002-06-25 | 2003-12-31 | The Regents Of The University Of California | Methods for inhibiting angiogenesis, cell migration, cell adhesion, and cell survival |
| JP4667873B2 (ja) | 2002-07-16 | 2011-04-13 | アベンティス・ファーマシューティカルズ・インコーポレイテッド | α５β１およびその細胞生存経路を調節する能力 |
| US7276589B2 (en) | 2002-11-26 | 2007-10-02 | Pdl Biopharma, Inc. | Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis |
| US7285268B2 (en) | 2002-11-26 | 2007-10-23 | Pdl Biopharma, Inc. | Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis |
| AU2003298783B2 (en) * | 2002-11-26 | 2010-11-04 | Abbvie Biotherapeutics Inc. | Chimeric and humanized antibodies to alpha5beta1 integrin that modulate angiogenesis |
| WO2004048938A2 (en) | 2002-11-26 | 2004-06-10 | Protein Design Labs, Inc. | Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators |
| CA2520121A1 (en) | 2003-04-03 | 2004-10-21 | Protein Design Labs, Inc. | Inhibitors of integrin alpha5beta1 and their use for the control of tissue granulation |
| DK1755659T3 (da) | 2004-03-24 | 2012-02-27 | Abbott Biotherapeutics Corp | Anvendelse af anti-alfa5beta1-antistoffer til inhibering af kræftcelleproliferation |
| US20060008415A1 (en) | 2004-06-25 | 2006-01-12 | Protein Design Labs, Inc. | Stable liquid and lyophilized formulation of proteins |
| CA2591148A1 (en) | 2004-12-09 | 2006-06-15 | Centocor, Inc. | Anti-integrin immunoconjugates, methods and uses |
| JP2009516730A (ja) | 2005-11-23 | 2009-04-23 | アストラゼネカ アクチボラグ | Ｌ−アラニン誘導体 |
| EP2091916A2 (en) | 2005-11-23 | 2009-08-26 | AstraZeneca AB | L-phenylalanine derivatives and their use as integrin antagonists |
| WO2007091046A1 (en) | 2006-02-09 | 2007-08-16 | Astrazeneca Ab | Chemical compounds |
| AR060040A1 (es) * | 2006-03-21 | 2008-05-21 | Genentech Inc | Antagonistas de vefg y de alfa5 beta 1 |
| MX2008014910A (es) | 2006-05-24 | 2009-01-23 | Bayer Schering Pharma Ag | Anticuerpos bloqueantes de la funcion de la integrina ?5?1 humanos y humanizados de gran afinidad con inmunogenicidad reducida. |
| TWI547503B (zh) | 2007-09-26 | 2016-09-01 | 建南德克公司 | 抗α5β1抗體、編碼其之核酸、包含其之組合物及其製造及使用方法 |
| RU2528736C2 (ru) | 2008-02-05 | 2014-09-20 | Бристоль-Мейерз Сквибб Компани | Антитела против альфа5-бета 1 и их применение |
-
2008
- 2008-09-25 TW TW097136935A patent/TWI547503B/zh not_active IP Right Cessation
- 2008-09-25 PE PE2008001669A patent/PE20091029A1/es not_active Application Discontinuation
- 2008-09-25 WO PCT/US2008/077622 patent/WO2009042746A1/en not_active Ceased
- 2008-09-25 AU AU2008304452A patent/AU2008304452B2/en not_active Ceased
- 2008-09-25 HR HRP20160308TT patent/HRP20160308T1/hr unknown
- 2008-09-25 MY MYPI20101284 patent/MY151191A/en unknown
- 2008-09-25 KR KR1020107006513A patent/KR20100065162A/ko not_active Abandoned
- 2008-09-25 DK DK08834260.5T patent/DK2200700T3/en active
- 2008-09-25 NZ NZ584838A patent/NZ584838A/xx not_active IP Right Cessation
- 2008-09-25 BR BRPI0816049A patent/BRPI0816049A2/pt not_active IP Right Cessation
- 2008-09-25 HU HUE08834260A patent/HUE027911T2/en unknown
- 2008-09-25 US US12/237,640 patent/US7973138B2/en not_active Expired - Fee Related
- 2008-09-25 MX MX2010003325A patent/MX2010003325A/es active IP Right Grant
- 2008-09-25 CL CL2008002856A patent/CL2008002856A1/es unknown
- 2008-09-25 SI SI200831589T patent/SI2200700T1/sl unknown
- 2008-09-25 AR ARP080104170A patent/AR066170A1/es unknown
- 2008-09-25 CN CN200880117702.0A patent/CN101888878B/zh not_active Expired - Fee Related
- 2008-09-25 CA CA2698609A patent/CA2698609A1/en not_active Abandoned
- 2008-09-25 EP EP08834260.5A patent/EP2200700B1/en active Active
- 2008-09-25 JP JP2010527128A patent/JP2011501656A/ja active Pending
- 2008-09-25 RU RU2010116184/10A patent/RU2490277C2/ru not_active IP Right Cessation
-
2010
- 2010-03-19 CO CO10033130A patent/CO6260094A2/es active IP Right Grant
-
2011
- 2011-05-20 US US13/112,839 patent/US8840887B2/en not_active Expired - Fee Related
- 2011-05-20 US US13/112,833 patent/US9284376B2/en not_active Expired - Fee Related
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