JP2011505875A5 - - Google Patents
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- JP2011505875A5 JP2011505875A5 JP2010539824A JP2010539824A JP2011505875A5 JP 2011505875 A5 JP2011505875 A5 JP 2011505875A5 JP 2010539824 A JP2010539824 A JP 2010539824A JP 2010539824 A JP2010539824 A JP 2010539824A JP 2011505875 A5 JP2011505875 A5 JP 2011505875A5
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- Prior art keywords
- antibody
- acid sequence
- amino acid
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 53
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- 201000005787 hematologic cancer Diseases 0.000 claims description 15
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 239000002246 antineoplastic agent Substances 0.000 claims description 14
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 11
- 150000007523 nucleic acids Chemical group 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 108091033319 polynucleotide Proteins 0.000 claims description 8
- 102000040430 polynucleotide Human genes 0.000 claims description 8
- 239000002157 polynucleotide Substances 0.000 claims description 8
- 206010009944 Colon cancer Diseases 0.000 claims description 6
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 6
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 6
- 206010017758 gastric cancer Diseases 0.000 claims description 6
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 201000002528 pancreatic cancer Diseases 0.000 claims description 6
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 6
- 201000011549 stomach cancer Diseases 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 229940127089 cytotoxic agent Drugs 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 238000004113 cell culture Methods 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 4
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 108010005832 Leukosialin Proteins 0.000 claims 2
- 102000005931 Leukosialin Human genes 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 101710112752 Cytotoxin Proteins 0.000 description 1
- 239000002619 cytotoxin Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1471607P | 2007-12-18 | 2007-12-18 | |
| US61/014,716 | 2007-12-18 | ||
| PCT/US2008/087515 WO2009079649A1 (en) | 2007-12-18 | 2008-12-18 | Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013183896A Division JP2013247963A (ja) | 2007-12-18 | 2013-09-05 | 癌細胞で発現するｃｄ−４３およびｃｅａの炭水化物含有エピトープを認識する抗体およびそれを使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011505875A JP2011505875A (ja) | 2011-03-03 |
| JP2011505875A5 true JP2011505875A5 (https=) | 2012-01-26 |
| JP5568478B2 JP5568478B2 (ja) | 2014-08-06 |
Family
ID=40578003
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010539824A Expired - Fee Related JP5568478B2 (ja) | 2007-12-18 | 2008-12-18 | 癌細胞で発現するｃｄ−４３およびｃｅａの炭水化物含有エピトープを認識する抗体およびそれを使用する方法 |
| JP2013183896A Withdrawn JP2013247963A (ja) | 2007-12-18 | 2013-09-05 | 癌細胞で発現するｃｄ−４３およびｃｅａの炭水化物含有エピトープを認識する抗体およびそれを使用する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013183896A Withdrawn JP2013247963A (ja) | 2007-12-18 | 2013-09-05 | 癌細胞で発現するｃｄ−４３およびｃｅａの炭水化物含有エピトープを認識する抗体およびそれを使用する方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7982017B2 (https=) |
| EP (1) | EP2245063B1 (https=) |
| JP (2) | JP5568478B2 (https=) |
| KR (1) | KR101672271B1 (https=) |
| CN (2) | CN101918448A (https=) |
| AU (1) | AU2008338313B2 (https=) |
| BR (1) | BRPI0820452A2 (https=) |
| CA (1) | CA2706502C (https=) |
| DK (1) | DK2245063T3 (https=) |
| ES (1) | ES2550757T3 (https=) |
| HU (1) | HUE026846T2 (https=) |
| IL (1) | IL205487A (https=) |
| NZ (1) | NZ585959A (https=) |
| RU (1) | RU2528738C2 (https=) |
| SG (1) | SG186669A1 (https=) |
| TW (1) | TWI439545B (https=) |
| WO (1) | WO2009079649A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3050963B1 (en) | 2005-03-31 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
| US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
| ES2892925T3 (es) | 2006-03-31 | 2022-02-07 | Chugai Pharmaceutical Co Ltd | Métodos para controlar la farmacocinética en sangre de anticuerpos |
| KR101496433B1 (ko) | 2006-06-07 | 2015-02-26 | 바이오얼라이언스 씨.브이. | 암세포 상에서 발현되는 ｃｄ-43 및 ｃｅａ 상의 에피토프를 함유하는 탄수화물을 인식하는 항체 및 이를 이용하는 방법 |
| WO2009032845A2 (en) | 2007-09-04 | 2009-03-12 | Compugen, Ltd. | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| AU2008304748C1 (en) | 2007-09-26 | 2014-06-12 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant region |
| KR101672271B1 (ko) | 2007-12-18 | 2016-11-03 | 바이오얼라이언스 씨.브이. | 암세포에서 발현된 ｃｄ-43 및 ｃｅａ 상의 탄수화물 함유 에피토프를 인식하는 항체 및 그것의 사용 방법 |
| TWI682995B (zh) | 2009-03-19 | 2020-01-21 | 日商中外製藥股份有限公司 | 抗體恆定區域改變體 |
| WO2010107110A1 (ja) | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
| US10150808B2 (en) | 2009-09-24 | 2018-12-11 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant regions |
| JP5889181B2 (ja) | 2010-03-04 | 2016-03-22 | 中外製薬株式会社 | 抗体定常領域改変体 |
| KR101244708B1 (ko) | 2010-10-07 | 2013-03-18 | 기아자동차주식회사 | 측면 조립형 트랜스미션 마운트 |
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| KR20140126357A (ko) | 2012-02-01 | 2014-10-30 | 컴퓨젠 엘티디. | C1orf32 항체 및 이의 암 치료를 위한 용도 |
| CN104837502B (zh) | 2012-10-12 | 2018-08-10 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其结合物 |
| RU2015129800A (ru) | 2012-12-21 | 2017-01-30 | Биоэллаенс К. В. | Гидрофильные саморазрушающиеся линкеры и их конъюгаты |
| CA2905181C (en) | 2013-03-13 | 2020-06-02 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy |
| JP6534615B2 (ja) | 2013-09-27 | 2019-06-26 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| EP2871190A1 (en) * | 2013-11-11 | 2015-05-13 | ATLAB Pharma | Antibody against GD2-O-acetylated ganglioside with pro-apoptotic activity |
| SG11201610620UA (en) | 2014-06-20 | 2017-01-27 | Bioalliance Cv | Anti-folate receptor aplha (fra) antibody-drug conjugates and methods of using thereof |
| JP6531166B2 (ja) | 2014-09-10 | 2019-06-12 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン及びそのコンジュゲート |
| JP7082484B2 (ja) | 2015-04-01 | 2022-06-08 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| CA2989551A1 (en) * | 2015-06-24 | 2016-12-29 | Aimm Therapeutics B.V. | Aml antigens and uses thereof |
| WO2017065493A1 (ko) | 2015-10-12 | 2017-04-20 | 다이노나(주) | 항-cd43 항체 및 이의 암 치료 용도 |
| US20180363000A1 (en) * | 2015-12-14 | 2018-12-20 | The Trustees Of The University Of Pennsylvania | Aav-anti pcsk9 antibody constructs and uses thereof |
| CN108368166B (zh) | 2015-12-28 | 2023-03-28 | 中外制药株式会社 | 提高含fc区多肽纯化效率的方法 |
| SG11201805557SA (en) | 2016-01-08 | 2018-07-30 | Bioalliance Cv | Tetravalent anti-psgl-1 antibodies and uses thereof |
| CN109862919A (zh) | 2016-10-11 | 2019-06-07 | 免疫医疗有限公司 | 抗体-药物缀合物联合免疫介导的治疗剂 |
| EP3697814A1 (en) * | 2017-10-16 | 2020-08-26 | Eisai R&D Management Co., Ltd. | Anti-tau antibodies and uses thereof |
| US12054558B2 (en) * | 2018-05-23 | 2024-08-06 | The Jackson Laboratory | Anti-NGly-1 antibodies and methods of use |
| CA3098103A1 (en) | 2018-05-23 | 2019-11-28 | Adc Therapeutics Sa | Molecular adjuvant |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020132190A1 (en) | 2018-12-21 | 2020-06-25 | Multitude Inc. | Antibodies specific to muc18 |
| CN117343187A (zh) * | 2018-12-21 | 2024-01-05 | 普众发现医药科技(上海)有限公司 | 对muc18特异性的抗体 |
| WO2021081515A2 (en) * | 2019-10-25 | 2021-04-29 | Cidara Therapeutics, Inc. | Compositions and methods for the treatment of human immunodeficiency virus |
| US20230372528A1 (en) | 2020-10-16 | 2023-11-23 | University Of Georgia Research Foundation, Inc. | Glycoconjugates |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
| WO2023091958A1 (en) | 2021-11-17 | 2023-05-25 | Altrubio Inc. | Methods of using anti-psgl-1 antibodies in combination with jak inhibitors to treat t-cell mediated inflammatory diseases or cancers |
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2008
- 2008-12-18 KR KR1020107011796A patent/KR101672271B1/ko not_active Expired - Fee Related
- 2008-12-18 CN CN2008801215817A patent/CN101918448A/zh active Pending
- 2008-12-18 NZ NZ585959A patent/NZ585959A/xx not_active IP Right Cessation
- 2008-12-18 WO PCT/US2008/087515 patent/WO2009079649A1/en not_active Ceased
- 2008-12-18 RU RU2010129423/10A patent/RU2528738C2/ru not_active IP Right Cessation
- 2008-12-18 JP JP2010539824A patent/JP5568478B2/ja not_active Expired - Fee Related
- 2008-12-18 TW TW097149465A patent/TWI439545B/zh not_active IP Right Cessation
- 2008-12-18 BR BRPI0820452-7A patent/BRPI0820452A2/pt not_active Application Discontinuation
- 2008-12-18 EP EP08863057.9A patent/EP2245063B1/en not_active Not-in-force
- 2008-12-18 CN CN201610109151.XA patent/CN105732813A/zh active Pending
- 2008-12-18 US US12/338,934 patent/US7982017B2/en not_active Expired - Fee Related
- 2008-12-18 DK DK08863057.9T patent/DK2245063T3/en active
- 2008-12-18 SG SG2012093167A patent/SG186669A1/en unknown
- 2008-12-18 ES ES08863057.9T patent/ES2550757T3/es active Active
- 2008-12-18 AU AU2008338313A patent/AU2008338313B2/en not_active Ceased
- 2008-12-18 CA CA2706502A patent/CA2706502C/en not_active Expired - Fee Related
- 2008-12-18 HU HUE08863057A patent/HUE026846T2/en unknown
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2010
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2011
- 2011-06-08 US US13/156,233 patent/US8568718B2/en not_active Expired - Fee Related
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- 2013-09-24 US US14/035,731 patent/US9334329B2/en not_active Expired - Fee Related
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