JP2019505564A5 - - Google Patents
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- JP2019505564A5 JP2019505564A5 JP2018544769A JP2018544769A JP2019505564A5 JP 2019505564 A5 JP2019505564 A5 JP 2019505564A5 JP 2018544769 A JP2018544769 A JP 2018544769A JP 2018544769 A JP2018544769 A JP 2018544769A JP 2019505564 A5 JP2019505564 A5 JP 2019505564A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- amino acid
- host cell
- binding moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562255255P | 2015-11-13 | 2015-11-13 | |
| US62/255,255 | 2015-11-13 | ||
| US201562257493P | 2015-11-19 | 2015-11-19 | |
| US62/257,493 | 2015-11-19 | ||
| PCT/US2016/061320 WO2017083511A1 (en) | 2015-11-13 | 2016-11-10 | Anti-bcma polypeptides and proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019505564A JP2019505564A (ja) | 2019-02-28 |
| JP2019505564A5 true JP2019505564A5 (https=) | 2019-12-19 |
| JP6901493B2 JP6901493B2 (ja) | 2021-07-14 |
Family
ID=57354453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544769A Active JP6901493B2 (ja) | 2015-11-13 | 2016-11-10 | 抗ｂｃｍａポリペプチド及びタンパク質 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10925969B2 (https=) |
| EP (1) | EP3374396A1 (https=) |
| JP (1) | JP6901493B2 (https=) |
| KR (1) | KR102776145B1 (https=) |
| CN (1) | CN108473575B (https=) |
| AU (1) | AU2016353067B2 (https=) |
| CA (1) | CA3005042A1 (https=) |
| WO (1) | WO2017083511A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2766608C2 (ru) | 2012-04-11 | 2022-03-15 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток |
| RS61907B1 (sr) | 2015-04-06 | 2021-06-30 | Subdomain Llc | Polipeptidi koji sadrže de novo vezujući domen i njihova primena |
| CN108778329B (zh) | 2016-02-17 | 2022-09-16 | 西雅图基因公司 | Bcma抗体和其用以治疗癌症和免疫病症的用途 |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| MX2019013514A (es) | 2017-05-12 | 2020-01-20 | Crispr Therapeutics Ag | Materiales y metodos para modificar celulas por ingenieria genetica y usos de los mismos en inmunooncologia. |
| US11464803B2 (en) | 2017-11-14 | 2022-10-11 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
| RS67119B1 (sr) * | 2017-11-14 | 2025-09-30 | Arcellx Inc | Polipeptidi koji obuhvataju d domen i njihove upotrebe |
| KR20250070609A (ko) | 2017-11-14 | 2025-05-20 | 아르셀엑스, 인크. | 다기능성 면역 세포 요법 |
| US11807663B2 (en) * | 2018-02-01 | 2023-11-07 | Innovent Biologics (Suzhou) Co., Ltd. | Fully humanized anti-B cell maturation antigen (BCMA) single-chain antibody and use thereof |
| BR112020017053A2 (pt) * | 2018-02-21 | 2020-12-15 | Celgene Corporation | Anticorpos que se ligam ao bcma e usos dos mesmos |
| MX2020012028A (es) | 2018-05-11 | 2021-03-29 | Crispr Therapeutics Ag | Metodos y composiciones para tratar el cancer. |
| EP3777895A4 (en) * | 2018-06-26 | 2021-12-22 | ABL Bio Inc. | ANTI-BCMA ANTIBODIES AND ASSOCIATED USE |
| MD3823665T2 (ro) | 2018-07-19 | 2024-05-31 | Regeneron Pharma | Receptori antigenci chimerici cu specificitate BCMA și utilizările acestora |
| TWI838389B (zh) | 2018-07-19 | 2024-04-11 | 美商再生元醫藥公司 | 雙特異性抗-BCMAｘ抗-CD3抗體及其用途 |
| MA53732A (fr) * | 2018-09-28 | 2022-01-05 | Amgen Inc | Anticorps dirigés contre bcma soluble |
| CN109503716B (zh) * | 2018-10-08 | 2021-04-27 | 浙江生研生物科技有限公司 | 一种双特异性嵌合抗原受体分子及其在肿瘤治疗上的应用 |
| CN112805302B (zh) * | 2018-10-10 | 2023-01-31 | 深圳华大生命科学研究院 | 抗BCMA单链抗体scFv及其制备方法和应用 |
| EP3873937A2 (en) | 2018-11-01 | 2021-09-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for g protein-coupled receptor class c group 5 member d (gprc5d) |
| MX2021013359A (es) | 2019-04-30 | 2022-01-31 | Crispr Therapeutics Ag | Terapia de celulas alogénicas de neoplasias malignas de células b usando células t modificadas genéticamente dirigidas a cd19. |
| MX2022001065A (es) * | 2019-07-30 | 2022-02-14 | Shanghai Hansoh Biomedical Co Ltd | Anticuerpo anti-bcma, fragmento de union al antigeno y uso medico del mismo. |
| CN112409482B (zh) * | 2019-08-20 | 2022-08-26 | 杭州尚健生物技术有限公司 | Bcma抗体 |
| WO2021190564A1 (zh) * | 2020-03-26 | 2021-09-30 | 上海翰森生物医药科技有限公司 | 抗体药物偶联物及其医药用途 |
| JP2025525937A (ja) | 2022-08-05 | 2025-08-07 | ジュノー セラピューティクス インコーポレイテッド | Ｇｐｒｃ５ｄおよびｂｃｍａに特異的なキメラ抗原受容体 |
| WO2024051796A1 (en) * | 2022-09-09 | 2024-03-14 | Wuxi Biologics (Shanghai) Co., Ltd. | Albumin binding proteins, fusion proteins and uses thereof |
| CN117164714B (zh) * | 2023-10-08 | 2024-04-23 | 北京奇迈永华生物科技有限公司 | 一种靶向bcma的抗体及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4892827A (en) | 1986-09-24 | 1990-01-09 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects |
| DK0531434T3 (da) | 1990-05-11 | 2000-01-31 | Us Health | Forbedrede Pseudomonas-exotoksiner med lav dyretoksicitet og høj cytocidal aktivitet |
| US5608039A (en) | 1990-10-12 | 1997-03-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Single chain B3 antibody fusion proteins and their uses |
| WO1993025690A1 (en) | 1992-06-18 | 1993-12-23 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant pseudomonas exotoxin with increased activity |
| UA74798C2 (uk) * | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| US8188223B2 (en) | 2005-05-18 | 2012-05-29 | Ablynx N.V. | Serum albumin binding proteins |
| ES2372537T3 (es) | 2005-07-29 | 2012-01-23 | The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services | Exotoxinas de pseudomonas mutadas con antigenicidad reducida. |
| WO2009032954A1 (en) | 2007-09-04 | 2009-03-12 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Deletions in domain ii of pseudomonas exotoxin a that reduce non-specific toxicity |
| GB0821806D0 (en) | 2008-11-28 | 2009-01-07 | Circassia Ltd | Compositions with reduced dimer formation |
| MX341884B (es) | 2009-03-10 | 2016-09-07 | Biogen Ma Inc | Anticuerpos anti-antigeno de maduracion de celulas b (bcma). |
| ES2544805T3 (es) | 2009-09-11 | 2015-09-04 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Exotoxina A de Pseudomonas mejorada con inmunogenicidad reducida |
| EP2488200A4 (en) * | 2009-10-14 | 2013-06-12 | Merck Sharp & Dohme | APRIL ANTAGONISTS AND METHOD FOR THEIR USE |
| KR101972446B1 (ko) * | 2011-05-27 | 2019-04-25 | 글락소 그룹 리미티드 | Ｂｃｍａ（ｃｄ２６９／ｔｎｆｒｓｆ１７）결합 단백질 |
| KR20140033391A (ko) | 2011-06-09 | 2014-03-18 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 면역원성이 보다 낮은 t 세포 및/또는 b 세포 에피토프를 갖는 슈도모나스 외독소 a |
| AU2012308591B2 (en) | 2011-09-16 | 2017-02-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Pseudomonas exotoxin a with less immunogenic B cell epitopes |
| RU2766608C2 (ru) * | 2012-04-11 | 2022-03-15 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток |
| WO2014068079A1 (en) | 2012-11-01 | 2014-05-08 | Max-Delbrück-Centrum für Molekulare Medizin | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
| TW201425336A (zh) * | 2012-12-07 | 2014-07-01 | Amgen Inc | Ｂｃｍａ抗原結合蛋白質 |
| WO2015051199A2 (en) | 2013-10-06 | 2015-04-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modified pseudomonas exotoxin a |
| BR112017001183A2 (pt) * | 2014-07-21 | 2017-11-28 | Novartis Ag | tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado |
-
2016
- 2016-11-10 CN CN201680065438.5A patent/CN108473575B/zh active Active
- 2016-11-10 CA CA3005042A patent/CA3005042A1/en active Pending
- 2016-11-10 KR KR1020187016668A patent/KR102776145B1/ko active Active
- 2016-11-10 JP JP2018544769A patent/JP6901493B2/ja active Active
- 2016-11-10 AU AU2016353067A patent/AU2016353067B2/en active Active
- 2016-11-10 WO PCT/US2016/061320 patent/WO2017083511A1/en not_active Ceased
- 2016-11-10 EP EP16798612.4A patent/EP3374396A1/en not_active Ceased
- 2016-11-10 US US15/773,687 patent/US10925969B2/en active Active
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