JP2011505369A5 - - Google Patents

Info

Publication number

JP2011505369A5

JP2011505369A5 JP2010536162A JP2010536162A JP2011505369A5 JP 2011505369 A5 JP2011505369 A5 JP 2011505369A5 JP 2010536162 A JP2010536162 A JP 2010536162A JP 2010536162 A JP2010536162 A JP 2010536162A JP 2011505369 A5 JP2011505369 A5 JP 2011505369A5

Authority

JP

Japan

Prior art keywords

polysaccharide

biocompatible

sulfate

target solute

gel composition

Prior art date

2008-11-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 150000004676 glycans Chemical class 0.000 claims 20
• 229920001282 polysaccharide Polymers 0.000 claims 20
• 239000005017 polysaccharide Substances 0.000 claims 20
• 238000000034 method Methods 0.000 claims 8
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 6
• 229920002674 hyaluronan Polymers 0.000 claims 6
• 229960003160 hyaluronic acid Drugs 0.000 claims 6
• 229960002117 triamcinolone acetonide Drugs 0.000 claims 5
• YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical group C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 claims 5
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 4
• 238000013268 sustained release Methods 0.000 claims 3
• 239000012730 sustained-release form Substances 0.000 claims 3
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 2
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
• 229920001661 Chitosan Polymers 0.000 claims 2
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 2
• 229920000045 Dermatan sulfate Polymers 0.000 claims 2
• 229920002971 Heparan sulfate Polymers 0.000 claims 2
• 102000011782 Keratins Human genes 0.000 claims 2
• 108010076876 Keratins Proteins 0.000 claims 2
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
• 229940072056 alginate Drugs 0.000 claims 2
• 229920000615 alginic acid Polymers 0.000 claims 2
• 235000010443 alginic acid Nutrition 0.000 claims 2
• 229940045110 chitosan Drugs 0.000 claims 2
• 229940059329 chondroitin sulfate Drugs 0.000 claims 2
• 238000004132 cross linking Methods 0.000 claims 2
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 2
• 229940051593 dermatan sulfate Drugs 0.000 claims 2
• 229960000633 dextran sulfate Drugs 0.000 claims 2
• -1 dextran sulfate Chemical compound 0.000 claims 2
• 229920000669 heparin Polymers 0.000 claims 2
• 229960002897 heparin Drugs 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000011159 matrix material Substances 0.000 claims 2
• 230000003750 conditioning effect Effects 0.000 claims 1
• 239000003431 cross linking reagent Substances 0.000 claims 1
• 238000009826 distribution Methods 0.000 claims 1