JP2011504169A5 - - Google Patents

Info

Publication number

JP2011504169A5

JP2011504169A5 JP2010532496A JP2010532496A JP2011504169A5 JP 2011504169 A5 JP2011504169 A5 JP 2011504169A5 JP 2010532496 A JP2010532496 A JP 2010532496A JP 2010532496 A JP2010532496 A JP 2010532496A JP 2011504169 A5 JP2011504169 A5 JP 2011504169A5

Authority

JP

Japan

Prior art keywords

carrier

solid phase

biological material

fragments

phase coating

Prior art date

2008-11-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000012634 fragment Substances 0.000 claims 13
• 239000011248 coating agent Substances 0.000 claims 11
• 238000000576 coating method Methods 0.000 claims 11
• 239000012620 biological material Substances 0.000 claims 10
• 238000000034 method Methods 0.000 claims 10
• 239000007790 solid phase Substances 0.000 claims 9
• 239000000203 mixture Substances 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 241000203069 Archaea Species 0.000 claims 4
• 239000002202 Polyethylene glycol Substances 0.000 claims 4
• 241000700605 Viruses Species 0.000 claims 4
• 210000003527 eukaryotic cell Anatomy 0.000 claims 4
• 229920001223 polyethylene glycol Polymers 0.000 claims 4
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
• 239000007864 aqueous solution Substances 0.000 claims 3
• 239000008280 blood Substances 0.000 claims 3
• 210000004369 blood Anatomy 0.000 claims 3
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 210000004880 lymph fluid Anatomy 0.000 claims 3
• 230000001954 sterilising effect Effects 0.000 claims 3
• 239000000126 substance Substances 0.000 claims 3
• 241000894006 Bacteria Species 0.000 claims 2
• IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 2
• 108091034117 Oligonucleotide Proteins 0.000 claims 2
• 229910019142 PO4 Inorganic materials 0.000 claims 2
• BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims 2
• 229920002472 Starch Polymers 0.000 claims 2
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 230000005250 beta ray Effects 0.000 claims 2
• 230000027455 binding Effects 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 230000005251 gamma ray Effects 0.000 claims 2
• 150000004676 glycans Chemical class 0.000 claims 2
• 239000003550 marker Substances 0.000 claims 2
• 244000052769 pathogen Species 0.000 claims 2
• 230000001717 pathogenic effect Effects 0.000 claims 2
• 235000021317 phosphate Nutrition 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• 229920001282 polysaccharide Polymers 0.000 claims 2
• 239000005017 polysaccharide Substances 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 229910000077 silane Inorganic materials 0.000 claims 2
• 239000000243 solution Substances 0.000 claims 2
• 235000019698 starch Nutrition 0.000 claims 2
• 238000004659 sterilization and disinfection Methods 0.000 claims 2
• 235000000346 sugar Nutrition 0.000 claims 2
• 230000003612 virological effect Effects 0.000 claims 2
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
• 235000001014 amino acid Nutrition 0.000 claims 1
• 210000001124 body fluid Anatomy 0.000 claims 1
• 239000010839 body fluid Substances 0.000 claims 1
• 238000004140 cleaning Methods 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 238000001914 filtration Methods 0.000 claims 1
• 230000002779 inactivation Effects 0.000 claims 1
• 239000002608 ionic liquid Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000011159 matrix material Substances 0.000 claims 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
• 239000010452 phosphate Substances 0.000 claims 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 230000009870 specific binding Effects 0.000 claims 1
• 239000008107 starch Substances 0.000 claims 1
• 150000005846 sugar alcohols Polymers 0.000 claims 1
• 150000008163 sugars Chemical class 0.000 claims 1