JP2011503110A5 - - Google Patents
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- Publication number
- JP2011503110A5 JP2011503110A5 JP2010533331A JP2010533331A JP2011503110A5 JP 2011503110 A5 JP2011503110 A5 JP 2011503110A5 JP 2010533331 A JP2010533331 A JP 2010533331A JP 2010533331 A JP2010533331 A JP 2010533331A JP 2011503110 A5 JP2011503110 A5 JP 2011503110A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- inflammatory effect
- hydroxyl
- hydrogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 20
- 241001465754 Metazoa Species 0.000 claims description 9
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 4
- 230000005764 inhibitory process Effects 0.000 claims description 4
- 102000003945 NF-kappa B Human genes 0.000 claims description 3
- 108010057466 NF-kappa B Proteins 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 230000023404 leukocyte cell-cell adhesion Effects 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- -1 heterocyclic amine Chemical class 0.000 claims description 2
- 150000002576 ketones Chemical class 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US261107P | 2007-11-09 | 2007-11-09 | |
| US61/002,611 | 2007-11-09 | ||
| PCT/US2008/083068 WO2009062200A1 (en) | 2007-11-09 | 2008-11-10 | Anti-inflammatory quinic acid derivatives for oral administration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011503110A JP2011503110A (ja) | 2011-01-27 |
| JP2011503110A5 true JP2011503110A5 (enExample) | 2011-10-06 |
| JP5660898B2 JP5660898B2 (ja) | 2015-01-28 |
Family
ID=40626242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010533331A Expired - Fee Related JP5660898B2 (ja) | 2007-11-09 | 2008-11-10 | 経口投与用の抗炎症性キナ酸誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8115031B2 (enExample) |
| EP (1) | EP2219445A4 (enExample) |
| JP (1) | JP5660898B2 (enExample) |
| AU (1) | AU2008323683B2 (enExample) |
| CA (1) | CA2713394C (enExample) |
| WO (1) | WO2009062200A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284799B (zh) * | 2007-03-23 | 2013-04-03 | 浙江医药股份有限公司新昌制药厂 | 咖啡酰奎宁酸含氮衍生物及其制备方法和其药物组合物及用途 |
| WO2010132504A1 (en) | 2009-05-11 | 2010-11-18 | University Of Tennessee Research Foundation | Anti-inflammatory quinic acid derivatives for radioprotection/radiomitigation |
| US10369133B2 (en) | 2013-07-23 | 2019-08-06 | The University Of Tennessee Research Foundation | Immunosuppressive compounds and therapeutics |
| TWI481600B (zh) * | 2013-07-24 | 2015-04-21 | Nat Applied Res Laboratories | 一種奎尼酸衍生物、其製程及其用途 |
| US11883457B1 (en) | 2022-09-06 | 2024-01-30 | Optigenex Inc. | Method of enhancing cognition in individuals with at least normal cognition |
| CN117547562A (zh) * | 2023-05-09 | 2024-02-13 | 北京农学院 | 一种用于抗炎的虎耳草提取物及其制备方法和用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017A (en) * | 1849-01-09 | Die for bending ttjbe-skelps | ||
| US7020A (en) * | 1850-01-15 | Improvement in harvesting-mac mines | ||
| US2918477A (en) * | 1954-12-28 | 1959-12-22 | Alberti Carlo Giuseppe | Caffeic esters of quinic acid and quinic acid amide and syntheses thereof |
| US2866734A (en) * | 1956-12-05 | 1958-12-30 | Us Vitamin Corp | 3-pyridylethyl 2, 4-oxazolidinediones and process |
| GB1460593A (en) * | 1973-06-22 | 1977-01-06 | Ici Ltd | Ethanolamine derivatives |
| US3968211A (en) * | 1974-02-11 | 1976-07-06 | The Upjohn Company | Compositions and methods of use of amidines for anti-arrhythmic purposes |
| GB1476351A (en) * | 1974-04-17 | 1977-06-10 | Wilkinson Sword Ltd | Compounds having a physiological cooling effect and compo sitions containing them |
| US4582855A (en) * | 1981-11-12 | 1986-04-15 | American Hospital Supply Corporation | Aromatic and esters of hydroxypropylamines |
| JPS61251616A (ja) * | 1985-04-30 | 1986-11-08 | Agency Of Ind Science & Technol | 溶質の放出量の制御方法 |
| HU906340D0 (en) * | 1986-10-13 | 1991-04-29 | Sandoz Ag | Synthesis in solid phase for producing peptonic alcohols |
| US6964784B2 (en) * | 2002-03-07 | 2005-11-15 | Optigenex, Inc. | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals |
| WO2005035534A1 (ja) * | 2003-10-08 | 2005-04-21 | Ono Pharmaceutical Co., Ltd. | 複素ビシクロ環および複素トリシクロ環化合物およびその医薬 |
| US7482378B2 (en) * | 2004-05-28 | 2009-01-27 | Millenium Specialty Chemicals, Inc. | Physiological cooling compositions |
| US8436006B2 (en) * | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| WO2007103719A2 (en) * | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| CN101400660A (zh) * | 2006-03-16 | 2009-04-01 | 安斯泰来制药有限公司 | 三唑衍生物或其盐 |
| CN101284799B (zh) * | 2007-03-23 | 2013-04-03 | 浙江医药股份有限公司新昌制药厂 | 咖啡酰奎宁酸含氮衍生物及其制备方法和其药物组合物及用途 |
-
2008
- 2008-11-10 AU AU2008323683A patent/AU2008323683B2/en not_active Ceased
- 2008-11-10 CA CA2713394A patent/CA2713394C/en not_active Expired - Fee Related
- 2008-11-10 JP JP2010533331A patent/JP5660898B2/ja not_active Expired - Fee Related
- 2008-11-10 WO PCT/US2008/083068 patent/WO2009062200A1/en not_active Ceased
- 2008-11-10 EP EP08847594.2A patent/EP2219445A4/en not_active Withdrawn
- 2008-11-10 US US12/268,432 patent/US8115031B2/en not_active Expired - Fee Related
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