JP2010535814A5 - - Google Patents
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- Publication number
- JP2010535814A5 JP2010535814A5 JP2010520325A JP2010520325A JP2010535814A5 JP 2010535814 A5 JP2010535814 A5 JP 2010535814A5 JP 2010520325 A JP2010520325 A JP 2010520325A JP 2010520325 A JP2010520325 A JP 2010520325A JP 2010535814 A5 JP2010535814 A5 JP 2010535814A5
- Authority
- JP
- Japan
- Prior art keywords
- motomeko
- opiate
- active ingredient
- side effects
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004480 active ingredient Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229940127240 opiate Drugs 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 206010010774 Constipation Diseases 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 206010028817 Nausea and vomiting symptoms Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 206010046555 Urinary retention Diseases 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000003871 intestinal function Effects 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95496007P | 2007-08-09 | 2007-08-09 | |
| US60/954,960 | 2007-08-09 | ||
| PCT/US2008/072632 WO2009023567A1 (en) | 2007-08-09 | 2008-08-08 | Quaternary opioid carboxamides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535814A JP2010535814A (ja) | 2010-11-25 |
| JP2010535814A5 true JP2010535814A5 (enExample) | 2011-09-22 |
| JP5581211B2 JP5581211B2 (ja) | 2014-08-27 |
Family
ID=39941437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520325A Active JP5581211B2 (ja) | 2007-08-09 | 2008-08-08 | 第四級オピオイドカルボキサミド |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US8263807B2 (enExample) |
| EP (1) | EP2190819B1 (enExample) |
| JP (1) | JP5581211B2 (enExample) |
| KR (1) | KR101519682B1 (enExample) |
| CN (1) | CN101827819B (enExample) |
| AU (1) | AU2008286979B2 (enExample) |
| BR (1) | BRPI0815020A2 (enExample) |
| CA (1) | CA2694497C (enExample) |
| EA (1) | EA020658B1 (enExample) |
| ES (1) | ES2586245T3 (enExample) |
| IL (1) | IL203459A (enExample) |
| MX (1) | MX2010001371A (enExample) |
| NO (1) | NO341089B1 (enExample) |
| WO (1) | WO2009023567A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010006027A (es) | 2007-11-30 | 2010-12-21 | Purdue Pharma Lp | Compuestos benzomorfano. |
| WO2010107457A1 (en) * | 2009-03-19 | 2010-09-23 | Alkermes, Inc. | Morphinan derivatives with high oral bioavailability |
| LT2506712T (lt) * | 2009-12-04 | 2019-06-25 | Alkermes Pharma Ireland Limited | Morfinano dariniai, skirti narkotinių medžiagų perdozavimo gydymui |
| US8436175B2 (en) * | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
| NZ605234A (en) * | 2010-07-08 | 2015-02-27 | Alkermes Pharma Ireland Ltd | Process for the synthesis of substituted morphinans |
| EP2407469A1 (en) * | 2010-07-13 | 2012-01-18 | Chemo Ibérica, S.A. | Salt of sitagliptin |
| SMT202400030T1 (it) | 2010-08-23 | 2024-03-13 | Alkermes Pharma Ireland Ltd | Metodi per trattare l'aumento di peso indotto da antipsicotici |
| US20120245193A1 (en) * | 2011-02-14 | 2012-09-27 | Alkermes, Inc. | PERIPHERIALLY ACTING μ OPIOID ANTAGONISTS |
| BR112013022504A8 (pt) * | 2011-03-03 | 2018-01-23 | Cadila Healthcare Ltd | sal de gentisato, de adipato, de ácido trifluoroacético, forma cristalina de hidrocloreto, forma cristalina de besilato, besilato amórfico e processos para a preparação dos mesmos |
| US9029543B2 (en) * | 2011-04-05 | 2015-05-12 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
| US8962646B2 (en) | 2011-06-29 | 2015-02-24 | Alkermes, Inc. | Peripherally acting opioid compounds |
| EP2788358B1 (en) * | 2011-12-08 | 2018-08-29 | Purdue Pharma LP | Quaternized buprenorphine analogs |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| ES2692771T3 (es) | 2011-12-15 | 2018-12-05 | Alkermes Pharma Ireland Limited | Samidorfano (ALKS 33) en combinación con buprenorfina para el tratamiento de trastornos depresivos |
| US20140066475A1 (en) | 2012-09-04 | 2014-03-06 | Euro-Celtique S.A. | Method For Treating Pruritus |
| EP3003311A2 (en) | 2013-05-24 | 2016-04-13 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
| AU2014268361B2 (en) * | 2013-05-24 | 2018-09-06 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
| WO2016138103A1 (en) * | 2015-02-25 | 2016-09-01 | Alkermes, Inc. | Treatments for alzheimer's related diseases and disorders |
| CN113248435B (zh) * | 2020-02-13 | 2024-06-04 | 上海翰森生物医药科技有限公司 | 3-甲酰胺基-4-羟基纳曲酮氘代衍生物、其制备方法及其在医药上的应用 |
| EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
| CN115521317B (zh) * | 2021-02-02 | 2025-07-25 | 山东新时代药业有限公司 | 一种制备纳呋拉啡中间体的方法 |
| WO2025104754A1 (en) * | 2023-11-17 | 2025-05-22 | Msn Laboratories Private Limited, R&D Center | A process for the preparation of samidorphan and its intermediates |
| CN118598813B (zh) * | 2024-08-08 | 2024-10-29 | 山东齐都药业有限公司 | L-苹果酸萨米多芬及其制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES252980A1 (es) * | 1958-10-30 | 1960-11-01 | Boehringer Sohn Ingelheim | Procedimiento para la obtencion de nuevas sales cuaternarias, terapéuticamente valiosas, de la normorfina y de sus derivados |
| DE2254298A1 (de) | 1972-11-06 | 1974-05-16 | Boehringer Sohn Ingelheim | Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| US4032529A (en) * | 1974-09-20 | 1977-06-28 | Sterling Drug Inc. | Aminomethanobenzazocine intermediates |
| GB1511319A (en) * | 1974-09-20 | 1978-05-17 | Sterling Drug Inc | 2,6-methane-3-benzazocine derivatives and their preparation |
| US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| FR2514644A1 (fr) | 1981-10-19 | 1983-04-22 | Sanofi Sa | Composition pharmaceutique a action antagoniste peripherique des opiaces |
| CA1315689C (en) * | 1987-09-03 | 1993-04-06 | Leon I. Goldberg | Quarternary derivatives of noroxymorphone which relieve nausea and emesis |
| KR19990077125A (ko) | 1996-01-10 | 1999-10-25 | 파올로 비지, 엔리꼬 카쭐라니 | 헤테로고리-축합 모르핀 유도체 (ⅱ) |
| ES2121553B1 (es) * | 1996-12-23 | 1999-06-16 | Univ Santiago Compostela | Nuevos endoperoxidos morfinicos funcionalizados en posiciones c-6 y c-14 del anillo c y procedimiento para su obtencion. |
| WO2001014382A1 (en) * | 1999-08-23 | 2001-03-01 | Toray Industries, Inc. | Analgesics containing as the active ingredient quaternary ammonium salt derivatives of morphinan |
| CA2380524A1 (en) * | 1999-08-25 | 2001-03-01 | Barrett R. Cooper | Compositions and methods for treating opiate intolerance |
| WO2001037785A2 (en) | 1999-11-29 | 2001-05-31 | Adolor Corporation | Novel methods and compositions involving opioids and antagonists thereof |
| ES2304477T3 (es) | 2000-10-31 | 2008-10-16 | Rensselaer Polytechnic Institute | Procedimiento de preparacion de compuestos con afinidad a receptores opioides. |
| US7375082B2 (en) | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| DE10229842A1 (de) | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
| CN100387600C (zh) * | 2002-09-25 | 2008-05-14 | 欧洲凯尔特股份有限公司 | N-取代的氢吗啡酮及其用途 |
| PT1562953E (pt) * | 2002-11-08 | 2009-11-19 | Mallinckrodt Inc | Processo para a preparação de sais quaternários de n -alquilmorfinano |
| ATE557006T1 (de) | 2004-11-05 | 2012-05-15 | Rensselaer Polytech Inst | 4-hydroxybenzomorphane |
| ES2714198T3 (es) | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
| AU2006272773B2 (en) | 2005-07-21 | 2012-03-08 | Rensselaer Polytechnic Institute | 8-carboxamido-substituted-2 , 6-methano-3-benzazocines and 3 - carboxamido- substituted morphanes as opioid receptor binding agents |
| WO2007022535A2 (en) * | 2005-08-19 | 2007-02-22 | Pharmacofore, Inc. | Prodrugs of active agents |
-
2008
- 2008-08-08 JP JP2010520325A patent/JP5581211B2/ja active Active
- 2008-08-08 WO PCT/US2008/072632 patent/WO2009023567A1/en not_active Ceased
- 2008-08-08 AU AU2008286979A patent/AU2008286979B2/en active Active
- 2008-08-08 EP EP08797495.2A patent/EP2190819B1/en active Active
- 2008-08-08 KR KR1020107005151A patent/KR101519682B1/ko active Active
- 2008-08-08 CA CA2694497A patent/CA2694497C/en active Active
- 2008-08-08 CN CN2008801024294A patent/CN101827819B/zh active Active
- 2008-08-08 EA EA201070237A patent/EA020658B1/ru active IP Right Revival
- 2008-08-08 MX MX2010001371A patent/MX2010001371A/es active IP Right Grant
- 2008-08-08 ES ES08797495.2T patent/ES2586245T3/es active Active
- 2008-08-08 US US12/188,814 patent/US8263807B2/en active Active
- 2008-08-08 BR BRPI0815020-6A2A patent/BRPI0815020A2/pt not_active Application Discontinuation
-
2010
- 2010-03-02 NO NO20100289A patent/NO341089B1/no unknown
-
2012
- 2012-08-09 US US13/570,925 patent/US8563572B2/en active Active
-
2013
- 2013-04-02 IL IL203459A patent/IL203459A/en active IP Right Grant
- 2013-09-27 US US14/039,175 patent/US20140107143A1/en not_active Abandoned
-
2016
- 2016-05-09 US US15/149,594 patent/US20170095469A1/en not_active Abandoned
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