GB874217A - Normorphine derivatives - Google Patents

Normorphine derivatives

Info

Publication number
GB874217A
GB874217A GB36582/59A GB3658259A GB874217A GB 874217 A GB874217 A GB 874217A GB 36582/59 A GB36582/59 A GB 36582/59A GB 3658259 A GB3658259 A GB 3658259A GB 874217 A GB874217 A GB 874217A
Authority
GB
United Kingdom
Prior art keywords
allyl
propyl
represent
different
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB36582/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ILSE LIEBRECHT
JULIUS LIEBRECHT
WALTER MAYER LIST
WALTER MAYER-LIST
Original Assignee
ILSE LIEBRECHT
JULIUS LIEBRECHT
WALTER MAYER LIST
WALTER MAYER-LIST
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ILSE LIEBRECHT, JULIUS LIEBRECHT, WALTER MAYER LIST, WALTER MAYER-LIST filed Critical ILSE LIEBRECHT
Publication of GB874217A publication Critical patent/GB874217A/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises quaternary salts having a cation of the general formula <FORM:0874217/IV (b)/1> (wherein R and R1 are the same or different and each represent a hydrogen atom or a C1-C3 acyl group, and R1 and R2 are the same or different and each represent an allyl, propyl or propargyl group) in association with a non-toxic anion, the preparation of those containing a halide anion by reacting normorphine or N-propyl-, N-allyl- or N-propargyl-normorphine, or an acyl derivative thereof, with an allyl, propyl or propargyl halide, and pharmaceutical compositions containing the salts (see Group VI).ALSO:Pharmaceutical compositions having an antagonistic action against morphine comprise, in association with a pharmaceutical carrier, a quarternary salt of normorphine containing a cation of the general formula <FORM:0874217/VI/1> (wherein R and R1 are the same or different and each represent a hydrogen atom or a C1-3 acyl group, and R1 and R2 are the same or different and each represent an allyl, propyl or propargyl group) in association with a non-toxic anion (e.g. a halide ion). The compositions may be in orally and parenterally administrable forms and may also be in suppository form. Examples are given of ampoules and tablets containing N-diallylnormorphinium bromide.
GB36582/59A 1958-10-30 1959-10-28 Normorphine derivatives Expired GB874217A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE874217X 1958-10-30

Publications (1)

Publication Number Publication Date
GB874217A true GB874217A (en) 1961-08-02

Family

ID=6816813

Family Applications (1)

Application Number Title Priority Date Filing Date
GB36582/59A Expired GB874217A (en) 1958-10-30 1959-10-28 Normorphine derivatives

Country Status (2)

Country Link
ES (1) ES252980A1 (en)
GB (1) GB874217A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009023567A1 (en) * 2007-08-09 2009-02-19 Rensselaer Polytechnic Institute Quaternary opioid carboxamides
US8436175B2 (en) 2010-03-22 2013-05-07 Rensselaer Polytechnic Institute Carboxamide bioisosteres of opiates
US8778960B2 (en) 2010-08-23 2014-07-15 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
US8962646B2 (en) 2011-06-29 2015-02-24 Alkermes, Inc. Peripherally acting opioid compounds
US9119848B2 (en) 2009-12-04 2015-09-01 Alkermes Pharma Ireland Limited Morphinan derivatives for the treatment of drug overdose
US9133125B2 (en) 2013-05-24 2015-09-15 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
US9656961B2 (en) 2013-05-24 2017-05-23 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
US11707466B2 (en) 2020-11-12 2023-07-25 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010535814A (en) * 2007-08-09 2010-11-25 レンセラール ポリテクニック インスティチュート Quaternary opioid carboxamide
US8263807B2 (en) 2007-08-09 2012-09-11 Rensselaer Polytechnic Institute Quaternary opioid carboxamides
AU2008286979B2 (en) * 2007-08-09 2013-03-28 Rensselaer Polytechnic Institute Quaternary opioid carboxamides
WO2009023567A1 (en) * 2007-08-09 2009-02-19 Rensselaer Polytechnic Institute Quaternary opioid carboxamides
US8563572B2 (en) 2007-08-09 2013-10-22 Rensselaer Polytechnic Institute Quaternary opioid carboxamides
NO341089B1 (en) * 2007-08-09 2017-08-21 Rensselaer Polytechnic Institute Office Of Tech Commercialization Quaternary opioid carboxamides
US9119848B2 (en) 2009-12-04 2015-09-01 Alkermes Pharma Ireland Limited Morphinan derivatives for the treatment of drug overdose
US8716306B2 (en) 2010-03-22 2014-05-06 Rensselaer Polytechnic Institute Carboxamide bioisosteres of opiates
US8957085B2 (en) 2010-03-22 2015-02-17 Rensselaer Polytechnic Institute Carboxamide bioisosteres of opiates
US8436175B2 (en) 2010-03-22 2013-05-07 Rensselaer Polytechnic Institute Carboxamide bioisosteres of opiates
US9422301B2 (en) 2010-03-22 2016-08-23 Rensselaer Polytechnic Institute Carboxamide bioisosteres of opiates
US8778960B2 (en) 2010-08-23 2014-07-15 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
US11351166B2 (en) 2010-08-23 2022-06-07 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
US11241425B2 (en) 2010-08-23 2022-02-08 Alkermes Pharma Ireland Limited Composition for treating mental illness
US8962646B2 (en) 2011-06-29 2015-02-24 Alkermes, Inc. Peripherally acting opioid compounds
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
US9682936B2 (en) 2013-05-24 2017-06-20 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
US9656961B2 (en) 2013-05-24 2017-05-23 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
US10231963B2 (en) 2013-05-24 2019-03-19 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
US10287250B2 (en) 2013-05-24 2019-05-14 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
US10736890B2 (en) 2013-05-24 2020-08-11 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
US10752592B2 (en) 2013-05-24 2020-08-25 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
US9416137B2 (en) 2013-05-24 2016-08-16 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
US9133125B2 (en) 2013-05-24 2015-09-15 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
US11534436B2 (en) 2013-05-24 2022-12-27 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
US11707466B2 (en) 2020-11-12 2023-07-25 Alkermes Pharma Ireland Limited Immediate release multilayer tablet
US11951111B2 (en) 2020-11-12 2024-04-09 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Also Published As

Publication number Publication date
ES252980A1 (en) 1960-11-01

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