GB874217A - Normorphine derivatives - Google Patents
Normorphine derivativesInfo
- Publication number
- GB874217A GB874217A GB36582/59A GB3658259A GB874217A GB 874217 A GB874217 A GB 874217A GB 36582/59 A GB36582/59 A GB 36582/59A GB 3658259 A GB3658259 A GB 3658259A GB 874217 A GB874217 A GB 874217A
- Authority
- GB
- United Kingdom
- Prior art keywords
- allyl
- propyl
- represent
- different
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises quaternary salts having a cation of the general formula <FORM:0874217/IV (b)/1> (wherein R and R1 are the same or different and each represent a hydrogen atom or a C1-C3 acyl group, and R1 and R2 are the same or different and each represent an allyl, propyl or propargyl group) in association with a non-toxic anion, the preparation of those containing a halide anion by reacting normorphine or N-propyl-, N-allyl- or N-propargyl-normorphine, or an acyl derivative thereof, with an allyl, propyl or propargyl halide, and pharmaceutical compositions containing the salts (see Group VI).ALSO:Pharmaceutical compositions having an antagonistic action against morphine comprise, in association with a pharmaceutical carrier, a quarternary salt of normorphine containing a cation of the general formula <FORM:0874217/VI/1> (wherein R and R1 are the same or different and each represent a hydrogen atom or a C1-3 acyl group, and R1 and R2 are the same or different and each represent an allyl, propyl or propargyl group) in association with a non-toxic anion (e.g. a halide ion). The compositions may be in orally and parenterally administrable forms and may also be in suppository form. Examples are given of ampoules and tablets containing N-diallylnormorphinium bromide.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE874217X | 1958-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB874217A true GB874217A (en) | 1961-08-02 |
Family
ID=6816813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB36582/59A Expired GB874217A (en) | 1958-10-30 | 1959-10-28 | Normorphine derivatives |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES252980A1 (en) |
GB (1) | GB874217A (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009023567A1 (en) * | 2007-08-09 | 2009-02-19 | Rensselaer Polytechnic Institute | Quaternary opioid carboxamides |
US8436175B2 (en) | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
US8778960B2 (en) | 2010-08-23 | 2014-07-15 | Alkermes Pharma Ireland Limited | Methods for treating antipsychotic-induced weight gain |
US8962646B2 (en) | 2011-06-29 | 2015-02-24 | Alkermes, Inc. | Peripherally acting opioid compounds |
US9119848B2 (en) | 2009-12-04 | 2015-09-01 | Alkermes Pharma Ireland Limited | Morphinan derivatives for the treatment of drug overdose |
US9133125B2 (en) | 2013-05-24 | 2015-09-15 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
US9656961B2 (en) | 2013-05-24 | 2017-05-23 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
US11707466B2 (en) | 2020-11-12 | 2023-07-25 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
-
1959
- 1959-10-28 GB GB36582/59A patent/GB874217A/en not_active Expired
- 1959-10-28 ES ES0252980A patent/ES252980A1/en not_active Expired
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010535814A (en) * | 2007-08-09 | 2010-11-25 | レンセラール ポリテクニック インスティチュート | Quaternary opioid carboxamide |
US8263807B2 (en) | 2007-08-09 | 2012-09-11 | Rensselaer Polytechnic Institute | Quaternary opioid carboxamides |
AU2008286979B2 (en) * | 2007-08-09 | 2013-03-28 | Rensselaer Polytechnic Institute | Quaternary opioid carboxamides |
WO2009023567A1 (en) * | 2007-08-09 | 2009-02-19 | Rensselaer Polytechnic Institute | Quaternary opioid carboxamides |
US8563572B2 (en) | 2007-08-09 | 2013-10-22 | Rensselaer Polytechnic Institute | Quaternary opioid carboxamides |
NO341089B1 (en) * | 2007-08-09 | 2017-08-21 | Rensselaer Polytechnic Institute Office Of Tech Commercialization | Quaternary opioid carboxamides |
US9119848B2 (en) | 2009-12-04 | 2015-09-01 | Alkermes Pharma Ireland Limited | Morphinan derivatives for the treatment of drug overdose |
US8716306B2 (en) | 2010-03-22 | 2014-05-06 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
US8957085B2 (en) | 2010-03-22 | 2015-02-17 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
US8436175B2 (en) | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
US9422301B2 (en) | 2010-03-22 | 2016-08-23 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
US8778960B2 (en) | 2010-08-23 | 2014-07-15 | Alkermes Pharma Ireland Limited | Methods for treating antipsychotic-induced weight gain |
US11351166B2 (en) | 2010-08-23 | 2022-06-07 | Alkermes Pharma Ireland Limited | Methods for treating antipsychotic-induced weight gain |
US11241425B2 (en) | 2010-08-23 | 2022-02-08 | Alkermes Pharma Ireland Limited | Composition for treating mental illness |
US8962646B2 (en) | 2011-06-29 | 2015-02-24 | Alkermes, Inc. | Peripherally acting opioid compounds |
US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
US9682936B2 (en) | 2013-05-24 | 2017-06-20 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
US9656961B2 (en) | 2013-05-24 | 2017-05-23 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
US10231963B2 (en) | 2013-05-24 | 2019-03-19 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
US10287250B2 (en) | 2013-05-24 | 2019-05-14 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
US10736890B2 (en) | 2013-05-24 | 2020-08-11 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
US10752592B2 (en) | 2013-05-24 | 2020-08-25 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
US9416137B2 (en) | 2013-05-24 | 2016-08-16 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
US9133125B2 (en) | 2013-05-24 | 2015-09-15 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
US11534436B2 (en) | 2013-05-24 | 2022-12-27 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
US11707466B2 (en) | 2020-11-12 | 2023-07-25 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
US11951111B2 (en) | 2020-11-12 | 2024-04-09 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Also Published As
Publication number | Publication date |
---|---|
ES252980A1 (en) | 1960-11-01 |
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