GB984361A - Pharmaceutical compositions containing quaternary ammonium salts - Google Patents
Pharmaceutical compositions containing quaternary ammonium saltsInfo
- Publication number
- GB984361A GB984361A GB8202/60A GB820260A GB984361A GB 984361 A GB984361 A GB 984361A GB 8202/60 A GB8202/60 A GB 8202/60A GB 820260 A GB820260 A GB 820260A GB 984361 A GB984361 A GB 984361A
- Authority
- GB
- United Kingdom
- Prior art keywords
- allyl
- propargyl
- methyl
- specifications
- isopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/10—Quaternary compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:0984361/C2/1> (wherein R1 and R2, which may be the same or different, represent methyl, ethyl, propyl, isopropyl, allyl, propargyl or 2-hydroxyethyl groups and X- represents a non-toxic anion, R1 and R2 being so chosen that when one of them is methyl and the other is not allyl or propargyl, then X- is not iodide, and when both are methyl, then X- is not bromide), and their preparation by heating a compound of the formula <FORM:0984361/C2/2> or <FORM:0984361/C2/3> with R2X or R1X. The compounds of the invention modify the action of the sympathomimetic amines (see Division A5). N - Allyl - 1,2,3,4 - tetrahydroisoqiunoline is prepared by reacting 1,2,3,4-tetrahydroisoquinoline with allyl bromide in the presence of potassium carbonate. Specifications 857,193, 857,194 and 984,362 are referred to.ALSO:The invention comprises 2-R1-2-R2-1,2,3,4 - tetrahydroisoquinolinium resinates, wherein R1 and R2 (which may be the same or different) represent methyl, ethyl, propyl, isopropyl, allyl, propargyl or 2-hydroxyethyl groups. Specifications 857,193, 857,194, and 984,362 are referred to.ALSO:Pharmaceutical and veterinary compositions comprise a pharmaceutical carrier and a quaternary ammonium salt of the general formula <FORM:0984361/A5-A6/1> (wherein R1 and R2, which may be the same or different, represent methyl, ethyl, propyl, isopropyl, allyl, propargyl or 2-hydroxyethyl groups and X- represents a non-toxic anion). The compositions may be administered orally or parenterally, e.g. in the form of solutions, suspensions, emulsions, elixirs, syrups, powders, tablets and capsules. The active ingredients modify the action of the sympathomimetic amines and may be used in the form of resinates. Specifications 857,193, 857,194 and 984,362 are referred to.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8202/60A GB984361A (en) | 1960-03-08 | 1960-03-08 | Pharmaceutical compositions containing quaternary ammonium salts |
US93874A US3175945A (en) | 1960-03-08 | 1961-03-07 | Antihypertensive quaternary ammonium salts of 1:2:3:4-tetrahydroisoquinoline |
FR41326A FR1453802A (en) | 1960-03-08 | 1961-03-08 | Method of preparation of new quaternary ammonium salts |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8202/60A GB984361A (en) | 1960-03-08 | 1960-03-08 | Pharmaceutical compositions containing quaternary ammonium salts |
Publications (1)
Publication Number | Publication Date |
---|---|
GB984361A true GB984361A (en) | 1965-02-24 |
Family
ID=9847820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8202/60A Expired GB984361A (en) | 1960-03-08 | 1960-03-08 | Pharmaceutical compositions containing quaternary ammonium salts |
Country Status (3)
Country | Link |
---|---|
US (1) | US3175945A (en) |
FR (1) | FR1453802A (en) |
GB (1) | GB984361A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3609154A (en) * | 1967-11-30 | 1971-09-28 | Hoffmann La Roche | 2-(arylpropyl)-1,2,3,4-tetrahydroisoquinolines, intermediates and processes |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB665192A (en) * | 1947-01-09 | 1952-01-16 | Abbott Lab | Improvements in or relating to pyridinium, quinolinium and isoquinolinium compounds |
NL90411C (en) * | 1953-12-04 | |||
US2957872A (en) * | 1957-10-21 | 1960-10-25 | Ciba Pharm Prod Inc | Phthalimidines and process for manufacturing same |
-
1960
- 1960-03-08 GB GB8202/60A patent/GB984361A/en not_active Expired
-
1961
- 1961-03-07 US US93874A patent/US3175945A/en not_active Expired - Lifetime
- 1961-03-08 FR FR41326A patent/FR1453802A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3609154A (en) * | 1967-11-30 | 1971-09-28 | Hoffmann La Roche | 2-(arylpropyl)-1,2,3,4-tetrahydroisoquinolines, intermediates and processes |
Also Published As
Publication number | Publication date |
---|---|
US3175945A (en) | 1965-03-30 |
FR1453802A (en) | 1966-07-22 |
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