GB984361A - Pharmaceutical compositions containing quaternary ammonium salts - Google Patents

Pharmaceutical compositions containing quaternary ammonium salts

Info

Publication number
GB984361A
GB984361A GB8202/60A GB820260A GB984361A GB 984361 A GB984361 A GB 984361A GB 8202/60 A GB8202/60 A GB 8202/60A GB 820260 A GB820260 A GB 820260A GB 984361 A GB984361 A GB 984361A
Authority
GB
United Kingdom
Prior art keywords
allyl
propargyl
methyl
specifications
isopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8202/60A
Inventor
Leslie Frederick Wiggins
Richard William Temple
Maurice Ward Gittos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aspro Nicholas Ltd
Original Assignee
Aspro Nicholas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspro Nicholas Ltd filed Critical Aspro Nicholas Ltd
Priority to GB8202/60A priority Critical patent/GB984361A/en
Priority to US93874A priority patent/US3175945A/en
Priority to FR41326A priority patent/FR1453802A/en
Publication of GB984361A publication Critical patent/GB984361A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0984361/C2/1> (wherein R1 and R2, which may be the same or different, represent methyl, ethyl, propyl, isopropyl, allyl, propargyl or 2-hydroxyethyl groups and X- represents a non-toxic anion, R1 and R2 being so chosen that when one of them is methyl and the other is not allyl or propargyl, then X- is not iodide, and when both are methyl, then X- is not bromide), and their preparation by heating a compound of the formula <FORM:0984361/C2/2> or <FORM:0984361/C2/3> with R2X or R1X. The compounds of the invention modify the action of the sympathomimetic amines (see Division A5). N - Allyl - 1,2,3,4 - tetrahydroisoqiunoline is prepared by reacting 1,2,3,4-tetrahydroisoquinoline with allyl bromide in the presence of potassium carbonate. Specifications 857,193, 857,194 and 984,362 are referred to.ALSO:The invention comprises 2-R1-2-R2-1,2,3,4 - tetrahydroisoquinolinium resinates, wherein R1 and R2 (which may be the same or different) represent methyl, ethyl, propyl, isopropyl, allyl, propargyl or 2-hydroxyethyl groups. Specifications 857,193, 857,194, and 984,362 are referred to.ALSO:Pharmaceutical and veterinary compositions comprise a pharmaceutical carrier and a quaternary ammonium salt of the general formula <FORM:0984361/A5-A6/1> (wherein R1 and R2, which may be the same or different, represent methyl, ethyl, propyl, isopropyl, allyl, propargyl or 2-hydroxyethyl groups and X- represents a non-toxic anion). The compositions may be administered orally or parenterally, e.g. in the form of solutions, suspensions, emulsions, elixirs, syrups, powders, tablets and capsules. The active ingredients modify the action of the sympathomimetic amines and may be used in the form of resinates. Specifications 857,193, 857,194 and 984,362 are referred to.
GB8202/60A 1960-03-08 1960-03-08 Pharmaceutical compositions containing quaternary ammonium salts Expired GB984361A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB8202/60A GB984361A (en) 1960-03-08 1960-03-08 Pharmaceutical compositions containing quaternary ammonium salts
US93874A US3175945A (en) 1960-03-08 1961-03-07 Antihypertensive quaternary ammonium salts of 1:2:3:4-tetrahydroisoquinoline
FR41326A FR1453802A (en) 1960-03-08 1961-03-08 Method of preparation of new quaternary ammonium salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8202/60A GB984361A (en) 1960-03-08 1960-03-08 Pharmaceutical compositions containing quaternary ammonium salts

Publications (1)

Publication Number Publication Date
GB984361A true GB984361A (en) 1965-02-24

Family

ID=9847820

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8202/60A Expired GB984361A (en) 1960-03-08 1960-03-08 Pharmaceutical compositions containing quaternary ammonium salts

Country Status (3)

Country Link
US (1) US3175945A (en)
FR (1) FR1453802A (en)
GB (1) GB984361A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3609154A (en) * 1967-11-30 1971-09-28 Hoffmann La Roche 2-(arylpropyl)-1,2,3,4-tetrahydroisoquinolines, intermediates and processes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB665192A (en) * 1947-01-09 1952-01-16 Abbott Lab Improvements in or relating to pyridinium, quinolinium and isoquinolinium compounds
NL90411C (en) * 1953-12-04
US2957872A (en) * 1957-10-21 1960-10-25 Ciba Pharm Prod Inc Phthalimidines and process for manufacturing same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3609154A (en) * 1967-11-30 1971-09-28 Hoffmann La Roche 2-(arylpropyl)-1,2,3,4-tetrahydroisoquinolines, intermediates and processes

Also Published As

Publication number Publication date
US3175945A (en) 1965-03-30
FR1453802A (en) 1966-07-22

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