GB846611A - Nitroquinolones - Google Patents

Nitroquinolones

Info

Publication number
GB846611A
GB846611A GB405758A GB405758A GB846611A GB 846611 A GB846611 A GB 846611A GB 405758 A GB405758 A GB 405758A GB 405758 A GB405758 A GB 405758A GB 846611 A GB846611 A GB 846611A
Authority
GB
United Kingdom
Prior art keywords
general formula
ethyl
compounds
amino
quinaldine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB405758A
Inventor
Walter Hepworth
John Selwyn Morley
Gilbert Joseph Stacey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB405758A priority Critical patent/GB846611A/en
Publication of GB846611A publication Critical patent/GB846611A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula :-<FORM:0846611/IV(b)/1> wherein R and R1 are the same or different and are alkyl radicals, and the preparation thereof by the alkylation of compounds of the general formula <FORM:0846611/IV(b)/2> or by the nitration of compounds of the general formula <FORM:0846611/IV(b)/3> or by the hydrolysis of salts of the general formula <FORM:0846611/IV(b)/4> where R2 represents a hydrolysable atom or group and X an anion 2-Ethyl-4-hydroxy-6-nitroquinoline is prepared by the nitration of 2-ethyl-4-hydro-xyquinoline ; 1 - ethyl - 2 - methyl - 4 - quinolone by hydrolysis with sodium hydroxide of 4-amino-1-ethyl-quinaldiniumiodide, in turn prepared from 4-aminoquinaldine and diethyl sulphate followed by treatment with potassium iodide ; and 4-amino-1:2-dimethyl-6-nitroquinolinium bromide from dimethyl sulphate, sodium bromide and 4-amino-6-nitro-quinaldine, in turn prepared from 4-chloro-6-nitro-quinaldine, acetamide, phenol and ammonia.ALSO:Antibacterial compositions (for oral or parenteral use) comprise as active ingredient or ingredients at least one of the compounds of the general formula: <FORM:0846611/VI/1> where R and R1 are the same or different alkyl groups in admixture with an inert diluent or carrier. The compositions may include aqueous and non-aqueous solutions or suspensions, dispersible powders and granules, creams and ointments, tablets, pills, pessaries, bougies, mixtures with foodstuffs and mixtures with solid diluents for admixture with foodstuffs and may contain other known therapeutic agents.
GB405758A 1958-02-07 1958-02-07 Nitroquinolones Expired GB846611A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB405758A GB846611A (en) 1958-02-07 1958-02-07 Nitroquinolones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB405758A GB846611A (en) 1958-02-07 1958-02-07 Nitroquinolones

Publications (1)

Publication Number Publication Date
GB846611A true GB846611A (en) 1960-08-31

Family

ID=9769913

Family Applications (1)

Application Number Title Priority Date Filing Date
GB405758A Expired GB846611A (en) 1958-02-07 1958-02-07 Nitroquinolones

Country Status (1)

Country Link
GB (1) GB846611A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3521264B2 (en) 1999-08-30 2004-04-19 丸石製薬株式会社 1,2-Disubstituted-1,4-dihydro-4-oxoquinoline compounds having antiviral activity
JP2020512356A (en) * 2017-03-30 2020-04-23 ザ ボード オブ レジェンツ オブ ザ ユニバーシティ オブ テキサス システム Quinoline-derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT) and uses thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3521264B2 (en) 1999-08-30 2004-04-19 丸石製薬株式会社 1,2-Disubstituted-1,4-dihydro-4-oxoquinoline compounds having antiviral activity
JP2020512356A (en) * 2017-03-30 2020-04-23 ザ ボード オブ レジェンツ オブ ザ ユニバーシティ オブ テキサス システム Quinoline-derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT) and uses thereof
EP3600317A4 (en) * 2017-03-30 2020-12-23 The Board of Regents of The University of Texas System Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof
US11401243B2 (en) * 2017-03-30 2022-08-02 The Board Of Regents Of The University Of Texas System Quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT) and uses thereof

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