ES252980A1 - Normorphine derivatives - Google Patents
Normorphine derivativesInfo
- Publication number
- ES252980A1 ES252980A1 ES0252980A ES252980A ES252980A1 ES 252980 A1 ES252980 A1 ES 252980A1 ES 0252980 A ES0252980 A ES 0252980A ES 252980 A ES252980 A ES 252980A ES 252980 A1 ES252980 A1 ES 252980A1
- Authority
- ES
- Spain
- Prior art keywords
- allyl
- propyl
- represent
- different
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises quaternary salts having a cation of the general formula <FORM:0874217/IV (b)/1> (wherein R and R1 are the same or different and each represent a hydrogen atom or a C1-C3 acyl group, and R1 and R2 are the same or different and each represent an allyl, propyl or propargyl group) in association with a non-toxic anion, the preparation of those containing a halide anion by reacting normorphine or N-propyl-, N-allyl- or N-propargyl-normorphine, or an acyl derivative thereof, with an allyl, propyl or propargyl halide, and pharmaceutical compositions containing the salts (see Group VI).ALSO:Pharmaceutical compositions having an antagonistic action against morphine comprise, in association with a pharmaceutical carrier, a quarternary salt of normorphine containing a cation of the general formula <FORM:0874217/VI/1> (wherein R and R1 are the same or different and each represent a hydrogen atom or a C1-3 acyl group, and R1 and R2 are the same or different and each represent an allyl, propyl or propargyl group) in association with a non-toxic anion (e.g. a halide ion). The compositions may be in orally and parenterally administrable forms and may also be in suppository form. Examples are given of ampoules and tablets containing N-diallylnormorphinium bromide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE874217X | 1958-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES252980A1 true ES252980A1 (en) | 1960-11-01 |
Family
ID=6816813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0252980A Expired ES252980A1 (en) | 1958-10-30 | 1959-10-28 | Normorphine derivatives |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES252980A1 (en) |
| GB (1) | GB874217A (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101519682B1 (en) * | 2007-08-09 | 2015-05-19 | 렌슬러 폴리테크닉 인스티튜트 | Quaternary opioid carboxamides |
| RS58894B1 (en) | 2009-12-04 | 2019-08-30 | Alkermes Pharma Ireland Ltd | Morphinan derivatives for the treatment of drug overdose |
| EP2550253B9 (en) | 2010-03-22 | 2016-09-21 | Rensselaer Polytechnic Institute | Morphinane derivatives containing a carboxamide group as opioid receptor ligands |
| HUE041981T2 (en) | 2010-08-23 | 2019-06-28 | Alkermes Pharma Ireland Ltd | Methods for treating antipsychotic-induced weight gain |
| JP5981992B2 (en) | 2011-06-29 | 2016-08-31 | アルカーメス，インコーポレイテッド | Peripherally acting opioid compounds |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| US9656961B2 (en) | 2013-05-24 | 2017-05-23 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
| AU2014268361B2 (en) | 2013-05-24 | 2018-09-06 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
| WO2022101444A1 (en) | 2020-11-12 | 2022-05-19 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
-
1959
- 1959-10-28 ES ES0252980A patent/ES252980A1/en not_active Expired
- 1959-10-28 GB GB36582/59A patent/GB874217A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB874217A (en) | 1961-08-02 |
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